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Dr. Helen Sheridan

Associate Professor (Pharmacy)
25/6/7 WESTLAND ROW


Helen Sheridan B. Sc (UCD), PhD (UCD), is Associate Professor in Pharmacognosy and former Director of Research at the School of Pharmacy and Pharmaceutical Sciences (SoPPS) at TCD. She is the academic founder and director of the TCD centre for natural product research, NatPro. She is a Fellow of Trinity College Dublin and the Royal Society of Chemistry; a recipient of the TCD Provost's award for teaching excellence and a recipient of the TCD Innovation Award for 'Societal Impact'. Helen has 96 publications including 7 international patents. She has graduated 33 PhD/ MSc students, and mentored 24 postdoctoral researchers. She has sixteen researchers in her group. She was awarded €19 million in grant income from national and international sources. Helen's collaborative and interdisciplinary research is in Natural Product (NP) chemistry; Traditional Medicine (TM); ethnopharmacology; global health and bioeconomy. Her research focusses on finding new therapies for disease and addressing global issues that may be resolved using NP approaches. During her career she identified a lead molecule from TM which her team advanced from discovery to human clinical trials. Helen co-founded the TCD Campus company, Trino Therapeutics Ltd, where she was co-PI on funding of approximately €13 million. She was also co-applicant on seven patents in the US, EU and Asia. In later years Helen has become involved in global ethnopharmacology, investigating quality, safety and efficacy of TMs, and the link between the established use of TM and its role in international development. She has supervised 5 research projects in sub-Saharan Africa. Helen was recently awarded €6M to direct a project entitled "Unlocking Nature's Pharmacy from Bogland Species" focused on the therapeutic and economic potential of the Irish bog land plants, from scientific and educational perspectives. She is a collaborator on a further successful €3.5m award to be announced Feb 2022. Helen is the Phytochemical expert to the Irish Health Products Regulatory Authority (HPRA). She is on the Board of the International Natural Product Sciences taskforce (INPST); was elected to the Board of the GP-TCM Research Association; and most recently was appointed by the Cross-Government Bioeconomy Implementation Group (BIG) to the Expert Advisory Group, as the expert in NP science, to support the National Bioeconomy Forum. Helen holds a TCD award for excellence in teaching. She has taught at all levels across the SoPPS curriculum and has contributed to courses across faculties. Her teaching is research led, maps frontier developments, is informed by government policy and international regulation, and is aligned with global development goals. Her course design and delivery involve synergy at the interfaces governing her discipline. She has recently been funded by the IRC 'New Foundations' scheme, to build educational and research collaborations between TCD, and Maseno University (Kenya). This project which involves bi-lateral travel, is on hold until the Covid situation has stabilised. Helen has held senior administrative positions in College, including Director of Research SoPPS (2016-9); Academic Disability Liaison Officer (2006-To date); positions in safety at school, faculty and college level and is the faculty representative on the College Safety Committee. She was faculty representative on the Trinity International Development Initiative steering committee. Helen has acted as external examiner to the School of Pharmacy in UCL (2015-8); has examined at masters and PhD level nationally and globally; has acted as an international grant reviewer on several programmes. Helen is engaged in outreach with a range of stakeholders. Most recently she and her group have launched a national programme for Transition Year students looking at biodiversity and scientific potential of bogland ecosystems. Helen hopes her research, teaching, and outreach will make a difference to society.
