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Professor Derek Doherty

Professor In / Head of Immunology (Immunology)

A graduate of Trinity College Dublin, I completed a PhD at King's College London and postdoctoral research in the University of Washington, Seattle and University College Dublin before holding lecturing positions at NUI Maynooth and subsequently Trinity College Dublin.
 CD1d binding peptide motifs for the stimulation of NKT cells.
 The role and treatment potential of innate lymphocytes in neonatal brain injury
 Metabolic profiles of innate lymphocytes from patients with sepsis
 The role and treatment potential of natural killer T cells in patients with upper gastrointestinal cancer
 Delivery of Gene Editing Tools to Primary T cells using Profector Technology

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Language Skill Reading Skill Writing Skill Speaking
English Fluent Fluent Fluent
Details Date From Date To
Secretary, Irish Society for Immunology 2000 2004
Committee member, Irish Society for Immunology 2000 2018
Deslyper,G., Murphy, D.M., Sowemimo, O.A., Holland, C.V. and Doherty, D.G., Distinct hepatic myeloid and lymphoid cell repertoires are associated with susceptibility and resistance to Ascaris infection, Parasitology, 148, (5), 2021, p539 - 549, Journal Article, PUBLISHED
Dean Huggard, Lynne Kelly, Emer Ryan, Fiona McGrane, Niamh Lagan, Edna Roche, Joanne Balfe, T. Ronan Leahy, Orla Franklin, Derek G. Doherty, Eleanor J. Molloy, Increased systemic inflammation in children with Down syndrome, Cytokine, 127, 2020, p154938 , Journal Article, PUBLISHED  DOI
Melo AM, Maher SG, O'Leary SM, Doherty DG, Lysaght J, Selective effects of radiotherapy on viability and function of invariant natural killer T cells in vitro, Radiotherapy and Oncology, 145, 2020, p128 - 136, Journal Article, PUBLISHED
Melo A.M., Conroy M.J., Foley E.K., Dockry E., Breen E.P., Reynolds J.V., Lysaght J., Doherty D.G., CD1d expression and invariant natural killer T-cell numbers are reduced in patients with upper gastrointestinal cancers and are further impaired by commonly used chemotherapies, Cancer Immunology, Immunotherapy, 69, (6), 2020, p969 - 982, p969-982 , Journal Article, PUBLISHED  DOI
Huggard D., Doherty D.G., Molloy E.J., Immune Dysregulation in Children With Down Syndrome, Frontiers in Pediatrics, 8, 2020, Journal Article, PUBLISHED  DOI
Coakley J.D., Breen E., Moreno-Olivera A., Al-Harbi A., Melo A., O'Connell B., McManus R., Doherty D., Ryan T. , Innate lymphocyte Th1 and Th17 responses in elderly hospitalised patients with infection and sepsis., Vaccines, 8, (2), 2020, p311-, Journal Article, PUBLISHED  DOI  URL
O'Gorman, P., Strahan, O., Ferguson, D., Monaghan, A., Kennedy, M., Forde, C., Melo, A., Doherty, D., O'Brien, K., McKiernan, S., Kenny, R., Coen, R.F., Doherty, C., Bergin, C., Gormley, J., Norris, S. , Improvement in cognitive impairment following a 12-week aerobic exercise intervention in individuals with non-cirrhotic chronic hepatitis C., Journal of Viral Hepatitis , 2020, Journal Article, IN_PRESS
Doherty, D.G., Antigen-specific immune tolerance in the liver, Nature Biomedical Engineering, 2019, Notes: [cited By 0], Journal Article, PUBLISHED  DOI
Deslyper, G., Doherty, D.G., Carolan, J.C. & Holland, Celia V., The role of the liver in the migration of parasites of global significance, Parasites & Vectors, 12, (531), 2019, Journal Article, PUBLISHED
Huggard D, Koay WJ, Kelly L, McGrane F, Ryan E, Lagan N, Roche E, Balfe J, Leahy TR, Franklin O, Moreno-Oliveira A, Melo AM, Doherty DG, Molloy EJ., Altered Toll-Like Receptor Signalling in Children with Down Syndrome., Mediators of inflammation, 2019, 2019, p4068734 , Journal Article, PUBLISHED  DOI

