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Professor Seamus Martin

Smurfit Professor of Medical Genetics (Genetics)

 martinsj@tcd.ie

 3531896 1289/1289


Biography

My lab works on the central mechanisms of apoptosis and how this programmed cell death process becomes dysregulated in disease states such as cancer and inflammation. Our work is highly cited (>12,000 citations to date) and, based upon independent citation analyses conducted by the Institute for Scientific Information in Boston, USA, our lab ranks within the top 10 labs working in the Apoptosis/Cell Death field worldwide (receiving approx. 150 cites per paper on average). We have published our research in Cell, EMBO J, Science, Nature, J. Exp. Med, JBC, Nature Medicine, as well as many other quality journals. I am currently a Principal Investigator with Science Foundation Ireland (funded by a €5 million award in 2001) and our work is also supported by The Wellcome Trust (UK) as well as several other funding agencies. My post-doctoral work was carried out with Dr. Doug Green (La Jolla Institute for Allergy & Immunology, San Diego, USA) and Prof. Ivan Roitt (University College London, UK). My PhD work was carried out with Prof. Tom Cotter, then at NUI Maytooth (now at UCC).

Research Tags

  Antisera   Apoptosis   Apoptosis, molecular control   Autophagy   Biochemical Markers   Biological Markers   Biological Response Modifiers   Biology   Biomedical sciences   Caenorhabditis elegans   Cancer Biology   Cancer chemotherapeutic drugs- mode of action   Cancer chemotherapy   Cancer genetics and cell biology including metastasis   Cancer/Carcinogenesis   Caspase proteases   Cell and tissue maintenance, repair and ageing   Cell Communication   Cell Components   Cell cycle control   Cell Death   Cell Lines   Cellular, molecular and developmental immunology   Chemotherapeutic Agents   Chemotherapy   Chronic inflamation   Commercialisation of scientific research   Cytotoxic T cell Killing   DIABLO   Genetics   Genomic structure and function, molecular approaches to gene function   Granzymes   HIV virology and pathogenesis   Immune Enhancers   Immune system   Immune System Disorders   Immunity   Immunization   Immunogenetics   Immunology   Immunopathology   Immunotherapies for Cancer   Immunotherapy   In Vitro Testing, Trial Methods   Inflammation   INHIBITION   Innate immunology   Intra and intercellular signalling   Leukemia   Leukemias and lymphomas   Leukocyte Biology   Lymphocytes   Lymphoma   Medical Sciences, Research   Mitochondrial fission & fusion mechanisms   Molecular Biology   Molecular Cloning   Molecular Genetics   Molecular/Cellular Entities   Monoclonal Antibodies   OLIGOMERIZATION   Oncogenes, apoptosis and tumour development   Programmed Cell Death   PROTEIN   Proteins and Macromolecules   Proteomics   Screening of Drugs/Agents   SMAC   Tissue Culture   Toxicity and toxinology   Tumour immunology and immunotherapy   Vaccine   Virology and viral pathogenesis

Representations

Details Date
Scientific Consultant, Clontech Inc. Palo Alto, USA. 1995-present
Appointed to the Board of the European working group on Apoptosis. 1994
Appointed to Editorial Board, Cell Death & Differentiation. 1996-present
Senior Editor, 'Cell Death & Differentiation', Nature Publishing Group 2000-present
Scientific Advisory Board, Association for International Cancer Research, UK. 2003-present
PhD examiner for The University of Dundee, University of Bristol, University of Leicester, Dublin Institute of Technology, NUI Maynooth.
Medical Research Council, UK Appointments & Tenure committees 2003, 2005
External Assessor for full professor & Personal Chair appointments, Scripps Institute, La Jolla, USA; University of Dundee, UK; University of Melbourne, Australia. 2004 & 2005

