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Dr. Frederick Sheedy

Associate Professor (Biochemistry)
      
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Dr. Frederick Sheedy

Associate Professor (Biochemistry)

 fsheedy@tcd.ie

 


I recently established my independent research group within the School of Biochemistry & Immunology at Trinity College, Dublin (TCD), Ireland, examining macrophage function in health and disease. I pioneered miRNA research in the field of innate immunity during my graduate studies in the O'Neill Lab, resulting in a Nature Immunology first author publication and this emerging field was highlighted by a Nature Reviews Immunology article, which I co-wrote. I obtained a postdoctoral fellowship from the American Heart Association to study the molecular mechanisms of inflammation in disease at NYU. This transformative work was published in Nature Immunology and alongside my recent work on tuberculosis, funded by a Starting Investigator grant from Science Foundation Ireland, fueled my interest in macrophage-driven disease. My recent work published in Cell Reports, J Immunology and AJRCMB (as last author), has uncovered the regulation of anti-microbial function by metabolism and through multiple industrial partnerships with local food companies , I have begun to examine the potential for β-glucan training of immunity. I aim to use this to consolidate my research in the emerging area of innate immune training and how this can improve resistance to infection.
  Bacteriology and bacterial pathogenesis   Host, Pathogen interactions   Immune system   Immunochemistry and immunogenetics   Immunodeficiency diseases   Immunology, Immunotherapy   Infectious diseases   Innate immunology   Lipid metabolism   Metabolism and metabolic diseases   Molecular Biology   Regulatory methods of gene expression   RNA processing, stability and degradation   Tumour immunology and immunotherapy   Vaccines   Vascular Biology, Thrombosis
Project Title
 Mushroom digestion as a model to re-define gut-immune system cross-talk via Innate Immune Training
From
March 2020
To
March 2022
Summary
Funding Agency
Enterprise Ireland
Programme
Innovation Partnership Program
Project Type
Collaborative Partnership
Project Title
 Wellmune trains monocytes to increase innate immune memory & resistance
From
01/06/2018
To
31/05/2020
Summary
Funding Agency
Enterprise Ireland
Programme
Innovation Partnership Project
Project Type
Idustry Collaborative
Project Title
  Targeting microRNA to drive a successful host response to Mycobacterium tuberculosis
From
09/2014
To
09/2018
Summary
Funding Agency
Science Foundation Ireland
Programme
Starting Investigator
Project Type
Research
Project Title
 Measuring monocyte function as a marker of cardiovascular disease and immune activation
From
02/2017
To
02/2018
Summary
Atherosclerosis, a leading cause of cardiovascular disease, is triggered by recruitment of macrophages to areas of lipid deposition along vessel walls. The macrophages are recruited as precursor monocytes and differentiate locally to proinflammatory macrophages. Evidence suggests the type of monocyte recruited is affected by numerous factors. This project proposes to develop technologies to profile monocyte precursors in circulation by examining key mRNA and protein expression as biomarkers. This can be applied to approaches to monitor monocytes in disease susceptible patients.
Funding Agency
Irish Heart Foundation
Programme
Stroke Prevention Research Bursary
Project Type
Research
Person Months
1
Project Title
 Metabolic control of tumor associated macrophage reprogramming by microRNA-21
From
01/10/2017
To
30/09/2021
Summary
Funding Agency
Irish Research Council
Programme
Government of Ireland PhD Scholarship
Project Type
PhD

