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Dr. Lydia Lynch

Visiting Academic (Biochemistry)


My lab is interested in understanding the cross-talk between the innate immune system and the metabolic system, and the key molecules involved. A major focus is to understand the cellular metabolic decisions controlling the effector fate of leukocytes that may ultimately open doors to manipulate the immune system in metabolic disorders. This also extends to other situations of altered metabolism, such as in the tumor microenvironment. The goal is to integrate the two aspects of immunometabolism (systemic and intrinsic bioenergetics) to enable us to find metabolic targets for immune cell modulation and ultimately manipulate them in human disease.
Harmon C, Robinson M.W, Hand F, Almuaili D, Mentor K, Houlihan D.D, Hoti E, Lynch L, Geoghegan J, O'Farrelly C, Lactate-Mediated Acidification of Tumor Microenvironment Induces Apoptosis of Liver-Resident NK Cells in Colorectal Liver Metastasis, Cancer immunology research, 7, (2), 2019, p335 - 346, Journal Article, PUBLISHED  DOI  URL
Kohlgruber A.C, Gal-Oz S.T, LaMarche N.M, Shimazaki M, Duquette D, Koay H.-F, Nguyen H.N, Mina A.I, Paras T, Tavakkoli A, von Andrian U, Uldrich A.P, Godfrey D.I, Banks A.S, Shay T, Brenner M.B, Lynch L, Erratum to: γΎ T cells producing interleukin-17A regulate adipose regulatory T cell homeostasis and thermogenesis (Nature Immunology, (2018), 19, 5, (464-474), 10.1038/s41590-018-0094-2), Nature Immunology, 20, (3), 2019, p373-, Journal Article, PUBLISHED  DOI  URL
Dyck, L. and Lynch, L., Cancer, obesity and immunometabolism â€" Connecting the dots, Cancer Letters, 417, 2018, p11-20 , Notes: [cited By 0], Journal Article, PUBLISHED  DOI
Wu D, Hu D, Chen H, Shi G, Fetahu I.S, Wu F, Rabidou K, Fang R, Tan L, Xu S, Liu H, Argueta C, Zhang L, Mao F, Yan G, Chen J, Dong Z, Lv R, Xu Y, Wang M, Ye Y, Zhang S, Duquette D, Geng S, Yin C, Lian C.G, Murphy G.F, Adler G.K, Garg R, Lynch L, Yang P, Li Y, Lan F, Fan J, Shi Y, Shi Y.G, Glucose-regulated phosphorylation of TET2 by AMPK reveals a pathway linking diabetes to cancer, Nature, 559, (7715), 2018, p637 - 641, Journal Article, PUBLISHED  DOI  URL
Hong, S. and Song, W. and Zushin, P.-J.H. and Liu, B. and Jedrychowski, M.P. and Mina, A.I. and Deng, Z. and Cabarkapa, D. and Hall, J.A. and Palmer, C.J. and Aliakbarian, H. and Szpyt, J. and Gygi, S.P. and Tavakkoli, A. and Lynch, L. and Perrimon, N. and Banks, A.S., Phosphorylation of Beta-3 adrenergic receptor at serine 247 by ERK MAP kinase drives lipolysis in obese adipocytes, Molecular Metabolism, 12, 2018, p25-38 , Notes: [cited By 0], Journal Article, PUBLISHED  TARA - Full Text  DOI
Kohlgruber, A.C. and Gal-Oz, S.T. and Lamarche, N.M. and Shimazaki, M. and Duquette, D. and Nguyen, H.N. and Mina, A.I. and Paras, T. and Tavakkoli, A. and Von Andrian, U. and Banks, A.S. and Shay, T. and Brenner, M.B. and Lynch, L., γΎ T cells producing interleukin-17A regulate adipose regulatory T cell homeostasis and thermogenesis /631/250/256 /631/250/2504 article, Nature Immunology, 19, (5), 2018, p464-474 , Notes: [cited By 2], Journal Article, PUBLISHED  DOI
LaMarche, N.M. and Lynch, L., Adipose Dendritic Cells Come Out of Hiding, Cell Metabolism, 27, (3), 2018, p485-486 , Notes: [cited By 0], Journal Article, PUBLISHED  DOI
Dyck, L. and Lynch, L., New Job for NK Cells: Architects of the Tumor Microenvironment, Immunity, 48, (1), 2018, p9-11 , Notes: [cited By 0], Journal Article, PUBLISHED  DOI
Michelet, X. and Dyck, L. and Hogan, A. and Loftus, R.M. and Duquette, D. and Wei, K. and Beyaz, S. and Tavakkoli, A. and Foley, C. and Donnelly, R. and O†Farrelly, C. and Raverdeau, M. and Vernon, A. and Pettee, W. and O†Shea, D. and Nikolajczyk, B.S. and Mills, K.H.G. and Brenner, M.B. and Finlay, D. and Lynch, L., Metabolic reprogramming of natural killer cells in obesity limits antitumor responses, Nature Immunology, 19, (12), 2018, p1330-1340 , Notes: [cited By 1], Journal Article, PUBLISHED  DOI
Nadine Assmann, Katie L. O'Brien, Raymond P. Donnelly, Lydia Dyck, Vanessa Zaiatz-Bittencourt, Róisín M. Loftus, Paul Heinrich, Peter J. Oefner, Lydia Lynch, Clair M. Gardiner, Katja Dettmer & David K. Finlay, Srebp-controlled glucose metabolism is essential for NK cell functional responses, Nature Immunology, 18, (11), 2017, p1197 - 1206, Journal Article, PUBLISHED  DOI  URL

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