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Professor Gwyneth Farrar

Research Professor (Genetics)

Research Professor (Trinity Inst. of Neurosciences (TCIN))


  Brittle bone disease   Inherited retinal diseases   Knockout & Transgenic animal models simulating human disease   Neuronal survival mechanisms   Novel approaches to gene therapy
Details Date
Member, DMMC Vascular Biology Principal Investigators, DMMC Principal Investigator leading research on Vascular Biology related projects
Member, Core Technology PI's, DMMC Principal Investigators leading the development of core technology platforms.
Kiang, A.-S. and Kenna, P.F. and Humphries, M.M. and Ozaki, E. and Koenekoop, R.K. and Campbell, M. and Jane Farrar, G. and Humphries, P., Properties and therapeutic implications of an enigmatic d477g rpe65 variant associated with autosomal dominant retinitis pigmentosa, Genes, 11, (12), 2020, p1-21 , Notes: [cited By 0], Journal Article, PUBLISHED  TARA - Full Text  DOI
Kenna, P.F. and Humphries, M.M. and Kiang, A.-S. and Brabet, P. and Guillou, L. and Ozaki, E. and Campbell, M. and Jane Farrar, G. and Koenekoop, R. and Humphries, P., Advanced late-onset retinitis pigmentosa with dominant-acting D477G RPE65 mutation is responsive to oral synthetic retinoid therapy, BMJ Open Ophthalmology, 5, (1), 2020, Notes: [cited By 3], Journal Article, PUBLISHED  TARA - Full Text  DOI
Palfi, A. and Yesmambetov, A. and Humphries, P. and Hokamp, K. and Farrar, G.J., Non-photoreceptor Expression of Tulp1 May Contribute to Extensive Retinal Degeneration in Tulp1-/- Mice, Frontiers in Neuroscience, 14, (656), 2020, Notes: [cited By 1], Journal Article, PUBLISHED  TARA - Full Text  DOI
Millington-Ward, S. and Chadderton, N. and Berkeley, M. and Finnegan, L.K. and Hanlon, K.S. and Carrigan, M. and Humphries, P. and Kenna, P.F. and Palfi, A. and Farrar, G.J., Novel 199 base pair NEFH promoter drives expression in retinal ganglion cells, Scientific Reports, 10, (1), 2020, Notes: [cited By 0], Journal Article, PUBLISHED  TARA - Full Text  DOI
Maloney, D.M. and Chadderton, N. and Millington-Ward, S. and Palfi, A. and Shortall, C. and O†Byrne, J.J. and Cassidy, L. and Keegan, D. and Humphries, P. and Kenna, P. and Farrar, G.J., Optimized OPA1 Isoforms 1 and 7 Provide Therapeutic Benefit in Models of Mitochondrial Dysfunction, Frontiers in Neuroscience, 14, (571479), 2020, Notes: [cited By 0], Journal Article, PUBLISHED  DOI
Palfi, A. and Yesmambetov, A. and Millington-Ward, S. and Shortall, C. and Humphries, P. and Kenna, P.F. and Chadderton, N. and Farrar, G.J., AAV-Delivered Tulp1 Supplementation Therapy Targeting Photoreceptors Provides Minimal Benefit in Tulp1â^'/â^' Retinas, Frontiers in Neuroscience, 14, (891), 2020, Notes: [cited By 0], Journal Article, PUBLISHED  TARA - Full Text  DOI
Lane, A. and Jovanovic, K. and Shortall, C. and Ottaviani, D. and Panes, A.B. and Schwarz, N. and Guarascio, R. and Hayes, M.J. and Palfi, A. and Chadderton, N. and Farrar, G.J. and Hardcastle, A.J. and Cheetham, M.E., Modeling and Rescue of RP2 Retinitis Pigmentosa Using iPSC-Derived Retinal Organoids, Stem Cell Reports, 15, (1), 2020, p67-79 , Notes: [cited By 12], Journal Article, PUBLISHED  DOI
Khan, M. and Cornelis, S.S. and Pozo-Valero, M.D. and Whelan, L. and Runhart, E.H. and Mishra, K. and Bults, F. and AlSwaiti, Y. and AlTalbishi, A. and De Baere, E. and Banfi, S. and Banin, E. and Bauwens, M. and Ben-Yosef, T. and Boon, C.J.F. and van den Born, L.I. and Defoort, S. and Devos, A. and Dockery, A. and Dudakova, L. and Fakin, A. and Farrar, G.J. and Sallum, J.M.F. and Fujinami, K. and Gilissen, C. and GlavaÄ , D. and Gorin, M.B. and Greenberg, J. and Hayashi, T. and Hettinga, Y.M. and Hoischen, A. and Hoyng, C.B. and Hufendiek, K. and JÀgle, H. and Kamakari, S. and Karali, M. and Kellner, U. and Klaver, C.C.W. and Kousal, B. and Lamey, T.M. and MacDonald, I.M. and Matynia, A. and McLaren, T.L. and Mena, M.D. and Meunier, I. and Miller, R. and Newman, H. and Ntozini, B. and Oldak, M. and Pieterse, M. and Podhajcer, O.L. and Puech, B. and Ramesar, R. and RÃŒther, K. and Salameh, M. and Salles, M.V. and Sharon, D. and Simonelli, F. and Spital, G. and Steehouwer, M. and Szaflik, J.P. and Thompson, J.A. and Thuillier, C. and Tracewska, A.M. and van Zweeden, M. and Vincent, A.L. and Zanlonghi, X. and Liskova, P. and Stöhr, H. and Roach, J.N.D. and Ayuso, C. and Roberts, L. and Weber, B.H.F. and Dhaenens, C.†M. and Cremers, F.P.M., Resolving the dark matter of ABCA4 for 1054 Stargardt disease probands through integrated genomics and transcriptomics, Genetics in Medicine, 22, (7), 2020, p1235-1246 , Notes: [cited By 8], Journal Article, PUBLISHED  DOI
Stephenson, K.A.J. and Dockery, A. and O†Keefe, M. and Green, A. and Farrar, G.J. and Keegan, D.J., A FBN1 variant manifesting as non-syndromic ectopia lentis with retinal detachment: clinical and genetic characteristics, Eye (Basingstoke), 34, (4), 2020, p690-694 , Notes: [cited By 1], Journal Article, PUBLISHED  DOI
Whelan, L. and Dockery, A. and Wynne, N. and Zhu, J. and Stephenson, K. and Silvestri, G. and Turner, J. and O†Byrne, J.J. and Carrigan, M. and Humphries, P. and Keegan, D. and Kenna, P.F. and Farrar, G.J., Findings from a genotyping study of over 1000 people with inherited retinal disorders in Ireland, Genes, 11, (1), 2020, Notes: [cited By 6], Journal Article, PUBLISHED  DOI
  

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