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Dr. Craig Mc Entee

Research Assistant Professor (Biochemistry)


Having graduated from Trinity College Dublin (TCD) in 2012 with a first class honours degree in Biochemistry with Immunology, I was awarded an Irish Research Council-Enterprise Partnership Scheme Scholarship to undertake a PhD in the School of Biochemistry and Immunology at TCD. This work, which had a focus on mucosal vaccine adjuvant discovery, was performed in the Adjuvant Research Group under the supervision of Professor Ed Lavelle at the Trinity Biomedical Sciences Institute. I successfully defended my PhD thesis in September 2016 and continued my research as a Post-doc in the same group until December 2017. In January 2018 I accepted a position as a Research Associate at the University of Manchester, working under the supervision of Professor Mark Travis. Here I investigated novel roles for TGFß-activating integrins in the context of anti-viral memory T cell biology, work I presented at a number of national and international conferences. I also contributed to work published in the Journal of Experimental Medicine, Science and the Journal of Immunology. In February 2021 I was awarded a Marie Sk"odowska-Curie Individual Fellowship by the European Commission to investigate the role of PYHIN family proteins in dendritic cell-mediated regulation of anti-viral memory T cell responses. I undertook this project in the Immune Sensing and Signalling Research Group, led by Prof. Andrew Bowie in the School of Biochemistry and Immunology at TCD and in July 2023 was awarded an eight year University Research Fellowship from The Royal Society to establish my own group at TCD, building on my previous work to investigate how modulating early innate immune responses following viral infection can influence protective memory T cell differentiation and function.
  Adaptive Immunity   DNA SENSING   Innate immunology   T cells   Virology and viral pathogenesis
Details Date
Selected to represent the School of Biochemistry & Immunology as a postdoctoral representative in audit meetings with both independent external reviewers and stakeholders (Science Foundation Ireland).
Language Skill Reading Skill Writing Skill Speaking
English Fluent Fluent Fluent
Details Date From Date To
Irish Society for Immunology 2021 Present
British Society for Immunology 2018 Present
Dow J, Cytlak UM, Casulli J, McEntee CP, Smedley C, Hodge SH, D'Elia RV, Hepworth MR, Travis MA., Group 2 Innate Lymphoid Cells Are Detrimental to the Control of Infection with Francisella tularensis., Journal of immunology (Baltimore, Md. : 1950), 210, (5), 2023, p618-627 , Journal Article, PUBLISHED  DOI
Muñoz-Wolf, N. and Ward, R.W. and Hearnden, C.H. and Sharp, F.A. and Geoghegan, J. and O'Grady, K. and McEntee, C.P. and Shanahan, K.A. and Guy, C. and Bowie, A.G. and Campbell, M. and Roces, C.B. and Anderluzzi, G. and Webb, C. and Perrie, Y. and Creagh, E. and Lavelle, E.C., Non-canonical inflammasome activation mediates the adjuvanticity of nanoparticles, Cell Reports Medicine, 4, (1), 2023, Notes: [cited By 1], Journal Article, PUBLISHED  DOI
Albutti, A. and Longet, S. and McEntee, C.P. and Quinn, S. and Liddicoat, A. and Rîmniceanu, C. and Lycke, N. and Lynch, L. and Cardell, S. and Lavelle, E.C., Type ii nkt cell agonist, sulfatide, is an effective adjuvant for oral heat-killed cholera vaccines, Vaccines, 9, (6), 2021, Notes: [cited By 0], Journal Article, PUBLISHED  TARA - Full Text  DOI
