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Dr. James Murray

External Examiner (Biochemistry)


James Murray's research group has a long-term interest in understanding cell signalling and how genetic mutations or cellular stress alters cell physiology to cause disease. In particular, his lab is working on the role of reversible phosphorylation in the control of cell growth and autophagy. Publications from his lab have recently described novel signalling mechanisms in cancer that control the autophagy pathway. Other work from his lab has reported the role of protein kinases in Alzheimer's disease and diabetes. Current work in his lab has turned its attention to how autophagy is regulated in new pathologies, including nephropathic cystinosis (funded in part by Cystinosis Ireland). Funding in his laboratory is provided by the IRC and HRB, with historical support from the BBSRC, Wellcome Trust, BHF and industry. James reviews papers Nature Communications, EMBO J, Biochem J, Cancer Research, PNAS and others, and he is a grant reviewer for national and international agencies. His recent seminars and invited talks have included the TRANSAUTOPHAGY conference in Oct 2016, and talks at the Universities of Paris, Descartes, Tubingen and Cardiff. James is also Chair for the European Commission funded TRANSAUTOPHAGY COST action (CA15138). He obtained his Bachelors degree in Molecular Biology from Queen's University, Belfast and a PhD in Molecular Immunology on a scholarship programme at the Yamanouchi Research Institute, Oxford. He has also had postdoctoral training at the Albert Einstein College of Medicine, New York and at the MRC Protein Phosphorylation Unit, University of Dundee. In 2002, he won a prestigious Juvenile Diabetes Research Foundation of America Fellowship and a second Fellowship, in 2005, from the British Heart Foundation. Prior to joining Trinity College Dublin, James was a group leader in the Centre for Cancer Research and Cell Biology, Queen's University Belfast.
  Autophagy   Drug Discovery   KINASE   kinase inhibitors   lipid phosphorylation   metabolism   mitophagy   PHOSPHATIDYLINOSITOL 3-KINASE   PHOSPHOINOSITIDE 3-KINASE   PHOSPHORYLATION   protein phosphorylation   reversible phosphorylation   Signal Transduction   xenophagy
Rad E, Murray JT, Tee AR., Oncogenic Signalling through Mechanistic Target of Rapamycin (mTOR): A Driver of Metabolic Transformation and Cancer Progression., Cancers, 10, (1), 2018, Journal Article, PUBLISHED  DOI
Simon J. Lawless, Nidhi Kedia-Mehta, Jessica F. Walls, Ryan McGarrigle, Orla Convery, Linda V. Sinclair, Maria N. Navarro, James Murray, David K. Finlay, Glucose represses dendritic cell-induced T cell responses, Nature Communications, (8), 2017, p15620-, Journal Article, PUBLISHED  TARA - Full Text  DOI  URL
Lane JD, Korolchuk VI, Murray JT., Signalling mechanisms in autophagy: an introduction to the issue., Essays in biochemistry, 61, (6), 2017, p561-563 , Journal Article, PUBLISHED  DOI
McCaig C, Ataliotis P, Shtaya A, Omar AS, Green AR, Kind CN, Pereira AC, Naray-Fejes-Toth A, Fejes-Toth G, Yáñez-Muñoz RJ, Murray JT, Hainsworth AH., Induction of the cell survival kinase Sgk1: A possible novel mechanism for "-phenyl-N-tert-butyl nitrone in experimental stroke., Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 2017, p271678X17746980 , Journal Article, PUBLISHED  DOI
Klionsky et al, Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)., Autophagy, 12, (1), 2016, p1 - 122, Journal Article, PUBLISHED  DOI
Chintapalli R, Murray MJ, Murray JT, Heat Inactivation of Garlic (Allium sativum) Extract Abrogates Growth Inhibition of HeLa Cells., Nutrition and cancer, 2016, p1-9 , Journal Article, PUBLISHED  DOI
Diez-Cecilia E, Carson R, Kelly B, van Schaeybroeck S, Murray JT, Rozas I, Probing a 3,4'-bis-guanidinium diaryl derivative as an allosteric inhibitor of the Ras pathway., Bioorganic & medicinal chemistry letters, 25, (19), 2015, p4287-92 , Journal Article, PUBLISHED  DOI
Huang YH, Al-Aidaroos AQ, Yuen HF, Zhang SD, Shen HM, Rozycka E, McCrudden CM, Tergaonkar V, Gupta A, Lin YB, Thiery JP, Murray JT, Zeng Q, A role of autophagy in PTP4A3-driven cancer progression., Autophagy, 10, (10), 2014, p1787-800 , Journal Article, PUBLISHED  TARA - Full Text  DOI
Dunlop EA, Seifan S, Claessens T, Behrends C, Kamps MA, Rozycka E, Kemp AJ, Nookala RK, Blenis J, Coull BJ, Murray JT, van Steensel MA, Wilkinson S, Tee AR, FLCN, a novel autophagy component, interacts with GABARAP and is regulated by ULK1 phosphorylation., Autophagy, 10, (10), 2014, p1749-60 , Journal Article, PUBLISHED  TARA - Full Text  DOI
D'Costa ZC, Higgins C, Ong CW, Irwin GW, Boyle D, McArt DG, McCloskey K, Buckley NE, Crawford NT, Thiagarajan L, Murray JT, Kennedy RD, Mulligan KA, Harkin DP, Waugh DJ, Scott CJ, Salto-Tellez M, Williams R, Mullan PB, TBX2 represses CST6 resulting in uncontrolled legumain activity to sustain breast cancer proliferation: a novel cancer-selective target pathway with therapeutic opportunities., Oncotarget, 5, (6), 2014, p1609-20 , Journal Article, PUBLISHED

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