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Dr. Niamh O'Boyle

Assistant Professor (Pharmacy)
23 WESTLAND ROW


Dr. Niamh O'Boyle is an Assistant Professor in Pharmaceutical Chemistry in Trinity College Dublin. She received her BSc(Pharm)(1st class) and PhD degree from Trinity College Dublin, working with Prof. Mary J. Meegan. She subsequently completed postdoctoral fellowships at the University of Gothenburg (Sweden) with Prof. Ann-Therese Karlberg and the School of Biochemistry and Immunology (TCD), working with Prof. Daniela Zisterer. Niamh is fascinated by the interaction of chemicals, both drugs and toxins, with the body. This inspires her research in the development of novel drugs for hard-to-treat cancers and in discovering the underlying mechanisms of skin allergy. She runs several diverse research projects and is currently supported by the TCD Provost's PhD Project Award, Panoz Pharmaceutical Innovation PhD Scholarship, Irish Research Council, EU MSCA-RISE (CRYSTAL3), Wellcome Trust, CAMS-UK, the Royal Society of Chemistry and Enterprise Ireland. Her research work is consistently published in high-quality international, peer-reviewed journals and she has been a co-applicant on two published patents. Niamh is a member of the Pharmaceutical Society of Ireland and the Royal Society of Chemistry. She is the early career representative on the Royal Society of Chemistry Ireland Regional Steering Group (2020 - 2023) and is a committee member of the international GP2A medicinal chemistry group. She has been appointed to the Physical, Chemical & Mathematical Sciences multidisciplinary committee of the Royal Irish Academy (2022-2026). She is also involved with AthenaSwan through the School of Pharmacy and Pharmaceutical Sciences Self-Assessment Team. She is passionate about outreach and has been involved in EU Researchers Night and Higher Options, amongst others. She developed and delivered an online interactive workshop called 'Kids Science: Coronavirus' to over 1500 children aged 7-10 across Ireland and abroad in 2020-21.
  ALLERGIC CONTACT DERMATITIS   Anticancer Drug Design   ANTICANCER DRUGS   Antiestrogens   ANTI-TUBULIN ACTIVITY   BREAST CANCER   Cancer drug discovery   COLON CANCER   Design, synthesis and mechanism of action of novel anti-estrogenic compounds   Drug discovery   EPOXY   EPOXY RESINS   ESTROGEN   Estrogen Receptor   INDUCED LIPID-PEROXIDATION   LIPID OXIDATION   Multidisciplinary approach to drug discovery and development   OESTROGEN   PHOTOALLERGIC CONTACT-DERMATITIS   TAMOXIFEN
 Biochemical Evaluation of the 'Combretazets' - Novel and Potent Drugs for Treating Multi-Drug Resistant Cancers
 Analysis of Skin Lipids in Contact Allergy by Mass Spectrometry
 Can the stress response to reactive oxygen species in tumours be exploited to give a new class of anti-cancer drugs? Dual-targeting of the stress response to reactive oxygen species and tubulin by piperlongumine and related analogues
 Development of Novel Anti-Tumour Beta-Lactams for Treatment of Aggressive Breast Cancer
 Investigation of the effects of hormonal cancer therapy on levels of interferon epsilon in cancer cells of female reproductive tract and breast

