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Professor Aoife Mc Lysaght

Professor (Genetics)

 Aoife.McLysaght@tcd.ie

 3531896 3161/3161


Research Tags

  ACCELERATED SEQUENCE EVOLUTION   ANCIENT   Biocomputing   BIOINFORMATICS   COEVOLUTION   COMPARATIVE GENOMICS   COMPLETE NUCLEOTIDE-SEQUENCE   CONCERTED EVOLUTION   Evolution   EVOLUTION RATE   Evolutionary Biology   EVOLUTIONARY CHANGES   EVOLUTIONARY RELATIONSHIPS   EVOLUTIONARY SIGNIFICANCE   GENES   Genetics   Genomes, Genomics   Genomics   HIGH-FREQUENCY RETROTRANSPOSITION   Human Evolution   HYPOTHESIS   LINKAGE   Molecular evolution   Molecular Genetics   MONOAMINE-OXIDASE-A   PATTERN   POLYPLOIDS   RECEPTOR   SEQUENCE   VERTEBRATE EVOLUTION

Research Projects

 Gene expression level as a keystone to understanding gene duplication: evolutionary constraints, opportunities, and disease
 SFI ERC Supplement
 Dosage-sensitive genes in evolution and disease
 SFI ERC Supplement
 Origin and Evolution of Vertebrate de novo Genes

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Representations

Details Date
President, Society for Molecular Biology and Evolution (SMBE) 2018
External Advisory Board for the Milner Centre for Evolution, Bath University 2016
Senior Editor of Molecular Biology and Evolution Journal 2015
Associate Editor of Molecular Biology and Evolution 2005
Associate Editor of Genome Biology and Evolution Journal 2015
Editorial Board Member of Cell Reports 2011
Elected as Treasurer of the Society for Molecular Biology and Evolution (three year term) 2012
External Examiner, Bioinformatics and Genetics Degree, NUI Maynooth 2008

Languages

Language Skill Reading Skill Writing Skill Speaking
English Fluent Fluent Fluent
French Medium Medium Medium
Italian Basic Basic Basic

Memberships

Membership of Professional Institutions, Associations, Societies

Details Date From Date To
President, Society for Molecular Biology and Evolution 2018 2020
Treasurer, Society for Molecular Biology and Evolution 2012 2014
Member - Society for Molecular Biology and Evolution (SMBE) 2005 present
Member - Genetics Society (UK) 1999 present
Vakirlis, N. and Acar, O. and Hsu, B. and Coelho, N.C. and Van Oss, S.B. and Wacholder, A. and Medetgul-Ernar, K. and Bowman, R.W. and Hines, C.P. and Iannotta, J. and Parikh, S.B. and McLysaght, A. and Camacho, C.J. and O†Donnell, A.F. and Ideker, T. and Carvunis, A.-R., Author Correction: De novo emergence of adaptive membrane proteins from thymine-rich genomic sequences (Nature Communications, (2020), 11, 1, (781), 10.1038/s41467-020-14500-z), Nature Communications, 12, (1), 2021, Notes: [cited By 0], Journal Article, PUBLISHED  DOI
Nikolaos Vakirlis, Omer Acar, Brian Hsu, Nelson Castilho Coelho, S. Branden Van Oss, Aaron Wacholder, Kate Medetgul-Ernar, Ray W. Bowman II, Cameron P. Hines, John Iannotta, Saurin Bipin Parikh, Aoife McLysaght, Carlos J. Camacho, Allyson F. O'Donnell, Trey Ideker & Anne-Ruxandra Carvunis , De novo emergence of adaptive membrane proteins from thymine-rich genomic sequences, Nature Communications, 11 , (781), 2020, p1-18 , Journal Article, PUBLISHED  TARA - Full Text  DOI
Vakirlis N, Carvunis AR, McLysaght A., Synteny-based analyses indicate that sequence divergence is not the main source of orphan genes., eLife, 9, 2020, Journal Article, PUBLISHED  TARA - Full Text  DOI
Vakirlis N, McLysaght A., Computational Prediction of De Novo Emerged Protein-Coding Genes., Methods in molecular biology (Clifton, N.J.), 1851, 2019, p63-81 , Journal Article, PUBLISHED  DOI
Yoichiro Nakatani and Aoife McLysaght, Macrosynteny analysis shows the absence of ancient whole-genome duplication in lepidopteran insects., Proceedings of the National Academy of Sciences (USA), 2019, p1816-1818 , Journal Article, PUBLISHED  TARA - Full Text  DOI
Vakirlis, N. and Monerawela, C. and McManus, G. and Ribeiro, O. and McLysaght, A. and James, T. and Bond, U., Evolutionary journey and characterisation of a novel pan-gene associated with beer strains of Saccharomyces cerevisiae, Yeast, 36, (7), 2019, p425-437 , Notes: [cited By 1], Journal Article, PUBLISHED  DOI
O'Toole, Ã .N. and Hurst, L.D. and McLysaght, A., Faster Evolving Primate Genes Are More Likely to Duplicate, Molecular Biology and Evolution, 35, (1), 2018, p107-118 , Notes: [cited By 0], Journal Article, PUBLISHED  TARA - Full Text  DOI
Conway E, Jerman E, Healy E, Ito S, Holoch D, Oliviero G, Deevy O, Glancy E, Fitzpatrick DJ, Mucha M, Watson A, Rice AM, Chammas P, Huang C, Bracken AP., A Family of Vertebrate-Specific Polycombs Encoded by the LCOR/LCORL Genes Balance PRC2 Subtype Activities., Molecular Cell, 70, (3), 2018, p408-421 , Journal Article, PUBLISHED  TARA - Full Text  DOI
Glenfield C, McLysaght A., Pseudogenes Provide Evolutionary Evidence for the Competitive Endogenous RNA Hypothesis., Molecular biology and evolution, 35, (12), 2018, p2886-2899 , Journal Article, PUBLISHED  TARA - Full Text  DOI
Nakatani Y, McLysaght A, Genomes as documents of evolutionary history: A probabilistic macrosynteny model for the reconstruction of ancestral genomes, Bioinformatics, 33, (14), 2017, pi369 - i378, Journal Article, PUBLISHED  TARA - Full Text  DOI  URL
  