  ALTERNATIVE MEDICINE   Antiinflammatory drugs   Autoimmune Diseases (Multiple Sclerosis, Rheumatoid Arthritis)   Biotransformation   Chemical Biology   Development of drugs for malaria, Cancer and inflammatory diseases   Drug discovery   Fungi   Herbal medicine   In Vitro Testing, Trial Methods   Indanes, indanones, muscel, nast cell stabilisation, immunosuppressants   Inflammation   Inflammatory Bowel Disease   Medicinal plants   Multiple Sclerosis   Natural Product Chemistry   Organic chemistry   Over-the-Counter Drugs   Pharmacognosy   Phytochemical and pharmacological evaluations of native and foreign plants   Phytomedicines   Plant and algal cell monocultures   Secondary plant metabolism   The use of cell cultures for the discovery of novel drugs   Traditional and Indigenous health systems in developing countries   Traditional Chinese Medicine
 Unlocking Nature's Pharmacy from Bogland Species
 Effect of novel indanes on mast cell function
 Novel neuroprotective agents for the treatment of Parkinsons disease and other neurodegenerative disorders
 Unlocking the Therapeutic Potential of Quinoa as Nutraceutical Modulator of the Farnesoid X Receptor
 Formulation development of natural products (NPs) from therapeutic plants

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Details Date
External examiner to the University of Westminster. UK December 2021
Natural Product advisor to the Health Products Regulatory Authority (HPRA) Herbal Medicines Sub-Committee 2006 to date
Irish Medicines Board Traditional Herbal Medicinal Products Ad Hoc sub-committee. 2000 - 2006
Board Member of the International Natural Product Science taskforce 2017 - To date
Grant evaluator: International Foundation for Science, Sweden; http://www.ifs.se/ 2009 to date
Grant evaluator for the Medical Research Council UK 2012
External Examiner to Victoria University of Wellington. Wellington, New Zealand 2014
External examiner for the University of Westminster. UK Autumn 2021
Examiner University College London 2019
External Examiner Cardiff University PhD Thesis 1991
Examiner King's College London 2019
Youth Science committee of the Royal Dublin Society 1990-1992
Member of an Expert Advisory Group to support the National Bioeconomy Forum August 2021
Elected Board member of the Good Practice in Traditional Chinese Medicine Research International Association (GP-TCM) August 2021
Grant evaluator for the ​Swiss National Science Foundation (SNSF) 2021
Expert on Advisory Board to the European Innovation Partnership -The Cultural Heritage of the Comeragh Mountains. June 2021
Academic Director of the NatPro The TCD Centre for Natural Product Research November 2019
Founder of 'NatPro', the TCD Centre for Natural Product Research and development December 2019
External Examiner to Postgraduate taught Master's Degrees in University College London (4 year term) 2015-2018
Founder of the TCD spinout company Trino Therapeutics Ltd 2000
Language Skill Reading Skill Writing Skill Speaking
English Fluent Fluent Fluent
French Medium Medium Medium
Details Date From Date To
Elected Board member of the Good Practice in Traditional Chinese Medicine Research Association (GP-TCM) Jan 2020 2022
Fellow of the Royal Society of Chemistry. 1989 To date
Board member of the Board of Directors of the Natural Product Sciences Task force INPST https://inpst.net/. 2016 To date
Life member GP-TCM RA (Good Practice in TCM Research Association). 2009 To date
Member of the Society for Medicinal Plant and Natural Product Research. Gesellschaft für Arzneipflanzen- und Naturstoff-Forschung e.V. (GA). 2014 To date
Member of the SCT (Societe De Chimie Therapeutique The French Society for Medicinal Chemistry) 2014 To date
NPRONET: Natural products discovery and bioengineering network 2017 to date
