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Dr. Michael Monaghan

Ussher Assistant Professor (Mechanical, Manuf & Biomedical Eng)
PARSONS BUILDING


Dr. Michael Monaghan is an Ussher Assistant Professor in Biomedical Engineering at Trinity College Dublin, the University of Dublin. His group's primary research areas are in biomaterials (in particular electroconductive biomaterials), advanced processing and rational design of biomaterials, cardiac tissue regeneration, and real-time imaging of extracellular matrix components and metabolism in differentiation and disease. He leads a number of interdiciplinary projects between other academic groups and industry ranging from immunometabolism, evaluation of fibrosis, biomaterial synthesis and induced pluripotent stem cell derivitisation of cardiac organoids.

Dr. Monaghan performed his Postdoctoral research in Germany as a recipient of a prestigious Marie Curie Individual Fellowship. His research was coordinated between the Department of Cell and Tissue Engineering in the Fraunhofer Institute for Interfacial Engineering and Biotechnology and the Department of Women's Health in University Clinic Tubingen. During this period he has published a number of key papers in the field of human valvulogenesis, embryonic stem cell research, cardiomyocyte differentiation, biomaterials and non-invasive optical characterisation (Raman microspectroscopy, fluorescent lifetime imaging (FLIM), multiphoton and second harmonic generation (SHG) imaging). Dr. Monaghan received both his B.Eng (Biomedical) and Ph.D. (Biomedical Engineering) from the National University of Ireland Galway (NUIG). During his Ph.D. Dr. Monaghan received a number of research awards such as travel awards from the European Molecular Biology Organisation (EMBO) and the German Academic Exchange Service (DAAD), and the 2015 Julia Polak European Doctorate Award in recognition of the achievements made during his Ph.D.

Dr. Monaghan is actively involved in the tissue engineering and regenerative medicine international society (TERMIS); previously as Chair of the EU Student and Young Investigator Section, and recently promoted full EU Council Member. He is council member of Matrix Biology Ireland and acts as treasurer of this society. More details of his groups resources and research can be found on the groups website. Lab Website: www.monaghanlab.com
  2ND HARMONIC GENERATION   3D Imaging Analysis   Bioengineering and radiologic imaging   Biomaterials   COLLAGEN   CONFOCAL IMAGING   Confocal photoluminescence imaging   DRUG TARGETING   DRUG-DELIVERY SYSTEM   EXTRACELLULAR MATRIX (ECM)   GENE SILENCING   GENE-THERAPY   Regenerative Medicine   Tissue Engineering
 Enabling Melt ElectroWriting of Electroconductive, Geometrically Defined 3D Biomaterials to Promote the Maturation of Cardiomyocytes for Cardiac Regeneration
 Cell-Specific Metabolic FLIM Profiling of the Ulcerative Colitis Microenvironment to Establish an Association with Patient Treatment Response
 The role of macrophage polarization in the generation of functional engineered mature myocardium organoids
 Recapitulating electrical, mechanical and extracellular-matrix cues via multifunctional biomaterials to engineer cardiac tissue
 3D Electroconductive biomaterial scaffolds as cardioinductive matrices for cardiac tissue engineering

