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Professor Daniel J Kelly

Professor (Mechanical, Manuf & Biomedical Eng)
BIOMEDICAL SCIENCES INSTITUTE

 kellyd9@tcd.ie

 3531896 3947


Biography

Dr Daniel Kelly is the Professor of Tissue Engineering in Trinity College Dublin and Director of the Trinity Centre for Bioengineering (TCBE). He is also one of the founding Principal Investigators of the Advanced Materials and Bioengineering Research (AMBER) centre based in Trinity College Dublin. Prof Kelly is a current or past recipient of a Science Foundation Ireland President of Ireland Young Researcher Award, a Fulbright Visiting Scholar grant (at the Department of Biomedical Engineering in Columbia University, New York) and three European Research Council awards (Starter grant 2010; Consolidator grant 2015; Proof of Concept grant 2017). His research focuses on developing novel tissue engineering and 3D bioprinting strategies to regenerate damaged and diseased musculoskeletal tissues. To date he has published over 130 articles in peer-reviewed journals.

Research Tags

  Arthritis   Bioengineering   Biomaterials   Biomechanics   Biomechanics, Biomedical Engineering   Biomolecules, Bioplastics, Biopolymers   Bioreactors   Cardiovascular System   Computational Biology   Computer-Aided Engineering   Mathematical modelling   Mechanical Engineering   Mechanics   Medical Devices Engineering   Solid Mechanics   Stem Cell   STEM-CELLS   STENTS   Tissue Engineering

Research Projects

 Articular cartilage regeneration through the recruitment of bone marrow derived mesenchymal stem cells into extracelluar matrix derived scaffolds anchored by 3D printed polymeric supports
 PreclinicAl Infrastructure Resource
 CarBon - Controlling Cartilage to Bone Transitions for Improved Treatment of Bone Defects and Osteoarthritis
 3D Printing of Cell Laden Biomimetic Materials and Biomolecules for Joint Regeneration. (ERC-2014-CoG -647004)
 A decellularised extracellular matrix derived scaffold incorporating freshly isolated joint tissue derived cells as a bioactive implant for cartilage repair. (CF/2014/4325)

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Representations

Details Date
Honorary Associate Professor, Royal College of Surgeons in Ireland. 2014 -
Affiliate Associate Professor, Colorado State University, USA. 2014 -
Behan, K. and Dufour, A. and Garcia, O. and Kelly, D., Methacrylated Cartilage ECM-Based Hydrogels as Injectables and Bioinks for Cartilage Tissue Engineering, Biomolecules, 12, (2), 2022, Notes: [cited By 0], Journal Article, PUBLISHED  TARA - Full Text  DOI
Burdis, R. and Chariyev-Prinz, F. and Kelly, D.J., Bioprinting of biomimetic self-organised cartilage with a supporting joint fixation device, Biofabrication, 14, (1), 2022, Notes: [cited By 0], Journal Article, PUBLISHED  DOI
Dufour, A. and Gallostra, X.B. and O'Keeffe, C. and Eichholz, K. and Von Euw, S. and Garcia, O. and Kelly, D.J., Integrating melt electrowriting and inkjet bioprinting for engineering structurally organized articular cartilage, Biomaterials, 283, (121405), 2022, Notes: [cited By 0], Journal Article, PUBLISHED  TARA - Full Text  DOI
Wang, B. and Chariyev-Prinz, F. and Burdis, R. and Eichholz, K. and Kelly, D.J., Additive manufacturing of cartilage-mimetic scaffolds as off-the-shelf implants for joint regeneration, Biofabrication, 14, (2), 2022, Notes: [cited By 0], Journal Article, PUBLISHED  DOI
Freeman F.E., Burdis R., Mahon O.R., Kelly D.J., Artzi N., A Spheroid Model of Early and Late-Stage Osteosarcoma Mimicking the Divergent Relationship between Tumor Elimination and Bone Regeneration, Advanced Healthcare Materials, 2021, Journal Article, PUBLISHED  TARA - Full Text  DOI
Freeman F.E., Burdis R., Kelly D.J., Printing New Bones: From Print-and-Implant Devices to Bioprinted Bone Organ Precursors, Trends in Molecular Medicine, 27, (7), 2021, p700 - 711, p700-711 , Journal Article, PUBLISHED  TARA - Full Text  DOI
Pauly, H. and Fischenich, K. and Kelly, D. and Popat, K. and Easley, J. and Palmer, R.H. and Haut Donahue, T.L., The Effect of Anterior Cruciate Ligament Reconstruction with an Electropsun Scaffold on Tibiofemoral Contact Mechanics, Annals of Biomedical Engineering, 49, (12), 2021, p3748-3759 , Notes: [cited By 0], Journal Article, PUBLISHED  DOI
Freeman, F.E. and Pitacco, P. and van Dommelen, L.H.A. and Nulty, J. and Browe, D.C. and Shin, J.-Y. and Alsberg, E. and Kelly, D.J., Development of a 3D Bioprinted Scaffold with Spatio-temporally Defined Patterns of BMP-2 and VEGF for the Regeneration of Large Bone Defects, Bio-protocol, 11, (21), 2021, Notes: [cited By 0], Journal Article, PUBLISHED  DOI
Shanley, L.C. and Mahon, O.R. and Kelly, D.J. and Dunne, A., Harnessing the innate and adaptive immune system for tissue repair and regeneration: Considering more than macrophages, Acta Biomaterialia, 133, 2021, p208-221 , Notes: [cited By 6], Journal Article, PUBLISHED  TARA - Full Text  DOI
Levingstone, T.J. and Moran, C. and Almeida, H.V. and Kelly, D.J. and O'Brien, F.J., Layer-specific stem cell differentiation in tri-layered tissue engineering biomaterials: Towards development of a single-stage cell-based approach for osteochondral defect repair, Materials Today Bio, 12, (100173), 2021, Notes: [cited By 0], Journal Article, PUBLISHED  TARA - Full Text  DOI
  

