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Professor Aoife Mc Lysaght

Professor (Genetics)

 Aoife.McLysaght@tcd.ie

 3531896 3161/3161


Research Tags

  ACCELERATED SEQUENCE EVOLUTION   ANCIENT   Biocomputing   BIOINFORMATICS   COEVOLUTION   COMPARATIVE GENOMICS   COMPLETE NUCLEOTIDE-SEQUENCE   CONCERTED EVOLUTION   Evolution   EVOLUTION RATE   Evolutionary Biology   EVOLUTIONARY CHANGES   EVOLUTIONARY RELATIONSHIPS   EVOLUTIONARY SIGNIFICANCE   GENES   Genetics   Genomes, Genomics   Genomics   HIGH-FREQUENCY RETROTRANSPOSITION   Human Evolution   HYPOTHESIS   LINKAGE   Molecular evolution   Molecular Genetics   MONOAMINE-OXIDASE-A   PATTERN   POLYPLOIDS   RECEPTOR   SEQUENCE   VERTEBRATE EVOLUTION

Research Projects

 Gene expression level as a keystone to understanding gene duplication: evolutionary constraints, opportunities, and disease
 SFI ERC Supplement
 Dosage-sensitive genes in evolution and disease
 SFI ERC Supplement
 Origin and Evolution of Vertebrate de novo Genes

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Representations

Details Date
Academic Editor for PLoS Biology journal 2022
President, Society for Molecular Biology and Evolution (SMBE) 2018
External Advisory Board for the Milner Centre for Evolution, Bath University 2016
Senior Editor of Molecular Biology and Evolution Journal 2015
Associate Editor of Molecular Biology and Evolution 2005
Associate Editor of Genome Biology and Evolution Journal 2015
Editorial Board Member of Cell Reports 2011
Elected as Treasurer of the Society for Molecular Biology and Evolution (three year term) 2012
External Examiner, Bioinformatics and Genetics Degree, NUI Maynooth 2008

Languages

Language Skill Reading Skill Writing Skill Speaking
English Fluent Fluent Fluent
French Medium Medium Medium
Italian Basic Basic Basic

Memberships

Membership of Professional Institutions, Associations, Societies

Details Date From Date To
President, Society for Molecular Biology and Evolution 2018 2020
Treasurer, Society for Molecular Biology and Evolution 2012 2014
Member - Society for Molecular Biology and Evolution (SMBE) 2005 present
Member - Genetics Society (UK) 1999 present
Vance Z, Niezabitowski L, Hurst LD, McLysaght A., Evidence from Drosophila Supports Higher Duplicability of Faster Evolving Genes., Genome biology and evolution, 14, (1), 2022, Journal Article, PUBLISHED  TARA - Full Text  DOI
Nakatani Y, Shingate P, Ravi V, Pillai NE, Prasad A, McLysaght A, Venkatesh B., Reconstruction of proto-vertebrate, proto-cyclostome and proto-gnathostome genomes provides new insights into early vertebrate evolution., Nature communications, 12, (1), 2021, p4489 , Journal Article, PUBLISHED  TARA - Full Text  DOI
Redmond, Anthony K., McLysaght, Aoife, Evidence for sponges as sister to all other animals from partitioned phylogenomics with mixture models and recoding, Nature Communications, 12, (1), 2021, Journal Article, PUBLISHED  TARA - Full Text  DOI
Nakatani, Y. and Shingate, P. and Ravi, V. and Pillai, N.E. and Prasad, A. and McLysaght, A. and Venkatesh, B., Publisher Correction: Reconstruction of proto-vertebrate, protocyclostome and proto-gnathostome genomes provides new insights into early vertebrate evolution (Nature Communications, (2021), 12, 1, (4489), 10.1038/s41467-021-24573-z), Nature Communications, 12, (1), 2021, Notes: [cited By 0], Journal Article, PUBLISHED  DOI
Vakirlis, N. and Acar, O. and Hsu, B. and Coelho, N.C. and Van Oss, S.B. and Wacholder, A. and Medetgul-Ernar, K. and Bowman, R.W. and Hines, C.P. and Iannotta, J. and Parikh, S.B. and McLysaght, A. and Camacho, C.J. and O†Donnell, A.F. and Ideker, T. and Carvunis, A.-R., Author Correction: De novo emergence of adaptive membrane proteins from thymine-rich genomic sequences (Nature Communications, (2020), 11, 1, (781), 10.1038/s41467-020-14500-z), Nature Communications, 12, (1), 2021, Notes: [cited By 0], Journal Article, PUBLISHED  DOI
Nikolaos Vakirlis, Omer Acar, Brian Hsu, Nelson Castilho Coelho, S. Branden Van Oss, Aaron Wacholder, Kate Medetgul-Ernar, Ray W. Bowman II, Cameron P. Hines, John Iannotta, Saurin Bipin Parikh, Aoife McLysaght, Carlos J. Camacho, Allyson F. O'Donnell, Trey Ideker & Anne-Ruxandra Carvunis , De novo emergence of adaptive membrane proteins from thymine-rich genomic sequences, Nature Communications, 11 , (781), 2020, p1-18 , Journal Article, PUBLISHED  TARA - Full Text  DOI
Vakirlis N, Carvunis AR, McLysaght A., Synteny-based analyses indicate that sequence divergence is not the main source of orphan genes., eLife, 9, 2020, Journal Article, PUBLISHED  TARA - Full Text  DOI
Vakirlis N, McLysaght A., Computational Prediction of De Novo Emerged Protein-Coding Genes., Methods in molecular biology (Clifton, N.J.), 1851, 2019, p63-81 , Journal Article, PUBLISHED  DOI
Yoichiro Nakatani and Aoife McLysaght, Macrosynteny analysis shows the absence of ancient whole-genome duplication in lepidopteran insects., Proceedings of the National Academy of Sciences (USA), 2019, p1816-1818 , Journal Article, PUBLISHED  TARA - Full Text  DOI
Vakirlis, N. and Monerawela, C. and McManus, G. and Ribeiro, O. and McLysaght, A. and James, T. and Bond, U., Evolutionary journey and characterisation of a novel pan-gene associated with beer strains of Saccharomyces cerevisiae, Yeast, 36, (7), 2019, p425-437 , Notes: [cited By 1], Journal Article, PUBLISHED  DOI
  

