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Dr. Helen Sheridan

Associate Professor (Pharmacy)
25/6/7 WESTLAND ROW


Helen Sheridan is an Associate Professor in the School of Pharmacy and Pharmaceutical Sciences (SoPPS) at TCD. She is co-founder and academic co-director of the NatPro the Centre for Natural Product Research at TCD, and was co-founder of the TCD Drug Discovery, Campus Company Trino Therapeutics. Helen's personal research interests lie in the area of Natural Product (NP) Chemistry and Traditional Medicine (TM), with an emphasis on Ethnopharmacology and Global health. Her work focuses on finding new therapies targeted at diseases with unmet clinical need, in addition to addressing key global issues that may be resolved by use of natural product approaches. Helen, with international collaborators, is also involved in establishing global standards for the quality, safety and efficacy of TMs; activities that are supported through her role on the Board of Directors of a Sino-European Consortium (previously funded by EU-FP7; http://www.gp-tcm.org/), her role on the Board of the International Natural Product Sciences Taskforce (INPST) society (The International Natural Product Sciences Taskforce (INPST) society), in her position as NP expert on the Irish medicines Board (HPRA: Health Products Regulatory Authority) and membership of NPRONET - Natural products discovery and bioengineering network UK. Helen has supervised 21 research students (PhDs and MScs) to completion, as well as 18 post-doctoral fellows. She currently has 11 researchers in her group. Helen is an NP/ organic chemist and has carried out research on a range of plant and fungal species. During her career she successfully identified a lead molecule from TM which her team brought through a programme from discovery, through medicinal chemistry, through all preclinical stages of development into human clinical trials. During this period Helen co-founded a TCD Campus company, Trino Therapeutics Ltd and was co-PI on funding of approximately €13 million. She has received significant translational investment from Venture Capital and the Wellcome Trust with €3.5 million as co-PI for a highly competitive Wellcome Strategic Translation Award (STA grant). During this time, she has also been co-applicant on seven published patents in the US, EU and Asia and has acted as patent expert on these projects with patenting agents in Ireland and the US. In later years Helen has become involved in ethnopharmacology on a global level, the link between the established use of traditional medicine and its role in international development. She has supervised 5 research projects in this field in sub-Saharan Africa. Helen has recently been awarded a €6M grant to direct a project entitled "Unlocking Nature's Pharmacy from Bogland Species". This project focused on studying the potential of the Irish bog land plants. Bogs of Ireland constitute an enormous national resource. The cessation of industrial harvesting of bogland provides a unique opportunity to unlock the potential of bogland species and thus confer socio-economic and ecological and educational benefits to local communities and nationally. The aim of this project is to investigate the potential of the flora of the Irish boglands as a source of novel plant derived therapeutic formulae. Plant species, native to these environments, may provide an environmental and economic solutions to the future of these resources and to the communities who have worked on them. The driving force behind Helen's work is to find new therapeutic treatments for unmet clinical need meaningful uses for natural molecules. She has learned a lot about the journey from therapeutic drug discovery to human trials, and the challenges and obstacles that line the road. However, experience led decision making in research is invaluable. Through this lens, Helen's the molecules Helen's group works on have real therapeutic potential and are designed to eliminate some of the insurmountable obstacles to health maintenance and disease prevention.
  ALTERNATIVE MEDICINE   Antiinflammatory drugs   Autoimmune Diseases (Multiple Sclerosis, Rheumatoid Arthritis)   Biotransformation   Chemical Biology   Development of drugs for malaria, Cancer and inflammatory diseases   Drug discovery   Fungi   Herbal medicine   In Vitro Testing, Trial Methods   Indanes, indanones, muscel, nast cell stabilisation, immunosuppressants   Inflammation   Inflammatory Bowel Disease   Medicinal plants   Multiple Sclerosis   Natural Product Chemistry   Organic chemistry   Over-the-Counter Drugs   Pharmacognosy   Phytochemical and pharmacological evaluations of native and foreign plants   Phytomedicines   Plant and algal cell monocultures   Secondary plant metabolism   The use of cell cultures for the discovery of novel drugs   Traditional and Indigenous health systems in developing countries   Traditional Chinese Medicine
 Unlocking Nature's Pharmacy from Bogland Species
 Formulation development of natural products (NPs) from therapeutic plants
 Functional Food and Pharmaceuticals - Marine Micro-Algae
 Assessment of the therapeutic potential of two lead anti-inflammatory molecules with a novel carbon scaffold in ex-vivo colonic explant tissue.