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Meyer, Eric, Low oxygen tension is a more potent regulator of chondrogenic differentiation than dynamic compression. , Bioengineering in Ireland., Malahide, Ireland, Jan. 22, 2010, Conference Paper, PRESENTED
Kelly DJ., "The role of environmental factors in regulating chondrogenesis of mesenchymal stem cells". , Aerospace and Mechanical Engineering, University of Notre Dame, Apr 22, 2010, Invited Talk, PRESENTED
Kelly DJ., The role of environmental factors in regulating chondrogenesis of mesenchymal stem cells, Department of Orthopedics, Rush University Medical Center, Chicago, Apr 21, 2010, Invited Talk, PRESENTED
Kelly DJ., The role of environmental factors in regulating chondrogenesis of mesenchymal stem cells". , , 2010., Graduate Seminar Series, Engineering Mechanics Department, Michigan Technological University, Mar 25, 2010, Invited Talk, PRESENTED
Vinardell T, Buckley C, Thorpe S, Kelly D, Functional properties of cartilaginous tissues generated from mesenchymal stem cells isolated from different tissue sources., 16th Annual Conference of the Section of Bioengineering, Dublin, Ireland, 2010, Notes: [ ], Oral Presentation, PRESENTED
Sheehy E.J., Buckley C.T. and Kelly D.J., Rotational culture differentially regulates chondrogenesis of bone marrow derived MSCs and chondrocytes., Proceedings of the 16th Annual Conference of the Section of Bioengineering of the Royal Academy of Medicine in Ireland. , 2010, Oral Presentation, PRESENTED
Kelly DJ., In Vitro and In Silico Models of Mechano-regulated Skeletal Tissue Differentiation, New York City Bone Seminar Series, CUNY Graduate Center, New York, Dec 8, 2009, Invited Talk, PRESENTED
Kelly DJ, The role of environmental factors in regulating chondrogenesis of mesenchymal stem cells , Dept of Biomedical Engineering Graduate Seminar Series, Columbia University, New York, Nov 6,, 2009, Invited Talk, PRESENTED
Kelly DJ., Cartilage and Bone Mechanobiology and Tissue Engineering, Short course delivered to the Interpolytechnic School of Doctorate, Politecnico di Bari, Italy, June 8-10, 2009, Invited Talk, PRESENTED
Kelly DJ., Mechanobiology of mesenchymal stem cells for articular cartilage repair , Seminars in Orthopaedic Science, REMEDI, NUI Galway, Ireland, May 1, 2009, Invited Talk, PRESENTED

  

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Awards and Honours

Award Date
Norman Gamble Award in Otology 2002
Hewlett Packard Prize 1999
Science Foundation Ireland President of Ireland Young Researcher Award (PIYRA) 2008
Fulbright Award 2009
Fellow of Trinity College Dublin 2010
European Research Council Starter Award, 2010
Senior author of paper awarded the 2012 Perren Award of the European Society of Biomechanics for best scientific paper (presented at 18th Congress of the ESB). 2012
European Research Council Consolidator Award 2015
European Research Council Proof of Concept Grant 2017

Research Interests

Description Of Research Interests

Articular cartilage tissue engineering: Dr. Kelly's lab is pioneering the use of adult stem cells isolated from synovial joints such as the knee, combined with bioreactors to mechanically stimulate these cells, to tissue engineer functional cartilage grafts. They have demonstrated that it is possible to engineer zonally organised tissues such as articular cartilage by recapitulating the gradients in regulatory signals that during development and skeletal maturation are believed to drive spatial changes in stem cell differentiation and tissue organization. They are also developing single stage therapies for articular cartilage regeneration that combine biomimetic scaffolds with freshly isolated stromal cells sourced from patients in-clinic. Bone, joint and limb regeneration: Dr. Kelly's lab have also demonstrated how complex tissues, such as the bone-cartilage interface, can be regenerated by designing tissue engineering strategies that recapitulate aspects of the normal long bone developmental process. They have also been able to scale-up this process to tissue engineer entire new bones. They are currently extending this strategy to tissue engineer whole joints using adult stem cells and 3D bioprinting. Stem cell mechanobiology: Dr. Kelly's lab is investigating how extrinsic mechanical cues can regulate stem cell fate. His lab has also identified novel roles for both mechanical signals and oxygen in regulating chondrogenesis and hypertrophy of MSCs.