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Dr. Bruce Murphy

Assoc Prof. in Biomechanical Engineering (Mechanical, Manuf & Biomedical Eng)
PARSONS BUILDING


Dr. Bruce Murphy is an Associate Professor in the Department of Mechanical, Manufacturing and Biomedical Engineering, Deputy Director of the Trinity Centre for Biomedical Engineering, and Principal Investigator (PI) in the Trinity Centre for Biomedical Engineering and the Advanced Materials and Bioengineering Research (AMBER) Centre at Trinity College Dublin (TCD). He runs one of the most successful medical device design incubator labs in the World. To date his lab has spun-out 4 TCD spin-outs: Croívalve, Selio Medical, Proverum and One Projects. The spinouts from his lab have raised over €100M in capital, employ over 100 full time equivalents, and have two devices in clinical trials. Current projects in his lab include: MitrAdapt " a new percutaneous solution for treating patients with mitral regurgitation, PLIO " a new laparoscopic solution to reduce the leakage rates of anastomosis in the GI tract, IndexiTap " a collaboration with TCD"s Academic Unit of Neurology and Beaumont Hospital to understand if enhanced measurement of patient dexterity can better track symptoms of Motor Neuron Disease. His lab is not only involved in translational Biomedical Engineering, he has published in many top journals in Biomedical Engineering. Including the top journal in the field, Nature Biomedical Engineering (IF >25). He is open to collaboration with artists and other professionals if they would like to explore or link aspects of medical device design or biomedical engineering to their work.
  Bioengineering   Medical Devices
 The Development of a Transcatheter Tricuspid Valve Repair System (CroiValve)
 CTO Re-entry Device Design & Development
 AMCARE - ADVANCED MATERIALS FOR CARDIAC REGENERATION
 Westland mitral valve
 The in vivo evaluation of an easy to position transcatheter mitral valve repair/replacement device

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Greg Campion, Kylie Hershberger, Alix Whelan, Jack Conroy, Caitr ona Lally & Bruce P. Murphy, A Biomechanical and Microstructural Analysis of Bovine and Porcine Pericardium for Use in Bioprosthetic Heart Valves, Structural Heart, 5, (5), 2021, p486 - 496, Journal Article, PUBLISHED  TARA - Full Text
Alix Whelan, Elizabeth Williams, David Nolan, Bruce Murphy, Paul Gunning, David O'Reilly, Caitríona Lally, Bovine pericardium of high fibre dispersion has high fatigue life and increased collagen content; potentially an untapped source of heart valve leaflet tissue , Annals of Biomedical Engineering, 2020, Journal Article, PUBLISHED  TARA - Full Text
Alix Whelan, Collagen fibre orientation and dispersion govern ultimate tensile strength, stiffness and the fatigue performance of bovine pericardium, Journal of the Mechanical Behavior of Biomedical Materials, 90, 2019, p54 - 60, Journal Article, PUBLISHED  TARA - Full Text  DOI
Dolan, E.B. and Hofmann, B. and de Vaal, M.H. and Bellavia, G. and Straino, S. and Kovarova, L. and Pravda, M. and Velebny, V. and Daro, D. and Braun, N. and Monahan, D.S. and Levey, R.E. and O'Neill, H. and Hinderer, S. and Greensmith, R. and Monaghan, M.G. and Schenke-Layland, K. and Dockery, P. and Murphy, B.P. and Kelly, H.M. and Wildhirt, S. and Duffy, G.P., A bioresorbable biomaterial carrier and passive stabilization device to improve heart function post-myocardial infarction, Materials Science and Engineering C, 103, (109751), 2019, Journal Article, PUBLISHED  DOI
Curley, C.J. and Dolan, E.B. and Otten, M. and Hinderer, S. and Duffy, G.P. and Murphy, B.P., An injectable alginate/extra cellular matrix (ECM) hydrogel towards acellular treatment of heart failure, Drug Delivery and Translational Research, 9, (1), 2019, Notes: [cited By 1], Journal Article, PUBLISHED  DOI
Whyte, W. and Roche, E.T. and Varela, C.E. and Mendez, K. and Islam, S. and O'Neill, H. and Weafer, F. and Shirazi, R.N. and Weaver, J.C. and Vasilyev, N.V. and McHugh, P.E. and Murphy, B. and Duffy, G.P. and Walsh, C.J. and Mooney, D.J., Sustained release of targeted cardiac therapy with a replenishable implanted epicardial reservoir /692/4019/2773 /639/301/54/152 /14/5 /14/35 /14/63 /59/5 /96/106 /96/100 /96/34 article, Nature Biomedical Engineering, 2, (6), 2018, p416-428 , Notes: [cited By 0], Journal Article, PUBLISHED  DOI
Dolan, E.B. and Kovarova, L. and O'Neill, H. and Pravda, M. and Sulakova, R. and Scigalkova, I. and Velebny, V. and Daro, D. and Braun, N. and Cooney, G.M. and Bellavia, G. and Straino, S. and Cavanagh, B.L. and Flanagan, A. and Kelly, H.M. and Duffy, G.P. and Murphy, B.P., Advanced Material Catheter (AMCath), a minimally invasive endocardial catheter for the delivery of fast-gelling covalently cross-linked hyaluronic acid hydrogels, Journal of Biomaterials Applications, 33, (5), 2018, p681-692 , Notes: [cited By 3], Journal Article, PUBLISHED  DOI
Curley, C.J. and Dolan, E.B. and Cavanagh, B. and O'Sullivan, J. and Duffy, G.P. and Murphy, B.P., An in vitro investigation to assess procedure parameters for injecting therapeutic hydrogels into the myocardium, Journal of Biomedical Materials Research - Part B Applied Biomaterials, 105, (8), 2017, p2618-2629 , Notes: [cited By 0], Journal Article, PUBLISHED  DOI
Dolan, E.B. and Gunning, G.M. and Davis, T.A. and Cooney, G. and Eufrasio, T. and Murphy, B.P., The development and mechanical characterisation of a novel reinforced venous conduit that mimics the mechanical properties of an arterial wall, Journal of the Mechanical Behavior of Biomedical Materials, 71, 2017, p23-31 , Notes: [cited By 0], Journal Article, PUBLISHED  DOI
O'Neill, H.S., Gallagher, L.B., O'Sullivan, J., Whyte, W., Curley, C., Dolan, E., Hameed, A., O'Dwyer, J., Payne, C., O'Reilly, D., Ruiz-Hernandez, E., Roche, E.T., O'Brien, F.J., Cryan, S.A., Kelly, H., Murphy, B., Duffy, G.P., Biomaterial-Enhanced Cell and Drug Delivery: Lessons Learned in the Cardiac Field and Future Perspectives, Advanced Materials, 2016, p5648-5661-, Journal Article, PUBLISHED  DOI
  