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Aoife McLysaght, Departmental seminar, North Carolina State University (via online), 31 Jan 2022, 2022, Oral Presentation, ACCEPTED
N. Vakirlis, KM Duggan, A McLysaght, De novo birth of functional, human-specific microproteins, bioRxiv, 2021, Notes: [Submitted to a peer reviewed journal for publication. https://www.biorxiv.org/content/10.1101/2021.10.01.462744v2.abstract], Journal Article, PUBLISHED
Aoife McLysaght, Invited Lecture, Gordon Research Conference, Ecological and Evolutionary Genomics, Rhode Island, USA, July 2021, 2021, Notes: [Postponed indefinitely due to COVID-19 pandemic], Oral Presentation, ACCEPTED
Aoife McLysaght, Seminar, Universitat Pompeu Fabra, Barcelona, Spain, October 2021, 2021, Oral Presentation, PRESENTED
Aoife McLysaght, Departmental Seminar, Cambridge University, Zoology Department, January 2021, 2021, Oral Presentation, PRESENTED
Aoife McLysaght, Invited Departmental Seminar, Max Planck Institute for Molecular Genetics, Berlin, January 2020, 2020, Oral Presentation, PRESENTED
Aoife McLysaght, Departmental Seminar, Bristol University, UK, November 2020, 2020, Oral Presentation, PRESENTED
Aoife McLysaght, Departmental Seminar, York University, UK, November 2020, 2020, Notes: [Online], Oral Presentation, PRESENTED
Aoife McLysaght, Lord Phillips Memorial Lecture (named lecture), Cardiff Scientific Society, Cardiff, 2019, Oral Presentation, PRESENTED
Aoife Mclysaght, Invited Lecture, Cambridge Society for the Application of Research, Cambridge University, 4th March 2019, 2019, Oral Presentation, PRESENTED

  

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Awards and Honours

Award Date
European Research Council (ERC) Consolidator Award 2019-2023
JBS Haldane Prize Lectures (Genetics Society UK) 2016
Selected for portrait in RIA as part of Women on Walls project: https://www.ria.ie/women-walls-0 2016
European Research Council (ERC) Starting Researcher Award 2013-2018
President of Ireland Young Researcher's Award (Science Foundation Ireland) 2005