Carissa spinarum L.: A Case Study in Ethnobotany and Bioprospecting Research in, editor(s)Dr. Sanjeet Kumar , Medicinal Plants, Intech Open, 2022, pp1 - 58, [Ciara Smyth and Helen Sheridan], Book Chapter, PUBLISHED  TARA - Full Text  DOI
Junying Liu, Shouli Yuan, Yao Yao, Jinfan Wang, Gaia Scalabrino, Shibo Jiang, and Helen Sheridan, Network Pharmacology and Molecular Docking Elucidate the Underlying Pharmacological Mechanisms of the Herb Houttuynia cordata in Treating Pneumonia Caused by SARS-CoV-2, Viruses, 14(7)), (7), 2022, p1588 - 1608, Journal Article, PUBLISHED  DOI
Guilherme Venâncio Símaro, Marivane Lemos, Jonas Joaquim Mangabeira da Silva, Wilson Roberto Cunha, Luiza Junqueira Carneiro, Sérgio Ricardo Ambrósio, Nayanne Larissa Cunha, Sérgio Faloni de Andrade, Caroline Arruda, Vilmar C Banderó-Filho, Astrid Sasse, Helen Sheridan, Jairo Kenupp Bastos, Márcio Luis Andrade e Silva, In vivo study of anti-inflammatory and antinociceptive activities of Copaifera pubiflora Benth oleoresin, Natural Product Research, 36, (4), 2022, p1129 - 1133, Journal Article, PUBLISHED  URL
Jinfan Wang, Elaine Dempsey, Sinéad Cristin Corr, Wirginia Kukula-Koch, Astrid Sasse Helen Sheridan, he Traditional Chinese Medicine Houttuynia cordata Thunb decoction alters intestinal barrier function via an EGFR dependent MAPK (ERK1/2) signalling pathway on July 26, 2022., Phytomedicine, 2022, Journal Article, PUBLISHED
Bahare Salehi, Natália Cruz-Martins, Monica Butnariu, Ioan Sarac, Iulia-Cristina Bagiu, Shahira M. Ezzat, Jinfan Wang, Aaron Koay, Helen Sheridan, Charles Oluwaseun Adetunji, Prabhakar Semwal, Mauricio Schoebitz, Miquel Martorell & Javad Sharifi-Rad, Hesperetin's health potential: moving from preclinical to clinical evidence and bioavailability issues, to upcoming strategies to overcome current limitations, Critical Reviews in Food Science and Nutrition, 2021, Journal Article, PUBLISHED  DOI
Andy Wai Kan Yeung, Atanas G. Atanasov , Helen Sheridan, Elisabeth Klager, Fabian Eibensteiner, Sabine Völkl-Kernstock, Maria Kletecka-Pulker, Harald Willschke, Eva Schaden, Open innovation in medical and pharmaceutical research: A literature landscape analysis, Frontiers in Pharmacology-Ethnopharmacology, 2021, p587526-, Journal Article, PUBLISHED  DOI
N.W. Muyumba a, c , S.C. Mutombo , H Sheridan , A. Nachtergael , P. Duex, Quality control of herbal drugs and preparations: The methods of analysis, their relevance and applications, Talanta Open, 2021, Journal Article, IN_PRESS  TARA - Full Text  DOI
Junying Liu, Ismael Obaidi, Shipra Nagar, Gaia Scalabrino, Helen Sheridan , The antiviral potential of algal-derived macromolecules, Current Research in Biotechnology, 2021, Journal Article, IN_PRESS  TARA - Full Text
Javad Sharifi-Rad, Elen Cristina Quispe Chávez, Mukazhanova Zhazira, Ewa Knut, Aknur Turgumbayeva, Aliya Kipchakbayeva, Gulnaz Seitimova, Fawzi Mohamad Mahomoodally, Devina Lobine, Aaron Koay, Jinfan Wang, Helen Sheridan, Gerardo Leyva-Gómez, Maria Luisa Del Prado, Hernan Cortes, Antonio Rescigno, Paolo Zucca, Oksana Sytar, Muhammad Imran, Célia F. Rodrigues, Natália Cruz-Martins, Halina Ekiert, Manoj Kumar, AHMAD FAIZAL ABDULL RAZIS, Usman Sunusi, Ramla Muhammad Kamal, Agnieszka Szopa , Resveratrol as an anti-cancer agent: Its nano-formulations as an emerging cancer therapy , Frontiers in Molecular Biosciences,, 2021, p1-71 , Journal Article, PUBLISHED
Atanasov, A.G., Zotchev, Sheridan, H [...], S.B., Dirsch, V.M. et al. , Natural products in drug discovery: advances and opportunities, NATURE Reviews Drug Discovery, 2021, p1 - 17, Journal Article, PUBLISHED  DOI
  

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Fiona Shannon, Astrid Sasse, Michael Heinrich and Helen Sheridan, A repository of knowledge - the Schools' Manuscript Collection, offering a unique insight into medicinal practices in 1930s Ireland, 'Interdisciplinary Approaches to the Study of Healing, Charms and Medicine'. , Department of Celtic languages and literature. Harvard University. , April 5-7th 2018., 2018, Conference Paper, PUBLISHED