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Details Date
Physical, Chemical & Mathematical Sciences multidisciplinary committee of the Royal Irish Academy (member) 2022-2026
Committee member of the GP2A Group of Medicinal Chemists of the Atlantic Arc (Groupement des Pharmacochimistes de l'Arc Atlantique) 2017 - present
Early Career Representative for the Ireland Regional Steering Group of the Royal Society of Chemistry 2020 - 2023
Management committee substitute (Ireland) and working group member - COST Action CA17104 Stratagem 2019
Member of the COST COVID-19 Task Force 2020
Language Skill Reading Skill Writing Skill Speaking
English Fluent Fluent Fluent
French Medium Basic Basic
Irish Medium Basic Medium
Swedish Fluent Fluent Fluent
Details Date From Date To
Member of the Pharmaceutical Society of Ireland 2007 Present
Member of the Royal Society of Chemistry 2017 Present
Member of the Irish Association for Cancer Research 2016 Present
Member of the European Association for Cancer Research 2016 Present
Member of the European Society for Contact Dermatitis 2019 Present
Member of Irish Platform for Patient Organisations, Science & Industry (IPPOSI) 2019 Present
O'Boyle, Niamh; Niklasson, Ida; Ponting, David; Ortega, Miguel; Seifert, Tina; Natsch, Andreas; Luthman, Kristina; Karlberg, Ann-Therese, Nature-Derived Epoxy Resins: Synthesis, Allergenicity and Thermosetting Properties of Pinoresinol Diglycidyl Ether, Toxicology and Industrial Health, 2022, Notes: [Accepted for publication 5th March 2022], Journal Article, PUBLISHED
Mary J. Meegan and Niamh M. O'Boyle, Anticancer Drugs 2021, MDPI, 2021, Book, PUBLISHED  URL
Sophie Knox, Niamh M. O'Boyle, Skin Lipids in Health and Disease: A Review, Chemistry and Physics of Lipids, 2021, p105055-, Journal Article, PUBLISHED  DOI  URL
Gloria Ana, Patrick M. Kelly, Azizah M. Malebari, Sara Noorani, Seema M. Nathwani, Brendan Twamley, Darren Fayne, Niamh M. O'Boyle, Daniela M. Zisterer, Elisangela Flavia Pimentel, Denise Coutinho Endringer and Mary J. Meegan, Synthesis and Biological Evaluation of 1-(Diarylmethyl)-1H-1,2,4-Triazoles and 1-(Diarylmethyl)-1H-Imidazoles as a Novel Class of Anti-Mitotic Agent for Activity in Breast Cancer, Pharmaceuticals, 14, (2), 2021, p169-, Journal Article, PUBLISHED  DOI  URL
Malebari A.M., Wang S., Greene T.F., O'Boyle N.M., Fayne D., Khan M.F., Nathwani S.M., Twamley B., McCabe T., Zisterer D.M., Meegan M.J., Synthesis and antiproliferative evaluation of 3-chloroazetidin-2-ones with antimitotic activity: Heterocyclic bridged analogues of combretastatin A-4, Pharmaceuticals, 14, (11), 2021, part. 1119-, Journal Article, PUBLISHED  DOI
Eavan C. McLoughlin and Niamh M. O'Boyle, Colchicine-Binding Site Inhibitors from Chemistry to Clinic: A Review , Pharmaceuticals, 13, (1), 2020, Journal Article, PUBLISHED  DOI  URL  Other
Miriam Carr, Andrew J.S. Knox, Daniel K. Nevin, Niamh O'Boyle, Shu Wang, Billy Egan, Thomas McCabe, Brendan Twamley, Daniela M. Zisterer, David G. Lloyd, Mary J. Meegan, Optimisation of Estrogen Receptor Subtype-Selectivity of a 4-Aryl-4H-Chromene Scaffold Previously Identified by Virtual Screening, Bioorganic & Medicinal Chemistry, 28, (5), 2020, p115261-, Journal Article, PUBLISHED
Twamley, B., O'Boyle, N.M., Meegan, M.J., Azetidin-2-ones: Structures of antimitotic compounds based on the 1-(3,4,5-trimethoxyphenyl)azetidin-2-one core, Acta Crystallographica Section E: Crystallographic Communications, 76, 2020, p1187 - 1194, Journal Article, PUBLISHED  DOI  URL
Azizah M. Malebari, Darren Fayne, Seema M. Nathwani, Fiona O'Connell, Sara Noorani, Brendan Twamley, Niamh M. O'Boyle, Jacintha O'Sullivan, Daniela M. Zisterer, Mary J. Meegan, Beta-lactams with antiproliferative and antiapoptotic activity in breast and chemoresistant colon cancer cells, European Journal of Medicinal Chemistry, 189, 2020, p112050-, Journal Article, PUBLISHED  DOI  URL
T. S. Ibrahim, M. M. Hawwas, A. M. Malebari, E. S. Taher, A. M. Omar, N. M. O'Boyle, E. McLoughlin, Z.K. Abdel-Samii, Y. A. M. M. Elshaier, Potent Quinoline-Containing Combretastatin A-4 Analogues: Design, Synthesis, Antiproliferative, and Anti-Tubulin Activity, Pharmaceuticals, 13, (11), 2020, p393-, Journal Article, PUBLISHED  DOI  URL
  

