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Dr. Colm Cunningham

Associate Professor - Neuroscience (Biochemistry)

Associate Professor - Neuroscience (Trinity Inst. of Neurosciences (TCIN))

  Ageing, Older People and Healthcare   Aging/Gerontology   Alzheimer's Disease   Amyotrophic Lateral Sclerosis (ALS)   Animal Models   Brain   Dementia   Dementia/ Alzheimer's Disease   Depression   Emotional/Mental Health--Geriatric   Inflammation   Neurodegeneration   Neurodegenerative Diseases/Disorders   Neurological Disorders   Parkinson's Disease   Senile Dementia   Stress
 Towards and understanding of infection-induced delirium
 Reconciling Cholinergic and inflammatory hypotheses of delirium: acute and lasting effects of systemic inflammation on chronic neurodegeneration
 Neuroinflammatory and cognitive consequences of losing cholinergic anti-inflammatory tone in the forebrain
 Fever & the brain in autism: temperature vs. inflammatory effects
 The impact of acute systemic inflammation upon CSF and blood biomarkers of brain inflammation and injury in dementia: a study in acute hip fracture and memory clinic patients

Details Date
As a member of the Association Executive I have contributed to discussions leading to a consensus adopted by the European Delirium Association and the American Delirium Society (BMC Medicine 201412:141 DOI: 10.1186/s12916-014-0141-2) that with respect to "The DSM-5 criteria, level of arousal and delirium diagnosis: inclusiveness is safer". I was also part of an international panel of experts gathered to write a definitive report on the "Intensive Care Medicine Research Agenda on Delirium" for publication in INTENSIVE CARE MEDICINE. I am an editorial board member of 2 journals: Brain Behavior and Immunity. Journal of Neuroinflammation.
Language Skill Reading Skill Writing Skill Speaking
English Fluent Fluent Fluent
Italian Basic Basic Basic
Details Date From Date To
European Delirium Association 2008 2017
Society for Neuroscience 2005 2015
Psychoneuroimmunology Research Society 2009 2014
Yin Yang, Tomas Ondrejcak, Neng-Wei Hu, Sadia Islam, Eugene O'Rourke, Richard Reilly, Colm Cunningham, Michael Rowan, Igor Klyubin, Gamma-patterned sensory stimulation reverses synaptic plasticity deficits in rat models of early Alzheimer"s disease, EUROPEAN JOURNAL OF NEUROSCIENCE, 2023, Journal Article, PUBLISHED
Tsui, A. and Yeo, N. and Searle, S.D. and Bowden, H. and Hoffmann, K. and Hornby, J. and Goslett, A. and Weston-Clarke, M. and Lanham, D. and Hogan, P. and Seeley, A. and Rawle, M. and Chaturvedi, N. and Sampson, E.L. and Rockwood, K. and Cunningham, C. and Wesley Ely, E. and Richardson, S.J. and Brayne, C. and Terrera, G.M. and Tieges, Z. and MacLullich, A.M.J. and Davis, D., Extremes of baseline cognitive function determine the severity of delirium: a population study, Brain, 146, (5), 2023, p2132-2141 , Notes: [cited By 2], Journal Article, PUBLISHED  DOI
Vasunilashorn, S.M. and Lunardi, N. and Newman, J.C. and Crosby, G. and Acker, L. and Abel, T. and Bhatnagar, S. and Cunningham, C. and de Cabo, R. and Dugan, L. and Hippensteel, J.A. and Ishizawa, Y. and Lahiri, S. and Marcantonio, E.R. and Xie, Z. and Inouye, S.K. and Terrando, N. and Eckenhoff, R.G., Preclinical and translational models for delirium: Recommendations for future research from the NIDUS delirium network, Alzheimer's and Dementia, 19, (5), 2023, p2150-2174 , Notes: [cited By 2], Journal Article, PUBLISHED  DOI
Bowman, E.M.L. and Brummel, N.E. and Caplan, G.A. and Cunningham, C. and Evered, L.A. and Fiest, K.M. and Girard, T.D. and Jackson, T.A. and LaHue, S.C. and Lindroth, H.L. and Maclullich, A.M.J. and McAuley, D.F. and Oh, E.S. and Oldham, M.A. and Page, V.J. and Pandharipande, P.P. and Potter, K.M. and Sinha, P. and Slooter, A.J.C. and Sweeney, A.M. and Tieges, Z. and Van Dellen, E. and Wilcox, M.E. and Zetterberg, H. and Cunningham, E.L., Advancing specificity in delirium: The delirium subtyping initiative, Alzheimer's and Dementia, 2023, Notes: [cited By 0], Journal Article, PUBLISHED  DOI