Languages

Language Skill Reading Skill Writing Skill Speaking
English Fluent Fluent Fluent

Memberships

Membership of Professional Institutions, Associations, Societies

Details Date From Date To
American Society for Biochemistry and Molecular Biology. 1999 -
American Association for the Advancement of Science. 1998 -
The Biochemical Society. 1987 -
Gemayel R, Martin S.J, How to prepare and deliver a great talk, FEBS Journal, 286, (1), 2019, p39 - 45, Journal Article, PUBLISHED  TARA - Full Text  DOI  URL
Martin S.J, The FEBS Journal in 2019: ensuring that casks of vintage wine remain unspoiled, FEBS Journal, 286, (1), 2019, p4 - 7, Journal Article, PUBLISHED  DOI  URL
Boeltz S, Amini P, Anders H.-J, Andrade F, Bilyy R, Chatfield S, Cichon I, Clancy D.M, Desai J, Dumych T, Dwivedi N, Gordon R.A, Hahn J, Hidalgo A, Hoffmann M.H, Kaplan M.J, Knight J.S, Kolaczkowska E, Kubes P, Leppkes M, Manfredi A.A, Martin S.J, Maueröder C, Maugeri N, Mitroulis I, Munoz L.E, Nakazawa D, Neeli I, Nizet V, Pieterse E, Radic M.Z, Reinwald C, Ritis K, Rovere-Querini P, Santocki M, Schauer C, Schett G, Shlomchik M.J, Simon H.-U, Skendros P, Stojkov D, Vandenabeele P, Berghe T.V, van der Vlag J, Vitkov L, von Köckritz-Blickwede M, Yousefi S, Zarbock A, Herrmann M, To NET or not to NET:current opinions and state of the science regarding the formation of neutrophil extracellular traps, Cell Death and Differentiation, 26, (3), 2019, p395 - 408, Journal Article, PUBLISHED  TARA - Full Text  DOI  URL
Galluzzi, L. and Vitale, I. and Aaronson, S.A. and Abrams, J.M. and Adam, D. and Agostinis, P. and Alnemri, E.S. and Altucci, L. and Amelio, I. and Andrews, D.W. and Annicchiarico-Petruzzelli, M. and Antonov, A.V. and Arama, E. and Baehrecke, E.H. and Barlev, N.A. and Bazan, N.G. and Bernassola, F. and Bertrand, M.J.M. and Bianchi, K. and Blagosklonny, M.V. and Blomgren, K. and Borner, C. and Boya, P. and Brenner, C. and Campanella, M. and Candi, E. and Carmona-Gutierrez, D. and Cecconi, F. and Chan, F.K.-M. and Chandel, N.S. and Cheng, E.H. and Chipuk, J.E. and Cidlowski, J.A. and Ciechanover, A. and Cohen, G.M. and Conrad, M. and Cubillos-Ruiz, J.R. and Czabotar, P.E. and D†Angiolella, V. and Dawson, T.M. and Dawson, V.L. and de Laurenzi, V. and de Maria, R. and Debatin, K.-M. and DeBerardinis, R.J. and Deshmukh, M. and Di Daniele, N. and Di Virgilio, F. and Dixit, V.M. and Dixon, S.J. and Duckett, C.S. and Dynlacht, B.D. and El-Deiry, W.S. and Elrod, J.W. and Fimia, G.M. and Fulda, S. and García-Sáez, A.J. and Garg, A.D. and Garrido, C. and Gavathiotis, E. and Golstein, P. and Gottlieb, E. and Green, D.R. and Greene, L.A. and Gronemeyer, H. and Gross, A. and Hajnoczky, G. and Hardwick, J.M. and Harris, I.S. and Hengartner, M.O. and Hetz, C. and Ichijo, H. and JÀÀttelÀ, M. and Joseph, B. and Jost, P.J. and Juin, P.P. and Kaiser, W.J. and Karin, M. and Kaufmann, T. and Kepp, O. and Kimchi, A. and Kitsis, R.N. and Klionsky, D.J. and Knight, R.A. and Kumar, S. and Lee, S.W. and Lemasters, J.J. and Levine, B. and Linkermann, A. and Lipton, S.A. and Lockshin, R.A. and López-Otín, C. and Lowe, S.W. and Luedde, T. and Lugli, E. and MacFarlane, M. and Madeo, F. and Malewicz, M. and Malorni, W. and Manic, G. and Marine, J.-C. and Martin, S.J. and Martinou, J.