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Aoife McLysaght, Invited Lecture, Gordon Research Conference, Ecological and Evolutionary Genomics, Rhode Island, USA, July 2021, 2021, Oral Presentation, ACCEPTED
Aoife McLysaght, Invited Lecture, Gordon Research Conference, Molecular Mechanisms of Evolution, Boston, USA, June 2021, 2021, Oral Presentation, ACCEPTED
Aoife McLysaght, Invited Departmental Seminar, Max Planck Institute for Molecular Genetics, Berlin, January 2020, 2020, Oral Presentation, PRESENTED
Aoife McLysaght, Lord Phillips Memorial Lecture (named lecture), Cardiff Scientific Society, Cardiff, 2019, Oral Presentation, PRESENTED
Aoife Mclysaght, Invited Lecture, Cambridge Society for the Application of Research, Cambridge University, 4th March 2019, 2019, Oral Presentation, PRESENTED
Aoife McLysaght, Nei Lectuire (Keynote), Society for Molecular Biology and Evolution, Manchester, UK, July 2019, 2019, Oral Presentation, PRESENTED
Aoife McLysaght, Departmental Seminar, University of Edinburgh, 13 February 2019, 2019, Oral Presentation, PRESENTED
Aoife McLysaght, Darwin Day Lecture, Centre for Ecology and Evolution, UCL, London, 7th February 2018, 2018, Oral Presentation, PRESENTED
Aoife McLysaght, Invited lecture, EMBO Workshop "Evolution in a Time of Genome Architecture", Naples, Italy, 13-15 Sept 2017 , 2017, Oral Presentation, ACCEPTED
Aoife McLysaght, Invited Lecture, Society for Molecular Biology and Evolution, Austin, Texas, USA, July 2017, 2017, Oral Presentation, PRESENTED

  

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Awards and Honours

Award Date
European Research Council (ERC) Consolidator Award 2019-2023
JBS Haldane Prize Lectures (Genetics Society UK) 2016
Selected for portrait in RIA as part of Women on Walls project: https://www.ria.ie/women-walls-0 2016
European Research Council (ERC) Starting Researcher Award 2013-2018
President of Ireland Young Researcher's Award (Science Foundation Ireland) 2005