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Biography

Dr Daniel Kelly is the Professor of Tissue Engineering in Trinity College Dublin and Director of the Trinity Centre for Bioengineering (TCBE). He is also one of the founding Principal Investigators of the Advanced Materials and Bioengineering Research (AMBER) centre based in Trinity College Dublin. Prof Kelly is a current or past recipient of a Science Foundation Ireland President of Ireland Young Researcher Award, a Fulbright Visiting Scholar grant (at the Department of Biomedical Engineering in Columbia University, New York) and three European Research Council awards (Starter grant 2010; Consolidator grant 2015; Proof of Concept grant 2017). His research focuses on developing novel tissue engineering and 3D bioprinting strategies to regenerate damaged and diseased musculoskeletal tissues. To date he has published over 130 articles in peer-reviewed journals.

Research Tags

Arthritis Bioengineering Biomaterials Biomechanics Biomechanics, Biomedical Engineering Biomolecules, Bioplastics, Biopolymers Bioreactors Cardiovascular System Computational Biology Computer-Aided Engineering Mathematical modelling Mechanical Engineering Mechanics Medical Devices Engineering Solid Mechanics Stem Cell STEM-CELLS STENTS Tissue Engineering

Research Projects

Project Title

Articular cartilage regeneration through the recruitment of bone marrow derived mesenchymal stem cells into extracelluar matrix derived scaffolds anchored by 3D printed polymeric supports

From

Jan 2018

June 2019

Summary

Osteoarthritis (OA), the most common form of arthritis, is a serious disease of the joints affecting nearly 10% of the population worldwide. The onset of OA has been associated with defects to articular cartilage that lines the bones of synovial joints. Current strategies to treat articular cartilage defects are ineffective and/or prohibitively expensive. The aim of ANCHOR is to develop and commercialise a new medicinal product for articular cartilage regeneration that recruits endogenous bone marrow derived stem cells into an extracellular matrix derived scaffold anchored to the subchondral bone by 3D printed polymeric supports. By recruiting endogenous cells into a supporting scaffold, ANCHOR will obviate the need for pre-seeding scaffolds with cells prior to implantation into cartilage defects, thereby dramatically reducing the cost and complexity of the repair procedure. It will also overcome the need for suturing of a scaffold into a cartilage defect, which is a very time consuming and technically challenging surgical procedure. Finally, the inherent chondro-inductivity of the cartilage ECM derived scaffolds developed by the applicant will maximise the potential for hyaline cartilage regeneration. The project will leverage the applicants extensive experience in ECM derived biomaterials and 3D printing to develop a new product with significant commercial potential. The impact of ANCHOR will be multi-faceted: it will transform how damaged joints are treated by orthopaedic surgeons, it will create economic value through the commercialization of IP, and most importantly it will improve patient experience and their long-term health and well-being.

Funding Agency

European Research Council

Programme

Proof of Concept

Project Title

PreclinicAl Infrastructure Resource

From

Jan 2017

Dec 2018

Summary

A significant investment has been made in Ireland in the research underpinning the development of new medical devices and implants to treat a range of diseases - from heart failure to arthritis. In order to commercialise this basic research and to ensure its translation into the clinic, there is a clear need for improved pre-clinical facilities to assess the safety and efficacy of these new approaches. This project will enable the development of a state of the art surgical facility for the pre-clinical evaluation of Advanced Therapeutic Medicinal Products (ATMPs) and next generation medical devices.

Funding Agency

Science Foundation Ireland

Programme

Research Infrastructure Award

Project Title

CarBon - Controlling Cartilage to Bone Transitions for Improved Treatment of Bone Defects and Osteoarthritis

From

Jan 2017

Dec 2020

Summary

Many people suffer from diseases of the locomotor system, such as bone defects or osteoarthritis, for which current treatments are insufficient. Understanding and controlling the dual character of cartilage is pivotal: insufficient transition impairs bone healing, and undesired transition to bone leads to osteoarthritis. In CarBon, state of the art in vitro, in silico and in vivo models will be uniquely combined to elucidate how this transition is orchestrated and how it can be modulated. In a multifactorial approach, a network of 14 young scientists will aim to identify the biological and physical factors that determine the fate of cartilage. Knowledge from the fields of tissue engineering, cartilage and bone developmental biology and pathobiology will be combined with skills from the disciplines of cell biology, computational modelling, biotechnology (bioreactors, biomaterials) and drug discovery.

Funding Agency

H2020

Programme

Marie Sklodowska-Curie Innovative Training Network

Project Title

3D Printing of Cell Laden Biomimetic Materials and Biomolecules for Joint Regeneration. (ERC-2014-CoG -647004)

From

2015

2020

Summary

Osteoarthritis (OA) is a serious disease of the joints affecting nearly 10% of the population worldwide. Realising an efficacious therapeutic solution for treating OA remains one of the greatest challenges in the field of orthopaedic medicine. This proposal envisions a future where 3D bioprinting systems located in hospitals will provide 'off-the-shelf', patient-specific biological implants to treat diseases such as OA. To realise this vision, this project will use 3D bioprinting to generate anatomically accurate, biomimetic constructs that can be used to regenerate both the cartilage and bone in a diseased joint. If successful, such an implant would form the basis of a truly transformative therapy for treating degenerative joint disease.

