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Professor Stephen Connon

Professor in Synthetic Chemistry (Chemistry)
BIOMEDICAL SCIENCES INSTITUTE


  CANCER CHEMOTHERAPY   CATALYSIS   CYCLIN   KINASE COMPLEX   ORGANIC-SYNTHESIS   ORGANOMETALLICS   TETRACYCLINE
Language Skill Reading Skill Writing Skill Speaking
English Fluent Fluent Fluent
French Medium Basic Basic
German Medium Medium Medium
Details Date From Date To
Council Member of the Instite of Chemistry of Ireland 2003 2005
Member of the RSC Ireland Committee 2005 -
Trujillo, C., Cronin, S.A., Connon, S.J., Mechanistic Insights into the Organocatalytic Kinetic Resolution of Oxazinones through Alcoholysis, European Journal of Organic Chemistry, 2022, (3), 2022, Journal Article, PUBLISHED  DOI
McDonnell, C.M. and Ghanim, M. and Mike Southern, J. and Kelly, V.P. and Connon, S.J., De-novo designed β-lysine derivatives can both augment and diminish the proliferation rates of E. coli through the action of Elongation Factor P, Bioorganic and Medicinal Chemistry Letters, 59, (128545), 2022, Journal Article, PUBLISHED  TARA - Full Text  DOI
Cronin, S.A., Connon, S.J., The kinetic resolution of oxazinones by alcoholysis: access to orthogonally protected ß-amino acids, Organic and Biomolecular Chemistry, 19, (34), 2021, p7348-7352 , Journal Article, PUBLISHED  DOI
Smith, S.N., Connon, S.J., Preparation of Lactams from Cyclic Anhydrides via N-Carboxyanhydride Intermediates, European Journal of Organic Chemistry, 2021, (40), 2021, p5540-5544 , Journal Article, PUBLISHED  DOI
Delany, E.G., Connon, S.J., Enantioselective N-heterocyclic carbene-catalysed intermolecular crossed benzoin condensations: Improved catalyst design and the role of in situ racemisation, Organic and Biomolecular Chemistry, 19, (1), 2021, p248-258 , Journal Article, PUBLISHED  DOI
Litvajova, M., Sorrentino, E., Twamley, B., Connon, S.J., Base-free enantioselective SN2 alkylation of 2-oxindoles via bifunctional phase-transfer catalysis, Beilstein Journal of Organic Chemistry, 17, 2021, p2287-2294 , Journal Article, PUBLISHED  DOI
Fergus C, Al-Qasem M, Cotter M, McDonnell CM, Sorrentino E, Chevot F, Hokamp K, Senge MO, Southern JM, Connon SJ, Kelly VP, The human tRNA-guanine transglycosylase displays promiscuous nucleobase preference but strict tRNA specificity., Nucleic acids research, 2021, p4877-4890 , Journal Article, PUBLISHED  TARA - Full Text  DOI
Smith, S.N., Craig, R., Connon, S.J., Divergent Synthesis of "-Amino Acid and "-Lactam Derivatives from meso-Glutaric Anhydrides, Chemistry - A European Journal, 26, (59), 2020, p13378-13382 , Journal Article, PUBLISHED  DOI
Curran, S.P., Fallon, B.J., Connon, S.J., C2-Symmetric Cinchona Alkaloid Derivatives: Versatile Catalysts for the Enantioselective C"C Bond Forming Conjugate Addition of Nucleophiles to Simple ",ß-Unsaturated Acyl Pyrazoles, ChemistrySelect, 5, (48), 2020, p15190-15194 , Journal Article, PUBLISHED  DOI
Mashael A. Alqasem, Claire Fergus, J. Mike Southern, Stephen J. Connon and Vincent P. Kelly, The eukaryotic tRNA-guanine transglycosylase enzyme inserts queuine into tRNA via a sequential bi-bi mechanism, Chemical communications, 56, 2020, p3915 - 3918, Journal Article, PUBLISHED  TARA - Full Text  DOI
  

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The design and synthesis of novel chiral organocatalysts (and immobilised versions thereof) for asymmetric transformations. Asymmetric bifunctional organocatalysis. Synthesis of novel cyclin-dependant kinase (CDK) inhibitors. Design of novel tetracycline derivatives to combat bacterial resistance. Novel synthetic methodology, including the scope expansion of several important carbon-carbon bond-forming reactions such as the asymmetric Baylis-Hillman reaction and ketone trifluoromethylation. The design of novel fast initiating olefin metathesis catalysts.