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Dr. David Hoey

Associate Professor (Mechanical, Manuf & Biomedical Eng)
PARSONS BUILDING


Dr. David Hoey is an Associate Professor in the School of Engineering and Principal Investigator (PI) in the Trinity Centre for Biomedical Engineering and the Advanced Materials and Bioengineering Research (AMBER) Centre at Trinity College Dublin (TCD). He is also an Honorary Senior Lecturer at the Royal College of Surgeons in Ireland, University of Medicine and Health Sciences. He leads a multidisciplinary research group focusing on musculoskeletal mechanobiology, mechanotransduction, and materials for regeneration in which he has pioneered research on the role of the primary cilium in loading-induced bone formation. This fundamental research underpins a more translational programme aimed at developing novel mechanotherapeutics and biomaterials that mimic the beneficial effect of biophysical stimuli to treat large bone defects and orthopaedic diseases such as osteoporosis. He has extensive experience in mechanobiology and tissue engineering and is also a PI on a major bioprinting initiative at Trinity to develop next generation implantable devices and tissues for orthopaedic applications. His laboratory has been awarded extensive funding, including two European Research Council awards (Starting grant 2013; PoC grant 2019) and SFI FFP grant (2020). He is also PI on several commercial projects developing novel biomaterials for musculoskeletal and vascular repair.
  BIOMATERIALS   BIOMECHANICS   Biomechanics, Biomedical Engineering   BONE ABNORMALITIES   BONE ADAPTATION   BONE CEMENT   BONE MASS   BONE METASTASIS   BONE REGENERATION   bone remodelling and repair   CELL BIOMECHANICS   MECHANOBIOLOGY   MESENCHYMAL STEM CELLS   Promotion of Bone Health throgh Exercise   Stem Cell Biology
 Mechanically Activated Extracellular Vesicles as a Multi-targeted Therapy to Enhance Bone Regeneration
 Microphysiological models of human bone: A new platform for investigation and drug screening.
 How to Promote Spinal Fusion in Osteoporosis: A Bioprinting Strategy
 Primary Cilium Mediated Mesenchymal Stem Cell Mechanobiology in Bone
 Osteoprogenitor Regulation in Loading-induced Bone Formation: An Alternative Approach to Treating Osteoporosis

Details Date
Editorial Board Member: Nature: Scientific Reports 2019 - Present
Reviewer for 9 leading funding agencies internationally: European Research Council Advanced Panel, France National Research Agency, Cancer Research UK, Dr. Hadwen Trust for Humane Research UK, Biotechnology and Biological Sciences Research Council UK, Einstein Foundation Germany, NOW Veni Gran Program New Zealand, Netherlands Organization for Scientific Research, University of Wisconsin Institute for Clinical and Translational Research KL2 Program US. 2013 - Present
Reviewer for 46 leading journals in the fields of Mechanobiology, Biomechanics, and Biomaterials incl..: Nature Nanotechnology, Nature Materials, Nature Scientific Reports, Science Advances, Advanced Materials, Advanced Functional Materials, Advanced Healthcare Materials, Acta Biomaterilia, ACS Applied Materials and Interfaces, ACS Biomaterials Science and Engineering, Aging Cell, Annals of Biomedical Engineering, Bioactive Materials, BIOCELL, Biofabrication, Biomechanics and Modelling in Mechanobiology, Biomedical Engineering Online, Bioresearch Open Access, Bone, Bone and Joint Research, Cell and Molecular Bioengineering, Cell and Molecular Life Sciences, Cellular Signaling, Cytoskeleton, DNA and Cell Biology, eCells and Materials, FASEB Journal, Frontiers in Medicine, International Journal of Clinical Rheumatology, International Journal of Nanomedicine, Journal of Anatomy, Journal of Applied Bioscience, Journal of Biomechanics 2011-Present
