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Dr. Melissa Conroy

Assistant Professor (Anatomy)

 


 Therapeutically targeting T cell trafficking in obese in vivo models using CCR1 antagonism
 Targeting T cell trafficking as a novel means to control obesity-associated chronic inflammation.
 Elucidating the potential of combination Olaparib and Natural Killer cell therapy in non-small lung cancer.
 Harnessing natural killer cell-mediated immune responses in obesity-associated cancer" "
 Boosting the heat on cold tomours; Augmenting susceptibility of solid malignancies to natural killer cell therapies

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Details Date From Date To
Irish Society for Immunology 2006
European Federation of Immunological Societies 2006
European Association for Cancer Research 2013
Irish Association for Cancer Research 2013
Davern M, O" Donovan C, Donlon NE, Mylod E, Gaughan C, Bhardwaj A, Sheppard AD, Bracken-Clarke D, " Lysaght, J., Conroy, M.J., Analysing the Combined Effects of Radiotherapy and Chemokine Receptor 5 Antagonism: Complementary Approaches to Promote T Cell Function and Migration in Oesophageal Adenocarcinoma., Biomedicines, 2024, Journal Article, PUBLISHED  TARA - Full Text  DOI
Mylod E, O'Connell F, Donlon NE, Davern M, Marion C, Butler C, Reynolds JV, Lysaght J, Conroy MJ., Real-time ex vivo monitoring of NK cell migration toward obesity-associated oesophageal adenocarcinoma following modulation of CX3CR1., Scientific reports, 14, (1), 2024, p4017 , Journal Article, PUBLISHED  DOI
Measuring Immune Cell Movement Toward the Soluble Microenvironment of Human Tissues Using a Boyden Chamber-Based Migration Assay. in, 2023, pp231-240 , [Mylod E, Lysaght J, Conroy MJ.], Book Chapter, PUBLISHED  DOI
Davern M, Donlon NE, O'Connell F, Gaughan C, O'Donovan C, Habash M, Sheppard AD, MacLean M, Dunne MR, Moore J, Temperley H, Conroy MJ, Butler C, Bhardwaj A, Ravi N, Donohoe CL, Reynolds JV, Lysaght J., Acidosis significantly alters immune checkpoint expression profiles of T cells from oesophageal adenocarcinoma patients, Cancer Immunology Immunotherapy, 2023, Journal Article, PUBLISHED  TARA - Full Text  DOI
Moran J, Mylod E, Kane LE, Marion C, Keenan E, Mekhaeil M, Lysaght J, Dev KK, O'Sullivan J, Conroy MJ., Investigating the Effects of Olaparib on the Susceptibility of Glioblastoma Multiforme Tumour Cells to Natural Killer Cell-Mediated Responses, Pharmaceutics, 2023, Journal Article, PUBLISHED  TARA - Full Text  DOI
Mekhaeil M, Conroy MJ, Dev KK., Olaparib Attenuates Demyelination and Neuroinflammation in an Organotypic Slice Culture Model of Metachromatic Leukodystrophy., Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics, 20, (5), 2023, p1347-1368 , Journal Article, PUBLISHED  DOI
Mekhaeil M, Conroy MJ, Dev KK., Elucidating the Therapeutic Utility of Olaparib in Sulfatide-Induced Human Astrocyte Toxicity and Neuroinflammation., Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology, 18, (4), 2023, p592-609 , Journal Article, PUBLISHED  DOI
Reynolds JV, Donlon NE, Elliott JA, Moran B, Temperley H, Nugent TS, Davern M, King S, Conroy M, Lysaght J, Ravi N, Ryan C, Finn S, Norris S, Donohoe CL., Incidence and Impact of Non-alcoholic Fatty Liver Disease (NAFLD) in Patients with Adenocarcinoma of the Esophagus Treated with Curative Intent., World Journal of Surgery, 2022, Journal Article, PUBLISHED  DOI
Mylod E, McKenna E, Davern M, Barr MP, Donlon NE, Bibby BA, Bhardwaj A, Reynolds JV, Lysaght J, Maher SG, Conroy MJ., Investigating the susceptibility of treatment-resistant oesophageal tumours to natural killer cell-mediated responses, Clinical and Experimental Medicine, 2022, Journal Article, ACCEPTED  TARA - Full Text  DOI
Mylod E, Lysaght J, Conroy MJ., Natural killer cell therapy: A new frontier for obesity-associated cancer, Cancer Letters, 2022, Journal Article, PUBLISHED  TARA - Full Text  DOI
  

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CX3CL1 Signalling in the Tumor Microenvironment. in, editor(s)Alexander Birbrair (Eds) , Tumor Microenvironment, Springer Nature, Springer Nature, 2020, [Conroy M.J. and J. Lysaght.], Book Chapter, PUBLISHED
Royds J., Conroy M.J., Dunne M.R., Cassidy H., Matallanas D.G., Lysaght J. and C. McCrory., Examination and characterisation of burst spinal cord stimulation on cerebrospinal fluid cellular and protein constituents in patient responders with chronic neuropathic pain - A Pilot Study, Journal of Neuroimmunology, 2020, Journal Article, PUBLISHED

  

Award Date
MA (jo), Trinity College Dublin 08/06/2024
HSE Open Access Research Award (Integrated Services Category) 15/12/2023
Appointed as Lead of Irish Society for Immunology Outreach Committee 12/04/2023
Ranked in Professional Top 100 2022 in Hospital Professional News December 2022
Ranked in Professional Top 100 2021 in Hospital Professional News December 2021
European Federation of Immunological Societies Travel Grant 2021
MSC Travel Bursary. 2019
Antibody Genie Young Researcher Award. 2018
Maynooth University Access Program Alumni Achievement Award 2017
ImmunoTools Special Award. 2018
Irish Society of Immunology Travel Bursary. 2018
Recognition in the rank of Senior Research Fellow. 2016
First Prize in Postdoctoral Research Blitz, Trinity Translational Medicine Institute. 2018
European Association for Cancer Research Travel Fellowship 2016
Appointed to Irish Society for Immunology Outreach Committee 2015
Irish Research Council Government of Ireland Postdoctoral Fellowship 2015
Best Poster Prize at Irish Association for Cancer Research Annual Meeting 2014
Best Oral Poster prize at Irish Society of Immunology Annual Meeting 2009
Denis Phelan Scholarship, National University of Ireland 2004