 Novel indanes as potential therapies for auto-immune disease

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Details Date
Member of an Expert Advisory Group to support the National Bioeconomy Forum August 2021
Elected Board member of the Good Practice in Traditional Chinese Medicine Research International Association (GP-TCM) August 2021
Advisory Board to the European Innovation Partnership -The Cultural Heritage of the Comeragh Mountains. June 2021
Academic co-Director of the NatPro The TCD Centre for Natural Product Research November 2019
Founder of 'NatPro', the TCD Centre for Natural Product Research and development December 2019
Co-Founder of the TCD spinout company Trino Therapeutics Ltd 2000
Natural Product advisor to the Health Products Regulatory Authority (HPRA) Herbal Medicines Sub-Committee 2006 to date
Irish Medicines Board Traditional Herbal Medicinal Products Ad Hoc sub-committee. 2000 - 2006
External Examiner to Postgraduate taught Master's Degrees in University College London (4 year term) 2015-2018
Board Member of the International Natural Product Science taskforce 2017 - To date
Grant evaluator for the ​Swiss National Science Foundation (SNSF) 2021
International Foundation for Science, Sweden; Grant reviewer http://www.ifs.se/ 2009 to date
Grant reviewer for the Medical Research Council UK 2012
External Examiner to Victoria University of Wellington. Wellington, New Zealand 2014
External examiner for the University of Westminster. UK Autumn 2021
External Examiner Cardiff University PhD Thesis 1991
Examiner University College London 2019
Examiner King's College London 2019
Youth Science committee of the Royal Dublin Society 1990-1992
Language Skill Reading Skill Writing Skill Speaking
English Fluent Fluent Fluent
French Medium Medium Medium
Details Date From Date To
Elected Board member of the Good Practice in Traditional Chinese Medicine Research Association (GP-TCM) Jan 2020 2022
Board member of the Board of Directors of the Natural Product Sciences Task force INPST https://inpst.net/. 2016 To date
Fellow of the Royal Society of Chemistry. 1989 To date
Life member GP-TCM RA (Good Practice in TCM Research Association). 2009 To date
Member of the SCT (Societe De Chimie Therapeutique The French Society for Medicinal Chemistry) 2014 To date
Member of the Society for Medicinal Plant and Natural Product Research. Gesellschaft für Arzneipflanzen- und Naturstoff-Forschung e.V. (GA). 2014 To date
NPRONET: Natural products discovery and bioengineering network 2017 to date
Bahare Salehi, Natália Cruz-Martins, Monica Butnariu, Ioan Sarac, Iulia-Cristina Bagiu, Shahira M. Ezzat, Jinfan Wang, Aaron Koay, Helen Sheridan, Charles Oluwaseun Adetunji, Prabhakar Semwal, Mauricio Schoebitz, Miquel Martorell & Javad Sharifi-Rad, Hesperetin's health potential: moving from preclinical to clinical evidence and bioavailability issues, to upcoming strategies to overcome current limitations, Critical Reviews in Food Science and Nutrition, 2021, Journal Article, PUBLISHED  DOI
Andy Wai Kan Yeung, Atanas G. Atanasov , Helen Sheridan, Elisabeth Klager, Fabian Eibensteiner, Sabine Völkl-Kernstock, Maria Kletecka-Pulker, Harald Willschke, Eva Schaden, Open innovation in medical and pharmaceutical research: A literature landscape analysis, Frontiers in Pharmacology-Ethnopharmacology, 2021, p587526-, Journal Article, PUBLISHED  DOI
N.W. Muyumba a, c , S.C. Mutombo , H Sheridan , A. Nachtergael , P. Duex, Quality control of herbal drugs and preparations: The methods of analysis, their relevance and applications, Talanta Open, 2021, Journal Article, IN_PRESS
Junying Liu, Ismael Obaidi, Shipra Nagar, Gaia Scalabrino, Helen Sheridan , The antiviral potential of algal-derived macromolecules, Current Research in Biotechnology, 2021, Journal Article, IN_PRESS  TARA - Full Text
Javad Sharifi-Rad, Elen Cristina Quispe Chávez, Mukazhanova Zhazira, Ewa Knut, Aknur Turgumbayeva, Aliya Kipchakbayeva, Gulnaz Seitimova, Fawzi Mohamad Mahomoodally, Devina Lobine, Aaron Koay, Jinfan Wang, Helen Sheridan, Gerardo Leyva-Gómez, Maria Luisa Del Prado, Hernan Cortes, Antonio Rescigno, Paolo Zucca, Oksana Sytar, Muhammad Imran, Célia F. Rodrigues, Natália Cruz-Martins, Halina Ekiert, Manoj Kumar, AHMAD FAIZAL ABDULL RAZIS, Usman Sunusi, Ramla Muhammad Kamal, Agnieszka Szopa , Resveratrol as an anti-cancer agent: Its nano-formulations as an emerging cancer therapy , Frontiers in Molecular Biosciences,, 2021, p1-71 , Journal Article, PUBLISHED
Atanasov, A.G., Zotchev, Sheridan, H [...], S.B., Dirsch, V.M. et al. , Natural products in drug discovery: advances and opportunities, NATURE Reviews Drug Discovery, 2021, p1 - 17, Journal Article, PUBLISHED  DOI