Fiona Shannon, Astrid Sasse and Helen Sheridan. , Ethnomedicinal practices in 1930s Ireland. History of Medicine Section of the Royal Academy of Medicine, History of Medicine, Dublin, Ireland, 9th May, 2018, Conference Paper, PRESENTED
Jinfan Wang, Ingrid Hook, Malte Brummerloh, Jandirk Sendker, Astrid Sasse and Helen Sheridan. , From Monograph to Metabolomics: A Scientific Evaluation of the Traditional Chinese Herbal Medicine Houttuynia cordata Thunb (鱼腥草Yu Xing Cao) Saururaceae - a case study, The 6th Annual Meeting of Good Practice in Traditional Chinese Medicine Research Association (GP-TCM RA). , Jordell Laboratories. Kew Gradens. London UK, July 4-6th. , 2018, Notes: [Joint First Prize], Conference Paper, PRESENTED
Ciara M Fallon, Jessica Smyth, Natalia Lajczak, Helen Sheridan and Stephen J Keely. , Neutraceutical targeting of the bile acid receptor, farnesoid X receptor, for intestinal disease, The FALK Symposium 211 XXV International Bile Acid Meeting: Bile Acids in Health and Disease. , Dublin, Ireland, July 6 - 7, 2018, Conference Paper, PUBLISHED
J. Wang, Ingrid Hook, Malte Brummerloh, Jandirk Sendker, Astrid Sasse and Helen Sheridan. , Best Practice for the Scientific Evaluation of Traditional Herbal Medicines: Houttuynia cordata Thunb (鱼腥草Yu Xing Cao) Saururaceae - A Case Study. , 66th International Congress and Annual Meeting of the Society for Medicinal Plant and Natural Product Research (GA) jointly with the 11th Shanghai TCM conference, Shanghai, August 26 - 29, 2018, Conference Paper, PUBLISHED
Helen Sheridan, Fiona Shannon, Astrid Sasse and Michael Heinrich, Insight into Healing Herbs used in Post-famine Ireland, 66th International Congress and Annual Meeting of the Society for Medicinal Plant and Natural Product Research (GA) jointly with the 11th Shanghai TCM conference, Shanghai, China, August 26 - 29, 2018, Conference Paper, PUBLISHED
Fiona Shannon, Astrid Sasse and Helen Sheridan., A repository of knowledge. The Schools' Manuscript Collection, offering a unique insight into medicinal practices in 1930s Ireland. , London, 2018, The British Society for the History of Pharmacy (BSHP)., Invited Talk, PUBLISHED
Shanahan, F., Michael heinrich, Sasse, A, Sheridan, H., Traditional Medicinal Knowledge in Ireland in the 1930s - Exploring Botanical Treatments. , 58th Annual Meeting of the Society of Economic Botany. L, Braganca, Portugal, 5th June 2017, edited by Conference Committee , 2017, Conference Paper, PUBLISHED
Helen Sheridan , Exploration of the feasibility of setting up the Trinity (or Irish) - Natural Product Foundation (Trinity-NPF of I-NPF) within TCD., CF-2017-0569Y. , Enterprise Ireland, 2017, Report, PUBLISHED
Shanahan, F., Sasse, A, Sheridan, H. , An Ethnomedicinal Study of Traditional Plant Remedies of Co. Wexford, Ireland in the 1930s. , 38th All Ireland Schools of Pharmacy Research Conference. , Royal College of Surgeons, Dublin 2. , 21st March 2016, 1, 2016, P1-, Conference Paper, PUBLISHED

  

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Award Date
Trinity Innovation Award in the category 'Societal Impact' December 2021
Irish American Partnership Research Award - with Pfizer 1992
Travel awards: British Council 1991
RIA Travelling award 1990
Department of Education Post Doctoral Fellowship (UCD). 1984-1985
Royal Commission for the 1851 Exhibition - Overseas Traveling Scholarship 1983-1984
French Government research Award - CNRS. Gif-Sur-Yvette 1983
NBST Young Researcher award with Dr. Hector Rubelcava (UCD) 1979
Government appointment as Natural Product expert to the Expert Advisory Group to the National Bioeconomy Forum July 2021
