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Dr. Margaret Dunne

Senior Research Fellow (Clinical Microbiology)

 


  Age related diseases   Angiogenesis   Biomedical sciences   Cancer genetics and cell biology including metastasis   cancer immunology   Cell and tissue maintenance, repair and ageing   Cellular, molecular and developmental immunology   Chronic inflamation   Coeliac disease   COLORECTAL CANCER   Diagnostics   gastrointestinal cancer   Health outcomes   HUMAN DENDRITIC CELLS   HUMAN T-CELLS   immune prognostic markers   Immune system   Immunoassays   In vitro testing, trial methods   Innate immunology   Leukocyte Biology   Medical Sciences, Research   Mucosal immunology   Mucosal-associated invariant T cells   OESOPHAGEAL ADENOCARCINOMA   Oesophageal cancer   Oesophageal, gastric, intestinal and pancreatic diseases   Pathology   Predictive Biomarkers   Public health   TCR GAMMA DELTA(+) T CELLS   Tumour immunology and immunotherapy   unconventional T cells
 Promoting Education and Research Knowledge (PERK)
 Assessment of the predictive value of immune and histological parameters in oesophageal adenocarcinoma using digital pathology
 Development of prognostic screening tools to predict patient response to neoadjuvant chemoradiotherapy treatment for oesophageal adenocarcinoma
 Investigating the role of innate lymphocyte subsets in oesophageal adenocarcinoma - is inflammation a negative regulator of response to therapy?
 Investigating the role of regulatory T cells in colorectal cancer