Annual Reviewer for Orthopaedic Research Society Meeting: Topic: Biomaterials Topic: Bone 2016 - Present
External PhD Examiner " Dr. Mylène de Ruijter, Utrecht University (2020) " Dr. Michael Collins, University of Limerick (2019) " Dr. Kristin Lee, Columbia University in the City of New York (2014) Doctoral Committee Member " Ms. Yuan Mu, Kings College London 2014 - Present
Engineers Ireland- Biomedical Engineering Committee member. " Committee member (2012-2018). Provided academic expertise to the secretariat with relevance to the Biomedical Sector. Organised a programme of events, such as evening lectures, to strengthen the learned body function and support the CPD requirements of members, and social events to facilitate networking. " Assistant secretary (2014-2015). Organized events throughout the year to promote Biomedical Engineering to members. This included visits to large multinational companies in the MedTech area. 2015-2018
External Academic Program Examiner- Cork IT Biomedical Engineering Programs (Level 7 and Level 8) 2016 - 2019
Details Date From Date To
Engineers Ireland (Committee member and Treasurer of the Biomedical Division 2012-2016) Present 2006
Tissue Engineering and Regenerative Medicine Society (TERMIS) 2015 Present
Orthopaedic Research Society (ORS) 2010 Present
Marie-Curie Fellow Association 2015 Present
Anatomical Society 2012 2009
European Society of Biomechanics (ESB) 2013 Present
Maryam Sarmast Shoushtari, David Hoey, Dayang Radiah Awang Biak, Norhafizah Abdullah, Suryani Kamarudin, Halimatun S. Zainuddin, Sol"gel"templated bioactive glass scaffold: a review, Research in Biomedical Engineering, 40, 2024, p281 - 296, Journal Article, PUBLISHED  TARA - Full Text  DOI
Maryam Sarmast Shoushtari, Aina Shafiqah Wan Mahmood, Dayang Radiah Awang Biak, Samaneh Alijantabar Aghouzi, David Hoey, Suryani Kamarudin, Norhafizah Abdullah, Halimatun Sakdiah Zainuddin, Effect of Starch Binders on the Properties of Bioglass Tablets for Bone Tissue Engineering Applications, Starch, 2024, Journal Article, PUBLISHED  DOI
Angelica S Federici, Brooke Tornifoglio, Caitríona Lally, Orquidea Garcia, Daniel J Kelly, David A Hoey, Melt electrowritten scaffold architectures to mimic tissue mechanics and guide neo-tissue orientation, Journal of the Mechanical Behavior of Biomedical Materials, 150, 2024, p1 - 15, Journal Article, PUBLISHED  TARA - Full Text  DOI
Shen, N., Woods, I., Lowery, M., Eichholz, K.F., Stavenschi, E., Martins, C.S., Maggio, M., O"Driscoll, L., Hoey D.A., , Mature bone cells drive vessel formation via an extracellular vesicle mediated mechanism following mechanical stimulation , Orthopaedic Research Society, Dallas, US, 2023, 2023, Conference Paper, PUBLISHED
Cobban, M., Martin, C., Maggio, M., Hoey D.A., , The Role of GPR-161 in Osteocyte Mechanosignalling and Osteoclastogenic Paracrine Signaling , Orthopaedic Research Society, Dallas, US, 10-14/02/2023, 2023, Conference Paper, PUBLISHED
Petrousek, S., Cobban, M., Kelly, D.J., Hoey D.A., , Targeting mechanosignalling to modulate the immune environment for bone repair , Orthopaedic Research Society, Dallas, U.S., 10/02/2023-14/10/202, 2023, Conference Paper, PUBLISHED
Ahern, D., Moran, B., Butler, J.S., Hoey D.A., , A Comparative analysis of the Human Skeletal Stem Cell and Mesenchymal Stromal Cell in Bone Tissue Regenerative Medicine , Orthopaedic Research Society, Dallas, U.S., 10/02/2023-14/02/202, 2023, Conference Paper, PUBLISHED
Federici, A., Garcia, O., Kelly, D.J., Hoey, D.A.,, Development of a bio-inspired off-the-shelf small diameter vascular graft, Meeting of the European Chapter of the Tissue Engineering and Regenerative Medicine International Society, Manchester, UK, 2023, Conference Paper, PUBLISHED
