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Dr. Rachel Mary Mc Loughlin

Professor in Immunology (Biochemistry)


  BACTERIAL INFECTION   BLOOD-STREAM INFECTIONS   CD4(+) T-CELLS   Hospital acquired infections   Human infection   HUMAN POLYMORPHONUCLEAR NEUTROPHILS   HUMAN T-CELLS   IMMUNE CELLS   IMMUNOLOGY   INFECTION   Infection and immunity   Infection Model   MONONUCLEAR-CELLS   Mucosal Immunology   STAPHYLOCOCCUS AUREUS INFECTION
 Skin delivery and tissue-resident T cell responses: implications for innovative vaccines
 Characterisation and exploitation of skin resident memory CD4 T cells for novel vaccines for Staphylococcus aureus
 Vaccination:Knowledge is Power
 Delineating immune memory to Staphylococcus aureus
 Staphylococcus aureus induced immunosuppressive memory: consequences for bug and for host

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Details Date
Member of the Welcome Immune System in Health and Disease Expert Review Group 2020
Associate editor PLOS Pathogens. 2020
Editorial board member Infection and Immunity 2019
Details Date From Date To
Irish Society of Immunology 2013 to date
British Society Immunology 2010 to date
American Association of Microbiology 2011 2013
Infectious Diseases Society of America 2006 2009
American Association of Immunology 2005 2013
International Cytokine Society 2016 to date
Ultán P. Doherty, Rachel McLoughlin, Tracey Claxton, Arthur White, gateTree: A user-informed tree algorithm for population identification in flow cytometry, International Workshop on Statistical Modelling 2024, Durham, United Kingdom, 14 to 19 July 2024, edited by Jochen Einbeck, Reza Drikvandi, Georgios Karagiannis, Konstantinos Perrakis, Qing Zhang , 2024, pp108 - 113, Conference Paper, PUBLISHED  URL
McCarthy KN, Hone S, McLoughlin RM, Mills KHG., IL-17 and IFN-"-producing respiratory tissue resident memory CD4"T cells persist for decades in adults immunized as children with whole cell pertussis vaccines., The Journal of infectious diseases, 2024, pjiae034 , Journal Article, PUBLISHED  DOI
Vozza EG, Daly CM, O'Rourke SA, Fitzgerald HK, Dunne A, McLoughlin RM., Staphylococcus aureus suppresses the pentose phosphate pathway in human neutrophils via the adenosine receptor A2aR to enhance intracellular survival., mBio : Duplicate, marked for deletion, 15, (1), 2024, pe0257123 , Journal Article, PUBLISHED  DOI
Kelly AM, McCarthy KN, Claxton TJ, Carlile SR, O'Brien EC, Vozza EG, Mills KH, McLoughlin RM., IL-10 inhibition during immunization improves vaccine-induced protection against Staphylococcus aureus infection., JCI insight, 9, (13), 2024, pe178216 , Journal Article, PUBLISHED  DOI
Clowry Juliann, Dempsey Daniel J, Claxton Tracey J, Towell Aisling M, Turley Mary B, Sutton Marti, Geoghegan Joan A, Kezic Sanj, Jakasa Ivon, White Arthu, Irvine Alan D, McLoughlin Rachel M, Distinct T cell signatures are associated with Staphylococcus aureus skin infection in pediatric atopic dermatitis, 9, (9), 2024, p1-19 , Journal Article, PUBLISHED  DOI  URL
Douglas EJA, Palk N, Brignoli T, Altwiley D, Boura M, Laabei M, Recker M, Cheung GYC, Liu R, Hsieh RC, Otto M, O'Brien E, McLoughlin RM, Massey RC., Extensive remodelling of the cell wall during the development of Staphylococcus aureus bacteraemia., eLife, 12, 2023, pRP87026 , Journal Article, PUBLISHED  DOI
Curham, L.M. and Mannion, J.M. and Daly, C.M. and Wilk, M.M. and Borkner, L. and Lalor, S.J. and McLoughlin, R.M. and Mills, K.H.G., Bystander activation of Bordetella pertussis-induced nasal tissue-resident memory CD4 T cells confers heterologous immunity to Klebsiella pneumoniae, European Journal of Immunology, 2023, Notes: [cited By 0], Journal Article, PUBLISHED  TARA - Full Text  DOI
Mannion JM, Segal BM, McLoughlin RM, Lalor SJ., Respiratory tract Moraxella catarrhalis and Klebsiella pneumoniae can promote pathogenicity of myelin-reactive Th17 cells., Mucosal immunology, 16, (4), 2023, p399-407 , Journal Article, PUBLISHED  DOI
Ward J, Zhang S, Sikora A, Michalski R, Yin Y, D'Alessio A, McLoughlin RM, Jaquet V, Fieschi F, Knaus UG., VEO-IBD NOX1 variant highlights a structural region essential for NOX/DUOX catalytic activity., Redox biology, 67, 2023, p102905 , Journal Article, PUBLISHED  DOI
Ryan, T.A.J. and Hooftman, A. and Rehill, A.M. and Johansen, M.D. and Brien, E.C.O. and Toller-Kawahisa, J.E. and Wilk, M.M. and Day, E.A. and Weiss, H.J. and Sarvari, P. and Vozza, E.G. and Schramm, F. and Peace, C.G. and Zotta, A. and Miemczyk, S. and Nalkurthi, C. and Hansbro, N.G. and McManus, G. and O†Doherty, L. and Gargan, S. and Long, A. and Dunne, J. and Cheallaigh, C.N. and Conlon, N. and Carty, M. and Fallon, P.G. and Mills, K.H.G. and Creagh, E.M. and Donnell, J.S.O. and Hertzog, P.J. and Hansbro, P.M. and McLoughlin, R.M. and Wygrecka, M. and Preston, R.J.S. and ZasÅ'ona, Z. and Neill, L.A.J.O., Dimethyl fumarate and 4-octyl itaconate are anticoagulants that suppress Tissue Factor in macrophages via inhibition of Type I Interferon, Nature Communications, 14, (1), 2023, Notes: [cited By 0], Journal Article, PUBLISHED  TARA - Full Text  DOI
  

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Award Date
TCD Faculty of STEM Award for excellence in postgraduate research supervision 2023
Panel Member St Brigid's Day Event, Irish Embassy London: Celebrating the creativity of Irish women 2018
Science Foundation Ireland Early Career Researcher of the Year 2017
Elected to Fellowship Trinity College Dublin 2016