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Dr. David Hoey

Associate Professor (Mechanical, Manuf & Biomedical Eng)
PARSONS BUILDING


Dr. David Hoey is an Associate Professor in the School of Engineering and Principal Investigator (PI) in the Trinity Centre for Biomedical Engineering and the Advanced Materials and Bioengineering Research (AMBER) Centre at Trinity College Dublin (TCD). He is also Director of the Discipline of Biomedical Engineering at TCD and Honorary Associate Professor in the University of Limerick, Ireland. He leads a multidisciplinary research group focusing on musculoskeletal mechanobiology, mechanotransduction, and materials for regeneration in which he has pioneered research on the role of the primary cilium in loading-induced bone formation. This fundamental research underpins a more translational programme aimed at developing novel mechanotherapeutics and biomaterials that mimic the beneficial effect of biophysical stimuli to treat large bone defects and orthopaedic diseases such as osteoporosis. He has extensive experience in mechanobiology and tissue engineering and is also a PI on a major bioprinting initiative at Trinity to develop next generation implantable devices and tissues for orthopaedic applications. His laboratory has been awarded >€3.4million as Principal Investigator, including two European Research Council awards (Starting grant 2013; PoC grant 2019). He is also PI on several commercial projects developing novel biomaterials for musculoskeletal and vascular repair.
  BIOMATERIALS   BIOMECHANICS   Biomechanics, Biomedical Engineering   BONE ABNORMALITIES   BONE ADAPTATION   BONE CEMENT   BONE MASS   BONE METASTASIS   BONE REGENERATION   bone remodelling and repair   CELL BIOMECHANICS   MECHANOBIOLOGY   MESENCHYMAL STEM CELLS   Promotion of Bone Health throgh Exercise   Stem Cell Biology
 Mechanically Activated Extracellular Vesicles as a Multi-targeted Therapy to Enhance Bone Regeneration
 Microphysiological models of human bone: A new platform for investigation and drug screening.
 How to Promote Spinal Fusion in Osteoporosis: A Bioprinting Strategy
 Primary Cilium Mediated Mesenchymal Stem Cell Mechanobiology in Bone
 Osteoprogenitor Regulation in Loading-induced Bone Formation: An Alternative Approach to Treating Osteoporosis

Details Date From Date To
Tissue Engineering and Regenerative Medicine Society (TERMIS) 2015 Present
Orthopaedic Research Society (ORS) 2010 Present
Marie-Curie Fellow Association 2015 Present
Engineers Ireland (Committee member and Treasurer of the Biomedical Division) 2006 2020
European Society of Biomechanics (ESB) 2013 Present
Luo, L., Foster, N.C., Man, K., Brunet, M., Hoey, D.A., Cox, S.C., Kimber, S.J., El Haj, A.J., Hydrostatic pressure promotes chondrogenic differentiation and microvesicle release from human embryonic and bone marrow stem cells, Biotechnology Journal, 2022, p1-11 , Notes: [10.1002/biot.202100401], Journal Article, PUBLISHED  URL
Brady, R.T., O'Brien, F.J., Hoey, D.A., The Impact of the Extracellular Matrix Environment on Sost Expression by the MLO-Y4 Osteocyte Cell Line, Bioengineering, 9, (1), 2022, p1-35 , Journal Article, PUBLISHED  DOI
Man, K., Barroso, I.A., Brunet, M., Peacock, B., Federici, A.S., Hoey, D.A., Cox, S.C., Controlled Release of Epigenetically-Enhanced Extracellular Vesicles from a GelMA/Nanoclay Composite Hydrogel to Promote Bone Repair, International Journal of Molecular Sciences, 23, (2), 2022, p1-22 , Journal Article, PUBLISHED  DOI
Man, K., Brunet, M., Fernandez-Rhodes, M., Williams, S., Davies, O., Federici, A., Hoey D.A., Cox, S.C., , Epigenetic reprogramming enhances the therapeutic efficacy of osteoblast-derived extracellular vesicles for bone regeneration, International Society of Extracellular Vesicles, Virtual, 2021, Conference Paper, PUBLISHED