Hough, K. and Verschuur, C.A. and Cunningham, C. and Newman, T.A., Macrophages in the cochlea; an immunological link between risk factors and progressive hearing loss, GLIA, 70, (2), 2022, p219-238 , Notes: [cited By 1], Journal Article, PUBLISHED  TARA - Full Text  DOI
Tsui, A. and Searle, S.D. and Bowden, H. and Hoffmann, K. and Hornby, J. and Goslett, A. and Weston-Clarke, M. and Hamill Howes, L. and Street, R. and Perera, R. and Taee, K. and Kustermann, C. and Chitalu, P. and Razavi, B. and Magni, F. and Das, D. and Kim, S. and Chaturvedi, N. and Sampson, E.L. and Rockwood, K. and Cunningham, C. and Ely, E.W. and Richardson, S.J. and Brayne, C. and Muniz Terrera, G. and Tieges, Z. and MacLullich, A. and Davis, D., The effect of baseline cognition and delirium on long-term cognitive impairment and mortality: a prospective population-based study, The Lancet Healthy Longevity, 3, (4), 2022, pe232-e241 , Notes: [cited By 4], Journal Article, PUBLISHED  DOI
Paolicelli, R.C. and Sierra, A. and Stevens, B. and Tremblay, M.-E. and Aguzzi, A. and Ajami, B. and Amit, I. and Audinat, E. and Bechmann, I. and Bennett, M. and Bennett, F. and Bessis, A. and Biber, K. and Bilbo, S. and Blurton-Jones, M. and Boddeke, E. and Brites, D. and BrÃŽne, B. and Brown, G.C. and Butovsky, O. and Carson, M.J. and Castellano, B. and Colonna, M. and Cowley, S.A. and Cunningham, C. and Davalos, D. and De Jager, P.L. and de Strooper, B. and Denes, A. and Eggen, B.J.L. and Eyo, U. and Galea, E. and Garel, S. and Ginhoux, F. and Glass, C.K. and Gokce, O. and Gomez-Nicola, D. and González, B. and Gordon, S. and Graeber, M.B. and Greenhalgh, A.D. and Gressens, P. and Greter, M. and Gutmann, D.H. and Haass, C. and Heneka, M.T. and Heppner, F.L. and Hong, S. and Hume, D.A. and Jung, S. and Kettenmann, H. and Kipnis, J. and Koyama, R. and Lemke, G. and Lynch, M. and Majewska, A. and Malcangio, M. and Malm, T. and Mancuso, R. and Masuda, T. and Matteoli, M. and McColl, B.W. and Miron, V.E. and Molofsky, A.V. and Monje, M. and Mracsko, E. and Nadjar, A. and Neher, J.J. and Neniskyte, U. and Neumann, H. and Noda, M. and Peng, B. and Peri, F. and Perry, V.H. and Popovich, P.G. and Pridans, C. and Priller, J. and Prinz, M. and Ragozzino, D. and Ransohoff, R.M. and Salter, M.W. and Schaefer, A. and Schafer, D.P. and Schwartz, M. and Simons, M. and Smith, C.J. and Streit, W.J. and Tay, T.L. and Tsai, L.-H. and Verkhratsky, A. and von Bernhardi, R. and Wake, H. and Wittamer, V. and Wolf, S.A. and Wu, L.-J. and Wyss-Coray, T., Microglia states and nomenclature: A field at its crossroads, Neuron, 110, (21), 2022, p3458-3483 , Notes: [cited By 25], Journal Article, PUBLISHED  DOI
Lopez-Rodriguez, A.B. and Hennessy, E. and Murray, C.L. and Nazmi, A. and Delaney, H.J. and Healy, D. and Fagan, S.G. and Rooney, M. and Stewart, E. and Lewis, A. and de Barra, N. and Scarry, P. and Riggs-Miller, L. and Boche, D. and Cunningham, M.O. and Cunningham, C., Acute systemic inflammation exacerbates neuroinflammation in Alzheimer's disease: IL-1β drives amplified responses in primed astrocytes and neuronal network dysfunction, Alzheimer's and Dementia, 17, (10), 2021, p1735-1755 , Notes: [cited By 9], Journal Article, PUBLISHED  TARA - Full Text  DOI
McGarry, N. and Murray, C.L. and Garvey, S. and Wilkinson, A. and Tortorelli, L. and Ryan, L. and Hayden, L. and Healy, D. and Griffin, E.W. and Hennessy, E. and Arumugam, M. and Skelly, D.T. and Mitchell, K.J. and Cunningham, C., Double stranded RNA drives anti-viral innate immune responses, sickness behavior and cognitive dysfunction dependent on dsRNA length, IFNAR1 expression and age, Brain, Behavior, and Immunity, 95, 2021, p413-428 , Notes: [cited By 4], Journal Article, PUBLISHED  TARA - Full Text  DOI
O'Neill, E. and Griffin, Ã .W. and O'Sullivan, R. and Murray, C. and Ryan, L. and Yssel, J. and Harkin, A. and Cunningham, C., Acute neuroinflammation, sickness behavior and working memory responses to acute systemic LPS challenge following noradrenergic lesion in mice, Brain, Behavior, and Immunity, 94, 2021, p357-368 , Notes: [cited By 4], Journal Article, PUBLISHED  TARA - Full Text  DOI