Funding Agency

European Research Council

Programme

Consolidator Award

Project Title

A decellularised extracellular matrix derived scaffold incorporating freshly isolated joint tissue derived cells as a bioactive implant for cartilage repair. (CF/2014/4325)

From

2014

2017

Summary

We have developed a new 'single-stage' or 'off-the-shelf' approach to articular cartilage regeneration that consists of a chondro-inductive extracellular matrix (ECM) derived scaffold seeded with freshly isolated joint tissue derived stromal cells that are processed 'in-theatre'. The primary objective of this project is to evaluate the efficacy of this 'single-stage' or 'in-theatre' therapy for articular cartilage regeneration in a large animal model study.

Funding Agency

Enterprise Ireland

Programme

Commercialization Fund

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Representations

Details	Date
Honorary Associate Professor, Royal College of Surgeons in Ireland.	2014 -
Affiliate Associate Professor, Colorado State University, USA.	2014 -

Publications and other Research Outputs

Olwyn R. Mahon, Daniel J. Kelly, Geraldine, M. McCarthy and Aisling Dunne, Osteoarthritis-associated basic calcium phosphate crystals alter immune cell metabolism , Osteoarthritis and Cartilage, 28, (5), 2020, 603-612 , Journal Article, PUBLISHED TARA - Full Text DOI

Olwyn R. Mahon, David C. Brow, Tomas Gonzalez-Fernandez, Pierluca Pitaccoc, Ian T. Whelan, Stanislas Von E, Christopher Hobbs, Valeria Nicolosi, Kyle T. Cunningham, Kingston. H. G. Mills , Daniel J. Kelly and Aisling Dunne, Nano-particle mediated M2 macrophage polarization enhances bone formation and MSC osteogenesis in an IL-10 dependent manner, Biomaterials, 239, 2020, p119833-, Journal Article, PUBLISHED TARA - Full Text DOI

Rossana Schipani, Stefan Scheurer, Romain Florentin, Susan E Critchley and Daniel J Kelly, Reinforcing interpenetrating network hydrogels with 3D printed polymer networks to engineer cartilage mimetic composites , Biofabrication, 12, (3), 2020, p1--, Journal Article, PUBLISHED TARA - Full Text URL

Kian F. Eichholz and Stanislas Von Euw and Ross Burdis and Daniel J. Kelly and David A. Hoey, Development of a New Bone"Mimetic Surface Treatment Platform: Nanoneedle Hydroxyapatite (nnHA) Coating, Advanced Healthcare Materials, 2020, p2001102 , Journal Article, PUBLISHED TARA - Full Text

Oâ doherty, M. and Mulholland, E.J. and Chambers, P. and Pentlavalli, S. and Ziminska, M. and Chalanqui, M.J. and Pauly, H.M. and Sathy, B.N. and Donahue, T.H. and Kelly, D.J. and Dunne, N. and McCarthy, H.O., Improving the intercellular uptake and osteogenic potency of calcium phosphate via nanocomplexation with the RALA peptide, Nanomaterials, 10, (12), 2020, p1-16 , Notes: [cited By 0], Journal Article, PUBLISHED TARA - Full Text DOI

Sridharan, R. and Genoud, K.J. and Kelly, D.J. and O'Brien, F.J., Hydroxyapatite Particle Shape and Size Influence MSC Osteogenesis by Directing the Macrophage Phenotype in Collagen-Hydroxyapatite Scaffolds, ACS Applied Bio Materials, 3, (11), 2020, p7562-7574 , Notes: [cited By 0], Journal Article, PUBLISHED DOI

Olvera, D. and Sathy, B.N. and Kelly, D.J., Spatial Presentation of Tissue-Specific Extracellular Matrix Components along Electrospun Scaffolds for Tissue Engineering the Bone-Ligament Interface, ACS Biomaterials Science and Engineering, 6, (9), 2020, p5145-5161 , Notes: [cited By 0], Journal Article, PUBLISHED DOI

Critchley, S. and Sheehy, E.J. and Cunniffe, G. and Diaz-Payno, P. and Carroll, S.F. and Jeon, O. and Alsberg, E. and Brama, P.A.J. and Kelly, D.J., 3D printing of fibre-reinforced cartilaginous templates for the regeneration of osteochondral defects, Acta Biomaterialia, 113, 2020, p130-143 , Notes: [cited By 3], Journal Article, PUBLISHED TARA - Full Text DOI

Lemoine, M. and Casey, S.M. and Oâ Byrne, J.M. and Kelly, D.J. and Oâ Brien, F.J., The development of natural polymer scaffold-based therapeutics for osteochondral repair, Biochemical Society Transactions, 48, (4), 2020, p1433-1445 , Notes: [cited By 0], Journal Article, PUBLISHED DOI

