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Professor Mark Little

Professor/Consultant of Nephrology (Clinical Medicine)

 


  ANTINEUTROPHIL CYTOPLASMIC ANTIBODIES   Biomarkers of disease   CRESCENTIC GLOMERULONEPHRITIS   IMMUNE-COMPLEX GLOMERULONEPHRITIS   Inflammation   MOUSE MODELS   Nephrology   NEUTROPHIL ADHESION   RAT MODEL   REGISTRY   SYSTEMIC VASCULITIS   VASCULITIS
 PARADISE: PersonAlisation of RelApse risk in autoimmune DISEase
 FAIRVASC " building registry interoperability to inform clinical care
 AVERT: Autoimmunity Relapse Prediction Using Multiple Parallel Data Sources
 HELICAL - Health Data Linkage for Clinical Benefit
 Urinary sCD163 as a biomarker in crescentic glomerulonephritis

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Details Date
Autoimmune strand lead, RITA European Reference Network 1/3/17
Co-chair UKIVAS national vasculitis registry 2010
Co-chair UKIVAS, the vasculitis rare disease group of the UK and Ireland 2011
Chair Dublin Vasculitis and Allergy Group 2018
Registries lead, European Vasculitis Society 2014
Chair RITA Ireland Vasculitis Registry and Biobank 2012
Language Skill Reading Skill Writing Skill Speaking
English Fluent Fluent Fluent
Details Date From Date To
Fellow of Trinity College Dublin 1/5/13
Fellow of the Royal College of Physicians 2012
American Society of Nephrology 2010
The Renal Association 2008
Karl Gisslander, Matthew Rutherford, Louis Aslett, Neil Basu, François Dradin, Lucy Hederman, Zdenka Hruskova, Dagmar Jäger, Hicham Kardaoui, Sabina Licholai, Declan O"Sullivan, Jennifer Scott, Mårten Segelmark, Richard Straka, Michelangelo Tesi, Augusto Vaglio, Arthur White, Krzysztof Wójcik, Beyza Yaman, Mark A Little, Aladdin J Mohammad*, Data quality and patient characteristics in European ANCA-associated vasculitis registries: data retrieval by federated querying, Annals of the Rheumatic Diseases, 83, (1), 2024, p112 - 120, Journal Article, PUBLISHED  DOI
Jennifer Scott, Arthur White, Cathal Walsh, Louis Aslett, Matthew A Rutherford, James Ng, Conor Judge, Kuruvilla Sebastian, Sorcha O'Brien, John Kelleher, Julie Power, Niall Conlon, Sarah M Moran, Raashid Ahmed Luqmani, Peter A Merkel, Vladimir Tesar, Zdenka Hruskova Mark A Little, Computable phenotype for real-world, data-driven retrospective identification of relapse in ANCA-associated vasculitis, RMD Open, 10, (2), 2024, p1-11 , Journal Article, PUBLISHED  DOI
Geetha D, Dua A, Yue H, Springer J, Salvarani C, Jayne D, Merkel P, ADVOCATE Study Group, Efficacy and safety of avacopan in patients with ANCA-associated vasculitis receiving rituximab in a randomised trial., Annals of the rheumatic diseases, 2023, Journal Article, PUBLISHED  DOI
Sánchez Álamo B, Moi L, Bajema I, Faurschou M, Flossmann O, Hauser T, Hruskova Z, Jayne D, Luqmani R, Mahr A, Åkesson A, Westman K, EUVAS , Long-term outcomes and prognostic factors for survival of patients with ANCA-associated vasculitis., Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, 2023, Journal Article, PUBLISHED  DOI
Hellmich B, Sanchez-Alamo B, Schirmer JH, Berti A, Blockmans D, Cid MC, Holle JU, Hollinger N, Karadag O, Kronbichler A, Little MA, Luqmani RA, Jayne D, EULAR recommendations for the management of ANCA-associated vasculitis: 2022 update., Annals of the rheumatic diseases, 2023, Journal Article, PUBLISHED  DOI
Lauren Floyd, Sebastian Bate, Abdul Hadi Kafagi, Nina Brown, Jennifer Scott, Mukunthan Srikantharajah, Marek Myslivecek, Graeme Reid, Faten Aqeel, Doubravka Frausova, Marek Kollar, Phuong Le Kieu, Bilal Khurshid, Charles D. Pusey, Ajay Dhaygude, Vladimir Tesar, Stephen McAdoo, Mark A. Little, Duvuru Geetha, Silke R. Brix, Risk Stratification to Predict Renal Survival in Anti"Glomerular Basement Membrane Disease, Journal of the American Society of Nephrology, 34, (3), 2023, p505--514 , Journal Article, PUBLISHED  DOI
Cortazar FB, Niles JL, Jayne DRW, Merkel PA, Bruchfeld A, Yue H, Schall TJ, Bekker P, ADVOCATE Study Group, Renal Recovery for Patients with ANCA-Associated Vasculitis and Low eGFR in the ADVOCATE Trial of Avacopan., Kidney international reports, 2023, Journal Article, PUBLISHED  DOI
Moiseev S, Bulanov N, Crnogorac M, Direskeneli H, Galesic K, Gazel U, Geetha D, Guillevin L, Hrušková Z, Little MA, O'Neill L, Makarov E, McAdoo SP, Jayne DRW, Traditional and Disease Specific Risk Factors for Cardiovascular Events in ANCA-Associated Vasculitis: A Multinational Retrospective Study., The Journal of rheumatology, 2023, Journal Article, PUBLISHED  DOI
Heike C. Hawerkamp, Adam H. Dyer, Neha D. Patil, Matt McElheron, Niamh O'dowd, Laura O'doherty, Aisling Ui Mhaonaigh, Angel M. George, Aisling M. O'halloran, Conor Reddy, Rose Anne Kenny, Mark A. Little, Ignacio Martin-Loeches, Colm J. Bergin, Sean Kennelly, Seamas C. Donnelly, Nollaig Bourke, Aideen Long, Jacklyn Sui, Derek G. Doherty, Niall Conlon, Cliona Ni Cheallaigh and Padraic Fallon, Characterisation of the Pro-Inflammatory Cytokine Signature in Severe COVID-19, Frontiers in Immunology , 2023, Journal Article, PUBLISHED
Roccatello, D., Padoan, R., Sciascia, S., Iorio, L., Nic An Ríogh, E., Little, M.A., Might maintenance therapy be discontinued once clinical remission is achieved in ANCA-associated vasculitis?, Autoimmunity Reviews, 2023, Journal Article, PUBLISHED  DOI
  

