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Professor Clive Williams

Fellow Emeritus (Fellows Emeritii)

 Clive.Williams@tcd.ie

 


Research Tags

  5-HYDROXYTRYPTAMINE UPTAKE   ANTIDEPRESSANT DRUGS   ANTIPROLIFERATIVE ACTION   APOPTOSIS   BCR-ABL   BENZODIAZEPINE BINDING-SITES   BENZODIAZEPINES   CANCER   CASPASES   CELL CYCLE   CELL PROLIFERATION   CHOLESTEROL   Computational Biology   DIFFERENTIATION   ESTROGEN-RECEPTOR   GABA TRANSPORTER   Immunology, Immunotherapy   In Vitro Testing, Trial Methods   INSECTICIDES   L-GLUTAMATE TRANSPORTER   LIGAND   MITOCHONDRIA   Molecular Biology   PERIPHERAL-TYPE BENZODIAZEPINE BINDING SITE   PYRROLO-1,5-BENZOXAZEPINES   PYRROLO-1,5-BENZOXAZEPINES INDUCE APOPTOSIS   RECEPTOR LIGANDS   RECEPTORS   SEROTONIN TRANSPORTER   Structural Biology, Determination, Function

Representations

Details Date
Member and sometime Chair of The National Committee for Biochemistry 1993-96,00-03
Secretary and Member of The Neurochemical Group Committee of The Biochemical Society 1990-95
Member of HRB Mental Health and Neurology, and Post-doctoral Fellowship Research Grants Committees 1991-2
Trustee of The Irish Area Section of The Biochemical Society FEBS Fund for Graduate students 1987-92
External examiner for research degrees in St Andrews, Leeds, Cardiff, Galway, Cork, Aarhus, etc
Chairman Organising committee for EU TMR Euroconference on Neuronal Transporters Dublin 1998 1998
Member Organising Committees for 636 and 648th Biochemical Society Meeting - Dublin 1990, 2002, 21st FEBS Meeting -Dublin 1992, INSERM Phillipe Laudet Conference on Neuronal transporters - Strasbourg, 1993
NUI Phelan Scholarship Evaluation Panel 2003-
Chair of Local Organising Committee, and Member of International Programme Committee for the 9th General Meeting of the European Society for Neurochemistry, Dublin 1992 1992

Memberships

Membership of Professional Institutions, Associations, Societies

Details Date From Date To
Member of the Society for Neuroscience 2000
Member and Council Member of European Society for Neurochemistry 1990
Member of The International Society for Neurochemistry 1990
Royal Irish Academy 1995
The Biochemical Society 1970
Fiore D, Proto MC, Pisanti S, Picardi P, Pagano Zottola AC, Butini S, Gemma S, Casagni A, Laezza C, Vitale M, Ligresti A, Di Marzo V, Zisterer DM, Nathwani S, Williams DC, Campiani G, Gazzerro P, Bifulco M, Antitumor effect of pyrrolo-1,5-benzoxazepine-15 and its synergistic effect with Oxaliplatin and 5-FU in colorectal cancer cells., Cancer biology & therapy, 17, (8), 2016, p849 - 858, Journal Article, PUBLISHED  DOI
Kinsella P, Greene LM, Bright SA, Pollock JK, Butini S, Campiani G, Bauer S, Williams DC, Zisterer DM, The novel pyrrolo-1,5-benzoxazepine, PBOX-15, synergistically enhances the apoptotic efficacy of imatinib in gastrointestinal stromal tumours; suggested mechanism of action of PBOX-15., Investigational new drugs, 34, (2), 2016, 159-167 , Journal Article, PUBLISHED  DOI
Kelly PM, Bright SA, Fayne D, Pollock JK, Zisterer DM, Williams DC, Meegan MJ, Synthesis, antiproliferative and pro-apoptotic activity of 2-phenylindoles., Bioorganic & medicinal chemistry, 24, (18), 2016, p4075-99 , Journal Article, PUBLISHED  DOI
Lennon JC, Butini S, Campiani G, O'Meara A, Williams DC, Zisterer DM, Involvement of AMP-activated protein kinase in mediating pyrrolo-1,5-benzoxazepine-induced apoptosis in neuroblastoma cells., Investigational new drugs, 34, (5), 2016, p663-76 , Journal Article, PUBLISHED  DOI
Nathwani SM, Greene LM, Butini S, Campiani G, Williams DC, Samali A, Szegezdi E, Zisterer DM, The pyrrolo-1,5-benzoxazepine, PBOX-15, enhances TRAIL"induced apoptosis by upregulation of DR5 and downregulation of core cell survival proteins in acute lymphoblastic leukaemia cells., International journal of oncology, 49, (1), 2016, p74-88 , Journal Article, PUBLISHED  DOI
O'Callaghan K, Palagano E, Butini S, Campiani G, Williams DC, Zisterer DM, O'Sullivan J, Induction of apoptosis in oral squamous carcinoma cells by pyrrolo-1,5-benzoxazepines., Molecular medicine reports, 12, (3), 2015, p3748-54 , Journal Article, PUBLISHED  TARA - Full Text  DOI
Ryan GJ, Poynton FE, Elmes RB, Erby M, Williams DC, Quinn SJ, Gunnlaugsson T, Unexpected DNA binding properties with correlated downstream biological applications in mono vs. bis-1,8-naphthalimide Ru(ii)-polypyridyl conjugates., Dalton transactions (Cambridge, England : 2003), 44, (37), 2015, p16332-44 , Journal Article, PUBLISHED
Cloonan SM, Elmes RB, Erby M, Bright SA, Poynton FE, Nolan DE, Quinn SJ, Gunnlaugsson T, Williams DC, Detailed Biological Profiling of a Photoactivated and Apoptosis Inducing pdppz Ruthenium(II) Polypyridyl Complex in Cancer Cells., Journal of medicinal chemistry, 58, (11), 2015, p4494-505 , Journal Article, PUBLISHED  DOI
Thorfinnur Gunnlaugsson, Miguel Martínez-Calvo, Kim Orange, Robert B. P. Elmes, Bjørn la Cour Poulsen and D. Clive Williams , Ru(II)-polypyridyl surface functionalised gold nano-particles as DNA targeting supramolecular structures and luminescent cellular imaging agents, Nanoscale, 2015, Journal Article, IN_PRESS  URL
Spallarossa A, Caneva C, Caviglia M, Alfei S, Butini S, Campiani G, Gemma S, Brindisi M, Zisterer DM, Bright SA, Williams CD, Crespan E, Maga G, Sanna G, Delogu I, Collu G, Loddo R, Unconventional Knoevenagel-type indoles: Synthesis and cell-based studies for the identification of pro-apoptotic agents., European journal of medicinal chemistry, 102, 2015, p648-60 , Journal Article, PUBLISHED  DOI
  