Freeman, F.E. and Pitacco, P. and van Dommelen, L.H.A. and Nulty, J. and Browe, D.C. and Shin, J.-Y. and Alsberg, E. and Kelly, D.J., 3D bioprinting spatiotemporally defined patterns of growth factors to tightly control tissue regeneration, Science Advances, 6, (33), 2020, Notes: [cited By 2], Journal Article, PUBLISHED TARA - Full Text DOI

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Meyer, Eric, Low oxygen tension is a more potent regulator of chondrogenic differentiation than dynamic compression. , Bioengineering in Ireland., Malahide, Ireland, Jan. 22, 2010, Conference Paper, PRESENTED

Kelly DJ., "The role of environmental factors in regulating chondrogenesis of mesenchymal stem cells". , Aerospace and Mechanical Engineering, University of Notre Dame, Apr 22, 2010, Invited Talk, PRESENTED

Kelly DJ., The role of environmental factors in regulating chondrogenesis of mesenchymal stem cells, Department of Orthopedics, Rush University Medical Center, Chicago, Apr 21, 2010, Invited Talk, PRESENTED

Kelly DJ., The role of environmental factors in regulating chondrogenesis of mesenchymal stem cells". , , 2010., Graduate Seminar Series, Engineering Mechanics Department, Michigan Technological University, Mar 25, 2010, Invited Talk, PRESENTED

Vinardell T, Buckley C, Thorpe S, Kelly D, Functional properties of cartilaginous tissues generated from mesenchymal stem cells isolated from different tissue sources., 16th Annual Conference of the Section of Bioengineering, Dublin, Ireland, 2010, Notes: [ ], Oral Presentation, PRESENTED

Sheehy E.J., Buckley C.T. and Kelly D.J., Rotational culture differentially regulates chondrogenesis of bone marrow derived MSCs and chondrocytes., Proceedings of the 16th Annual Conference of the Section of Bioengineering of the Royal Academy of Medicine in Ireland. , 2010, Oral Presentation, PRESENTED

Kelly DJ., In Vitro and In Silico Models of Mechano-regulated Skeletal Tissue Differentiation, New York City Bone Seminar Series, CUNY Graduate Center, New York, Dec 8, 2009, Invited Talk, PRESENTED

Kelly DJ, The role of environmental factors in regulating chondrogenesis of mesenchymal stem cells , Dept of Biomedical Engineering Graduate Seminar Series, Columbia University, New York, Nov 6,, 2009, Invited Talk, PRESENTED

Kelly DJ., Cartilage and Bone Mechanobiology and Tissue Engineering, Short course delivered to the Interpolytechnic School of Doctorate, Politecnico di Bari, Italy, June 8-10, 2009, Invited Talk, PRESENTED

Kelly DJ., Mechanobiology of mesenchymal stem cells for articular cartilage repair , Seminars in Orthopaedic Science, REMEDI, NUI Galway, Ireland, May 1, 2009, Invited Talk, PRESENTED

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Awards and Honours

Award	Date
Norman Gamble Award in Otology	2002
Hewlett Packard Prize	1999
Science Foundation Ireland President of Ireland Young Researcher Award (PIYRA)	2008
Fulbright Award	2009
Fellow of Trinity College Dublin	2010
European Research Council Starter Award,	2010
Senior author of paper awarded the 2012 Perren Award of the European Society of Biomechanics for best scientific paper (presented at 18th Congress of the ESB).	2012
European Research Council Consolidator Award	2015
European Research Council Proof of Concept Grant	2017

Research Interests

Description Of Research Interests

Articular cartilage tissue engineering: Dr. Kelly's lab is pioneering the use of adult stem cells isolated from synovial joints such as the knee, combined with bioreactors to mechanically stimulate these cells, to tissue engineer functional cartilage grafts. They have demonstrated that it is possible to engineer zonally organised tissues such as articular cartilage by recapitulating the gradients in regulatory signals that during development and skeletal maturation are believed to drive spatial changes in stem cell differentiation and tissue organization. They are also developing single stage therapies for articular cartilage regeneration that combine biomimetic scaffolds with freshly isolated stromal cells sourced from patients in-clinic. Bone, joint and limb regeneration: Dr. Kelly's lab have also demonstrated how complex tissues, such as the bone-cartilage interface, can be regenerated by designing tissue engineering strategies that recapitulate aspects of the normal long bone developmental process. They have also been able to scale-up this process to tissue engineer entire new bones. They are currently extending this strategy to tissue engineer whole joints using adult stem cells and 3D bioprinting. Stem cell mechanobiology: Dr. Kelly's lab is investigating how extrinsic mechanical cues can regulate stem cell fate. His lab has also identified novel roles for both mechanical signals and oxygen in regulating chondrogenesis and hypertrophy of MSCs.

Trinity College Dublin, The University of Dublin

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Professor Daniel J Kelly

Professor Daniel J Kelly

Professor (Mechanical, Manuf & Biomedical Eng)

BIOMEDICAL SCIENCES INSTITUTE

kellyd9@tcd.ie

3531896 3947

http://people.tcd.ie/kellyd9

Biography

Research Tags

Research Projects

Representations

Publications and other Research Outputs

Publications

Awards and Honours

Research Interests

Description Of Research Interests