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Award Date
President of Ireland Young Researchers Award 2012
I run a translational medicine research programme focused on investigation of pathogenesis and discovery of biomarkers of disease in glomerulonephritis. My principal research interest is in ANCA vasculitis, an autoimmune condition that causes multi-organ failure as a consequence of overwhelming necrotising inflammation affecting small blood vessels. My lab spans cellular immunology in the Trinity Translational Medicine Institute and health data informatics in the ADAPT SFI Centre. We are addressing the following questions: 1. What biomarkers accurately track glomerular inflammation in ANCA vasculitis? 2. What molecular and cellular events lead to myeloid cell dysfunction in ANCA vasculitis? 3. What underpins the large variability in clinical phenotype observed in ANCA associated vasculitis? 4. How can we minimise the adverse events associated with existing immunosuppressive therapies? 5. How do we predict relapse in ANCA vasculitis? This research spans two primary areas: 1. Health data informatics. Massive challenges exist in this area in Ireland, where health data is fragmented and difficult to access. I currently lead a trans-disciplinary "Chronic Disease Informatics Group", which links basic immunology, health informatics and data analytics. The HELICAL (HEalth data LInkage for ClinicAL benefit) MSCA Innovative Training Network explored the impact of health and research data linkage to address complex challenges in autoimmune disease. It was followed by the FAIRVASC (Building registry interoperability to inform clinical care) European Joint Programme for Rare Diseases funded EU consortium, which used a knowledge graph approach to link rare disease registries for the first time into a federated learning platform. We applied semantic web technology to large scale data integration challenges in autoimmune disease, leading to a pipeline for multi-modal algorithm development and linkage to, for example, environmental datasets. This semantic web user interface now runs queries over federated databases containing >5000 patients across Europe and will become part of the rare disease discovery platform under development by the European Joint Programme for Rare Disease. An example of application of this data linkage approach is the discovery that ultraviolet-B radiation exposure is linked to autoimmune disease relapse. 2. Translational immunology of autoimmune disease, specifically the rare immune disorder ANCA vasculitis. A cornerstone of this was creation of a national biobank and registry of patients with this disease (RITA-Ireland registry and biobank), which is now among the most extensive globally. This has provided an unrivalled substrate for biomarker discovery, the most impactful of which is urine sCD163. This translational work extends into study of disease pathogenesis using primary biological samples and data, for example the identification of novel subsets of neutrophils and monocytes in ANCA vasculitis. Linking this with the heath data informatics research, the PARADISE (PersonAlisation of RelApse risk in autoimmune DISEase) ERA-PerMed funded EU consortium is currently driving translational innovation, applying multi-modal deep phenotyping to develop algorithms for individual level prediction of vasculitis relapse. Aligning with the FAIRVASC initiative, I lead a trans-European data linkage infrastructure for ANCA vasculitis, which integrates clinical (from registries), biomarker (proteomic, transcriptomic and genomic) and patient-reported data (from wearable devices) at the level of the individual, supporting multi-modal assessment and personalised medicine.