Martins, C.S., Maggio, M., Tsiapalis, D., O"Driscoll, L., Hoey D.A.,, Mature bone cells drive vessel formation via an extracellular vesicle mediated mechanism following mechanical stimulation, European Chapter of the Tissue Engineering and Regenerative Medicine International Society, Manchester, UK, 2023, Conference Paper, PUBLISHED
Maggio, M., Martins, C.S., Petrousek, S., Hoey, D.A.,, Bone cell regulation of osteoclastogenesis is dependent on the stage of lineage commitment and mechanical environment, Meeting of the European Chapter of the Tissue Engineering and Regenerative Medicine International Society, Manchester, UK, 2023, Conference Paper, PUBLISHED
  

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Federici, A., Garcia, O., Kelly, D.J., Hoey, D.A.,, Development of a bio-inspired off-the-shelf small diameter vascular graft, 28th Annual Conference of the section of Bioengineering of the Royal Academy of Medicine in Ireland, Enfield, 2023, Conference Paper, PUBLISHED
Martins, C.S., Maggio, M., Tsiapalis, D., O"Driscoll, L., Hoey D.A.,, Mature bone cells drive vessel formation via an extracellular vesicle mediated mechanism following mechanical stimulation, 28th Annual Conference of the section of Bioengineering of the Royal Academy of Medicine in Ireland, Enfield, Ireland, 2023, Conference Paper, PUBLISHED
Maggio, M., Martins, C.S., Petrousek, S., Hoey, D.A., , Bone cell regulation of osteoclastogenesis is dependent on the stage of lineage commitment and mechanical environment , 28th Annual Conference of the section of Bioengineering of the Royal Academy of Medicine in Ireland, Enfield, Ireland, 2023, Conference Paper, PUBLISHED
Petrousek, S., Kelly, D.J., Hoey, D.A.,, Targeting mechanosignaling to modulate the immune environment for bone repair, 28th Annual Conference of the section of Bioengineering of the Royal Academy of Medicine in Ireland, Enfield, Ireland, 2023, Conference Paper, PUBLISHED
Cobban, M., Martin, C., Maggio, M., Hoey D.A.,, The Role of GPR-161 in Osteocyte Mechanosignalling and Osteoclastogenic Paracrine Signaling, 28th Annual Conference of the section of Bioengineering of the Royal Academy of Medicine in Ireland, Enfield, Ireland, 2023, Conference Paper, PUBLISHED
Cobban, M., Martins, C., Kelly, D.J., Hoey D.A., , The role of GPR161 in osteocyte physiology and mechanobiology , 27th Annual Conference of the section of Bioengineering of the Royal Academy of Medicine in Ireland, Galway, Ireland, 2022, Conference Paper, PUBLISHED
Federici, A., Kelly, D.J., Hoey, D.A., , Development of a bio-inspired scaffold for small diameter vascular regeneration , 27th Annual Conference of the section of Bioengineering of the Royal Academy of Medicine in Ireland, Galway, Ireland, 2022, 2022, Conference Paper, PUBLISHED
Petrousek, S., Kelly, D.J., Hoey D.A., , Identification of mechanotherapeutics to modulate the immune environment for bone repai, 27th Annual Conference of the section of Bioengineering of the Royal Academy of Medicine in Ireland, Galway, Ireland, 2022, 2022, Conference Paper, PUBLISHED
Martins, C., Hoey, D.A., , Mechanical stimulation of osteocytes enhances the regenerative capacity of the secretome, 27th Annual Conference of the section of Bioengineering of the Royal Academy of Medicine in Ireland, Galway, Ireland, 2022, 2022, Conference Paper, PUBLISHED
Maggio, M., Hoey, D.A., , Identification of mechanically regulated miRNAs in osteocytes and secreted extracellular vesicles, 27th Annual Conference of the section of Bioengineering of the Royal Academy of Medicine in Ireland, Galway, Ireland, 2022, 2022, Conference Paper, PUBLISHED

  