Selected for participation in the Science Foundation Ireland - National Science Foundation US, for participation in the NSF Innovation Corps (I-CorpsTM) Programme. June 2021
Appointed to Fellowship of Trinity College Dublin -FTCD 20.04.2020
Co-founder NatPro - The TCD Centre for Natural Product Research November 2019
Trinity College Dublin: Trinity Excellence in Teaching Awards - Provost's Teaching Award 2019
SFI TIDA Award 2017
Appointed to Fellowship of The Royal Society of Chemistry 2017
Wellcome Trust Strategic Translation Award (co-PI) 2013
My research has always been multidisciplinary; built on collaboration with pharmacologists/ molecular-biologists/ bio-technologists/ botanists/anthropologists and sociologists and is recognised at a national and inter-national level. The driving force behind my work is to find new therapeutic treatments for unmet clinical need and to finding meaningful uses for natural molecules, and to improve the position on communities in the developing world who have a cultural and financial reliance on Traditional Medicine. I have learned a lot about the journey from therapeutic drug discovery to human trials, and the challenges and obstacles that line the road. However, experience led decision making about research is invaluable. Through this lens of experience, the molecules my group is working on have real therapeutic potential and have been designed to eliminate some of the insurmountable obstacles to drug development. My drug discovery focus, has been informed by the natural world, ethnomedical practice across the globe; molecular design, based on hybridised natural molecules; and using computer modelling to find natural molecules that target important receptors. In my natural product research I have engaged with International, multidisciplinary Consortia establishing good practice and gold standards for quality, safety and efficacy of complex natural medicines as nutraceuticals, and as food supplements. One of my core research and teaching beliefs is that 'it is at the interface of disciplines and expertise that new ideas and creativity emerge'. My current research falls under four main themes. 1) Multidisciplinary approach Drug discovery for the treatment of inflammatory disease and cancer Finding new therapies targeted at diseases with unmet clinical need. Currently I am PI on an SFI TIDA award and have 50 molecules being tested at level 2 in the Lilly Open Innovation Platform, with six significant nanomolar hits against a key target in Chemotherapy and radiation resistant cancer cells. 2) Drug discovery from the natural world is still ongoing. We use of natural materials (plants, cell cultures, microalgae) for the discovery of novel bio-active materials. 3) Traditional Herbal Medicine. Overview the best practice methodology, recommend applications, and future directions for metabolic profiling, component analysis and purification of secondary metabolites in preparations utilised in Traditional Medicine by large populations (Asia and Africa). Utilising metabolomic techniques to establish best practice for the determination of quality, safety and efficacy of herbal medicines for human and veterinary use. 4) Exploring traditional medicine (TM) in Ireland and in Sub-Saharan-Africa in the context of a changing global healthcare landscape, using a community in West Pokot, Kenya as a case study. I am Co-founder of Trino Therapeutics (Formerly Pharmatrin ltd), a TCD campus company whose activities are centered on drug discovery/development. Through this vehicle my research progressed through a significant Medicinal Chemistry programme of lead optimisation, GMP synthesis of lead, pre-clinical evaluation, regulatory approval and progression through Phase 1 Clinical trials. My ethnomedical research was presented in Harvard (2018), and my overall research work has been presented internationally and most recently on an invited lecture tour in China.