-C. and Medema, J.P. and Mehlen, P. and Meier, P. and Melino, S. and Miao, E.A. and Molkentin, J.D. and Moll, U.M. and Muñoz-Pinedo, C. and Nagata, S. and Nuñez, G. and Oberst, A. and Oren, M. and Overholtzer, M. and Pagano, M. and Panaretakis, T. and Pasparakis, M. and Penninger, J.M. and Pereira, D.M. and Pervaiz, S. and Peter, M.E. and Piacentini, M. and Pinton, P. and Prehn, J.H.M. and Puthalakath, H. and Rabinovich, G.A. and Rehm, M. and Rizzuto, R. and Rodrigues, C.M.P. and Rubinsztein, D.C. and Rudel, T. and Ryan, K.M. and Sayan, E. and Scorrano, L. and Shao, F. and Shi, Y. and Silke, J. and Simon, H.-U. and Sistigu, A. and Stockwell, B.R. and Strasser, A. and Szabadkai, G. and Tait, S.W.G. and Tang, D. and Tavernarakis, N. and Thorburn, A. and Tsujimoto, Y. and Turk, B. and Vanden Berghe, T. and Vandenabeele, P. and Vander Heiden, M.G. and Villunger, A. and Virgin, H.W. and Vousden, K.H. and Vucic, D. and Wagner, E.F. and Walczak, H. and Wallach, D. and Wang, Y. and Wells, J.A. and Wood, W. and Yuan, J. and Zakeri, Z. and Zhivotovsky, B. and Zitvogel, L. and Melino, G. and Kroemer, G., Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018, Cell Death and Differentiation, 2018, p1-56 , Notes: [cited By 1; Article in Press], Journal Article, PUBLISHED  TARA - Full Text  DOI
Martin, S.J., The FEBS Journal in 2018 â€" putting a bit of color in your life, and your figures, FEBS Journal, 285, (1), 2018, p4-7 , Notes: [cited By 0], Journal Article, PUBLISHED  DOI
Sullivan, G.P. and Davidovich, P.B. and Sura-Trueba, S. and Belotcerkovskaya, E. and Henry, C.M. and Clancy, D.M. and Zinoveva, A. and Mametnabiev, T. and Garabadzhiu, A.V. and Martin, S.J., Identification of small-molecule elastase inhibitors as antagonists of IL-36 cytokine activation, FEBS Open Bio, 8, (5), 2018, p751-763 , Notes: [cited By 0], Journal Article, PUBLISHED  TARA - Full Text  DOI
Feltham, R. and Jamal, K. and Tenev, T. and Liccardi, G. and Jaco, I. and Domingues, C.M. and Morris, O. and John, S.W. and Annibaldi, A. and Widya, M. and Kearney, C.J. and Clancy, D. and Elliott, P.R. and Glatter, T. and Qiao, Q. and Thompson, A.J. and Nesvizhskii, A. and Schmidt, A. and Komander, D. and Wu, H. and Martin, S. and Meier, P., Mind Bomb Regulates Cell Death during TNF Signaling by Suppressing RIPK1's Cytotoxic Potential, Cell Reports, 23, (2), 2018, p470-484 , Notes: [cited By 0], Journal Article, PUBLISHED  TARA - Full Text  DOI
Clancy, D.M. and Sullivan, G.P. and Moran, H.B.T. and Henry, C.M. and Reeves, E.P. and McElvaney, N.G. and Lavelle, E.C. and Martin, S.J., Extracellular Neutrophil Proteases Are Efficient Regulators of IL-1, IL-33, and IL-36 Cytokine Activity but Poor Effectors of Microbial Killing, Cell Reports, 22, (11), 2018, p2809-2817 , Notes: [cited By 1], Journal Article, PUBLISHED  TARA - Full Text  DOI
Sullivan G.P, Henry C.M, Clancy D.M, Mametnabiev T, Belotcerkovskaya E, Davidovich P, Sura-Trueba S, Garabadzhiu A.V, Martin S.J, Suppressing IL-36-driven inflammation using peptide pseudosubstrates for neutrophil proteases, Cell Death and Disease, 9, (3), 2018, Journal Article, PUBLISHED  DOI  URL
Martin S.J, A Guide to â€~A Guide to
.†articles, some thoughts on impact, and why you really should publish with The FEBS Journal, FEBS Journal, 285, (13), 2018, p2364 - 2366, Journal Article, PUBLISHED  DOI  URL
  