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Award Date
KTI People's Choice Award Trinity College Dublin and ProVerum Ltd 2022
Trinity Invention Challenge Med Tech Prize 2021 2021
Trinity College Dublin Innovation Awards 2020 Winner of the inventor category 2020
Trinity Innovation Awards 2018 -Campus Company Founders Award 2018
CroíValve - Medtech Strategist 2018 Winner 2018
CroíValve - National Start Up Early Stage Category Winner 2018
Selio Medical - Medtech Strategist 2017 Winner 2017
Enterprise Ireland "one to Watch" award 2009 2009
I am a World leading expert in the process of innovating medical technologies. My research focus is the development of transformative medical technologies. In my lab this journey starts with a valid clinical need, to building and mentoring teams, and developing solid engineering solutions that address clinical needs. These solutions are designed to have the ability to enhance quality of life, prolong life, avoid adverse events and enhance patient outcomes. My lab has excelled in this field. For example, my lab has translated a heart valve concept from clinical need to forming the key asset of a TCD spin-out company. Croívalve has raised in excess of €18m in capital, employs 30 staff members, and has performed first in human implants, which have demonstrated transformative improvements in symptoms of patients. Another example of this type of translational research is associated with the clinical need of alleviating the symptoms of benign prostate hyperplasia. My lab developed the core technology that formed the technical assets of the TCD spin-out. Proverum has gone on to raise over €40m, employs 30 employees and has started to enrol patients into a prospective, multi-centre, double-blind controlled study to evaluate the safety, and effectiveness of the technology that was developed in my lab. In total four medical device TCD spin outs were established from research in my lab. These companies employ over 100 staff members and have raised over €100m in capital. My lab's solutions have a high profile in their respective medical fields, which has raised the profile of TCD in the field of medical device design. Demonstrating that my research has the ability to have a global impact on healthcare. In summary, my philosophy to Biomedical Engineering is that I believe I have a duty to use my substantial biomedical engineering knowledge to improve patient outcomes.