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Award Date
Senior author on paper awarded 1st prize in the `Regenerative Medicine' section (Early Career) at the Bioengineering in Ireland Conference, Galway, Ireland. Awarded to Ms. Mimma Maggio, 2022. 2022
Senior author on paper awarded 1st prize in the `Mechanobiology' section (Early Career) at the Bioengineering in Ireland Conference, Galway, Ireland. Awarded to Ms. Morgan Cobban, 2022. 2022
Senior author on paper awarded 2nd prize in the `Mechanobiology' section at the Bioengineering in Ireland Conference, Dublin, Ireland. Awarded to Stephane Petrousek, 2022. 2022
Senior author on talk awarded 1st prize in the `Orthopaedics" section at the Trinity Centre for Biomedical Engineering Research Day, Dublin, Ireland. Awarded to Mr. Stephane Petrousek, 2022. 2022
Senior author on poster awarded 1st prize in the `Orthopaedics" section at the Trinity Centre for Biomedical Engineering Research Day, Dublin, Ireland. Awarded to Ms. Mimma Maggio, 2022. 2022
Co-author on paper awarded the New Investigator Recognition Award at the Orthopaedic Research Society Meeting, Florida, US. 2022 2022
Fellow of Trinity College Dublin (FTCD) 2021
Senior author on paper awarded 1st prize in the 'Biomechanics' section at the Bioengineering in Ireland Conference, Dublin, Ireland. Awarded to Dr. Mathieu Riffault 2020
Senior author on paper awarded the 'Engineers Ireland Biomedical Research Medal' from the Society of Engineers Ireland. Awarded to Mr. Kian Eichholz 2019
Co-author on paper awarded 1st prize in the student poster competition at the 2018 Health Research Institute Conference, University of Limerick, Ireland. Awarded to Ms. Anushree Dwivedi. 2018
Co-author on paper awarded 'Lab on a Chip Poster Prize' at Organ on a Chip and Tissue on a Chip Conference, Rotterdam, The Netherlands. Awarded to Mr. Ian Whelan 2018
Senior author on paper awarded 2nd prize in the student competition at the 2017 Bioengineering in Ireland Conference, Belfast, Northern Ireland. Awarded to Ms. Michele Corrigan. 2017
Senior author of paper awarded 1st prize at the Sir Bernard Crossland Symposium, Ireland. Awarded to Mr. Kian Eichholz. 2016 2016
Senior author on paper awarded 2nd prize at the Thesis in 3 Trinity Centre for Bioengineering competition, Dublin, Ireland. Awarded to Mr. Kian Eichholz. 2016
Co-author on paper awarded 3rd prize in the poster competition at the 2016 UL/NUIG Research Day. Awarded to Ms. Gillian Johnson. 2016
Senior author on paper awarded 1st prize at the Sir Bernard Crossland Symposium, Queens University Belfast, Northern Ireland. Awarded to Mr. Kian Eichholz. 2016
Senior author on paper shortlisted for the 'New Investigator Recognition Award' at the 61st Orthopaedic Research Council Meeting, Las Vegas, U.S. 2015
Marie Sk"odowska"Curie Curie COFUND Excellence award, Luxembourg. 2015
University of Limerick Award for Research Excellence (Early Career) 2014
Co-author on paper awarded the 'New Investigator Recognition Award' at the 60th Orthopaedic Research Council Meeting, New Orleans, U.S. 2014
Senior author on paper awarded 'Best poster in the Technology and Health Section' at the 2nd University Hospital Limerick Research Symposium, Limerick, Ireland. 2014
Senior author on thesis awarded 'Best Undergraduate Final Year Project' awarded to Mr. Kian Eichholz at the Materials and Surface Science Institute Research Day, University of limerick, Limerick, Ireland. 2014
Senior author on paper awarded 'Best poster in the Technology and Health Section' of the Inaugural University Hospital Limerick Research Symposium, Limerick, Ireland. 2013
