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Professor Gwyneth Farrar

Research Professor (Genetics)

Head of School Genetics & Microbiology (Trinity Inst. of Neurosciences (TCIN))

  Brittle bone disease   Inherited retinal diseases   Knockout & Transgenic animal models simulating human disease   Neuronal survival mechanisms   Novel approaches to gene therapy
Details Date
Member, DMMC Vascular Biology Principal Investigators, DMMC Principal Investigator leading research on Vascular Biology related projects
Member, Core Technology PI's, DMMC Principal Investigators leading the development of core technology platforms.
de Bruijn, S.E. and Rodenburg, K. and Corominas, J. and Ben-Yosef, T. and Reurink, J. and Kremer, H. and Whelan, L. and Plomp, A.S. and Berger, W. and Farrar, G.J. and Ferenc Kovács, à . and Fajardy, I. and Hitti-Malin, R.J. and Weisschuh, N. and Weener, M.E. and Sharon, D. and Pennings, R.J.E. and Haer-Wigman, L. and Hoyng, C.B. and Nelen, M.R. and Vissers, L.E.L.M. and van den Born, L.I. and Gilissen, C. and Cremers, F.P.M. and Hoischen, A. and Neveling, K. and Roosing, S., Optical genome mapping and revisiting short-read genome sequencing data reveal previously overlooked structural variants disrupting retinal diseaseâ^'associated genes, Genetics in Medicine, (100345), 2023, Notes: [cited By 1], Journal Article, PUBLISHED  DOI
Chadderton, N. and Palfi, A. and Maloney, D.M. and Carrigan, M. and Finnegan, L.K. and Hanlon, K.S. and Shortall, C. and O†Reilly, M. and Humphries, P. and Cassidy, L. and Kenna, P.F. and Millington-Ward, S. and Farrar, G.J., Optimisation of AAV-NDI1 Significantly Enhances Its Therapeutic Value for Correcting Retinal Mitochondrial Dysfunction, Pharmaceutics, 15, (2), 2023, Notes: [cited By 0], Journal Article, PUBLISHED  DOI
Millington-Ward, S. and Chadderton, N. and Finnegan, L.K. and Post, I.J.M. and Carrigan, M. and Nixon, R. and Humphries, M.M. and Humphries, P. and Kenna, P.F. and Palfi, A. and Farrar, G.J., RPE-Directed Gene Therapy Improves Mitochondrial Function in Murine Dry AMD Models, International Journal of Molecular Sciences, 24, (4), 2023, Notes: [cited By 0], Journal Article, PUBLISHED  DOI
Laura K Finnegan, Naomi Chadderton, Paul F Kenna, Arpad Palfi, Michael Carty, Andrew G Bowie, Sophia Millington-Ward, Gwyneth Jane Farrar, SARM1 Ablation Is Protective and Preserves Spatial Vision in an In Vivo Mouse Model of Retinal Ganglion Cell Degeneration, International Journal of Molecular Sciences, 2022, Journal Article, PUBLISHED  TARA - Full Text  URL
Velde, H.M. and Reurink, J. and Held, S. and Li, C.H.Z. and Yzer, S. and Oostrik, J. and Weeda, J. and Haer-Wigman, L. and Yntema, H.G. and Roosing, S. and Pauleikhoff, L. and Lange, C. and Whelan, L. and Dockery, A. and Zhu, J. and Keegan, D.J. and Farrar, G.J. and Kremer, H. and Lanting, C.P. and Damme, M. and Pennings, R.J.E., Usher syndrome type IV: clinically and molecularly confirmed by novel ARSG variants, Human Genetics, 2022, Notes: [cited By 0], Journal Article, PUBLISHED  TARA - Full Text  DOI
Stephenson, K.A.J. and Zhu, J. and Dockery, A. and Whelan, L. and Burke, T. and Turner, J. and O†byrne, J.J. and Jane Farrar, G. and Keegan, D.J., Clinical and Genetic Re-Evaluation of Inherited Retinal Degeneration Pedigrees following Initial Negative Findings on Panel-Based Next Generation Sequencing, International Journal of Molecular Sciences, 23, (2), 2022, Notes: [cited By 0], Journal Article, PUBLISHED  TARA - Full Text  DOI
Palfi, A. and Chadderton, N. and Millington-Ward, S. and Post, I. and Humphries, P. and Kenna, P.F. and Farrar, G.J., AAV-PHP.eB transduces both the inner and outer retina with high efficacy in mice, Molecular Therapy - Methods and Clinical Development, 25, 2022, p236-249 , Notes: [cited By 0], Journal Article, PUBLISHED  DOI
Fadaie, Z. and Whelan, L. and Dockery, A. and Li, C.H.Z. and Van Den Born, L.I. and Hoyng, C.B. and Gilissen, C. and Corominas, J. and Rowlands, C. and Megaw, R. and Lampe, A.K. and Cremers, F.P.M. and Farrar, G.J. and Ellingford, J.M. and Kenna, P.F. and Roosing, S., BBS1 branchpoint variant is associated with non-syndromic retinitis pigmentosa, Journal of Medical Genetics, 59, (5), 2022, p438-444 , Notes: [cited By 5], Journal Article, PUBLISHED  DOI
O'Connell, A. and Zhu, J. and Stephenson, K.A.J. and Whelan, L. and Dockery, A. and Turner, J. and O'Byrne, J.J. and Farrar, G.J. and Keegan, D., MFRP -Associated Retinopathy and Nanophthalmos in Two Irish Probands: A Case Report, Case Reports in Ophthalmology, 13, (3), 2022, p1015-1023 , Notes: [cited By 0], Journal Article, PUBLISHED  DOI
Hitti-Malin, R.J. and Dhaenens, C.-M. and Panneman, D.M. and Corradi, Z. and Khan, M. and den Hollander, A.I. and Farrar, G.J. and Gilissen, C. and Hoischen, A. and van de Vorst, M. and Bults, F. and Boonen, E.G.M. and Saunders, P. and Roosing, S. and Cremers, F.P.M., Using single molecule Molecular Inversion Probes as a cost-effective, high-throughput sequencing approach to target all genes and loci associated with macular diseases, Human Mutation, 43, (12), 2022, p2234-2250 , Notes: [cited By 2], Journal Article, PUBLISHED  DOI

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