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Dr. Roisin Mc Mackin

Assistant Professor (Physiology)
BIOMEDICAL SCIENCES INSTITUTE

 mcmackro@tcd.ie

 3531896 2718


Biography

Dr Roisin McMackin was awarded a PhD in Clinical Medicine in 2021 from Trinity College Dublin for investigation of electrophysiological biomarkers of ALS. This research was undertaken at the Academic Unit of Neurology, where she subsequently continued her research postdoctorally with the support of a prestigious MNDA Non-Clinical Fellowship. Dr McMackin began her role as Assistant Professor in the Discipline of Physiology in October 2022, and now leads a team of research students who use electrophysiology based measures to understand brain function in health and disease. Dr McMackin's research is supported by the Motor Neurone Disease Association UK, the ALS Association, The Irish Health Research Board and Research Motor Neurone, in addition to previous support from the Irish Research Council.

Research Tags

  Age related diseases   Biomedical sciences   Biostatistical methods   Clinical research, trials   Genomes, Genomics   Human genetics   Neurodegeneration   Neuropsychology

Representations

Details Date
Trinity College Dublin Representative of the Neuroscience Ireland Committee 14/08/2023
Coordinator of Civic Engagement activities for the Discipline of Physiology 01/2024

Memberships

Membership of Professional Institutions, Associations, Societies

Details Date From Date To
Royal Academy of Medicine in Ireland 04/2024 Present
Neuroscience Ireland 09/2022 Present
Irish Electrophysiology Research Clinic 26/05/2020 Present
Roisin McMackin, Yasmine Tadjine, Antonio Fasano, Matthew Mitchell, Mark Heverin, Friedemann Awiszus, Bahman Nasseroleslami, Richard G Carson, Orla Hardiman, Examining short interval intracortical inhibition with different transcranial magnetic stimulation-induced current directions in ALS, Clinical Neurophysiology Practice, 13, (9), 2024, p120 - 129, Journal Article, PUBLISHED  TARA - Full Text  DOI  URL
Dukic S, Fasano A, Coffey A, Buxó T, McMackin R, Chipika R, Heverin M, Bede P, Muthuraman M, Lowery M, Carson RG, Hardiman O, Nasseroleslami B., Electroencephalographic ß-band oscillations in the sensorimotor network reflect motor symptom severity in amyotrophic lateral sclerosis., Eur J Neurol., 2024, Notes: [2024 Jan 18:e16201. doi: 10.1111/ene.16201. Online ahead of print. PMID: 38235854], Journal Article, PUBLISHED  DOI  URL
Metzger M, Dukic S, McMackin R, Giglia E, Mitchell M, Bista S, Costello E, Peelo C, Tadjine Y, Sirenko V, Plaitano S, Coffey A, McManus L, Farnell Sharp A, Mehra P, Heverin M, Bede P, Muthuraman M, Pender N, Hardiman O, Nasseroleslami B., Functional network dynamics revealed by EEG microstates reflect cognitive decline in amyotrophic lateral sclerosis., Hum Brain Mapp., 2023, Notes: [2023 Dec 13. doi: 10.1002/hbm.26536. Online ahead of print. PMID: 38087950], Journal Article, PUBLISHED  DOI  URL
McMackin R, Bede P, Ingre C, Malaspina A, Hardiman O., Biomarkers in amyotrophic lateral sclerosis: current status and future prospects., Nat Rev Neurol., 2023, Notes: [2023 Nov 10. doi: 10.1038/s41582-023-00891-2. Online ahead of print. PMID: 37949994], Journal Article, PUBLISHED  URL
McMackin R, Dukic S, Costello E, Pinto-Grau M, McManus L, Broderick M, Chipika R, Iyer PM, Heverin M, Bede P, Muthuraman M, Pender N, Hardiman O, Nasseroleslami B. , Cognitive network hyperactivation and motor cortex decline correlate with ALS prognosis., Neurobiol Aging, 104, 2021, p57-70 , Notes: [doi: 10.1016/j.neurobiolaging.2021.03.002. Online ahead of print. PMID: 33964609], Journal Article, PUBLISHED
Costello E, Rooney J, Pinto-Grau M, Burke T, Elamin M, Bede P, McMackin R, Dukic S, Vajda A, Heverin M, Hardiman O, Pender N. , Cognitive reserve in amyotrophic lateral sclerosis (ALS): a population-based longitudinal study. , J Neurol Neurosurg Psychiatry. , 92, (5), 2021, p460-465 , Notes: [doi: 10.1136/jnnp-2020-324992. Epub 2021 Feb 9. PMID: 33563807], Journal Article, PUBLISHED  TARA - Full Text
Dukic S, McMackin R, Costello E, Metzger M, Buxo T, Fasano A, Chipika R, Pinto-Grau M, Schuster C, Hammond M, Heverin M, Coffey A, Broderick M, Iyer PM, Mohr K, Gavin B, McLaughlin R, Pender N, Bede P, Muthuraman M, van den Berg L, Hardiman O, Nasseroleslami B., Resting-state EEG reveals four subphenotypes of amyotrophic lateral sclerosis., Brain : a journal of neurology, (awab3222), 2021, Journal Article, PUBLISHED  DOI
McMackin R, Dukic S, Costello E, Pinto-Grau M, Keenan O, Fasano A, Buxo T, Heverin M, Reilly RB, Pender N, Hardiman O, Nasseroleslami B, Sustained attention to response task-related beta oscillations relate to performance and provide a functional biomarker in ALS., Journal of neural engineering, 18, (2), 2021, p026006 , Journal Article, PUBLISHED  DOI
Calvert GHM, McMackin R, Carson RG., Probing interhemispheric dorsal premotor-primary motor cortex interactions with threshold hunting transcranial magnetic stimulation., Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology, 131, (11), 2020, p2551-2560 , Journal Article, PUBLISHED  DOI
McMackin R, Dukic S, Costello E, Pinto-Grau M, Fasano A, Buxo T, Heverin M, Reilly R, Muthuraman M, Pender N, Hardiman O, Nasseroleslami B., Localization of Brain Networks Engaged by the Sustained Attention to Response Task Provides Quantitative Markers of Executive Impairment in Amyotrophic Lateral Sclerosis., Cerebral cortex (New York, N.Y. : 1991), 2020, Notes: [DOI: 10.1093/cercor/bhaa076], Journal Article, PUBLISHED  DOI
  

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Awards and Honours

Award Date
Neuroscience Ireland Early Career Investigator Award 2022
Brainbox Research Challenge Award 2020
Omniscient Neurotechnology Infinitome Imaging Award 2021
Trinity College Dublin University Gold Medal 2016
Trinity College Dublin Non-Foundation Scholarship 2014
Barbara Ryan Prize (TCD) 2015
Julian Boldy Prize (TCD) 2013
Eli Lilly Chemistry Prize 2013

Research Interests

Description Of Research Interests

Dr McMackin's research includes the use of electroencephalography (EEG) and transcranial magnetic stimulation (TMS) to investigate neural network function in health and neurodegenerative diseases. Her research aims are (i) to improve understanding of the cellular, neurochemical and and network physiology captured by electrophysiological measurements and (ii) to use electrophysiological measurements to progress understanding of neurodegenerative disease mechanisms, to identify diagnostic and prognostic biomarkers and to improve the outcome measures used to test potential therapies in neurological clinical trials. Dr McMackin has a particular interest in amyotrophic lateral sclerosis (ALS), the most common form of Motor Neurone Disease, and Huntington's Disease. Dr McMackin is also actively involved in preclinical drug development wet lab studies.