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Dr. Mary O'Sullivan

Research Fellow (Clinical Medicine)

Associate Research Lecturer (Trinity Translational Medicine Institute)

  Apoptosis   Autophagy   Caspase proteases   CELL DEATH   Host, Pathogen interactions   Imaging Techniques   Immunology   Infectious diseases   Inflammation   Innate immunology   Intra and intercellular signalling   Metabolism   Mycobacterium tuberculosis
 Investigation of the fungicidal activity of macrophages against the fungal pathogen Aspergillus fumigatus with an automated live cell imaging microscope.
 Correcting Pulmonary Immunity through manipulation of CFTR
 Defining the role of human dendritic cell subsets in host immune responses to mycobacterial infection.
 Immunometabolic manipulation of pulmonary immunity - towards TB host directed therapy
 Towards host-directed therapies to overcome immune impairment in cigarette smokers during mycobacterial infection

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Details Date
Member, Imaging Focus Group Meeting, 1-Day meeting on Biomedical Imaging - 8th June 2004 run in conjunction with TCINFrom single cell & molecular through to organ & whole bodyLast Revised : 22 May 2004
Member, PHG Funded PI's and Researchers, All Researchers funded under Cycle 3 PRTLI - Programme for Human Genomics
Details Date From Date To
American Association for the Advancement of Science 1995 Present
American Thoracic Society 2009
Klionsky DJ et al., Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition), Autophagy, 2021, Notes: [10.1080/15548627.2020.1797280], Journal Article, IN_PRESS  URL
Phelan J.J., McQuaid, K., Kenny C., Gogan K.M., Cox D.J., Basdeo S.A., O'Leary S., Tazoll S.C., Ó Maoldomhnaigh C., O'Sullivan M.P., O'Neill LA, O'Sullivan M.J. & Keane J., Desferrioxamine supports metabolic function in primary human macrophages infected with Mycobacterium tuberculosis, Frontiers in Immunology, 2020, Journal Article, PUBLISHED  TARA - Full Text  DOI  URL
O'Connor G, Krishnan N, Fagan-Murphy A, Cassidy J, O'Leary S, Robertson BD, Keane J, O'Sullivan MP, Cryan SA., Inhalable poly(lactic-co-glycolic acid) (PLGA) microparticles encapsulating all-trans-Retinoic acid (ATRA) as a host-directed, adjunctive treatment for Mycobacterium tuberculosis infection., European Journal of Pharmaceutics and Biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V, 134, 2019, p153-165 , Journal Article, PUBLISHED  DOI
Cambier CJ, O'Leary SM, O'Sullivan MP, Keane J, Ramakrishnan L., Phenolic Glycolipid Facilitates Mycobacterial Escape from Microbicidal Tissue-Resident Macrophages., Immunity, 47, (3), 2017, p552 - 565, Journal Article, PUBLISHED  TARA - Full Text  DOI
Berg RD, Levitte S, O'Sullivan MP, O'Leary SM, Cambier CJ, Cameron J, Takaki KK, Moens CB, Tobin DM, Keane J, Ramakrishnan L, Lysosomal Disorders Drive Susceptibility to Tuberculosis by Compromising Macrophage Migration., Cell, 165, (1), 2016, p139 - 152, Journal Article, PUBLISHED  URL
Ní Cheallaigh, C., Sheedy, F.J., Harris, J., Muñoz-Wolf, N., Lee, J., West, K., McDermott, E.P., Smyth, A., Gleeson, L.E., Coleman, M., Martinez, N., Hearnden, C.H., Tynan, G.A., Carroll, E.C., Jones, S.A., Corr, S.C., Bernard, N.J., Hughes, M.M., Corcoran, S.E., O'Sullivan, M., Fallon, C.M., Kornfeld, H., Golenbock, D., Gordon, S.V., O'Neill, L.A., Keane, J. Lavelle, E.C, A Common Variant in the Adaptor Mal Regulates Interferon Gamma Signaling., Immunity, 44, (2), 2016, p368 - 379, Journal Article, PUBLISHED  TARA - Full Text  URL
O'Connor G, Gleeson LE, Fagan-Murphy A, Cryan SA, O'Sullivan MP, Keane J, Sharpening nature's tools for efficient tuberculosis control: A review of the potential role and development of host-directed therapies and strategies for targeted respiratory delivery., Advanced Drug Delivery Reviews, 102, 2016, p33 - 54, Journal Article, PUBLISHED  URL
Lawlor C, O'Connor G, O'Leary S, Gallagher PJ, Cryan SA, Keane J, O'Sullivan MP, Treatment of Mycobacterium tuberculosis-Infected Macrophages with Poly(Lactic-Co-Glycolic Acid) Microparticles Drives NF"B and Autophagy Dependent Bacillary Killing., PloS one, 11, (2), 2016, pe0149167 , Journal Article, PUBLISHED  TARA - Full Text  DOI  URL
Gleeson LE, Sheedy FJ, Palsson-McDermott EM, Triglia D, O'Leary SM, O'Sullivan MP, O'Neill LA, Keane J, Cutting Edge: Mycobacterium tuberculosis Induces Aerobic Glycolysis in Human Alveolar Macrophages That Is Required for Control of Intracellular Bacillary Replication., Journal of immunology (Baltimore, Md. : 1950), 196, (6), 2016, p2444-2449 , Journal Article, PUBLISHED  TARA - Full Text  DOI  URL
O'Leary SM, Coleman MM, Chew WM, Morrow C, McLaughlin AM, Gleeson LE, O'Sullivan MP, Keane J., Cigarette smoking impairs human pulmonary immunity to Mycobacterium tuberculosis., American Journal of Respiratory and Critical Care Medicine, 190, (12), 2014, p1430 - 1436, Journal Article, PUBLISHED  URL

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Regulation of epithelial-leukocyte interaction and epithelial immune-response genes in, Asthma and Rhinitis, Cambridge, MA, Blackwell Scientific, 2000, pp784 - 800, [MJ Holtzman, M Castro, DC Look, M O'Sullivan, MJ Walter], Book Chapter, PUBLISHED


Award Date
Dean's Research Initiatives Research Fund Bursary February 2016
American Thoracic Society Travel Award 2007
Irish Thoracic Society Award for Best Oral Presentation 2008