Co-author on paper awarded the 'Harold M. Frost Young Investigator Award' at the 43rd International Bone and Mineral Society Sun Valley Workshop, Idaho, U.S. 2013
Co-author on paper awarded the 'ASBMR Young Investigator Award' at the American Society for Bone and Mineral Research, Baltimore, U.S. 2013
Finalist for the 'New Investigator Recognition Award' at the Orthopaedic Research Society, San Francisco, US. 2012
'Symington Bequest Fund Award' from the Anatomical Society, U.K. 2012
2nd prize in the poster competition at the 4th Mechanics of Biomaterials and Tissues Meeting, Hawaii, U.S. 2011
'Outstanding Junior Investigator' at the 4th New York Skeletal Biology and Medicine Meeting, New York, U.S. 2011
'Short talk travel award' at the Society for Physical Regulation in Biology and Medicine, Florida, U.S. 2011
'Best presentation in the Postdoctoral Category' at the Society for Physical Regulation in Biology and Medicine, Florida, U.S. 2011
'Best presentation in the Postdoctoral Category' at the Society for Physical Regulation in Biology and Medicine, Arizona, U.S. 2010
1st prize in the PhD poster competition at the American Society of Mechanical Engineers Bioengineering Division Summer Conference, Florida, U.S. 2008
'Engineers Ireland Biomedical Research Medal' from the Society of Engineers Ireland. 2008
1st prize at the Sir Bernard Crossland Symposium, National University of Ireland: Galway. 2007
The focus of my lab (www.hoeylab.com) is to delineate the importance of mechanics in human physiology and utilise this fundamental information to inform the development of novel strategies for tissue regeneration. Core Research areas: " Biomechanics, Mechanobiology, and Mechanotransduction " Primary Cilium and Ciliotherapies " Extracellular Vesicles and Related Therapies " Organ-on-Chip, Biofabrication, Melt Electrowriting I have secured considerable competitive research funding in the form of multiple European Research Council grants (Starting-2013&PoC-2018) and a Science Foundation Ireland (SFI) Frontier"s grant (2020). This facilitated a transformational research program where I am uncovering the role of mechanics and particularly the role of the primary cilium in bone mechanoadaptation. This very successful program has led to a series of high impact papers (Stem Cells-JIF:6.94, Nature Aging-projectedJIF:40) and established me as a world leader in cilia mechanobiology, best reflected by the numerous invited keynotes/awards at leading global conferences (Eg: Gordon conference/Orthopaedic Research Society (sect.6.5)). This funding has also formed the basis of a new research program on extracellular vesicles (SFI-Frontiers-2020). Utilising mechanics to prime the regenerative properties of vesicles, I am discovering novel mechanisms by which exercise promotes health, that I am harnessing therapeutically. I have published extensively in the leading journals in this area (J.EV-JIF:21.2) and delivered multiple international keynote talks (Eg: eCM2022 (sect.6.5)). I am also an Investigator in the world-leading SFI-AMBER centre. I have collaborative funding with the multinational company Johnson&Johnson, stemming from exciting technological advancements I"ve made in Melt-Electrowriting. Through fundamental discovery (ActaBiomaterilia-JIF:10.6) and commercial exploitation (4xIDFs) I have established myself as pioneer in this area as demonstrated by keynote talk at TERMIS-EU. My research has defined important transformational research questions that has established me as an international leader in my field. Key achievements since last promotion, " €2,114,986 additional funding " Published 44 journal articles " h-index 6->24. " Citations 250->1810. " 6xIDFs " Graduated 8xPhDs/1xMD " 19 Invited/keynote talks