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Dr. Michael Monaghan

Ussher Assistant Professor (Mechanical, Manuf & Biomedical Eng)
PARSONS BUILDING


Dr. Michael Monaghan is an Associate Professor in Biomedical Engineering at Trinity College Dublin, the University of Dublin. His group's primary research areas are in biomaterials (in particular electroconductive biomaterials), advanced processing and rational design of biomaterials, cardiac tissue regeneration, and real-time imaging of extracellular matrix components and metabolism in differentiation and disease. He leads a number of interdiciplinary projects between other academic groups and industry ranging from immunometabolism, evaluation of fibrosis, biomaterial synthesis and induced pluripotent stem cell derivitisation of cardiac organoids.

Dr. Monaghan performed his Postdoctoral research in Germany as a recipient of a prestigious Marie Curie Individual Fellowship. His research was coordinated between the Department of Cell and Tissue Engineering in the Fraunhofer Institute for Interfacial Engineering and Biotechnology and the Department of Women's Health in University Clinic Tubingen. During this period he has published a number of key papers in the field of human valvulogenesis, embryonic stem cell research, cardiomyocyte differentiation, biomaterials and non-invasive optical characterisation (Raman microspectroscopy, fluorescent lifetime imaging (FLIM), multiphoton and second harmonic generation (SHG) imaging). Dr. Monaghan received both his B.Eng (Biomedical) and Ph.D. (Biomedical Engineering) from the National University of Ireland Galway (NUIG). During his Ph.D. Dr. Monaghan received a number of research awards such as travel awards from the European Molecular Biology Organisation (EMBO) and the German Academic Exchange Service (DAAD), and the 2015 Julia Polak European Doctorate Award in recognition of the achievements made during his Ph.D.

Dr. Monaghan is actively involved in the tissue engineering and regenerative medicine international society (TERMIS); previously as Chair of the EU Student and Young Investigator Section, and recently promoted full EU Council Member. He is council member of Matrix Biology Ireland and acts as treasurer of this society. More details of his groups resources and research can be found on the groups website. Lab Website: www.monaghanlab.com
  2ND HARMONIC GENERATION   3D Imaging Analysis   Bioengineering and radiologic imaging   Biomaterials   COLLAGEN   CONFOCAL IMAGING   Confocal photoluminescence imaging   DRUG TARGETING   DRUG-DELIVERY SYSTEM   EXTRACELLULAR MATRIX (ECM)   GENE SILENCING   GENE-THERAPY   Regenerative Medicine   Tissue Engineering
 Enabling Melt ElectroWriting of Electroconductive, Geometrically Defined 3D Biomaterials to Promote the Maturation of Cardiomyocytes for Cardiac Regeneration
 Cell-Specific Metabolic FLIM Profiling of the Ulcerative Colitis Microenvironment to Establish an Association with Patient Treatment Response
 The role of macrophage polarization in the generation of functional engineered mature myocardium organoids
 Recapitulating electrical, mechanical and extracellular-matrix cues via multifunctional biomaterials to engineer cardiac tissue
 3D Electroconductive biomaterial scaffolds as cardioinductive matrices for cardiac tissue engineering

