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Dr. Russell Mc Laughlin

Ussher Assistant Professor (Genetics)


 Detecting the dark matter of neurodegeneration: repeat expansions in amyotrophic lateral sclerosis
 The genetic pleiotropy of neurodegenerative mutations
 Whole-genome sequencing of 1000 Irish ALS patients and controls to identify novel ALS genes and pathways
 Project MinE Ireland: sequencing and analysis of 1,050 Irish genomes to identify the causes of amyotrophic lateral sclerosis
 Advancing research in neurodegenerative disease: genome analysis in amyotrophic lateral sclerosis

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Details Date
UCL PhD external examiner 21-Oct-2019
Member, Scientific Advisory Board for ALS Online Genetics Database April 2019-ongoing
Panel member, judging committee for ALS Prize4Life Genetic Data Challenge (University of Massachusetts Medical School) 2017
Journal reviewer: Nature Communications; Journal of Neurology, Neurosurgery and Psychiatry; Acta Neuropathologica; PLOS One; Neurobiology of Aging; BMC Medical Genomics; Genome Medicine; Amyotrophic Lateral Sclerosis and Frontotemporal dementia 2012-present
Grant proposal reviewer: MND Association (UK); Academy of Medical Sciences (UK); Strasbourg Institute for Advanced Study (UK); Association of British Neurologists (UK) 2015-present
Progress review committee, SFI CRT in Genomic Data Science Apr 2020-onwards
Language Skill Reading Skill Writing Skill Speaking
English Fluent Fluent Fluent
German Medium Basic Basic
Details Date From Date To
Irish Society of Human Genetics 01/09/2016 Ongoing
American Society of Human Genetics 01/11/2016 31/12/2017
European Society of Human Genetics 01/06/2019 Onging
European Network to Cure ALS 01/09/2008 Ongoing
Project MinE Consortium 01/09/2014 Ongoing
Bede P, Chipika RH, Finegan E, Li Hi Shing S, Chang KM, Doherty MA, Hengeveld JC, Vajda A, Hutchinson S, Donaghy C, McLaughlin RL, Hardiman O., Progressive brainstem pathology in motor neuron diseases: Imaging data from amyotrophic lateral sclerosis and primary lateral sclerosis. , Data in Brief, 2020, Notes: [2020 Feb 3;29:105229. doi: 10.1016/j.dib.2020.105229. eCollection 2020 Apr. PMID: 32083157 ], Journal Article, PUBLISHED  DOI
Finegan E, Hi Shing SL, Chipika RH, McKenna MC, Doherty MA, Hengeveld JC, Vajda A, Donaghy C, McLaughlin RL, Hutchinson S, Hardiman O, Bede P, Thalamic, hippocampal and basal ganglia pathology in primary lateral sclerosis and amyotrophic lateral sclerosis: Evidence from quantitative imaging data, Data in Brief, 2020, Notes: [2020 Jan 10;29:105115. doi: 10.1016/j.dib.2020.105115. eCollection 2020 Apr. PMID: 32055654], Journal Article, PUBLISHED  DOI
Dekker, A.M. and Diekstra, F.P. and Pulit, S.L. and Tazelaar, G.H.P. and van der Spek, R.A. and van Rheenen, W. and van Eijk, K.R. and Calvo, A. and Brunetti, M. and Damme, P.V. and Robberecht, W. and Hardiman, O. and McLaughlin, R. and Chiò, A. and Sendtner, M. and Ludolph, A.C. and Weishaupt, J.H. and Pardina, J.S.M. and van den Berg, L.H. and Veldink, J.H., Exome array analysis of rare and low frequency variants in amyotrophic lateral sclerosis, Scientific Reports, 9, (1), 2019, Notes: [cited By 0], Journal Article, PUBLISHED  DOI
