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Dr. Gary Moran

Associate Professor (Dental Science)

My research focuses on the pathogenicity of oral microorganisms, specifically the fungal pathogen Candida albicans and the oral bacterium Fusobacterium nucleatum. Our research involves a combination of molecular genetics, genomics and transcriptomics. We also carry out 16s profiling of the oral microbiome to better understand oral disease. Our research is carried out in the Microbiology laboratory at the Dublin Dental University Hospital, which is on the campus of Trinity College Dublin.
  16s Profiling   antifungal drug resistance   CANDIDA ALBICANS   comparative genomics   fungal morphogenesis   Fusobacterium nucleatum   Genomes, Genomics   in vitro models of infection   microbiome   Molecular Biology   Periodontal disease   Porphyromonas gingivalis   Tissue Culture   transcriptomics   virulence factors
 The TLO genes of Candida albicans
 Analysis of the oral metagenome for markers of malignant transformation of oral leukoplakia
 The Oral Microbiome in Disease
 The role of Tor kinase in filamentation in Candida albicans and Candida dubliniensis
 The Hag genes of Porphyromonas gingivalis

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Details Date
President of the Irish Fungal Society 2015-2019
Meetings Secretary of the British Society of Medical Mycology 2006-2009
Details Date From Date To
British Society for Medical Mycology 1994 Present
Internation Association of Dental Research (IADR) 1998 Present
American Society for Microbiology 2000 Present
Society for General Microbiology 2007 Present
Dublin Academy of Pathogenomics and Infection Biology 2010 Present
Irish Fungal Scoiety (IFS) 2010 Present
Amer A., Whelan A., Al-Hebshi N.N., Healy C.M., Moran G.P., Acetaldehyde production by Rothia mucilaginosa isolates from patients with oral leukoplakia, Journal of Oral Microbiology, 12, (1), 2020, Journal Article, PUBLISHED  DOI
Moran, Gary P., Al-Hebshi, Nezar, Editorial: The Human Microbiome and Cancer, Frontiers in Microbiology, 11, 2020, p1514-, Journal Article, PUBLISHED  DOI
Hern├índez-Cervantes A, Znaidi S, van Wijlick L, Denega I, Basso V, Ropars J, Sertour N, Sullivan D, Moran G, Basmaciyan L, Bon F, Dalle F, Bougnoux ME, Boekhout T, Yang Y, Li Z, Bachellier-Bassi S, d'Enfert C., A conserved regulator controls asexual sporulation in the fungal pathogen Candida albicans., Nature communications, 11, (1), 2020, p6224 , Journal Article, PUBLISHED  DOI
Elmaghrawy K, Hussey S, Moran GP., The Oral Microbiome in Pediatric IBD: A Source of Pathobionts or Biomarkers?, Frontiers in pediatrics, 8, 2020, p620254 , Journal Article, PUBLISHED  DOI
Alotaibi M, Moran G, Grufferty B, Renvert S, Polyzois I , The effect of a decontamination protocol on contaminated titanium dental implant surfaces with different surface topography in edentulous patients, Acta Odontologica Scandinavica, 77, (1), 2019, p66 - 75, Journal Article, PUBLISHED  DOI
Moran GP, Anderson MZ, Myers LC, Sullivan DJ., Role of Mediator in virulence and antifungal drug resistance in pathogenic fungi., Current genetics, 65, 2019, p621 - 630, Journal Article, PUBLISHED  DOI
Healy C.M., Moran G.P., The microbiome and oral cancer: More questions than answers, Oral Oncology, 89, 2019, p30 - 33, Journal Article, PUBLISHED  DOI
Peter R. Flanagan, Jessica Fletcher, Hannah Boyle, Razvan Sulea, Gary P. Moran, Derek J. Sullivan, Expansion of the TLO gene family enhances the virulence of Candida species, PLoS One, 13, (7), 2018, Journal Article, PUBLISHED  TARA - Full Text  DOI
Westman J, Moran G, Mogavero S, Hube B, Grinstein S., Candida albicans Hyphal Expansion Causes Phagosomal Membrane Damage and Luminal Alkalinization., mBio, 9, (5), 2018, Journal Article, PUBLISHED  DOI
Fungal infections of humans in, editor(s)Kavanagh, K. , Fungi: Biology and applications, third edition, Oxford, John Wiley & Sons Ltd., 2017, pp251 - 274, [Derek J. Sullivan, Gary P. Moran and David C. Coleman], Book Chapter, PUBLISHED  DOI

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GARY P. MORAN, WHY CANDIDA ALBICANS FILAMENTS BETTER THAN ITS BUDDING COUSIN, EUKARYOTIC CELL, 9, (9), 2010, p1299 - 1299, Notes: [Spotlight feature on O'Connor et al. 2010, an "Article of Significant Interest Selected from This Issue by the Editors."], Journal Article, PUBLISHED


Award Date
Irish Division of International Association of Dental Research (IADR) Elida Gibbs Award 1998
F.S. Stewart prize (Awarded by Dept. of Microbiology, TCD, for highest grade in moderatorship exam) 1994
EMBO Short-term Fellowship 1997
My research interests focus on oral microbiology, including: 1) The pathogenic yeast Candida albicans, responsible for oral and systemic fungal infections - I am interested in a telomeric gene family (TLO genes) that encode subunits of the Mediator transcriptional complex. This family of 14 genes regulate virulence traits and we are currently mutating this family using CRISPR-Cas mutagenesis. 2) The oral microbiome: using 16s community profiling identify new disease associations and diagnostic markers in the oral microbiome. Projects include the oral Crohn's disease and Oral cancer microbiomes. 3) Pathogenicity of the oral anaerobic bacterium Fusobacterium nucleatum.