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Bouchier-Hayes L & Martin SJ, CARDINAL roles in apoptosis and NFkappaB activation., Vitamins and Hormones, 67, 2004, p133 - 147, Journal Article, PUBLISHED
Caspases: Structure, activation pathways and substrates in, X.-M. Yin and Z. Dong , In Essentials of Apoptosis-A guide for basic and Clinical Research, New Jersey,USA, Humana Press, 2003, pp3 - 12, [Murphy, B.M. and S.J Martin], Book Chapter, PUBLISHED
Caspase detection and analysis in, editor(s)Edited by D. Hughes and H. Mehmet , Cell Proliferation and Apoptosis , Oxford, UK, Bios Scientific Publishers, 2003, pp233 - 253, [Creagh, E. M., Adrain C., and S.J Martin], Book Chapter, PUBLISHED
Martin, S. J. , Caspase activation cascades in apoptosis., Chemtracts-Biochemistry and Molecular Biology, 16, 2003, p352 - 360, Journal Article, PUBLISHED
Caspase cascades in apoptosis in, editor(s)M. Los and H. Walczak , In Caspases-Their role in Cell Death and Cell Survival, New York, USA, Landes Bioscience/Kluwer Academic/Plenum Publishers, 2002, pp41 - 51, [S.J Martin], Book Chapter, PUBLISHED
Apoptosis and Cancer: an overview in, editor(s)S. J. Martin , In Apoptosis and Cancer , Austin, Texas, USA, S.J. Martin, 1997, pp1 - 8, [S.J. Martin], Book Chapter, PUBLISHED
Apoptosis: an introduction in, S. J. Martin , In Apoptosis and Cancer , Austin, Texas, USA, Landes Bioscience Publishers, 1997, pp9 - 24, [Martin, S. J], Book Chapter, PUBLISHED
Cell-free apoptosis in, editor(s)Martin, S. J., and D. R. Green , In Techniques in Apoptosis: A User's Guide , Portland Press, London, S.J Martin and D. R. Green, 1996, [S.J Martin], Book Chapter, PUBLISHED
Annexin V in, editor(s)Edited by T. G. Cotter and S. J. Martin , a specific probe for apoptotic cells. In Techniques in Apoptosis: A User's Guide , Portland Press, London, S. J Martin,C.P.M, Reutelingsperger and D. R. Green, 1996, [S. J Martin], Book Chapter, PUBLISHED
S. J Martin,Amarante-Mendes, G. P., and Green, D. R, Cytotoxic lymphocyte killing enters the ICE age, Adv. Exp. Med. Biol, 406, 1996, p29 - 37, Journal Article, PUBLISHED

  

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Awards and Honours

Award Date
Institute of Biology of Ireland Gold Medal 1987
Elected to the Board of Directors of ECDO 2005
The BA Charles Darwin Award Lecture 2005
GlaxoSmithKline Award (Biochemical Society UK) 2005 2005
Human Frontier Science Program Organization Long-term Fellowship Award 1994
Wellcome Trust International Prize Travelling Fellowship Award. 1994
Wellcome Trust Senior Fellowship in Biomedical Science 1997
Elected to Fellowship of Trinity College Dublin. 2002
Science Foundation Ireland Fellow 2001
Scientific Advisory Board, Association of International Cancer Research, UK 2003
Short-listed for The Royal Irish Academy Boyle Medal 2002
Elected to the Board of Directors, International Cell Death Society, New York 2004

Research Interests

Description Of Research Interests

Molecular Control of Apoptosis (programmed cell death). Natural Killer Cell and CTL proteases (particularly granzyme B) and their mode of action. The role of caspases in inflammation. The role of Bcl-2 family proteins in chemoresistance in cancer. Cancer chemotherapy.