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Core concepts in immunology. in, editor(s)Gershwin ME, Vierling JM, Manns MP , Liver Immunology: Principles and Practice, New York, Springer Science and Business Media, 2014, pp11 - 26, [O'Farrelly C, Doherty DG], Book Chapter, PUBLISHED
Innate immune mechanisms in the liver. in, editor(s)Gershwin ME, Vierling JM, Manns MP , Liver Immunology: Principles and Practices, New Jersey, Humana Press, 2007, pp41-48 , [O'Farrelly C, Doherty DG. ], Notes: [2nd edition], Book Chapter, PUBLISHED
A short primer on fundamental immunology in, editor(s)Gershwin ME, Vierling JM, Manns MP , Liver Immunology: Principles and Practices, New Jersey, Humana Press, 2007, pp15-24 , [O'Farrelly C, Doherty DG. ], Notes: [2nd edition], Book Chapter, PUBLISHED
Lymphocyte repertoires in healthy liver. in, editor(s)Gershwin ME, Vierling JM, Manns MP , Liver Immunology, Philadelphia, Hanley & Belfus, 2003, pp31-46 , [Doherty DG, O'Farrelly C.], Book Chapter, PUBLISHED
Basic immunological terms and concepts: a short primer of fundamental immunology in, editor(s)Gershwin ME, Vierling JM, Manns MP , Liver Immunology, Philadelphia, Hanley & Belfus, 2003, pp1 - 13, [O'Farrelly C, Doherty DG], Book Chapter, PUBLISHED
The human major histocompatibility complex and disease susceptibility. in, Rimoin DL, Connor JM, Pyeritz RE , Emery and Rimoin's Principles and Practice of Medical Genetics, New York, Churchill Livingstone, 1997, pp497-504 , [Doherty DG, Nepom GT. ], Notes: [third edition], Book Chapter, PUBLISHED


Award Date
Elected to Fellowship of Trinity College Dublin 2012
Our research is aimed at finding out how the immune system protects against or causes disease in humans and how it can be manipulated for the development of novel therapies. We are particularly interested in populations of 'innate lymphocytes' (natural killer cells, natural killer T cells, gamma/delta T cells and mucosal-associated invariant T cells), which appear to be master regulators of the immune system. Innate lymphocytes can be trained to prevent and treat infectious and immune-mediated diseases and cancers in animal models. Various innate lymphocyte populations are being targeted in clinical trials for cancer in humans, and although the results are promising, no such cellular therapy has yet received approval. In order to improve the efficacy of innate lymphocyte therapies that are currently being tested and to develop new treatments, we are investigating the molecular and cellular interactions that take place between innate lymphocytes, pathogens and other cells. We have shown that innate lymphocytes are heterogeneous with diverse effector functions including tumour cell killing, the release of cytokines that activate or suppress the actions of T cells, and contact-dependent stimulatory and regulatory interactions with monocytes, macrophages, dendritic cells and B cells. In collaboration with clinical colleagues, we have found that innate lymphocyte populations are numerically and/or functionally impaired in patients with hepatitis B and C, HIV, candidiasis, chronic lymphocytic leukaemia, oesophageal, stomach, colorectal, liver and lung cancer, post-operative infection and sepsis, coeliac disease, autoimmune vasculitis, antibody deficiencies and neonatal encephalopathy. Our results show that various innate lymphocyte populations can be manipulated to promote the generation of desirable immune responses for the treatment of multiple diseases and this has led to funded collaborations with three biotechnology/pharmaceutical companies, in which we are pooling our efforts to develop robust therapies for cancer, infectious and autoimmune disease.