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Details Date
Elected Council Member -Tissue Engineering and Regenerative Medicine International Society (EU Chapter) 01-Jan-2018
Elected Treasurer- Matrix Biology Ireland 2017 Meeting 30 Nov 2016
Reviewer for leading journals in the fields of Biomaterials and Tissue Engineering (selection only): Biomaterials, RSC Biomaterials Science, Advanced Optical Materials, ACS Biomaterials Science and Engineering, Macromolecular Materials and Engineering, Small, Macromolecular Bioscience, Advanced Functional Materials, Advanced NanoBiomed Research, Advanced Materials Technologies, Journal of Controlled Release, Molecular Therapy, Advanced Healthcare Materials, Tissue Engineering Part A, Tissue Engineering Part B, Acta Biomaterialia, ACS Applied Materials and Interfaces, Advanced Drug Delivery Reviews, Lab on a Chip, Nature Scientific Reports, Journal of Tissue Engineering and Regenerative Medicine, npj 2D Materials and Applications 2015-Present
External Examiner PhD Thesis Progress- Royal College of Surgeons in Ireland 2017
Grant Reviewer for National and International Granting Bodies Including: European Research Council ADVANCED GRANTS European Research Council Starting Grants Wellcome Trust (2020-Present) MRC-AMED Regenerative Medicine and Stem Cell Research Initiative (2020- Present) Israel Science Foundation (2020-Present) Marie Sklowdowska-Curie Individual Fellowships (2019-Present) Freiburg Institute for Advanced Studies Deutsche Forschungsgemeinschaft (DFG) (2029-Present) Canada Foundation for Innovation (CFI) through the John R. Evans Leaders Fund (2021) 2018
Language Skill Reading Skill Writing Skill Speaking
English Fluent Fluent Fluent
German Medium Medium Medium
Details Date From Date To
Royal Academy of Medicine in Ireland (RAMI)- Bioengineering Section 2017 Present
MBI- Matrix Biology Ireland (elected council member and Society Treasurer) 2016 Present
ESB- European Society for Biomaterials 2010 Present
TERMIS - Tissue Engineering and Regenerative Medicine Society 2009 Present
DGMB-German Matrix Biology Society 2013 2016
Funded Investigator: SFI Funded Centre AMBER (Advanced Materials and BioEngineering Research) 2019 Present
Funded Investigator: SFI Funded Centre CÚRAM (Designing The Next Generation of 'Smart' Medical Devices) 2019 Present
Fitzgerald, H.K.; O'Rourke, S.A.; Desmond, E.; Neto, N.G.B.; Monaghan, M.G.; Tosetto, M.; Doherty, J.; Ryan, E.J.; Doherty, G.A.; Nolan, D.P.; Fletcher, J.M.; Dunne, A, The Trypanosoma brucei-Derived Ketoacids, Indole Pyruvate and Hydroxyphenylpyruvate, Induce HO-1 Expression and Suppress Inflammatory Responses in Human Dendritic Cells, Antioxidants, 11, 2022, p164-, Journal Article, PUBLISHED  DOI
Perottoni S, Neto NGB, Di Nitto C, Dmitriev RI, Raimondi MT, Monaghan MG., Intracellular label-free detection of mesenchymal stem cell metabolism within a perivascular niche-on-a-chip., Lab on a chip, 21, (7), 2021, p1395-1408 , Journal Article, PUBLISHED  DOI
Solazzo M, Monaghan MG., Structural crystallisation of crosslinked 3D PEDOT:PSS anisotropic porous biomaterials to generate highly conductive platforms for tissue engineering applications., Biomaterials science, 9, (12), 2021, p4317-4328 , Journal Article, PUBLISHED  DOI
Meenakshi Suku, Lesley Forrester, Manus Biggs, Michael G. Monaghan, Resident macrophages and their potential in cardiac tissue engineering, Tissue Engineering Part B Reviews, 2021, Journal Article, ACCEPTED  TARA - Full Text
Floudas A, Neto N, Orr C, Canavan M, Gallagher P, Hurson C, Monaghan MG, Nagpar S, Mullan RH, Veale DJ, Fearon U., Loss of balance between protective and pro-inflammatory synovial tissue T-cell polyfunctionality predates clinical onset of rheumatoid arthritis., Annals of the rheumatic diseases, 2021, Journal Article, PUBLISHED  DOI
Saha, Uttariyo, Nairn, Rory, Keenan, Orla, Monaghan, Michael G., A Deeper Insight into the Influence of the Electric Field Strength When Melt"Electrowriting on Non"Planar Surfaces, Macromolecular Materials and Engineering, 2021, p2100496 , Journal Article, PUBLISHED  DOI
Coulter, Fergal B., Levey, Ruth E., Robinson, Scott T., Dolan, Eimear B., Deotti, Stefano, Monaghan, Michael, Dockery, Peter, Coulter, Brian S., Burke, Liam P., Lowery, Aoife J., Beatty, Rachel, Paetzold, Ryan, Prendergast, James J., Bellavia, Gabriella, Straino, Stefania, Cianfarani, Francesca, Salamone, Monica, Bruno, Carmelo M., Moerman, Kevin M., Ghersi, Giulio, Duffy, Garry P., O'Cearbhaill, Eoin D., Soft Tissue Implants: Additive Manufacturing of Multi"Scale Porous Soft Tissue Implants That Encourage Vascularization and Tissue Ingrowth (Adv. Healthcare Mater. 14/2021), Advanced Healthcare Materials, 10, (14), 2021, p2170063 , Journal Article, PUBLISHED  DOI
Old Drugs, New Tricks - Redefining Therapeutic Strategies For Tissue Regeneration., Advanced Drug Delivery Reviews- Elsevier, 2021, -, Notes: [This is the preface to a special-edition of this Journal where I acted as lead guest editor. ], Critical Edition (Chapter), PUBLISHED  DOI
Fitzgerald H., Williams D. G., Campbell N. K., Barry P, O'Rourke S. A. Neto N., Monaghan M. G., Nolan D. P., Dunne A, Aromatic ketoacids represent novel therapies for autoimmune diseases through activation of the Nrf2/HO-1 pathway and suppression of pro-inflammatory responses in primary human immune cells, British Society for Immunology 2021 Congress, Edinburgh, 30th November, 2021, Meeting Abstract, PUBLISHED
Shanley L., Mahon O. R., O'Rourke S. A., Neto N., Monaghan M. G., Kelly D., Dunne A, Particle size alters macrophage metabolism: Implications for bone tissue engineering, British Society for Immunology 2021 Congress, Edinburgh, 30th November, 2021, Meeting Abstract, PUBLISHED
  

