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Dr. David Hoey

Associate Professor (Mechanical, Manuf & Biomedical Eng)

Dr. David Hoey is an Associate Professor in Biomedical Engineering within the Department of Mechanical and Manufacturing Engineering and PI within the Trinity Centre for Biomedical Engineering in Trinity College Dublin (TCD). Dr. Hoey leads a multidisciplinary experimental mechanobiology research group where his goal is to integrate engineering mechanics into the understanding of the molecular basis of physiology and disease. Dr. Hoey's research has discovered novel mechanisms by which bone can sense and respond to a biophysical stimulus. In particular, he is focused on determining indirect and direct biophysical regulation of mesenchymal stem cell contributions to bone formation and repair and how this is altered in disease. These platforms have potential to result in new therapeutics that mimic the beneficial effect of biophysical stimuli and treat orthopaedic diseases such as osteoporosis and osteoarthritis. In 2009 Dr. Hoey received his PhD in Bioengineering from the Trinity Centre for Bioengineering and went on to complete postdoctoral fellowships in Columbia University in the US and the Royal College of Surgeons in Ireland under the Marie-Curie/IRCSET programme. In 2012 he joined the University of Limerick as a Lecturer and was awarded the European Research Council Starting Grant in 2013 to explore the role the primary cilium in stem cell mechanobiology in bone and has recently returned to TCD in 2015 as Associate Professor to continue this work.
  BIOMATERIALS   BIOMECHANICS   Biomechanics, Biomedical Engineering   BONE ABNORMALITIES   BONE ADAPTATION   BONE CEMENT   BONE MASS   BONE METASTASIS   BONE REGENERATION   bone remodelling and repair   CELL BIOMECHANICS   MECHANOBIOLOGY   MESENCHYMAL STEM CELLS   Promotion of Bone Health throgh Exercise   Stem Cell Biology
 Primary Cilium Mediated Mesenchymal Stem Cell Mechanobiology in Bone
 Osteoprogenitor Regulation in Loading-induced Bone Formation: An Alternative Approach to Treating Osteoporosis

Details Date From Date To
Engineers Ireland (Treasurer of the Biomedical Division) 2006 -
Orthopedic Research Society 2010 -
Marie-Curie Fellow Association 2015 -
Anushree Dwivedi, Patrick A. Kiely, David A. Hoey, Mechanically stimulated osteocytes promote the proliferation and migration of breast cancer cells via a potential CXCL1/2 mechanism, Biochemical and Biophysical Research Communications, 534, 2021, p14--20 , Journal Article, PUBLISHED  TARA - Full Text
Eichholz KF, Woods I, Riffault M, Johnson GP, Corrigan M, Lowry MC, Shen N, Labour M, Wynne K, O'Driscoll L, Hoey DA., Human bone marrow stem/stromal cell osteogenesis is regulated via mechanically activated osteocyte-derived extracellular vesicles, Stem Cells Translational Medicine , 2020, Journal Article, PUBLISHED  TARA - Full Text  DOI
Parmentier L, Riffault M, Hoey DA., Utilizing Osteocyte Derived Factors to Enhance Cell Viability and Osteogenic Matrix Deposition within IPN Hydrogels., Materials (Basel, Switzerland), 13, (7), 2020, Journal Article, PUBLISHED  TARA - Full Text  DOI
Mathieu Riffault, Gillian P Johnson, Madeline M Owen, Behzad Javaheri, Andrew A Pitsillides, David A Hoey, Loss of Adenylyl Cyclase 6 in Leptin Receptor"Expressing Stromal Cells Attenuates Loading"Induced Endosteal Bone Formation, JBMR Plus, 2020, Journal Article, PUBLISHED  TARA - Full Text
Kian F. Eichholz and Stanislas Von Euw and Ross Burdis and Daniel J. Kelly and David A. Hoey, Development of a New Bone"Mimetic Surface Treatment Platform: Nanoneedle Hydroxyapatite (nnHA) Coating, Advanced Healthcare Materials, 2020, p2001102 , Journal Article, PUBLISHED  TARA - Full Text
M. A. Corrigan, T. M. Ferradaes, M. Riffault, D. A. Hoey, Ciliotherapy Treatments to Enhance Biochemically- and Biophysically-Induced Mesenchymal Stem Cell Osteogenesis: A Comparison Study, Cellular and Molecular Bioengineering, 12, (1), 2019, p53--67 , Journal Article, PUBLISHED  TARA - Full Text
Geoghegan IP, Hoey DA, McNamara LM., Estrogen deficiency impairs integrin "vß3-mediated mechanosensation by osteocytes and alters osteoclastogenic paracrine signalling., Scientific reports, 9, (1), 2019, p4654 , Journal Article, PUBLISHED  TARA - Full Text  DOI
Brennan CM, Eichholz KF, Hoey DA., The effect of pore size within fibrous scaffolds fabricated using melt electrowriting on human bone marrow stem cell osteogenesis., Biomedical materials (Bristol, England), 14, (6), 2019, p065016 , Journal Article, PUBLISHED  TARA - Full Text  DOI
Geoghegan IP, Hoey DA, McNamara LM., Integrins in Osteocyte Biology and Mechanotransduction., Current osteoporosis reports, 17, (4), 2019, p195-206 , Journal Article, PUBLISHED  DOI
Corrigan MA, Coyle S, Eichholz KF, Riffault M, Lenehan B, Hoey DA., Aged Osteoporotic Bone Marrow Stromal Cells Demonstrate Defective Recruitment, Mechanosensitivity, and Matrix Deposition., Cells, tissues, organs, 207, (2), 2019, p83-96 , Journal Article, PUBLISHED  DOI

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Award Date
Senior author of paper awarded 1st prize at the Sir Bernard Crossland Symposium (Kian Eichholz) 2016
Marie-Skłodowska Curie COFUND Excellence award 2015
University of Limerick Award for Research Excellence (Early Career) 2014
European Research Council Starting Grant 2013
Orthopaedic Biomechanics and Mechanobiology Mechanotransduction mechanisms Biomaterials Primary Cilia Extracellular Vesicles/Exosomes