Man, K., Louth, S., Brunet, M., Hoey D.A., Cox, S.C., , The influence of 3D printed scaffold architecture on osteoblast-derived extracellular vesicles therapeutic efficacy for bone repair, International Society of Extracellular Vesicles, Virtual, 2021, Conference Paper, PUBLISHED
Brunet, M.Y., Man, K., Williams, S., Davies, O., Hoey D.A., Jones, M-C., Cox, S.C., , Isolation and characterisation of osteoblast-derived extracellular vesicles for the development of bio-inspired osteogenic proteoliposomes., TRAIN-EV International Conference, Dublin, Ireland, 2021, Conference Paper, PUBLISHED
Riffault, M., Johnson, G.P., Javaheri, B., Pitsillides, A., Hoey D.A., , Loss of IFT88/primary cilia in leptin receptor expressing stromal cells selectively attenuates loading-induced endosteal bone formation, Orthopaedic Research Society, Virtual, 2021, Conference Paper, PUBLISHED
Man, K., Brunet, M., Fernandez-Rhodes, M., Williams, S., Davies, O., Federici, A., Hoey D.A., Cox, S.C., , Epigenetic reprogramming enhances the therapeutic efficacy of osteoblast-derived extracellular vesicles for bone regeneration, 6th World Congress of the Tissue Engineering and Regenerative Medicine International Society, The Netherlands, 2021, Conference Paper, PUBLISHED
Man, K., Louth, S., Brunet, M., Hoey D.A., Cox, S.C., , The influence of scaffold architecture and composition on osteoblast-derived extracellular vesicles therapeutic efficacy for bone regeneration, 6th World Congress of the Tissue Engineering and Regenerative Medicine International Society, The Netherlands, 2021, Conference Paper, PUBLISHED
Federici, A., Kelly, D.J., Hoey, D.A., , Development of bio-inspired Melt-Electrowritten scaffolds for vascular regeneration, 6th World Congress of the Tissue Engineering and Regenerative Medicine International Society, The Netherlands, 2021, Conference Paper, PUBLISHED
  

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Riffault, M., Johnson, G.P., Owen, M., Javaheri, B., Pitsillides, A., Hoey D.A., , Leptin Receptor expressing stromal cells give rise to a bone lining cell population that mediates loading induced bone formation via adenylyl cyclase 6. , 26th Annual Conference of the section of Bioengineering of the Royal Academy of Medicine in Ireland, Ireland, 2020, Conference Paper, PUBLISHED
Whelan, I., Moeendarbary, E., Hoey, D.A., Kelly, D.J., , A microphysiological model of human bone tissue , 26th Annual Conference of the section of Bioengineering of the Royal Academy of Medicine in Ireland, Ireland, 2020, Conference Paper, PUBLISHED
Federici, A., Eichholz, K., Cunniffe, G.M., Kelly, D.J., Hoey, D.A., , Development of bio-inspired scaffolds for vascular tissue engineering applications, 26th Annual Conference of the section of Bioengineering of the Royal Academy of Medicine in Ireland, Ireland, 2020, Conference Paper, PUBLISHED
Geoghegan, I.P., Hoey, D.A., McNamara, L., , The role of integrin αvβ3 in osteocyte mechanotransduction during estrogen deficiency, 25th Annual Conference of the section of Bioengineering of the Royal Academy of Medicine in Ireland, Ireland, 2019, Conference Paper, PUBLISHED
Federici, A., Eichholz, K., Kelly, D.J., Hoey, D.A., Development of melt electrospun written tubular scaffolds for vascular tissue engineering applications , 25th Annual Conference of the section of Bioengineering of the Royal Academy of Medicine in Ireland, Ireland, 2019, Conference Paper, PUBLISHED
Parmentier, L., Hoey D.A., , Upscaling the production of mechanically activated secreted factors and optimising their local delivery via material functionalisation, 25th Annual Conference of the section of Bioengineering of the Royal Academy of Medicine in Ireland, Ireland, 2019, Conference Paper, PUBLISHED
