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Dr. Mary O'Sullivan

Research Fellow (Clinical Medicine)

 Mary.OSullivan@tcd.ie

 3531896 4296

Associate Research Lecturer (Trinity Translational Medicine Institute)


Research Tags

  Apoptosis   Autophagy   Caspase proteases   CELL DEATH   Host, Pathogen interactions   Imaging Techniques   Immunology   Infectious diseases   Inflammation   Innate immunology   Intra and intercellular signalling   Metabolism   Mycobacterium tuberculosis

Research Projects

 Investigation of the fungicidal activity of macrophages against the fungal pathogen Aspergillus fumigatus with an automated live cell imaging microscope.
 Investigation of the fungicidal activity of macrophages against the fungal pathogen Aspergillus fumigatus with an automated live cell imaging microscope.
 Correcting Pulmonary Immunity through manipulation of CFTR
 Defining the role of human dendritic cell subsets in host immune responses to mycobacterial infection.
 Immunometabolic manipulation of pulmonary immunity - towards TB host directed therapy

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Representations

Details Date
Member, Imaging Focus Group Meeting, 1-Day meeting on Biomedical Imaging - 8th June 2004 run in conjunction with TCINFrom single cell & molecular through to organ & whole bodyLast Revised : 22 May 2004
Member, PHG Funded PI's and Researchers, All Researchers funded under Cycle 3 PRTLI - Programme for Human Genomics

Memberships

Membership of Professional Institutions, Associations, Societies

Details Date From Date To
American Association for the Advancement of Science 1995 Present
American Thoracic Society 2009
Bahlool AZ, Cavanagh B, Sullivan AO, MacLoughlin R, Keane J, Sullivan MPO, Cryan SA., Microfluidics produced ATRA-loaded PLGA NPs reduced tuberculosis burden in alveolar epithelial cells and enabled high delivered dose under simulated human breathing pattern in 3D printed head models., European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, 2024, p106734 , Journal Article, PUBLISHED  DOI
Bedard M, van der Niet S, Bernard EM, Babunovic GH, Cheng TY, Aylan B, Grootemaat AE, Raman S, Botella L, Ishikawa E, O'Sullivan MP, O'Leary S, Mayfield JA, Buter J, Minnaard AJ, Fortune SM, Murphy LO, Ory DS, Keane J, Yamasaki S, Gutierrez MG, van der Wel N, Moody DB., A terpene nucleoside from M. tuberculosis induces lysosomal lipid storage in foamy macrophages., The Journal of clinical investigation, 2023, pe161944 , Journal Article, PUBLISHED  DOI
Triglia D, Gogan KM, Keane J, O'Sullivan MP., Glucose metabolism and its role in the maturation and migration of human CD1c+ dendritic cells following exposure to BCG., Frontiers in cellular and infection microbiology, 13, 2023, p1113744 , Journal Article, PUBLISHED  DOI
Bahlool AZ, Fattah S, O'Sullivan A, Cavanagh B, MacLoughlin R, Keane J, O'Sullivan MP, Cryan SA., Development of Inhalable ATRA-Loaded PLGA Nanoparticles as Host-Directed Immunotherapy against Tuberculosis., Pharmaceutics, 14, (8), 2022, p1745 , Journal Article, PUBLISHED  DOI
Bahlool AZ, Grant C, Cryan SA, Keane J, O'Sullivan MP., All trans retinoic acid as a host-directed immunotherapy for tuberculosis., Curr Res Immunol, 3, 2022, p54-72 , Journal Article, PUBLISHED  DOI
O'Leary S, Bahlool AZ, O'Connor G, Cryan SA, Keane JM, O'Sullivan MP., An Automated Culture System for Use in Preclinical Testing of Host-Directed Therapies for Tuberculosis., Journal of visualized experiments : JoVE, (174), 2021, Journal Article, PUBLISHED  DOI
Phelan J.J., McQuaid, K., Kenny C., Gogan K.M., Cox D.J., Basdeo S.A., O'Leary S., Tazoll S.C., Ó Maoldomhnaigh C., O'Sullivan M.P., O'Neill LA, O'Sullivan M.J. & Keane J., Desferrioxamine supports metabolic function in primary human macrophages infected with Mycobacterium tuberculosis, Frontiers in Immunology, 2020, Journal Article, PUBLISHED  TARA - Full Text  DOI  URL
O'Connor G, Krishnan N, Fagan-Murphy A, Cassidy J, O'Leary S, Robertson BD, Keane J, O'Sullivan MP, Cryan SA., Inhalable poly(lactic-co-glycolic acid) (PLGA) microparticles encapsulating all-trans-Retinoic acid (ATRA) as a host-directed, adjunctive treatment for Mycobacterium tuberculosis infection., European Journal of Pharmaceutics and Biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V, 134, 2019, p153-165 , Journal Article, PUBLISHED  DOI
Cambier CJ, O'Leary SM, O'Sullivan MP, Keane J, Ramakrishnan L., Phenolic Glycolipid Facilitates Mycobacterial Escape from Microbicidal Tissue-Resident Macrophages., Immunity, 47, (3), 2017, p552 - 565, Journal Article, PUBLISHED  TARA - Full Text  DOI
Berg RD, Levitte S, O'Sullivan MP, O'Leary SM, Cambier CJ, Cameron J, Takaki KK, Moens CB, Tobin DM, Keane J, Ramakrishnan L, Lysosomal Disorders Drive Susceptibility to Tuberculosis by Compromising Macrophage Migration., Cell, 165, (1), 2016, p139 - 152, Journal Article, PUBLISHED  URL
  

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Regulation of epithelial-leukocyte interaction and epithelial immune-response genes in, Asthma and Rhinitis, Cambridge, MA, Blackwell Scientific, 2000, pp784 - 800, [MJ Holtzman, M Castro, DC Look, M O'Sullivan, MJ Walter], Book Chapter, PUBLISHED

  

Awards and Honours

Award Date
Dean's Research Initiatives Research Fund Bursary February 2016
American Thoracic Society Travel Award 2007
Irish Thoracic Society Award for Best Oral Presentation 2008