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Details Date
Elected Council Member -Tissue Engineering and Regenerative Medicine International Society (EU Chapter) 01-Jan-2018
Elected Treasurer- Matrix Biology Ireland 2017 Meeting 30 Nov 2016
Language Skill Reading Skill Writing Skill Speaking
English Fluent Fluent Fluent
German Medium Medium Medium
Details Date From Date To
Royal Academy of Medicine in Ireland (RAMI)- Bioengineering Section 2017 Present
MBI- Matrix Biology Ireland 2016 Present
ESB- European Society for Biomaterials 2010 Present
TERMIS - Tissue Engineering and Regenerative Medicine Society 2009 Present
DGMB-German Matrix Biology Society 2013 2016
Seeing Is Believing: Noninvasive Microscopic Imaging Modalities for Tissue Engineering and Regenerative Medicine in, editor(s)Heinz Redl, Jeff Gimble, Darja Marolt Presen, Richard Oreffo and Susanne Wolbank , Tissue Engineering and Regeneration. Cell Engineering and Regeneration, Switzerland, Springer, 2020, ppAccepted- - In Press, [Neto N, Dmitriev R, Monaghan MG], Book Chapter, IN_PRESS
Extrusion-based additive manufacturing techniques for biomedical applications in, editor(s)Dermot Brabazon , Encyclopedia of Materials: Composites, Philadelphia, Elsevier, 2020, ppIn Press - [Tadayyon G, Kelly DJ, Monaghan MG], Book Chapter, ACCEPTED
Olvera D., Sohrabi Molina M., Hendy G., Monaghan M.G., Electroconductive Melt Electrowritten Patches Matching the Mechanical Anisotropy of Human Myocardium, Advanced Functional Materials, 2020, Journal Article, PUBLISHED  TARA - Full Text  DOI
Ukkelman IA, Neto N, Papkovsky DB, Monaghan MG, Dmitriev RI., A deeper understanding of intestinal organoid metabolism revealed by combining fluorescence lifetime imaging microscopy (FLIM) and extracellular flux analyses., Redox biology, 30, 2020, p101420 , Journal Article, PUBLISHED  TARA - Full Text  DOI
Ozaki, Ema, Gibbons, Luke, Neto, Nuno GB, Kenna, Paul, Carty, Michael, Humphries, Marian, Humphries, Pete, Campbell, Matthew, Monaghan, Michael, Bowie, Andrew and Doyle, Sarah L, SARM1 deficiency promotes rod and cone photoreceptor cell survival in a model of retinal degeneration, Life Science Alliance, 3, (5), 2020, Journal Article, PUBLISHED  TARA - Full Text  DOI
Olvera D, Monaghan MG, Electroactive biomaterial-based biosensors for detection and drug delivery , Advanced Drug Delivery Reviews, 2020, Journal Article, IN_PRESS
Dolan, E.B. and Hofmann, B. and de Vaal, M.H. and Bellavia, G. and Straino, S. and Kovarova, L. and Pravda, M. and Velebny, V. and Daro, D. and Braun, N. and Monahan, D.S. and Levey, R.E. and O'Neill, H. and Hinderer, S. and Greensmith, R. and Monaghan, M.G. and Schenke-Layland, K. and Dockery, P. and Murphy, B.P. and Kelly, H.M. and Wildhirt, S. and Duffy, G.P., A bioresorbable biomaterial carrier and passive stabilization device to improve heart function post-myocardial infarction, Materials Science and Engineering C, 103, (109751), 2019, Journal Article, PUBLISHED  DOI
Solazzo M, Krukiewicz K, Zhussupbekova A, Fleischer K, Biggs MJ, Monaghan MG., PEDOT:PSS interfaces stabilised using a PEGylated crosslinker yield improved conductivity and biocompatibility., J Mater Chem B, 7, (31), 2019, p4811-4820 , Journal Article, PUBLISHED  TARA - Full Text  DOI
O'Rourke SA, Dunne A, Monaghan MG., The Role of Macrophages in the Infarcted Myocardium: Orchestrators of ECM Remodeling., Frontiers in cardiovascular medicine, 6, 2019, p101 , Journal Article, PUBLISHED  TARA - Full Text  DOI
Solazzo M, O'Brien FJ, Nicolosi V, Monaghan MG., The rationale and emergence of electroconductive biomaterial scaffolds in cardiac tissue engineering., APL Bioeng, 3, (4), 2019, p041501 , Journal Article, PUBLISHED  TARA - Full Text  DOI
  

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Michael Monaghan, Non-invasive, nonlinear microscopy in the evaluation of extracellular matrix and cell metabolic activity, ORS Musculoskeletal Summer Symposium, Dublin, 6-7th July, 2017, Dvid Hoey, Invited Talk, PRESENTED

  

Award Date
European Doctoral Award, Issued by the European Society of Biomaterials 2015
Deutscher Akademischer Austausch Dienst, Short Term Travel Award to conduct research in University Hospital Tübingen 2012
EMBO Short Term Travel Award to conduct research in Fraunhofer IGB Stuttgart 2011
Roche Best Poster Award, NCBES Research day 2008
NUI Galway College of Engineering and Informatics Research Fellow 2007
University Scholar (Based on end of term results) NUI Galway 2005
Dr. Monaghan's research focus is the generation of cardiac tissue in vitro towards the purpose of disease modelling and therapeutic transplantation. Heart attacks are an increasing healthcare burden and despite many medical advances, once heart muscle dies following a heart attack it does not heal sufficiently, and becomes scarred, leading to reduced function and quality of health. It is possible to generate new heart muscle from stem cells and more recently from adult cells of the body (e.g. skin cells) but such new heart muscle is not fully functional or mature as it is not experiencing the natural environment of the heart. His research is focused on the use of tunable biomaterial scaffolds using both biomechanical and biomolecular stimuli to mimic the cardiac environment and achieve robust cardiomyocyte transdifferentiation. Dr. Monaghan research interests also include non-invasive microscopy. Multiphoton microscopy is a powerful method for the nondestructive evaluation of deep-tissue, cells and extracellular matrix (ECM) structures. By interacting with highly non-centrosymmetric molecular assemblies, the non-linear phenomenon of second harmonic generation (SHG) has also proven to be an important diagnostic tool for the visualization of collagen and myosin. Multiphoton microscopy can be additionally equipped with time correlated single photon counting boards which allow extensive analysis of the photons being emitted from any material due to excitation by a specific wavelength and provides a photon distribution analysis. Notably, this facilitates fluorescence lifetime imaging (FLIM), which produces images based on the differences in the exponential decay rate of the fluorescence from a fluorescent sample, where the lifetime of a fluorophore signal is used to create the image. This method reduces the effect of photon scattering in thick samples and also avoids sample bleaching and photo-induced toxicity. Investigated fluorophores can be naturally present in the cell (e.g. NAD(P)H, which is indicative of cellular metabolism), or fluorophores that we can introduce externally to understand cell pathways and signaling. Link to PubMed: http://www.ncbi.nlm.nih.gov/pubmed/?term=monaghan+AND+(pandit+OR+Walles+OR+schenke-layland) Link to Google Scholar: https://scholar.google.com/citations?user=X1mgIbEAAAAJ&hl=en&oi=sra