Turley, J.L. and Moran, H.B.T. and McEntee, C.P. and O'Grady, K. and Muñoz-Wolf, N. and Jin, L. and Follmann, F. and Andersen, P. and Andersson, M. and Lavelle, E.C., Chitin-derived polymer deacetylation regulates mitochondrial reactive oxygen species dependent cGAS-STING and NLRP3 inflammasome activation, Biomaterials, 275, (120961), 2021, Notes: [cited By 0], Journal Article, PUBLISHED  DOI
McEntee, Craig P., Gunaltay, Sezin, Travis, Mark A., Regulation of barrier immunity and homeostasis by integrin"mediated transforming growth factor ß activation, Immunology, 160, (2), 2020, p139-148 , Journal Article, PUBLISHED  DOI
Craig P. McEntee, Hannah B.T. Moran, Natalia Muñoz-Wolf, Alex M. Liddicoat, Elizabeth C. Carroll, Jeanette Erbo-Wern, Ivan S. Coulter, Peter Andersen, Frank Follmann, Ed C. Lavelle, Type I IFN signalling is required for cationic adjuvant formulation (CAF)01-induced cellular immunity and mucosal priming, Vaccine, 38, (3), 2020, p635--643 , Journal Article, PUBLISHED
Mani V, Bromley SK, Äijö T, Mora-Buch R, Carrizosa E, Warner RD, Hamze M, Sen DR, Chasse AY, Lorant A, Griffith JW, Rahimi RA, McEntee CP, Jeffrey KL, Marangoni F, Travis MA, Lacy-Hulbert A, Luster AD, Mempel TR., Migratory DCs activate TGF-ß to precondition naïve CD8+ T cells for tissue-resident memory fate., Science (New York, N.Y.), 366, (6462), 2019, peaav5728 , Journal Article, PUBLISHED  DOI
McEntee, C.P. and Finlay, C.M. and Lavelle, E.C., Divergent roles for the IL-1 family in gastrointestinal homeostasis and inflammation, Frontiers in Immunology, 10, (JUN), 2019, Notes: [cited By 0], Journal Article, PUBLISHED  TARA - Full Text  DOI
Davitt, C.J.H. and Longet, S. and Albutti, A. and Aversa, V. and Nordqvist, S. and Hackett, B. and McEntee, C.P. and Rosa, M. and Coulter, I.S. and Lebens, M. and Tobias, J. and Holmgren, J. and Lavelle, E.C., Alpha-galactosylceramide enhances mucosal immunity to oral whole-cell cholera vaccines, Mucosal Immunology, 12, (4), 2019, p1055-1064 , Notes: [cited By 0], Journal Article, PUBLISHED  TARA - Full Text  DOI
Longet, S. and Abautret-Daly, A. and Davitt, C.J.H. and McEntee, C.P. and Aversa, V. and Rosa, M. and Coulter, I.S. and Holmgren, J. and Raghavan, S. and Lavelle, E.C., An oral alpha-galactosylceramide adjuvanted Helicobacter pylori vaccine induces protective IL-1R- and IL-17R-dependent Th1 responses, npj Vaccines, 4, (1), 2019, Notes: [cited By 0], Journal Article, PUBLISHED  TARA - Full Text  DOI

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CP McEntee, S Houston, CM Finlay, S Rossi, G Liu, TN Shaw, J Casulli, M Fife, C Smedley, View ORCID ProfileTS Griffith, View ORCID ProfileM Pepper, T Hussell, PM Hansbro, View ORCID ProfileJ-M Schwartz, H Paidassi, MA Travis, A subset of CD4+ effector memory T cells limit immunity to pulmonary viral infection and prevent tissue pathology via activation of latent TGFß, BioRxiv, (2023.03.02.527395), 2023, Journal Article, PUBLISHED
Chapter 63 - Antigen Delivery Systems I: Nonliving Microparticles, Liposomes, and Immune-Stimulating Complexes (ISCOMs) in, editor(s)Jiri Mestecky Michael W. Russell Hilde Cheroutre Warren Strober Brian L. Kelsall Bart N. Lambrecht , Mucosal Immunology (Fourth Edition),, 2015, pp1211 - 1231, [C. McEntee, E.C. Lavelle and D.T. O'Hagan], Book Chapter, PUBLISHED


Award Date
Royal Society University Research Fellowship 01/10/2023
Marie Curie Individual Fellowship 01/09/2021
Irish Research Council Enterprise Partnership Scheme Scholarship 01/10/2012