Ryan, M. and Zaldívar Vaillant, T. and McLaughlin, R.L. and Doherty, M.A. and Rooney, J. and Heverin, M. and Gutierrez, J. and Lara-Fernández, G.E. and Pita Rodríguez, M. and Hackembruch, J. and Perna, A. and Vazquez, M.C. and Musio, M. and Ketzoian, C.N. and Logroscino, G. and Hardiman, O., Comparison of the clinical and genetic features of amyotrophic lateral sclerosis across Cuban, Uruguayan and Irish clinic-based populations, Journal of Neurology, Neurosurgery and Psychiatry, 90, (6), 2019, p659-665 , Notes: [cited By 0], Journal Article, PUBLISHED  DOI
Tazelaar, G.H.P. and Dekker, A.M. and van Vugt, J.J.F.A. and van der Spek, R.A. and Westeneng, H.-J. and Kool, L.J.B.G. and Kenna, K.P. and van Rheenen, W. and Pulit, S.L. and McLaughlin, R.L. and Sproviero, W. and Iacoangeli, A. and HÃŒbers, A. and Brenner, D. and Morrison, K.E. and Shaw, P.J. and Shaw, C.E. and Panadés, M.P. and Mora Pardina, J.S. and Glass, J.D. and Hardiman, O. and Al-Chalabi, A. and van Damme, P. and Robberecht, W. and Landers, J.E. and Ludolph, A.C. and Weishaupt, J.H. and van den Berg, L.H. and Veldink, J.H. and van Es, M.A., Association of NIPA1 repeat expansions with amyotrophic lateral sclerosis in a large international cohort, Neurobiology of Aging, 74, 2019, p234.e9-234.e15 , Notes: [cited By 3], Journal Article, PUBLISHED  DOI
Ryan, M. and Heverin, M. and McLaughlin, R.L. and Hardiman, O., Lifetime Risk and Heritability of Amyotrophic Lateral Sclerosis, JAMA Neurology, 2019, Notes: [cited By 0], Journal Article, PUBLISHED  DOI
Finegan E, Chipika RH, Li Hi Shing S, Doherty MA, Hengeveld JC, Vajda A, Donaghy C, McLaughlin RL, Pender N, Hardiman O, Bede P, The clinical and radiological profile of primary lateral sclerosis: a population-based study., Journal of Neurology, 2019, Notes: [J Neurol. 2019 Jul 19. doi: 10.1007/s00415-019-09473-z. [Epub ahead of print]PMID: 31325016 ], Journal Article, PUBLISHED
Nasseroleslami B, Dukic S, Broderick M, Mohr K, Schuster C, Gavin B, McLaughlin R, Heverin M, Vajda A, Iyer PM, Pender N, Bede P, Lalor EC, Hardiman O., Characteristic Increases in EEG Connectivity Correlate With Changes of Structural MRI in Amyotrophic Lateral Sclerosis., Cereb Cortex, 29, (1), 2019, p27 - 41, Notes: [doi: 10.1093/cercor/bhx301, PMID: 29136131 ], Journal Article, PUBLISHED
Byrne RP, Martiniano R, Cassidy LM, Carrigan M, Hellenthal G, Hardiman O, Bradley DG, McLaughlin RL, Insular Celtic population structure and genomic footprints of migration, PLOS Genetics, 14, 2018, pe1007152 , Journal Article, PUBLISHED  TARA - Full Text  DOI
Bede P, Omer T, Finegan E, Chipika RH, Iyer PM, Doherty MA, Vajda A, Pender N, McLaughlin RL, Hutchinson S, Hardiman O., Connectivity-based characterisation of subcortical grey matter pathology in frontotemporal dementia and ALS: a multimodal neuroimaging study., Brain Imaging Behav, 2018, p1 - 19, Notes: [ doi: 10.1007/s11682-018-9837-9. [Epub ahead of print] PMID:29423814 ], Journal Article, PUBLISHED  DOI

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Byrne RP, van Rheenen W, Project MinE ALS GWAS Consortium, van den Berg LH, Veldink JH, McLaughlin RL, Dutch population structure across space, time and GWAS design, bioRxiv, 2020, Journal Article, PUBLISHED


Award Date
European Network to Cure ALS Young Investigator Award 2018
Irish Laboratory Awards Young Leader of the Year 2018
Best presentation award, 4th Frontiers in Neurology conference 2014
Best poster award, 10th Meeting of the European Network for the Cure of ALS 2012