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O'Rourke S., Neto N., Devilly E., Shanley L., Dunne A., Monaghan M. G, Immunometabolism in atherosclerosis: Investigating cholesterol crystals as potent drivers of metabolic reprogramming and M1 macrophage polarisation, 6th European Congress for Immunology Meeting, Online, 1-4th September , 2021, Meeting Abstract, PUBLISHED
Shanley L., Mahon O. R., O'Rourke S. A., Neto N., Monaghan M. G., Kelly D., Dunne A, Particle size alters macrophage metabolism: Implications for bone tissue engineering, 34th Conference of the European Macrophage and Dendritic Cell Society, Online, 24-25th June , 2021, Meeting Abstract, PUBLISHED
Shanley L., Mahon O. R., O'Rourke S. A., Neto N., Monaghan M. G., Kelly D., Dunne A, Particle size alters macrophage metabolism: Implications for bone tissue engineering, 6th European Congress for Immunology Meeting, Online, 1-4th September , 2021, Meeting Abstract, PUBLISHED
O'Rourke S., Neto N., Devilly E., Shanley L., Dunne A., Monaghan M. G, ., Immunometabolism in atherosclerosis: Investigating cholesterol crystals as potent drivers of metabolic reprogramming and M1 macrophage polarisation, 34th Conference of the European Macrophage and Dendritic Cell Society, Online, 24-25th June , 2021, Meeting Abstract, PUBLISHED
Fitzgerald H., Williams D. G., Campbell N. K., Barry P, O'Rourke S. A. Neto N., Monaghan M. G., Nolan D. P., Dunne A, Trypanosoma brucei secreted aromatic ketoacids activate the Nrf2/HO-1 pathway and suppress pro-inflammatory responses in primary murine and human immune cells, . 34th Conference of the European Macrophage and Dendritic Cell Society. Virtual conference , Online, 24-25th June, 2021, Meeting Abstract, PUBLISHED
O'Rourke S., Neto N., Devilly E., Shanley L., Dunne A., Monaghan M. G, Inflammation in atherosclerosis: Investigating cholesterol crystals as potent drivers of metabolic reprogramming and M1 macrophage polarisation, Termis Workshop: Cell-Matrix Interaction and Mechanobiology in Regenerative Medicine, Online, 11-12th June, 2021, Oral Presentation, PUBLISHED
Suku. M., Forrester. L., Biggs. M, Monaghan, M. G, Tuning of Macrophage Polarization in the generation of functional cardiac organoids, EPSRC-SFI Joint Student Day, Online, 7th September, 2021, Oral Presentation, PUBLISHED
O'Rourke S., Neto N., Dunne A., Monaghan M. G., , Immune modulation in atherosclerosis: Investigating cholesterol crystals as potent drivers of metabolic reprogramming and M1 macrophage polarisation, Drexel Immune Modulation and Engineering Symposium, , Philadelphia, U.S.A, 11-13th November , 2020, Oral Presentation, PUBLISHED
Neto N, O'Rourke S., Vishwanathan A., Dunne A., O'Farrelly C., Monaghan M. G., , Metabolic Profiling of Macrophage Polarization by Fluorescence Lifetime Imaging Microscopy, Immunometabolism Symposium, Dublin, 5th April , 2019, Oral Presentation, PUBLISHED
Solazzo, M.*. Monaghan, M. G, Engineered electroconductive biomaterial platforms for cardiac tissue engineering applications, TBSI Research Symposium 2019, Dublin, 4th September , 2019, Oral Presentation, PUBLISHED