Guilherme Venâncio Símaro, Marivane Lemos [ ..], Helen Sheridan, Márcio Luis Andrade e Silva, Jairo Kenupp Bastos., Antinociceptive and anti-inflammatory activities of Copaifera pubiflora Benth oleoresin and its major metabolite ent-hardwickiic acid, Journal of Ethnopharmacology, 2021, Journal Article, PUBLISHED  DOI
Helen Sheridan, Unlocking Nature's Pharmacy - from plant to product: An academic odyssey, Planta Medica, 69th International Congress and Annual Meeting of the Society for Medicinal Plant and Natural Product Research (GA), Bonn. FRG, September 6-8th, edited by Thieme , 2021, Oral Presentation, PUBLISHED
Eoin Ó Briain, Robbie Kelleher, Jamie Rice, Helen Sheridan. , Medicinal plants and natural product research on Traditional Medicines , Planta Medica, 69th International Congress and Annual Meeting of the Society for Medicinal Plant and Natural Product Research (GA), Bonn. FRG, September 6-8th, edited by Thieme , 2021, Poster, PUBLISHED
Amy F. Walsh, Antonia Dunbar, Helen Sheridan, Mark O. Cunningham, Examination of the effect of cannabis derived terpenes on acute seizure activity in rodent brain slices. , Planta Medica, 69th International Congress and Annual Meeting of the Society for Medicinal Plant and Natural Product Research (GA), Bonn. FRG, September 6-8th, edited by Thieme , 2021, Poster, PUBLISHED
  

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Fiona Shannon, Astrid Sasse, Michael Heinrich and Helen Sheridan, A repository of knowledge - the Schools' Manuscript Collection, offering a unique insight into medicinal practices in 1930s Ireland, 'Interdisciplinary Approaches to the Study of Healing, Charms and Medicine'. , Department of Celtic languages and literature. Harvard University. , April 5-7th 2018., 2018, Conference Paper, PUBLISHED
Fiona Shannon, Astrid Sasse and Helen Sheridan. , Ethnomedicinal practices in 1930s Ireland. History of Medicine Section of the Royal Academy of Medicine, History of Medicine, Dublin, Ireland, 9th May, 2018, Conference Paper, PRESENTED
Jinfan Wang, Ingrid Hook, Malte Brummerloh, Jandirk Sendker, Astrid Sasse and Helen Sheridan. , From Monograph to Metabolomics: A Scientific Evaluation of the Traditional Chinese Herbal Medicine Houttuynia cordata Thunb (鱼腥草Yu Xing Cao) Saururaceae - a case study, The 6th Annual Meeting of Good Practice in Traditional Chinese Medicine Research Association (GP-TCM RA). , Jordell Laboratories. Kew Gradens. London UK, July 4-6th. , 2018, Notes: [Joint First Prize], Conference Paper, PRESENTED
Ciara M Fallon, Jessica Smyth, Natalia Lajczak, Helen Sheridan and Stephen J Keely. , Neutraceutical targeting of the bile acid receptor, farnesoid X receptor, for intestinal disease, The FALK Symposium 211 XXV International Bile Acid Meeting: Bile Acids in Health and Disease. , Dublin, Ireland, July 6 - 7, 2018, Conference Paper, PUBLISHED
J. Wang, Ingrid Hook, Malte Brummerloh, Jandirk Sendker, Astrid Sasse and Helen Sheridan. , Best Practice for the Scientific Evaluation of Traditional Herbal Medicines: Houttuynia cordata Thunb (鱼腥草Yu Xing Cao) Saururaceae - A Case Study. , 66th International Congress and Annual Meeting of the Society for Medicinal Plant and Natural Product Research (GA) jointly with the 11th Shanghai TCM conference, Shanghai, August 26 - 29, 2018, Conference Paper, PUBLISHED
Helen Sheridan, Fiona Shannon, Astrid Sasse and Michael Heinrich, Insight into Healing Herbs used in Post-famine Ireland, 66th International Congress and Annual Meeting of the Society for Medicinal Plant and Natural Product Research (GA) jointly with the 11th Shanghai TCM conference, Shanghai, China, August 26 - 29, 2018, Conference Paper, PUBLISHED
Fiona Shannon, Astrid Sasse and Helen Sheridan., A repository of knowledge. The Schools' Manuscript Collection, offering a unique insight into medicinal practices in 1930s Ireland. , London, 2018, The British Society for the History of Pharmacy (BSHP)., Invited Talk, PUBLISHED
Shanahan, F., Michael heinrich, Sasse, A, Sheridan, H., Traditional Medicinal Knowledge in Ireland in the 1930s - Exploring Botanical Treatments. , 58th Annual Meeting of the Society of Economic Botany. L, Braganca, Portugal, 5th June 2017, edited by Conference Committee , 2017, Conference Paper, PUBLISHED
Helen Sheridan , Exploration of the feasibility of setting up the Trinity (or Irish) - Natural Product Foundation (Trinity-NPF of I-NPF) within TCD., CF-2017-0569Y. , Enterprise Ireland, 2017, Report, PUBLISHED
Shanahan, F., Sasse, A, Sheridan, H. , An Ethnomedicinal Study of Traditional Plant Remedies of Co. Wexford, Ireland in the 1930s. , 38th All Ireland Schools of Pharmacy Research Conference. , Royal College of Surgeons, Dublin 2. , 21st March 2016, 1, 2016, P1-, Conference Paper, PUBLISHED

  