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Donal Skelly, Eadaoin W Griffin, Carol Murray, Sarah Harney, Conor O'Boyle, Edel Hennessy, Nicholas Rawlins, David Bannerman, Colm Cunningham, Acute transient cognitive dysfunction and acute brain injury induced by systemic inflammation occur by dissociable IL-1-dependent mechanisms, bioRxiv, 2017, Dataset, PUBLISHED
Colm Cunningham, European Delirium Association annual meeting 2017, Oslo, Autumn, 2017, Invited Talk, APPROVED
Colm Cunningham, American Delirium Society Annual Meeting, Nashville, June, 2016, Invited Talk, PRESENTED
Colm Cunningham, Immunology research series, University of Cambridge, October, 2016, Invited Talk, PRESENTED
Colm Cunningham, Neurosciences in Intensive Care Symposium, Pasteur institute, Paris, June, 2016, Invited Talk, PRESENTED
Colm Cunningham, Keynote lecture, European Delirium Associaton/British Geriatric Society Meeting, London, September, 2015, BGS/EDA, Invited Talk, PRESENTED
Colm Cunningham, British Association for Psychopharmacology Conference, Bristol, August, 2015, BAP, Invited Talk, PRESENTED
Colm Cunningham, "Delirium in Older Adults: Finding Order in the Disorder", , NIH, Bethesda, Maryland, USA, February, 2014, National Institute of Aging & American Geriatrics Society, Invited Talk, PRESENTED
Robert Dantzer(ed.), Cytokines in the ageing brain, Trends in Neurosciences, Arcachon, France, 25, ((11)), June 2002, Elsevier, 2002, 546-547 p, Notes: [Author list: Colm Cunningham, Jan-Pieter Konsman and Tammy Cartmell], Proceedings of a Conference, PUBLISHED


Award Date
Wellcome Trust Research Career Development Fellowship 2006
Wellcome Trust Senior Research Fellowship 2010