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Haase, J., Killian, A-M., Magnani, F., and Williams, D.C., Regulation of the serotonin transporter by interacting proteins, Biochem. Soc. Trans., 29, 2001, p722 - 728, Journal Article, PUBLISHED
Zisterer, D.M., McGee, M.M., Campiani.G.C., Ramunno, A., Fattorusso, C., Nacci, V., Lawler,M., and Williams, D.C., Pyrrolo-1,5, benzoxazepines: a new class of apoptotic agents, Biochem. Soc. Trans., 29, 2001, 704 - 706, Journal Article, PUBLISHED
Meegan, M.J., Hughes, R.B., Lloyd, D.G., Williams, D.C., and Zisterer, D.M., Novel antiestrogens - synthesis, computational modelling and biological inhibition of MCF-7 cells, Proceedings of the 23rd Annual Pharmacy Joint Research Seminar, Trinity College Dublin, 2000, Conference Paper, PUBLISHED
Meegan, M.J., Hughes, R.B., Lloyd, D.G., Williams, D.C., Zisterer, D.M., Campiani, G.C., Fattorusso, C., and Catalanotti, B., Novel conformationally restrained estrogen receptor modulators - design, synthesis, and antagonistic effects in human breast cancer cells, Proceedings of the Molecular Graphics and Modelling Society Symposium on Structure-Based Drug Design, St. Catherine's College, University of Oxford, 2000, Notes: [Abstract will also be published in Journal of Molecular Modelling, 2001], Conference Paper, PUBLISHED
Hughes, R.B., Meegan, M.J., Lloyd, D.G., Williams, D.C. and Zisterer, D.M., Investigation of diaryl benzoxepines as novel antiestrogens and selective estrogen receptor modulators (SERMs), Proceedings of the 22nd Annual Pharmacy Joint Research Seminar, Queens University Belfast, 1999, 1999, Conference Paper, PUBLISHED
Meegan, M.J., Hughes, R.B., Lloyd, D.G., Williams, D.C., and Zisterer, D.M., Novel antiestrogens - synthesis, computational modelling and biological inhibition of MCF-7 cells, Proceedings of the 10th International RSC-SCI Medicinal Chemistry Symposium, Cambridge, UK, 1999, Conference Paper, PUBLISHED
Griffiths, R., Grieve, A., Scollon, J., Scott, M., Williams., D.C. and Meredith, C., Preliminary validation of an in vitro test for assessment of excitotoxicity by measurement of early c-fos mRNA levels, J. Neurochem., 73, 1999, pS146A , Journal Article, PUBLISHED
Haase, J., Schloss, P., and Williams, D.C., Regulation of the serotonin transporter: Identification of interacting proteins using a yeast two-hybrid system, J.Neurochem., 73, 1999, pS98D , Journal Article, PUBLISHED
Elliott, G., Campiani, G., Drejer, J., Griffiths, R., Hildebrand, H., Meredith, C., Schousboe, A., Schmuck, G. and Williams, D.C., Demonstration of an in vitro test for excitotoxicity based on early response gene measurement, Alternatives to Laboratory Animals (ATLA), 27, 1999, p289 , Journal Article, PUBLISHED
Zisterer, D.M. & Williams, D.C., Hexachlorocyclohexanes inhibits steroidogenesis in Y1 cells: Absence of correlation with binding to the peripheral-type benzodiazepine receptor, J. Neurochem., 66, (suppl. 2), 1996, pS87C , Journal Article, PUBLISHED

  

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Awards and Honours

Award Date
Elected Fellow of Trinity College 1987
Elected To Membership of Royal Irish Academy 1995

Research Interests

Description Of Research Interests

Current Research Interests and Projects