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Award Date
Government appointment as Natural Product expert to the Expert Advisory Group to the National Bioeconomy Forum July 2021
Selected for participation in the Science Foundation Ireland - National Science Foundation US, for participation in the NSF Innovation Corps (I-CorpsTM) Programme. June 2021
Appointed to Fellowship of Trinity College Dublin -FTCD 20.04.2020
Co-founder NatPro - The TCD Centre for Natural Product Research November 2019
Trinity College Dublin: Trinity Excellence in Teaching Awards - Provost's Teaching Award 2019
SFI TIDA Award 2017
Appointed to Fellowship of The Royal Society of Chemistry 2017
Wellcome Trust Strategic Translation Award (co-PI) 2013
Irish American Partnership Research Award - with Pfizer 1992
Travel awards: British Council 1991
RIA Travelling award 1990
Department of Education Post Doctoral Fellowship (UCD). 1984-1985
Royal Commission for the 1851 Exhibition - Overseas Traveling Scholarship 1983-1984
French Government research Award - CNRS. Gif-Sur-Yvette 1983
NBST Young Researcher award with Dr. Hector Rubelcava (UCD) 1979
My research has always been multidisciplinary; built on collaboration with pharmacologists/ molecular-biologists/ bio-technologists/ botanists/anthropologists and sociologists and is recognised at a national and inter-national level. The driving force behind my work is to find new therapeutic treatments for unmet clinical need and to finding meaningful uses for natural molecules, and to improve the position on communities in the developing world who have a cultural and financial reliance on Traditional Medicine. I have learned a lot about the journey from therapeutic drug discovery to human trials, and the challenges and obstacles that line the road. However, experience led decision making about research is invaluable. Through this lens of experience, the molecules my group is working on have real therapeutic potential and have been designed to eliminate some of the insurmountable obstacles to drug development. My drug discovery focus, has been informed by the natural world, ethnomedical practice across the globe; molecular design, based on hybridised natural molecules; and using computer modelling to find natural molecules that target important receptors. In my natural product research I have engaged with International, multidisciplinary Consortia establishing good practice and gold standards for quality, safety and efficacy of complex natural medicines as nutraceuticals, and as food supplements. One of my core research and teaching beliefs is that 'it is at the interface of disciplines and expertise that new ideas and creativity emerge'. My current research falls under four main themes. 1) Multidisciplinary approach Drug discovery for the treatment of inflammatory disease and cancer Finding new therapies targeted at diseases with unmet clinical need. Currently I am PI on an SFI TIDA award and have 50 molecules being tested at level 2 in the Lilly Open Innovation Platform, with six significant nanomolar hits against a key target in Chemotherapy and radiation resistant cancer cells. 2) Drug discovery from the natural world is still ongoing. We use of natural materials (plants, cell cultures, microalgae) for the discovery of novel bio-active materials. 3) Traditional Herbal Medicine. Overview the best practice methodology, recommend applications, and future directions for metabolic profiling, component analysis and purification of secondary metabolites in preparations utilised in Traditional Medicine by large populations (Asia and Africa). Utilising metabolomic techniques to establish best practice for the determination of quality, safety and efficacy of herbal medicines for human and veterinary use. 4) Exploring traditional medicine (TM) in Ireland and in Sub-Saharan-Africa in the context of a changing global healthcare landscape, using a community in West Pokot, Kenya as a case study. I am Co-founder of Trino Therapeutics (Formerly Pharmatrin ltd), a TCD campus company whose activities are centered on drug discovery/development. Through this vehicle my research progressed through a significant Medicinal Chemistry programme of lead optimisation, GMP synthesis of lead, pre-clinical evaluation, regulatory approval and progression through Phase 1 Clinical trials. My ethnomedical research was presented in Harvard (2018), and my overall research work has been presented internationally and most recently on an invited lecture tour in China.