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Professor Laura Gleeson

Associate Professor Consultant (Clinical Medicine)

 lgleeson@tcd.ie

 


Biography

Laura graduated from Trinity College Dublin Medicine in 2010, and attained membership of the Royal College of Physicians of Ireland (MRCPI) in 2013. She completed her Higher Specialist Training in Respiratory and General Internal Medicine in 2020, before embarking upon a Clinical Fellowship in Pleural Disease and Interventional Pulmonology in Imperial NHS Trust in London. Throughout her training, Laura was actively involved in translational medical research, and was awarded the Health Research Board's (HRB) Health Professional Fellowship to fund her PhD work examining the immunometabolic response of human macrophages to Mycobacterium tuberculosis (Mtb) infection. Through this work, she demonstrated for the first time the centrality of glycolytic reprogramming in the early innate immune response to Mtb infection, and crucially demonstrated defects in this essential immunometabolic response in alveolar macrophages from smokers' lungs. In 2023, she was appointed as Associate Professor in Clinical Medicine, Trinity College Dublin, and Consultant Respiratory Physician in St James's Hospital. With the support of HRB funding through the Clinician Scientist Fellowship, she is exploring the role of safe, FDA-approved metabolic manipulators on the immunometabolic innate immune response to infection and the impact of macrophage ontogeny on metabolic and functional outcomes in infection, with a view to developing new treatments for TB and other respiratory pathogens. Laura is passionate about promoting the clinical / scientific collaborations to promote truly transformative translational research that addresses questions that really matter and delivers solutions to the patient's bedside.

Memberships

Membership of Professional Institutions, Associations, Societies

Details Date From Date To
European Respiratory Society
Irish Society of Immunology
Royal College of Physicians of Ireland
Irish Thoracic Society
Gleeson LE, Waterer G, Beyond antibiotics: recent developments in the diagnosis and management of NTM infection, Breathe (Sheffield, England), 18, (2), 2022, Journal Article, PUBLISHED
Gleeson LE, Waterer G., Beyond antibiotics: recent developments in the diagnosis and management of nontuberculous mycobacterial infection., Breathe (Sheffield, England), 18, (2), 2022, p210171 , Journal Article, PUBLISHED  DOI
Gleeson, L.E. and Roche, H.M. and Sheedy, F.J., Obesity, COVID-19 and innate immunometabolism, British Journal of Nutrition, 125, (6), 2021, p628-632 , Notes: [cited By 18], Journal Article, PUBLISHED  DOI
Hackett, E.E., Charles-Messance, H., O'Leary, S.M., Gleeson, L.E., Muñoz-Wolf, N., Case, S., Wedderburn, A., Johnston, D.G.W., Williams, M.A., Smyth, A., Ouimet, M., Moore, K.J., Lavelle, E.C., Corr, S.C., Gordon, S.V., Keane, J., Sheedy, F.J., Mycobacterium tuberculosis Limits Host Glycolysis and IL-1ß by Restriction of PFK-M via MicroRNA-21, Cell Reports, 30, (1), 2020, p124-136.e4 , Journal Article, PUBLISHED  TARA - Full Text  DOI
O'Brien CM, O'Brien AC, Gleeson L, Conlon K, Feeney J, Malone DE., Imaging of genetically-mediated pancreatitis., Clinical imaging, 65, 2020, p113-118 , Journal Article, PUBLISHED  DOI
Gleeson LE, Gary Lee YC., Predicting Patient Outcome in the Evolving Field of Malignant Pleural Effusion., Journal of bronchology & interventional pulmonology, 27, (1), 2020, p1-3 , Journal Article, PUBLISHED  DOI
Herron M, Chong SG, Gleeson L, Nicholson S, Fahy RJ., Paraneoplastic sarcoidosis: a review., QJM : monthly journal of the Association of Physicians, 113, (1), 2020, p17-19 , Journal Article, PUBLISHED  DOI
Dockry É, O'Leary S, Gleeson LE, Lyons J, Keane J, Gray SG, Doherty DG, Epigenetic induction of CD1d expression primes lung cancer cells for killing by invariant natural killer T cells, OncoImmunology, 2018, pe1428156-, Journal Article, PUBLISHED  URL
Gleeson LE, O'Leary SM, Ryan D, McLaughlin AM, Sheedy FJ, Keane JM., Cigarette Smoking Impairs the Bioenergetic Immune Response to Mycobacterium Tuberculosis Infection., American journal of respiratory cell and molecular biology, 2018, Journal Article, PUBLISHED  DOI
Ní Cheallaigh, C., Sheedy, F.J., Harris, J., Muñoz-Wolf, N., Lee, J., West, K., McDermott, E.P., Smyth, A., Gleeson, L.E., Coleman, M., Martinez, N., Hearnden, C.H., Tynan, G.A., Carroll, E.C., Jones, S.A., Corr, S.C., Bernard, N.J., Hughes, M.M., Corcoran, S.E., O'Sullivan, M., Fallon, C.M., Kornfeld, H., Golenbock, D., Gordon, S.V., O'Neill, L.A., Keane, J. Lavelle, E.C, A Common Variant in the Adaptor Mal Regulates Interferon Gamma Signaling., Immunity, 44, (2), 2016, p368 - 379, Journal Article, PUBLISHED  TARA - Full Text  URL
  

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