Skip to main content

Trinity College Dublin, The University of Dublin

Menu Search


Trinity College Dublin By using this website you consent to the use of cookies in accordance with the Trinity cookie policy. For more information on cookies see our cookie policy.

      
Profile Photo

Dr. Joanne Lysaght

Associate Professor (Surgery)
TRINITY CENTRE, S J H


Dr. Joanne Lysaght graduated with B.Sc.(Hons) in Science from Maynooth University with maths and biology. She then went on to complete a PhD in 2005, in the Department of Biochemistry and Immunology in Trinity College Dublin, in the area of Tumour Immunology. Following completion of her PhD, she worked in the Cancer Molecular Diagnostic Laboratory based in St. James's Hospital and then took up a post-doctoral position in the Department of Haematology and Oncology, TCD, where she worked on a novel family of chemotherapeutic drugs for the treatment of childhood leukemias. Dr. Lysaght then moved to the Department of Surgery, TCD/St. James's Hospital where her research focused on the role of the adaptive immune system in the link between obesity and gastrointestinal cancer. In 2011, Dr. Lysaght was appointed Ussher Assistant Professor in Molecular Oncology, in 2015 she was appointed Assistant Professor in the School of Medicine, TCD and promoted to Associate Professor in 2017 where she continues her research in cancer immunology and immunotherapy. Dr. Lysaght's research group focus on a number of different areas around the central theme of cancer immunology and immunotherapy. Currently, a major research focus is investigating the impact and scheduling of chemotherapy and radiotherapy, and targeting immunometabolism to enhance anti-tumour immunity when used in combination with immunotherapies, namely immune checkpoint inhibitors. The majority of research in the cancer immunology and immunotherapy group is focused on upper gastrointestinal cancer, particularly oesophageal cancer. Research into how the regulation and trafficking of lymphocytes can be targeted to reduced adipose tissue and liver-associated inflammation is also a research interest within the group. Other areas of interest include identifying novel immunotherapeutic targets in the pre-malignant setting such as Barrett's Oesophagus, which can be used to slow or prevent progression to malignancy. Another research interest is the area of obesity and cancer, and how this impacts anti-tumour immunity. Dr. Lysaght's group also investigates the role of adaptive immunity and obesity in the debilitating cancer-associated wasting disease cachexia and sarcopenia.
  ADIPOCYTES   ADIPOSE TISSUE   ADIPOSE-TISSUE DISTRIBUTION   ADJUVANT RADIOTHERAPY   ADVANCED CANCER   Anticancer therapies   Autoimmunity   BARRETTS ESOPHAGUS   CACHEXIA   Cancer Biology   CANCER BIOPSIES   CANCER CHEMOTHERAPY   CANCER CLASSIFICATION   CANCER DEVELOPMENT   CANCER PATIENTS   CANCER RISK   Cancer Therapy   Cancer/Carcinogenesis   CD4+ T CELLS   CHEMO-RADIOTHERAPY   COMBINATION IMMUNOTHERAPY   Design and evaluation of novel anti-cancer therapies   Development of novel neo-adjuvant treatments for oesophageal and prostate cancer   ESOPHAGEAL CANCER   GASTRIC CANCER   Gastrointestinal cancer   HUMAN ESOPHAGEAL CANCER   HUMAN T-CELLS   Immune system   Immunoassays   Immunology, Immunotherapy   Immunotherapies for Cancer   Innate immunology   METABOLIC DISORDERS   NK CELLS   OBESITY   Radiotherapy, Biological response modifiers and chemoprevention   Regulatory T cells   Sarcopenia   Tumour immunology and immunotherapy   TUMOUR IMMUNOTHERAPY
 Evaluating the role of T cells in the progression of Barrett's Oesophagus to Oesophageal Adenocarcinoma: identification of novel immunotherpeutic targets
 Investigating the role of T cells in adipose tissue and hepatic inflammation in obesity associated cancer.
 Investigating the immunomodulatory properties of adipose tissue in oesophageal and colorectal cancer.

