Skip to main content

Trinity College Dublin, The University of Dublin

Menu Search


Trinity College Dublin By using this website you consent to the use of cookies in accordance with the Trinity cookie policy. For more information on cookies see our cookie policy.

      
Profile Photo

Professor Daniel J Kelly

Professor (Mechanical, Manuf & Biomedical Eng)
BIOMEDICAL SCIENCES INSTITUTE


Professor Daniel Kelly holds the Chair of Tissue Engineering at Trinity College Dublin. The goal of his laboratory is to develop novel tissue engineering and 3D bioprinting strategies to regenerate damaged and diseased musculoskeletal tissues. To date he has published over 220 articles in peer-reviewed journals, and has successfully supervised over 25 PhD students to completion. He is the recipient of five European Research Council awards (Starter grant 2010; Consolidator grant 2015; Proof of Concept grant 2017, 2023; Advanced grant 2021), which have led to the development of new single stage strategies for bone and cartilage repair and innovations in 3D (bio)printing for the regeneration of musculoskeletal tissues. He is also a co-founder of Altach Biomedical, which is pioneering the development of extracellular matrix derived scaffolds to regenerate damaged knee joints. Other notable recognitions of Prof Kelly"s academic work include being awarded the Science Foundation Ireland Industry Partnership Award (2019), the Silver Medal from the Section of Bioengineering of the Royal Academy of Medicine in Ireland (2022) and the mid-term career award from the Tissue Engineering and Regenerative Medicine International (TERMIS) EU society (2023).
  Arthritis   Bioengineering   Biomaterials   Biomechanics   Biomechanics, Biomedical Engineering   Biomolecules, Bioplastics, Biopolymers   Bioreactors   Cardiovascular System   Computational Biology   Computer-Aided Engineering   Mathematical modelling   Mechanical Engineering   Mechanics   Medical Devices Engineering   Solid Mechanics   Stem Cell   STEM-CELLS   STENTS   Tissue Engineering
 Articular cartilage regeneration through the recruitment of bone marrow derived mesenchymal stem cells into extracelluar matrix derived scaffolds anchored by 3D printed polymeric supports
 Printing spatially and temporally defined boundaries to direct the self-organization of cells and cellular aggregates to engineer functional tissues
 PreclinicAl Infrastructure Resource
 Melt Electrowriting of Multi-layered Scaffolds for osteochondral defect repair
 CarBon - Controlling Cartilage to Bone Transitions for Improved Treatment of Bone Defects and Osteoarthritis

Page 1 of 5
Details Date
Honorary Associate Professor, Royal College of Surgeons in Ireland. 2014 -
Affiliate Associate Professor, Colorado State University, USA. 2014 -
Salinas-Fernandez, S. and Garcia, O. and Kelly, D.J. and Buckley, C.T., The influence of pH and salt concentration on the microstructure and mechanical properties of meniscus extracellular matrix-derived implants, Journal of Biomedical Materials Research - Part A, 112, (3), 2024, p359-372 , Notes: [cited By 0], Journal Article, PUBLISHED  DOI
Sadowska, J.M. and Power, R.N. and Genoud, K.J. and Matheson, A. and González-Vázquez, A. and Costard, L. and Eichholz, K. and Pitacco, P. and Hallegouet, T. and Chen, G. and Curtin, C.M. and Murphy, C.M. and Cavanagh, B. and Zhang, H. and Kelly, D.J. and Boccaccini, A.R. and O'Brien, F.J., A Multifunctional Scaffold for Bone Infection Treatment by Delivery of microRNA Therapeutics Combined With Antimicrobial Nanoparticles, Advanced Materials, 36, (6), 2024, Notes: [cited By 0], Journal Article, PUBLISHED  DOI
Angelica S Federici, Brooke Tornifoglio, Caitríona Lally, Orquidea Garcia, Daniel J Kelly, David A Hoey, Melt electrowritten scaffold architectures to mimic tissue mechanics and guide neo-tissue orientation, Journal of the Mechanical Behavior of Biomedical Materials, 150, 2024, p1 - 15, Journal Article, PUBLISHED  TARA - Full Text  DOI
Burdis, R. and Gallostra, X.B. and Kelly, D.J., Temporal Enzymatic Treatment to Enhance the Remodeling of Multiple Cartilage Microtissues into a Structurally Organized Tissue, Advanced Healthcare Materials, 13, (3), 2024, Notes: [cited By 0], Journal Article, PUBLISHED  DOI
Gierlich, P. and Donohoe, C. and Behan, K. and Kelly, D.J. and Senge, M.O. and Gomes-Da-Silva, L.C., Antitumor Immunity Mediated by Photodynamic Therapy Using Injectable Chitosan Hydrogels for Intratumoral and Sustained Drug Delivery, Biomacromolecules, 25, (1), 2024, p24-42 , Notes: [cited By 0], Journal Article, PUBLISHED  DOI
Baptista, L.S. and Porrini, C. and S. Kronemberger, G. and Kelly, D.J. and Perrault, C.M., Corrigendum: 3D organ-on-a-chip: the convergence of microphysiological systems and organoids (Frontiers in Cell and Developmental Biology, (2022), 10, (1043117), 10.3389/fcell.2022.1043117), Frontiers in Cell and Developmental Biology, 12, (1365671), 2024, Notes: [cited By 0], Journal Article, PUBLISHED  DOI
Barceló, X. and Eichholz, K. and Gonçalves, I. and Kronemberger, G.S. and Dufour, A. and Garcia, O. and Kelly, D.J., Bioprinting of scaled-up meniscal grafts by spatially patterning phenotypically distinct meniscus progenitor cells within melt electrowritten scaffolds, Biofabrication, 16, (1), 2024, Notes: [cited By 0], Journal Article, PUBLISHED  DOI
Barceló, X. and Eichholz, K.F. and Gonçalves, I.F. and Garcia, O. and Kelly, D.J., Bioprinting of structurally organized meniscal tissue within anisotropic melt electrowritten scaffolds, Acta Biomaterialia, 158, 2023, p216-227 , Notes: [cited By 0], Journal Article, PUBLISHED  DOI
Shanley, L.C. and Mahon, O.R. and O'Rourke, S.A. and Neto, N.G.B. and Monaghan, M.G. and Kelly, D.J. and Dunne, A., Macrophage metabolic profile is altered by hydroxyapatite particle size, Acta Biomaterialia, 2023, Notes: [cited By 0], Journal Article, PUBLISHED  DOI
Guler, S. and Eichholz, K. and Chariyev-Prinz, F. and Pitacco, P. and Aydin, H.M. and Kelly, D.J. and Vargel, Ä°., Biofabrication of Poly(glycerol sebacate) Scaffolds Functionalized with a Decellularized Bone Extracellular Matrix for Bone Tissue Engineering, Bioengineering, 10, (1), 2023, Notes: [cited By 0], Journal Article, PUBLISHED  DOI
  