  

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Award Date
European Doctoral Award, Issued by the European Society of Biomaterials 2015
Deutscher Akademischer Austausch Dienst, Short Term Travel Award to conduct research in University Hospital Tübingen 2012
EMBO Short Term Travel Award to conduct research in Fraunhofer IGB Stuttgart 2011
Roche Best Poster Award, NCBES Research day 2008
NUI Galway College of Engineering and Informatics Research Fellow 2007
University Scholar (Based on end of term results) NUI Galway 2005
The focus of the Monaghan lab (www.monaghanlab.com) is the development of novel biomaterial design-based strategies to regenerate or repair damaged tissues and restore biomechanical function using informed and optimised design approaches. Core Research Areas: . Cardiac tissue engineering and cell derivitisation from multi/pluripotent stem cell sources . Macrophage assessment and inclusion in advanced biomaterial culture platforms. . In silico predictive modelling and optimisation of biomaterial geometries . Electroconductive biomaterial synthesis, fabrication and applications . Advanced non-linear microscopy using multiphoton microscopy for non-invasive imaging of extracellular matrix . Advanced fluoresecent lifetime imaging microscopy (FLIM) in the assessment of cellular metabolism during disease, differentiation and regeneration. . Melt-electrowriting development, optimisation and application My lab is pioneering new approaches for biomaterial fabrication and design using advanced biomaterials, tissue engineering, biofabrication and in silico predictive modelling. My labs work will create a paradigm shift in which the scientific community, industry partners and clinical investigators approach biomaterial design. My lab is recognised internationally as world class where I am regularly invited to deliver keynote talks at major international meetings, and our papers have received awards for being most downloaded in our field. Members of my team have also been awarded prizes at national/international level in recognition of the scientific quality of our labs work. I have coordinated and elevated the Med3DP initiative over the past five years (www.med3dp.com) which develops medical devices for healthcare using 3D printing technology, demonstrating research led teaching and student led learning. My lab also has collaborative funding with small-medium enterprises such as Spraybase® (Bioprinting; next generation implantable devices) and I am a funded investigator in the SFI funded centres AMBER and CURAM. My work spans across and engages with several disciplines which includes Physics and Chemistry, Computer Science, Biochemistry and Immunology, Pharmacy, Surgery, Oncology and Endocrinology. This is strongly reflective in our illustrious repertoire of publications. Link to PubMed: http://www.ncbi.nlm.nih.gov/pubmed/?term=monaghan+AND+(pandit+OR+Walles+OR+schenke-layland) Link to Google Scholar: https://scholar.google.com/citations?user=X1mgIbEAAAAJ&hl=en&oi=sra