Language Skill Reading Skill Writing Skill Speaking
English Fluent Fluent Fluent
Irish Basic Basic Medium
Details Date From Date To
Treasurer and executive committee member for the Irish Society for Immunology 2014
Irish Association for Cancer Research 2011
European Association for Cancer Research 2011
European Federation of Immunological Societies 2014
Donlon, N.E. and Power, R. and Hayes, C. and Reynolds, J.V. and Lysaght, J., Radiotherapy, immunotherapy, and the tumour microenvironment: Turning an immunosuppressive milieu into a therapeutic opportunity, Cancer Letters, 502, 2021, p84-96 , Notes: [cited By 0], Journal Article, PUBLISHED  TARA - Full Text  DOI
Donlon, N.E. and Power, R. and Hayes, C. and Davern, M. and Reynolds, J.V. and Lysaght, J., Radiation and immunotherapy in upper gastrointestinal cancers: The current state of play, International Journal of Molecular Sciences, 22, (3), 2021, p1-15 , Notes: [cited By 0], Journal Article, PUBLISHED  TARA - Full Text  DOI
CX3CL1 Signaling in the Tumor Microenvironment in, Advances in Experimental Medicine and Biology , 2020, pp1 - 12, [Conroy, M.J. and Lysaght, J.], Notes: [cited By 7], Book Chapter, PUBLISHED  DOI
Davern, M. and Lysaght, J., Cooperation between chemotherapy and immunotherapy in gastroesophageal cancers, Cancer Letters, 495, 2020, p89-99 , Notes: [cited By 1], Journal Article, PUBLISHED  TARA - Full Text  DOI
Cannon, A. and Clarke, N. and MacCarthy, F. and Dunne, C. and Kevans, D. and Mahmud, N. and Lysaght, J. and O'Sullivan, J., Effect of cigarette smoke extract on the intestinal microenvironment of ulcerative colitis tissue, JGH Open, 4, (6), 2020, p1191-1198 , Notes: [cited By 0], Journal Article, PUBLISHED  TARA - Full Text  DOI
Buckley AM, Dunne MR, Morrissey ME, Kennedy SA, Nolan A, Davern M, Foley EK, Clarke N, Lysaght J, Ravi N, O'Toole D, MacCarthy F, Reynolds JV, Kennedy BN, O'Sullivan J., Real-time metabolic profiling of oesophageal tumours reveals an altered metabolic phenotype to different oxygen tensions and to treatment with Pyrazinib., Scientific reports, 10, (1), 2020, p12105 , Journal Article, PUBLISHED  TARA - Full Text  DOI
Noel E. Donlon and Andrew Sheppard and Maria Davern and Fiona O'Connell and James J. Phelan and Robert Power and Timothy Nugent and Kate Dinneen and John Aird and John Greene and Paul Nevins Selvadurai and Anshul Bhardwaj and Emma K. Foley and Narayanasamy Ravi and Claire L. Donohoe and John V. Reynolds and Joanne Lysaght and Jacintha O'Sullivan and Margaret R. Dunne, Linking Circulating Serum Proteins with Clinical Outcomes in Esophageal Adenocarcinoma"An Emerging Role for Chemokines, Cancers, 12, (11), 2020, p3356 , Journal Article, PUBLISHED  TARA - Full Text
Royds J, Conroy MJ, Dunne MR, Cassidy H, Matallanas D, Lysaght J, McCrory C., Examination and characterisation of burst spinal cord stimulation on cerebrospinal fluid cellular and protein constituents in patient responders with chronic neuropathic pain - A Pilot Study., Journal of neuroimmunology, 344, 2020, p577249 , Journal Article, PUBLISHED  DOI
Morrissey ME, Byrne R, Nulty C, McCabe NH, Lynam-Lennon N, Butler CT, Kennedy S, O'Toole D, Larkin J, McCormick P, Mehigan B, Cathcart MC, Lysaght J, Reynolds JV, Ryan EJ, Dunne MR, O'Sullivan J., The tumour microenvironment of the upper and lower gastrointestinal tract differentially influences dendritic cell maturation., BMC Cancer, 20, (1), 2020, p566 , Journal Article, PUBLISHED  TARA - Full Text  DOI
Moore D, Galvin D, Conroy MJ, Das B, Dunne M, Lysaght J, McCrory C., Characterisation of the effects of pulsed radio frequency treatment of the dorsal root ganglion on cerebrospinal fluid cellular and peptide constituents in patients with chronic radicular pain: A randomised, triple-blinded, controlled trial., Journal of neuroimmunology, 343, 2020, p577219 , Journal Article, PUBLISHED  DOI
  

Page 1 of 7

  

Award Date
HRB Fellowship 2009
CROSS Research Fellowship 2008
Dr. Lysaght's research group focus on a number of different areas around the central theme of tumour immunology and immunotherapy. A major research interest is the area of obesity and cancer, and how this impacts anti-tumour immunity. The majority of research in the tumour immunology group is focused on upper gastrointestinal cancer, particularly oesophageal cancer. Research into how the regulation and trafficking of lymphocytes can be targeted to reduced adipose tissue and liver-associated inflammation is a major theme within the group. Other areas of interest include identifying novel immunotherapeutic targets in the pre-malignant setting such as Barrett's Oesophagus, which can be used to slow or prevent progression to malignancy. We are also currently investigating the impact of chemotherapy and radiotherapy on anti-tumour immunity and immunotherapies. Another area under current investigation is the role of adaptive immunity and obesity in the debilitating cancer-associated wasting disease cachexia and sarcopenia, which is directly responsible for up to 20% of all cancer deaths.