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Dr. Tony Mc Elligott

Assistant Prof in Molecular Haematology (Haematology)
TRINITY CENTRE, S J H

Assistant Prof in Molecular Haematology (Molecular Medicine Ireland)

I am a graduate of University College Cork with a BSc(Hons) in Biochemistry. Following a number of years as a Research Assistant in the University of Ulster at Coleraine, working in the area of molecular analysis of pathogenic bacteria, I undertook a PhD under the supervision of Dr Hugh McGlynn in the area of cancer cell invasion and metastasis. A Research Fellow (post-doc) position with Dr Richie Porter in the area of mitochondrial bioenergetics brought me to Trinity College Dublin in 1999 and I have remained here ever since. I joined the laboratory of Prof Mark Lawlor in 2001 and have subsequently built a research career focusing on the molecular basis of blood cancer and development of novel therapies. I was appointed as the Bone Marrow for Leukaemia Trust Assistant Professor in Molecular Haematology in 2016.
  Apoptosis   Biology and therapy of myeloma   Drug development and evaluation   Haemotology   Leukemias and lymphomas   Multiple Myeloma
 Assessing the functional impact of NOTCH1 mutations in chronic B-cell malignancies
 'STAT3 signalling as a therapeutic target in multiple myeloma'
 Blood Cancer Network Ireland
 Investigation of the therapeutic potential of secondary metabolites produced by Rasamsonia emersonii.
 Cancer Biobanking Awareness: Improving Research & Healthcare

Details Date
Scientific Secretary of the Haematology Association of Ireland. 2017
Details Date From Date To
Irish Association for Cancer Research 1995
Haematology Association of Ireland 2001
American Association for Cancer Research 2004
European Association for Cancer Research 2006
Rebecca Amet, Viola Previtali, Helene B. Mihigo, Emily Sheridan, Sarah Brophy , Nadhim Kamil Hante, Maria Jose Santos-Martinez, Patrick J. Hayden, Paul V. Browne, Isabel Rozas, Anthony M. McElligott , Daniela M. Zisterer , A novel aryl-guanidinium derivative, VP79s, targets the signal transducer and activator of transcription 3 signaling pathway, downregulates myeloid cell leukaemia-1 and exhibits preclinical activity against multiple myeloma , Life Sciences, 290, 2022, Journal Article, PUBLISHED  TARA - Full Text  DOI
McElligott, AM, Maginn, EN, Greene, LM, McGuckin, S, Hayat, A, Browne, PV, Butini, S, Campiani, G, Catherwood, MA, Vandenberghe, E, Williams, DC, Zisterer, DM, Lawler, M, The Novel Tubulin-Targeting Agent Pyrrolo-1,5-Benzoxazepine-15 Induces Apoptosis in Poor Prognostic Subgroups of Chronic Lymphocytic Leukemia., Cancer Research, 69, (21), 2009, p8366 - 8375, Notes: [PMID 19479253], Journal Article, PUBLISHED  DOI
Maginn EN, Browne PV, Hayden P, Vandenberghe E, McDonagh B, Evans P, Goodyer M, Tewari P, Campiani G, Butini S, Williams DC, Zisterer DM, Lawler MP, McElligott AM., PBOX-15, a novel microtubule targeting agent, induces apoptosis, upregulates death receptors, and potentiates TRAIL-mediated apoptosis in multiple myeloma cells., British Journal of Cancer, 104, (2), 2011, p281 - 289, Journal Article, PUBLISHED  DOI
Lysaght J, Verma NK, Maginn EN, Ryan JM, Campiani G, Zisterer DM, Williams DC, Browne PV, Lawler MP, McElligott AM., The microtubule targeting agent PBOX-15 inhibits integrin-mediated cell adhesion and induces apoptosis in acute lymphoblastic leukaemia cells, International Journal of Oncology, 42, (1), 2013, p239 - 249, Journal Article, PUBLISHED  TARA - Full Text  DOI
Sarah Brophy , Fiona M Quinn, David O'Brien, Paul Browne, Elisabeth A. Vandenberghe , Anthony M. McElligott, The Regulation of STAT3 and Its Role in the Adhesion and Migration of Chronic Lymphocytic Leukaemia Cells, Blood, American Society of Hematology Annual Meeting, San Diego, CA, USA, 3-6, December, 201, 128, (22), American Society of Hematology, 2016, pp4347-, Poster, PUBLISHED  URL
Viola Previtali , Helene B Mihigo , Rebecca Amet, Anthony M McElligott , Daniela M Zisterer , Isabel Rozas , Exploring the Anti-Cancer Mechanism of Novel 3,4'-Substituted Diaryl Guanidinium Derivatives, Pharmaceuticals (Basel), 13, (12), 2020, p485 , Journal Article, PUBLISHED  DOI
Laura Christine Kickham, Anthony M McElligott, Adriele Prina-Mello, Elisabeth A Vandenberghe, Yuri Volkov, Paul Browne, Interrogating the Interaction of CD52 Functionalised Metallic Nanoparticles with Malignant B Lymphocytes , Blood, 126 , (23 ), 2015, Journal Article, PUBLISHED  URL
Anthony M McElligott , Eamon P Breen , Ruth Cleary , Sarah Brophy, Fiona McCarthy , Emma Heffernan , Vincent O'Mahony , Nicola Gardiner , Derek G Doherty, Bridgette Byrne , Paul V Browne , Catherine M Flynn, , Characterisation of Naive Immunological Profile of Umbilical Cord Blood: The Role of Mucosal-Associated Invariant T Cells and Functional Defects of T Cells and Natural Killer Cells, Blood, American Society of Hematology, San Diego, CA, USA, 1-4 Dec, 2018, 130, (1), American Society of Hematology, 2017, pp3590-, Poster, PUBLISHED  DOI
Ghnewa YG, O'Reilly VP, Vandenberghe E, Browne PV, McElligott AM, Doherty DG, Retinoic acid induction of CD1d expression primes chronic lymphocytic leukemia B cells for killing by CD8+ invariant natural killer T cells, Clinical Immunology, 183, 2017, p91 - 98, Journal Article, PUBLISHED  URL
Rebecca Amet, Viola Previtali, Helene Mihigo, Emily Sheridan, Sarah Brophy, Patrick J. Hayden, Paul V. Browne, Isabel Rozas, Daniela Zisterer, and Anthony M. McElligott., A Novel Aryl-Guanidinium Based Compound Targets the STAT3 Signalling Pathway, Downregulates MCL-1 Expression and Induces Anti-Myeloma Activity., Blood, American Society of Hematology, 4 -8 December 2020, 136, 2021, Poster, PUBLISHED  DOI
  