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Details Date
Presented a poster at the European Congress for Immunology, Amsterdam 2-5th Sept
Presented a poster at the 2017 Cell Symposium in San Diego, USA. 12-06-2017
Presented a poster at the CRUK's Oesophageal Symposium, Cambridge, UK. 27/04/2017
Poster presentation at the 9th International Cancer Conference, Trinity Biomedical Sciences Institute, Dublin Sept 2014
Oral presentation at the 8th National Barrett's Symposium, University College London April 2014
Presented 2 posters at the Irish Association for Cancer Research annual meeting, Galway Feb 2014
Oral presentations at the Irish Society for Immunology annual meeting 2013, 2009, 2008 & 2007
Poster presentation at the 5th International γδ T cell conference, Freiburg, Germany 2012
Oral presentation at the 25th Working Group on Prolamin Analysis & Toxicity (WGPAT), Fellbach, Germany 2011
Poster presentation at the 14th International Coeliac Disease Symposium, Oslo, Norway 2011
Poster presentation at Trinity College Dublin Tercentenary Symposium, Dublin 2011
Poster presentation at 4th International γδ T cell conference, Kiel, Germany 2010
Poster presentation at Institute of Molecular Medicine annual conference, Dublin 2008
Poster presentations at Irish Society for Immunology annual meetings 2010 & 2011
Language Skill Reading Skill Writing Skill Speaking
English Fluent Fluent Fluent
Details Date From Date To
Member of the Irish Society for Immunology 2005 Present
Member of the Irish and European Associations for Cancer Research (IACR, EACR) 2013 Present
Member of the γδ T cell forum 2010 Present
Aisling B. Heeran, Margaret R. Dunne, Maria E. Morrissey, Croí E. Buckley, Niamh Clarke, Aoife Cannon, Noel E. Donlon, Timothy S. Nugent, Michael Durand, Cara Dunne, John O. Larkin, Brian Mehigan, Paul McCormick, Niamh Lynam-Lennon, Jacintha O"Sullivan, The Protein Secretome Is Altered in Rectal Cancer Tissue Compared to Normal Rectal Tissue, and Alterations in the Secretome Induce Enhanced Innate Immune Responses, Cancers, 13, (3), 2021, p571 , Journal Article, PUBLISHED
Orumaa K, Dunne MR., The role of unconventional T cells in COVID-19., Ir J Med Sci, 2021, Journal Article, PUBLISHED  DOI
Dunne MR, Wagener J, Loeffler J, Doherty DG, Rogers TR, Unconventional T cells - New players in antifungal immunity, Clinical Immunology, 2021, p108734-, Journal Article, PUBLISHED  DOI  URL
Davern M, Donlon NE, Power R, Hayes C, King R, Dunne MR, Reynolds JV., The tumour immune microenvironment in oesophageal cancer., British journal of cancer, 2021, Journal Article, PUBLISHED  DOI
King R, Hayes C, Donohoe CL, Dunne MR, Davern M, Donlon NE., Hypoxia and its impact on the tumour microenvironment of gastroesophageal cancers., World journal of gastrointestinal oncology, 13, (5), 2021, p312-331 , Journal Article, PUBLISHED  DOI
Kennedy, S.A., Annett, S.L., Dunne, M.R., Boland, F., O'Neill, L.M., Guinan, E.M., Doyle, S.L., Foley, E.K., Elliott, J.A., Murphy, C.F., Bennett, A.E., Carey, M., Hillary, D., Robson, T., Reynolds, J.V., Hussey, J., O'Sullivan, J.N., Effect of the Rehabilitation Program, ReStOre, on Serum Biomarkers in a Randomized Control Trial of Esophagogastric Cancer Survivors, Frontiers in Oncology, 11, (669078), 2021, p1-11 , Journal Article, PUBLISHED  DOI
Susan A. Kennedy and Maria E. Morrissey and Margaret R. Dunne and Fiona O'Connell and Clare T. Butler and Mary-Clare Cathcart and Amy M. Buckley and Brian J. Mehigan and John O. Larkin and Paul McCormick and Breand{\'{a, Combining 1,4-dihydroxy quininib with Bevacizumab/FOLFOX alters angiogenic and inflammatory secretions in ex vivo colorectal tumors, BMC Cancer, 20, (1), 2020, Journal Article, PUBLISHED
Noel E. Donlon and Andrew Sheppard and Maria Davern and Fiona O'Connell and James J. Phelan and Robert Power and Timothy Nugent and Kate Dinneen and John Aird and John Greene and Paul Nevins Selvadurai and Anshul Bhardwaj and Emma K. Foley and Narayanasamy Ravi and Claire L. Donohoe and John V. Reynolds and Joanne Lysaght and Jacintha O'Sullivan and Margaret R. Dunne, Linking Circulating Serum Proteins with Clinical Outcomes in Esophageal Adenocarcinoma"An Emerging Role for Chemokines, Cancers, 12, (11), 2020, p3356 , Journal Article, PUBLISHED  TARA - Full Text
Royds J, Cassidy H, Conroy MJ, Dunne MR, Matallanas D, Lysaght J, McCrory C., An Investigation into Proteomic Constituents of Cerebrospinal Fluid in Patients with Chronic Peripheral Neuropathic Pain Medicated with Opioids- a Pilot Study., Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology, 2020, Journal Article, PUBLISHED  DOI
Moore D, Galvin D, Conroy MJ, Das B, Dunne M, Lysaght J, McCrory C., Characterisation of the effects of pulsed radio frequency treatment of the dorsal root ganglion on cerebrospinal fluid cellular and peptide constituents in patients with chronic radicular pain: A randomised, triple-blinded, controlled trial., Journal of neuroimmunology, 343, 2020, p577219 , Journal Article, PUBLISHED  DOI
  

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Award Date
Health Research Award 02/05/2016
Irish Research Council Government of Ireland Postdoctoral Fellow 2014
Dorothy Price medal (NUI Maynooth) 2008
John & Pat Hume Postgraduate Scholarship 2005
Irish Research Council for Science, Engineering & Technology Postgraduate Scholarship 2005
My research involves improving the understanding of roles played by innate immune cells in human health and disease, and translation of this information for therapeutic applications. My research projects to date have focused on elucidating the function of innate lymphocytes, in particular γδ T cells and dendritic cells and their contribution to host immunity in diseases such as coeliac disease and cancer. My current work involves investigating the prognostic potential of immune markers in oesophageal cancer.