|
Murphy DM, Batten I, O'Farrell A, Carlile SR, O'Rourke SA, Court C, Morris B, Leisching G, Jameson G, Connolly SA, Dyer AH, McGrath JP, McNally E, Basdeo SA, IFN-Y-induced trained immunity enhances killing of priority pathogens in healthy and genetically vulnerable individuals., JCI insight, 2026,
Journal Article,
PUBLISHED
DOI
|
|
Thong L, Sandby Thomas O, Ó Gallchobhair O, Duffin E, Yennemadi AS, Leisching G, Murphy DM, Nadarajan P, O'Connell F, O'Sullivan MP, Basdeo SA, Cox DJ, Keane J., Dexamethasone inhibits Mycobacterium tuberculosis-induced glycolysis but preserves antimicrobial function in primary human macrophages., Scientific Reports, 15, (1), 2025, p34310 ,
Journal Article,
PUBLISHED
DOI
|
|
Murphy DM, Walsh A, Stein L, Petrasca Andreea, Cox DJ, Brown K, Duffin E, Jameson G, Connolly SA, O'Connell F, O'Sullivan J, Basdeo SA, Keane J, Phelan JJ., Human Macrophages Activate Bystander Neutrophils' Metabolism and Effector Functions When Challenged with Mycobacterium tuberculosis., International journal of molecular sciences, 25, (5), 2024, p2898 ,
Journal Article,
PUBLISHED
DOI
|
|
Cox DJ, Connolly SA, Ó Maoldomhnaigh C, Brugman AAI, Sandby Thomas O, Duffin E, Gogan KM, Ó Gallchobhair O, Murphy DM, O'Rourke SA, O'Connell F, Keane J, Human airway macrophages are metabolically reprogrammed by IFN-" resulting in glycolysis-dependent functional plasticity., eLife, 2024,
Journal Article,
PUBLISHED
DOI
|
|
Murphy, D.M., Cox, D.J., Connolly, S.A., Breen, E.P., Brugman, A.A.I., Phelan, J.J., Keane, J., Basdeo, S.A., Trained immunity is induced in humans after immunization with an adenoviral vector COVID-19 vaccine, Journal of Clinical Investigation, 133, (2), 2023,
Journal Article,
PUBLISHED
DOI
|
|
Christina Cahill, Dónal J. Cox, Fiona O'Connell, Sharee A. Basdeo, Karl M. Gogan, Cilian Ó'Maoldomhnaigh, Jacintha O'Sullivan, Joseph Keane and James J. Phelan., The Effect of Tuberculosis Antimicrobials on the Immunometabolic Profiles of Primary Human Macrophages Stimulated with Mycobacterium tuberculosis, International Journal of Molecular Sciences, 2021,
Journal Article,
PUBLISHED
TARA - Full Text
DOI
URL
|
|
Cilian Ó Maoldomhnaigh, Donal J Cox, James Joseph Phelan, Karl M. Gogan, Kate McQuaid, Amy Martina Coleman, Sharee Ann Basdeo and Joseph Keane., Lactate alters metabolism in human macrophages and improves their ability to kill Mycobacterium tuberculosis, Frontiers in Immunology, 2021,
Journal Article,
PUBLISHED
DOI
|
|
Ó Maoldomhnaigh C, Cox DJ, Phelan JJ, Malone FD, Keane J, Basdeo SA., The Warburg Effect Occurs Rapidly in Stimulated Human Adult but Not Umbilical Cord Blood Derived Macrophages., Frontiers in immunology, 12, 2021, p657261 ,
Journal Article,
PUBLISHED
DOI
|
|
Cahill C, O'Connell F, Gogan KM, Cox DJ, Basdeo SA, O'Sullivan J, Gordon SV, Keane J, Phelan JJ., The Iron Chelator Desferrioxamine Increases the Efficacy of Bedaquiline in Primary Human Macrophages Infected with BCG., International journal of molecular sciences, 22, (6), 2021,
Journal Article,
PUBLISHED
DOI
|
|
Cox, D.J., Coleman, A.M., Gogan, K.M., Phelan, J.J., Maoldomhnaigh, C., Dunne, P.J., Basdeo, S.A. and Keane, J., Inhibiting histone deacetylases in human macrophages promotes glycolysis, IL-1β and T helper cell responses to Mycobacterium tuberculosis, Frontiers in Immunology, 2020,
Journal Article,
PUBLISHED
TARA - Full Text
DOI
URL
|
|
|