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Award Date
Irish Heathcare Awards -Education Project of the Year 2021
Haematology Association of Ireland Research Award (Mentor) 2021
I lead the translational research programme of the Discipline of Haematology in the Trinity Translational Medicine Institute (TTMI) at Trinity College Dublin (TCD). This research programme is closely aligned with the Department of Haematology, Cancer Molecular Diagnostics Laboratory and Cryobiology (stem cell) Laboratories in St James's Hospital (SJH) and, as a result, my research is positioned at the intersection of basic, translational and clinical research in blood cancers at SJH and TCD. Highlighting the significance of my research direction is my role as the Scientific Lead of the Blood Cancer Research Programme in the Trinity /St James Cancer Institute. For over 10 years I have been involved in running a biorepository of clinically and molecularly annotated blood cancer patient material (RNA, DNA and cryopreserved cells). This biobank has developed into an all-Ireland resource through involvement with Blood Cancer Network Ireland and allows for high quality clinical and translational research, as well as facilitating collaboration with groups investigating novel therapeutic agents and immunotherapy strategies. My research is multidisciplinary in nature and encompasses the molecular profiling of blood cancer at diagnosis and in response to therapy; molecular analysis of diagnostic and prognostic biomarkers; the investigation of novel therapeutic strategies, including immunotherapy, nanotherapeutics and small molecule therapeutics; and the molecular mediators of leukemic cell homing and trafficking. Current research projects focus on chronic B-cell malignancies, in particular chronic lymphocytic leukaemia and multiple myeloma, the immunomodulatory and molecular aspects of allogeneic stem cell therapy as part of a cellular therapeutic programme.