Page 1 of 38
Meyer, Eric, Low oxygen tension is a more potent regulator of chondrogenic differentiation than dynamic compression. , Bioengineering in Ireland., Malahide, Ireland, Jan. 22, 2010, Conference Paper, PRESENTED
Kelly DJ., "The role of environmental factors in regulating chondrogenesis of mesenchymal stem cells". , Aerospace and Mechanical Engineering, University of Notre Dame, Apr 22, 2010, Invited Talk, PRESENTED
Kelly DJ., The role of environmental factors in regulating chondrogenesis of mesenchymal stem cells, Department of Orthopedics, Rush University Medical Center, Chicago, Apr 21, 2010, Invited Talk, PRESENTED
Kelly DJ., The role of environmental factors in regulating chondrogenesis of mesenchymal stem cells". , , 2010., Graduate Seminar Series, Engineering Mechanics Department, Michigan Technological University, Mar 25, 2010, Invited Talk, PRESENTED
Vinardell T, Buckley C, Thorpe S, Kelly D, Functional properties of cartilaginous tissues generated from mesenchymal stem cells isolated from different tissue sources., 16th Annual Conference of the Section of Bioengineering, Dublin, Ireland, 2010, Notes: [ ], Oral Presentation, PRESENTED
Sheehy E.J., Buckley C.T. and Kelly D.J., Rotational culture differentially regulates chondrogenesis of bone marrow derived MSCs and chondrocytes., Proceedings of the 16th Annual Conference of the Section of Bioengineering of the Royal Academy of Medicine in Ireland. , 2010, Oral Presentation, PRESENTED
Kelly DJ., In Vitro and In Silico Models of Mechano-regulated Skeletal Tissue Differentiation, New York City Bone Seminar Series, CUNY Graduate Center, New York, Dec 8, 2009, Invited Talk, PRESENTED
Kelly DJ, The role of environmental factors in regulating chondrogenesis of mesenchymal stem cells , Dept of Biomedical Engineering Graduate Seminar Series, Columbia University, New York, Nov 6,, 2009, Invited Talk, PRESENTED
Kelly DJ., Cartilage and Bone Mechanobiology and Tissue Engineering, Short course delivered to the Interpolytechnic School of Doctorate, Politecnico di Bari, Italy, June 8-10, 2009, Invited Talk, PRESENTED
Kelly DJ., Mechanobiology of mesenchymal stem cells for articular cartilage repair , Seminars in Orthopaedic Science, REMEDI, NUI Galway, Ireland, May 1, 2009, Invited Talk, PRESENTED

  