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Mary J. Meegan and Niamh M. O'Boyle, Special Issue "Anticancer Drugs 2021" , Pharmaceuticals, 15, (4), 2022, p479-, Journal Article, PUBLISHED
Niamh O'Boyle, Probing the Skin with ToF-SIMS: do Metal Allergens Change Lipid Composition?, 29th Meeting of the European Research Group on Experimental Contact Dermatitis, Online, 3rd February, 2021, Invited Talk, PUBLISHED
Helesbeux J.-J., Carro L., McCarthy F.O., Moreira V.M., Giuntini F., O'Boyle N.M., Matthews S.E., Bayraktar G., Bertrand S., Rochais C., Marchand P., 29th Annual GP2A Medicinal Chemistry Conference, Pharmaceuticals, 14, (12), 2021, part. 1278 , Journal Article, PUBLISHED
Eavan C. McLoughlin, Nithya Valupadasu, Niamh M. O''Boyle, A phosphate prodrug of pyrazinib: Improved solubility and antiproliferative activity, 7th International Electronic Conference on Medicinal Chemistry, November 2021, edited by Jean Jacques Vanden Eynde , 2021, Poster, PUBLISHED
Eavan C. McLoughlin, Niamh M. O'Boyle, Combretazets: Enantiomeric Beta−Lactams for the Treatment of Breast Cancer, 6th International Electronic Conference on Medicinal Chemistry, Online (https://ecmc2020.sciforum.net/), 01-30 November 2020, edited by Dr. Jean Jacques Vanden Eynde , MDPI, 2020, Oral Presentation, PUBLISHED
Niamh O'Boyle, Epoxy Resins - From Chemistry to Clinic, Occupational and Environmental Exposure of the Skin to Chemicals, Dublin, 16 - 18 Sept. 2019, 2019, Oral Presentation, PUBLISHED
Niamh O'Boyle, Organic chemistry practicals: introduction of pre-laboratory assessments for first year pharmacy students, Irish Variety in Chemistry Education 2019, Dublin Institute of Technology, Kevin Street, 26th April 2019, edited by Claire McDonnell , 2019, Oral Presentation, PUBLISHED
Eavan Ciara McLoughlin, Niamh O'Boyle, Mary Meegan, Stories from Staudinger: Synthesis of chiral beta-lactams, 5th International Electronic Conference on Medicinal Chemistry, Online at https://sciforum.net/conference/ECMC2019, November 2019, 2019, Poster, PUBLISHED
Niamh O'Boyle, Benzoxepin-Type Selective Estrogen Receptor (ER) Modulators and Downregulators with Subtype-Specific ERalpha and ERbeta Activity, 26th Annual GP2A Medicinal Chemistry Conference & 32nd Journées Franco-Belges de Pharmacochimie, Asnelles sur Mer, Normandie, France, 13th June 2018, 2018, GP2A, Invited Talk, PUBLISHED
James Patrick Mc Keown, Clara Charleton, Keith Ferris, Sara Noorani, Niamh M O'Boyle, Mary J Meegan, Ethanoanthracenes: Potential chemotherapeutics for chronic lymphocytic leukaemia (CLL), 4th International Electronic Conference on Medicinal Chemistry, Online at www.sciforum.net/conference/ecmc-4, November 2018, edited by MDPI , 2018, Poster, PUBLISHED

  

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Award Date
Best Poster Presentation, STRATAGEM WG2 Meeting and International Online Symposium on "Synthesis and nanodelivery strategies for new therapeutic tools against Multidrug Resistant Tumours" (online) 15-Dec-2020
CAMS-UK Fellowship 2019
Trinity College Dublin Provost's PhD Project Award 2018
Outstanding Reviewer Award, European Journal of Medicinal Chemistry 2017
Irish Research Council Government of Ireland Postdoctoral Fellowship 2014 - 2016
University of Gothenburg Department of Chemistry Postdoctoral Scholarship 2010 - 2012
XVIIIth European Conference of GP2A: Best Presentation 2009
Trinity College Dublin Postgraduate Research Studentship 2009
Irish Cancer Society Oncology Scholars Travel Award 2008
Trinity College Dublin Postgraduate Research Studentship (1252) 2006
Pharmaceutical Society of Ireland Young Pharmacist's forum: Best poster presentation 2006
Trinity College Dublin Foundation Scholarship 2003
I am working to discover new treatments for cancer and inflammatory disease. The driving force behind my work is to improve patient health and treatment options by applying principles of medicinal chemistry. My research focuses on hard-to-treat cancers including multi-drug resistant breast cancer, colon cancer and leukaemias. Drug targets of interest in cancer are microtubules and the estrogen and progesterone receptors, as well as the role of reactive oxygen species. I have previously developed novel compounds targeting heat shock protein 90. I am also extremely interested in drug discovery from natural sources and traditional Irish remedies. In the inflammation strand of my research, I aim to discover the underlying reasons that certain chemicals cause skin allergy. I am especially interested in profiling the interactions between skin-sensitizing chemicals and biomolecules in skin. I am developing safer alternatives to known chemical skin sensitizers, e.g. epoxy resins. My background provides me with expertise in many areas of pharmaceutical sciences (including organic & medicinal chemistry, pharmaceutical analysis) and biochemistry (cell culture, western blotting, and flow cytometry). I run several diverse research projects and my work is currently supported by a TCD Provost's PhD Project Award, CAMS-UK, the Royal Society of Chemistry and Science Foundation Ireland. My research work is consistently published in high-quality international, peer-reviewed journals and I have been a co-applicant on two published patents.