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Language Skill Reading Skill Writing Skill Speaking
English Fluent Fluent Fluent
Details Date From Date To
Irish Society of Immunology 2014 2022
European Federation of Immunology Societies 2021 2022
American Heart Association - ATVB Council 2010 2013
Trinity Biochemical Society 2005 2022
Ledwith A.E., Prendeville H., Horneck Johnston C.J., Cunningham S.P., McGrath J.P., Corkish C., Walsh A.M., Koc F., Charles-Messance H., Sularea V.M., Chasaide C.N., Hawerkamp H.C., Finlay D.K., Lynch L., Mills K.H.G., Stanton C., Roche H.M., Sheedy F.J., Yeast ß-glucan supplementation supports immunometabolic anti-tumor responses and reverses obesity-induced dysfunction via trained hematopoiesis, Cell Reports, 45, (7), 2026, Journal Article, PUBLISHED  DOI
Lynch R.I., Gorman A.L., McCluskey S., Horneck-Johnston C.J.H., Roche K., Sheedy F.J., Munoz-Wolf N., Lavelle E.C., Biodegradable microparticles promote anti-inflammatory innate immune memory through a size- and mTOR-dependent process, Journal of Leukocyte Biology, 118, (2), 2026, Journal Article, PUBLISHED  DOI
Connolly, Sarah A.; Walsh, Aaron; Ledwith, Anna E.; McCarthy, Karen N.; O'Rourke, Sinead A.; Murphy, Dearbhla M.; Blasinska, Anna; Dunne, Aisling; Fletcher, Jean M.; Mills, Kingston H.G.; McManus, Ross; Sheedy, Frederick J.; Basdeo, Sharee A., BNT162b2 mRNA vaccination attenuates innate immune function in humans, Clinical Immunology, 276, 2025, Notes: [Cited by: 0], Journal Article, PUBLISHED  DOI
Aaron M. Walsh, Emma Roycroft, Kate Hinchion, Sharee A. Basdeo, Frederick J. Sheedy, Fiona Crispie, Paul D. Cotter, Anne-Marie McLaughlin, Joseph Keane, Margaret Fitzgibbon, Laura E. Gleeson, Genomic characterisation of recurrent Mycobacterium avium isolates from chronically infected patients reveals patterns of within-host evolution, Genome Medicine, 17, (1), 2025, p120 - 120, p120-120 , Journal Article, PUBLISHED  DOI
Dempsey E., Walsh A.M., Yadav S., Wilson J., Sheedy F.J., Corr S.C., Protective Properties of the White Button Mushroom, Agaricus bisporus, in a Mouse Model of Colitis, Molecular Nutrition and Food Research, 69, (19), 2025, Journal Article, PUBLISHED  DOI
Rehill A.M., McCluskey S., Ledwith A.E., Ryan T.A.J., Unlu B., Leon G., Charles-Messance H., Gilbert E.H., Klavina P., Day E.A., Coppinger J., O'Sullivan J.M., McMahon C., O'Donnell J.S., Curtis A.M., O'Neill L.A.J., Sheedy F.J., Preston R.J.S., Trained immunity causes myeloid cell hypercoagulability, Science Advances, 11, (10), 2025, Journal Article, PUBLISHED  DOI
Burak, M.F. and Stanley, T.L. and Lawson, E.A. and Campbell, S.L. and Lynch, L. and Hasty, A.H. and Domingos, A.I. and Dixit, V.D. and HotamıŠlıgil, G.S. and Sheedy, F.J. and Dixon, A.E. and Brinkley, T.E. and Hill, J.A. and Donath, M.Y. and Grinspoon, S.K., Adiposity, immunity, and inflammation: interrelationships in health and disease: a report from 24th Annual Harvard Nutrition Obesity Symposium, June 2023, American Journal of Clinical Nutrition, 120, (1), 2024, p257-268 , Notes: [cited By 0], Journal Article, PUBLISHED  DOI
Horneck Johnston, C.J.H. and Ledwith, A.E. and Lundahl, M.L.E. and Charles-Messance, H. and Hackett, E.E. and O'Shaughnessy, S.D. and Clegg, J. and Prendeville, H. and McGrath, J.P. and Walsh, A.M. and Case, S. and Austen Byrne, H. and Gautam, P. and Dempsey, E. and Corr, S.C. and Sheedy, F.J., Recognition of yeast β-glucan particles triggers immunometabolic signaling required for trained immunity, iScience, 27, (3), 2024, Notes: [cited By 0], Journal Article, PUBLISHED  DOI
Case, S. and O'Brien, T. and Ledwith, A.E. and Chen, S. and Horneck Johnston, C.J.H. and Hackett, E.E. and O'Sullivan, M. and Charles-Messance, H. and Dempsey, E. and Yadav, S. and Wilson, J. and Corr, S.C. and Nagar, S. and Sheedy, F.J., β-glucans from Agaricus bisporus mushroom products drive Trained Immunity, Frontiers in Nutrition, 11, (1346706), 2024, Notes: [cited By 0], Journal Article, PUBLISHED  DOI
Sheedy FJ, Kaufmann E., Linking metabolic and epigenetic changes in immune tolerance., Proceedings of the National Academy of Sciences of the United States of America, 121, (46), 2024, pe2419751121 , Journal Article, PUBLISHED  DOI
  

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Award Date
Knowledge Transfer Ireland "Industry Engagement Impact" Award short-list 01/12/2022
Trinity Innovation Award - Industry Engagement 2020
Provost PhD Award 2020
Trinity Innovation Awards - short-listed in Industry Engagement 2019
Irish Heart Foundation Stroke Prevention Research Bursary Award 02/2017
Senior Research Fellow, Trinity College Dublin 01/2014
Researcher of the Year, Trinity Institute of Molecular Medicine 11/2013
Highest achieving undergraduate student in first year of novel BSc Genetics, UCC 06/2004