Page 1 of 3
Award Date
Membership of the Royal Irish Academy. 2024
Mid-term career award from the Tissue Engineering and Regenerative Medicine International (TERMIS) EU society 2023
Silver Medal, Royal Academy of Medicine in Ireland (Bioengineering Division) 2022
European Research Council Advanced Award 2021
Industry Engagement Award at the Trinity College Dublin Innovation Awards 2021
Science Foundation Ireland Industry Partnership Award 2019
One-2-Watch Award at the Trinity College Dublin Innovation Awards 2018
Norman Gamble Award in Otology 2002
Hewlett Packard Prize 1999
Science Foundation Ireland President of Ireland Young Researcher Award (PIYRA) 2008
Fulbright Award 2009
Fellow of Trinity College Dublin 2010
European Research Council Starter Award, 2010
Senior author of paper awarded the 2012 Perren Award of the European Society of Biomechanics for best scientific paper (presented at 18th Congress of the ESB). 2012
European Research Council Consolidator Award 2015
European Research Council Proof of Concept Grant 2017
Bone and cartilage tissue engineering My lab has demonstrated that it is possible to engineer zonal tissues such as articular cartilage by recapitulating the gradients in regulatory signals that during development and skeletal maturation are believed to drive spatial changes in stem cell differentiation and tissue organization (10.1371/journal.pone.0060764). We have demonstrated how complex tissues, such as the bone-cartilage interface, can be regenerated by designing tissue engineering strategies that recapitulate aspects of the normal long bone developmental process (10.1016/j.actbio.2012.11.008). We have also shown that it is possible to scale-up such developmentally inspired processes to regenerate large bone defects (10.1016/j.biomaterials.2018.01.057), or tissue engineer entire new bones (10.1089/biores.2015.0014) or biological implants for whole joint resurfacing (10.1016/j.biomaterials.2022.121750). To extend the utility of this strategy, we have used 3D bioprinting to engineer scaled-up hypertrophic cartilage templates for bone organ engineering (10.1002/adhm.201600182) and large bone defect repair (10.1016/j.actbio.2022.07.037). We have also used phenotypically distinct microtissues within microphysiological models of bone (10.1088/1758-5090/acd6be) and as biological building blocks for the biofabrication of osteochondral grafts for synovial joint regeneration (10.1016/j.biomaterials.2022.121750). Single stage strategies for bone and cartilage repair In 2010 I was awarded a European Research Council (ERC) starter grant to develop novel stem cell based therapies to regenerate damaged articular cartilage. To realise the goals of this project, we first developed a range of decellularized extracellular matrix (ECM) derived scaffolds for articular cartilage (10.1016/j.actbio.2014.05.030 & 10.1016/j.mtbio.2022.100343), bone (10.22203/eCM.v033a10) and osteochondral defect repair (10.1016/j.biomaterials.2018.09.044 & 10.1016/j.actbio.2022.03.009), and have tested these scaffolds in relevant pre-clinical animal models. We have also demonstrated that the source tissue of ECM scaffolds plays a key role in regulating the phenotype of both macrophages and skeletal stem cells (10.1016/j.regen.2021.100041). We recently completed an ERC proof-of-concept to address challenges with the clinical translation of this project (10.1016/j.mtbio.2022.100343), and have recently established a TCD spin-out company (in partnership with NLC Health) to move this technology into the clinic. 3D (bio)printing for the regeneration of musculoskeletal tissues In recent years we have utilised emerging biofabrication and bioprinting strategies to engineer prevascularised implants for bone repair (10.1016/j.actbio.2021.03.003) and structurally organised articular cartilage (10.1016/j.biomaterials.2018.12.028 & 10.1016/j.biomaterials.2022.121405) and meniscus tissue (10.1016/j.actbio.2022.12.047). As part of my ERC consolidator grant, we modified such inks for gene (10.1016/j.jconrel.2019.03.006 & 10.1089/ten.tea.2016.0498) and growth factor (10.1016/j.actbio.2021.04.016 & 10.1038/s41598-017-17286-1) delivery. Furthermore, we bioprinted implants containing spatiotemporally defined patterns of growth factors and demonstrated that printed constructs containing a gradient of VEGF, coupled with spatially defined BMP-2 localization and release kinetics, accelerated large bone defect healing 10.1126/sciadv.abb5093). We have also used 3D printing techniques to produce fibre-reinforced cartilaginous templates, and assessed the efficacy of such constructs in a caprine model of osteochondral defect repair (10.1016/j.actbio.2020.05.040). We have also demonstrated how emerging additive manufacturing techniques such as melt electrowriting (10.1016/j.addma.2022.102998) can be used to produce scaffolds capable of directing angiogenesis and the regeneration of large bone defects (10.1088/1758-5090/ac88a1 & 10.1002/adhm.202302057).