Eichholz, K., Woods, I., Johnson, G.P., Mahon, O.R., Federici, A., Corrigan, M., Lowery, M., O'Driscoll, L., Hoey D.A., , Mimicking cellular and ECM mechanobiological cues to drive MSC osteogenesis and bone regeneration, 25th Annual Conference of the section of Bioengineering of the Royal Academy of Medicine in Ireland, Ireland, 2019, Conference Paper, PUBLISHED
Johnson, G., Corrigan, M., Stavenschi, E., Hoey, D.A., , MSC contributions to loading induced bone formation: a role for Adenylyl Cyclase 6. , 25th Annual Conference of the section of Bioengineering of the Royal Academy of Medicine in Ireland, Ireland, 2019, Conference Paper, PUBLISHED
Riffault, M., Hoey, D.A., , Role of ATP signalling in primary cilium mediated mechanotransduction in human skeletal stem cells. , 24th Annual Conference of the section of Bioengineering of the Royal Academy of Medicine in Ireland, Ireland, 2018, Conference Paper, PUBLISHED
Geoghegan, I.P., Hoey, D.A., McNamara, L., , The role of integrin αvβ3 in osteocyte mechanotransduction during estrogen deficiency. , 24th Annual Conference of the section of Bioengineering of the Royal Academy of Medicine in Ireland, Ireland, 2018, Conference Paper, PUBLISHED

  

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Award Date
Co-author on paper shortlisted for the New Investigator Recognition Award at the Orthopaedic Research Society Meeting 2022 2022
Fellow of Trinity College Dublin (FTCD) 2021
Senior author on paper awarded 1st prize in the 'Biomechanics' section at the Bioengineering in Ireland Conference, Dublin, Ireland. Awarded to Dr. Mathieu Riffault 2020
Science Foundation Ireland Frontiers for the Future Project Grant (€622K). 2020
European Research Council Proof of Concept Award (€150K) 2018
Co-author on paper awarded 1st prize in the student poster competition at the 2018 Health Research Institute Conference, University of Limerick, Ireland. Awarded to Ms. Anushree Dwivedi. 2018
Co-author on paper awarded 'Lab on a Chip Poster Prize' at Organ on a Chip and Tissue on a Chip Conference, Rotterdam, The Netherlands. Awarded to Mr. Ian Whelan 2018
Senior author on paper awarded 2nd prize in the student competition at the 2017 Bioengineering in Ireland Conference, Belfast, Northern Ireland. Awarded to Ms. Michele Corrigan. 2017
Senior author of paper awarded 1st prize at the Sir Bernard Crossland Symposium (Kian Eichholz) 2016
Senior author on paper awarded 2nd prize at the Thesis in 3 Trinity Centre for Bioengineering competition. Awarded to Mr. Kian Eichholz. 2016
Co-author on paper awarded 3rd prize in the poster competition at the 2016 UL/NUIG Research Day. Awarded to Ms. Gillian Johnson. 2016
Senior author on paper awarded 1st prize at the Sir Bernard Crossland Symposium, Queens University Belfast, Northern Ireland. Awarded to Mr. Kian Eichholz. 2016
Senior author on paper shortlisted for the 'New Investigator Recognition Award' at the 61st Orthopaedic Research Council Meeting, Las Vegas, U.S. 2015
Marie-Skłodowska Curie COFUND Excellence award 2015
University of Limerick Award for Research Excellence (Early Career) 2014
Co-author on paper awarded the 'New Investigator Recognition Award' at the 60th Orthopaedic Research Council Meeting, New Orleans, U.S. 2014
Senior author on paper awarded 'Best poster in the Technology and Health Section' at the 2nd University Hospital Limerick Research Symposium, Limerick, Ireland. 2014
Senior author on thesis awarded 'Best Undergraduate Final Year Project' awarded to Mr. Kian Eichholz at the Materials and Surface Science Institute Research Day, University of limerick, Limerick, Ireland. 2014
Senior author on paper awarded 'Best poster in the Technology and Health Section' of the Inaugural University Hospital Limerick Research Symposium, Limerick, Ireland. 2013
Co-author on paper awarded the 'Harold M. Frost Young Investigator Award' at the 43rd International Bone and Mineral Society Sun Valley Workshop, Idaho, U.S. 2013
Co-author on paper awarded the 'ASBMR Young Investigator Award' at the American Society for Bone and Mineral Research, Baltimore, U.S. 2013
European Research Council Starting Grant (€1.45M) 2013
Finalist for the 'New Investigator Recognition Award' at the Orthopaedic Research Society 2012
'Symington Bequest Fund Award' from the Anatomical Society, U.K. 2012
2nd prize in the poster competition at the 4th Mechanics of Biomaterials and Tissues Meeting, Hawaii, U.S. 2011
'Outstanding Junior Investigator' at the 4th New York Skeletal Biology and Medicine Meeting, New York, U.S. 2011
'Short talk travel award' at the Society for Physical Regulation in Biology and Medicine, Florida, U.S. 2011
'Best presentation in the Postdoctoral Category' at the Society for Physical Regulation in Biology and Medicine, Florida, U.S. 2011
'Best presentation in the Postdoctoral Category' at the Society for Physical Regulation in Biology and Medicine, Arizona, U.S. 2010
'IRCSET Marie-Curie INSPIRE fellowship in Science, Engineering and Technology', jointly from the Irish Research Council and Marie-Cure Foundation. 2009
Senior author on paper awarded the 'Engineers Ireland Biomedical Research Medal' from the Society of Engineers Ireland. Awarded to Mr. Kian Eichholz 2009
1st prize in the PhD poster competition at the American Society of Mechanical Engineers Bioengineering Division Summer Conference, Florida, U.S. 2008
'Engineers Ireland Biomedical Research Medal' from the Society of Engineers Ireland. 2008
1st prize at the Sir Bernard Crossland Symposium, National University of Ireland: Galway. 2007
The focus of my lab (www.hoeylab.com) is to delineate the importance of mechanics in human physiology and utilise this fundamental information to inform the development of novel strategies for tissue regeneration. Core Research areas: . Musculoskeletal Biomechanics, Mechanobiology, and Mechanotransduction . Primary Cilium Biology, Mechanobiology, and Ciliotherapies . Extracellular Vesicles, Exosomes, and Related Therapies . Biofabrication, 3D Printing, Melt Electrowriting . I have secured considerable competitive research funding in the form of multiple European Research Council grants (Starting-2013; PoC-2018) and a Science Foundation Ireland (SFI) Frontier's grant (2020). This funding facilitated a transformational research program where I am uncovering the role of mechanics and particularly the role of a cellular organelle, the cilium, in bone mechanoadaptation. This very successful program has led to a series of high impact papers (Stem Cells-JIF:6.94, Nature Aging) and established me as a world leader in cilia mechanobiology, best reflected by the many invited keynotes/awards (Gordon conference). This funding has also formed the basis of a new research program on extracellular vesicles (SFI Frontiers-2020). Utilising mechanics to prime the regenerative properties of vesicles, I am discovering novel mechanisms by which exercise promotes health, that I am harnessing therapeutically. I have published extensively in the leading journals in this area (J.EV-JIF:25.8) and recently delivered an invited talk (WebEVTalk). I am also an Investigator (FI) in the world leading SFI AMBER centre. I have collaborative funding with the large multinational company J&J, stemming from exciting technological advancements I have made in Melt Electrowriting. Through fundamental discovery (Advanced Healthcare Materials-JIF:9.93) and commercial exploitation (3xIDFs) I have established myself as pioneer in this area as demonstrated by an invited talk at TERMIS-EU. My research has defined important and transformational research questions across multiple evolving core areas that has resulted in novel therapies and has established me as an international leader in my field.