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Dr. Lara Cassidy

Assistant Professor (Genetics)


Lara Cassidy graduated in Human Genetics from Trinity College Dublin in 2013, receiving a gold medal for her academic achievements. She worked as a research assistant under Prof. Jun Kitano at the National Institute of Genetics in Japan, publishing on speciation in stickleback fish populations. She was subsequently awarded a scholarship by the Irish Research Council to pursue a Ph.D. in ancient genomics at Prof. Dan Bradley's lab at the Trinity, which she was awarded in 2018. Her doctoral focus was the application of next generation sequencing technologies to the study of Irish prehistory, which resolved longstanding questions on the origins of the modern population. She expanded upon this work as a postdoctoral researcher, before soon joining the staff at the Department of Genetics as an assistant professor in 2020. Throughout her career, Lara has published extensively and with wide-reaching impact in ancient genomics. Her research has been repeatedly featured in top journals such as Nature, Science, PNAS and Nature Communications and covered by major international news outlets (New York Times, Washington Post, The Guardian, BBC). In 2019, she was awarded an honorary life fellowship at the Adelphi Genetics Forum.
  Archaeology   Genetic Selection   Genetics   Genomes, Genomics   Molecular Biology
Details Date From Date To
Treasurer and Vice-Chairperson of Irish Society of Human Genetics September 2022
Iseult Jackson, Peter Woodman, Marion Dowd, Linda Fibiger, Lara M Cassidy, Ancient Genomes From Bronze Age Remains Reveal Deep Diversity and Recent Adaptive Episodes for Human Oral Pathobionts, Molecular Biology and Evolution, 41, (3), 2024, Journal Article, PUBLISHED
Jackson I, Mattiangeli V, Cassidy LM, Murphy E, Bradley DG., Millennium-old pathogenic Mendelian mutation discovery for multiple osteochondromas from a Gaelic Medieval graveyard, Eur J Hum Genet, 2023, Journal Article, PUBLISHED
Niall P Cooke, Valeria Mattiangeli, Lara M Cassidy, Kenji Okazaki, Kenji Kasai, Daniel G Bradley, Takashi Gakuhari, Shigeki Nakagome, Genomic insights into a tripartite ancestry in the Southern Ryukyu Islands, Evolutionary Human Sciences, 5, 2023, pe23-, Journal Article, PUBLISHED
Ariano B, Mattiangeli V, Breslin EM, Parkinson EW, McLaughlin TR, Thompson JE, Power RK, Stock JT, Mercieca-Spiteri B, Stoddart S, Malone C, Gopalakrishnan S, Cassidy LM, Bradley DG., Ancient Maltese genomes and the genetic geography of Neolithic Europe, Current Biology, 2022, Journal Article, PUBLISHED
Maisano Delser P., Jones E.R., Hovhannisyan A., Cassidy L., Pinhasi R., Manica A., A curated dataset of modern and ancient high-coverage shotgun human genomes, Scientific Data, 8, (1), 2021, Journal Article, PUBLISHED  DOI
Cooke, N.P. and Mattiangeli, V. and Cassidy, L.M. and Okazaki, K. and Stokes, C.A. and Onbe, S. and Hatakeyama, S. and Machida, K. and Kasai, K. and Tomioka, N. and Matsumoto, A. and Ito, M. and Kojima, Y. and Bradley, D.G. and Gakuhari, T. and Nakagome, S., Ancient genomics reveals tripartite origins of Japanese populations, Science Advances, 7, (38), 2021, Notes: [cited By 3], Journal Article, PUBLISHED  DOI
Speidel L., Cassidy L., Davies R.W., Hellenthal G., Skoglund P., Myers S.R., Inferring Population Histories for Ancient Genomes Using Genome-Wide Genealogies, Molecular Biology and Evolution, 38, (9), 2021, p3497 - 3511, p3497-3511 , Journal Article, PUBLISHED  DOI
Cassidy LM, Maoldúin RÓ, Kador T, Lynch A, Jones C, Woodman PC, Murphy E, Ramsey G, Dowd M, Noonan A, Campbell C, Jones ER, Mattiangeli V, Bradley DG., A dynastic elite in monumental Neolithic society., Nature, 582, (7812), 2020, p384-388 , Journal Article, PUBLISHED  DOI
Margaryan A, Lawson DJ, Sikora M, Racimo F, Rasmussen S, Moltke I, Cassidy LM, Jørsboe E, Ingason A, Pedersen MW, Korneliussen T, Wilhelmson H, Bu" MM, de Barros Damgaard P, Martiniano R, Renaud G, Bhérer C, Moreno-Mayar JV, Fotakis AK, Allen M, Allmäe R, Molak M, Cappellini E, Scorrano G, McColl H, Buzhilova A, Fox A, Albrechtsen A, Schütz B, Skar B, Arcini C, Falys C, Jonson CH, B"aszczyk D, Pezhemsky D, Turner-Walker G, Gestsdóttir H, Lundstrøm I, Gustin I, Mainland I, Potekhina I, Muntoni IM, Cheng J, Stenderup J, Ma J, Gibson J, Peets J, Gustafsson J, Iversen KH, Simpson L, Strand L, Loe L, Sikora M, Florek M, Vretemark M, Redknap M, Bajka M, Pushkina T, Søvsø M, Grigoreva N, Christensen T, Kastholm O, Uldum O, Favia P, Holck P, Sten S, Arge SV, Ellingvåg S, Moiseyev V, Bogdanowicz W, Magnusson Y, Orlando L, Pentz P, Jessen MD, Pedersen A, Collard M, Bradley DG, Jørkov ML, Arneborg J, Lynnerup N, Price N, Gilbert MTP, Allentoft ME, Bill J, Sindbæk SM, Hedeager L, Kristiansen K, Nielsen R, Werge T, Willerslev E., Population genomics of the Viking world., Nature, 585, (7825), 2020, p390-396 , Journal Article, PUBLISHED  DOI
Hui R, D'Atanasio E, Cassidy LM, Scheib CL, Kivisild T., Evaluating genotype imputation pipeline for ultra-low coverage ancient genomes., Scientific reports, 10, (1), 2020, p18542 , Journal Article, PUBLISHED  DOI

Page 1 of 3
Islands apart? Genomics perspectives on the Mesolithic-Neolithic transition in Ireland. in, editor(s)Alasdair Whittle, Joshua Pollard, Susan Greaney , Ancient DNA and the European Neolithic: Relations and Descent, Oxbow Books, 2023, Book Chapter, PUBLISHED
A genomic survey of the Ranelagh population in, editor(s)Murphy E and Delany S , The Forgotten Cemetery: Excavations at Ranelagh, Co. Roscommon, 2022, pp194 - 198, [Cassidy LM, Jackson I, Mattiangeli V], Book Chapter, PUBLISHED
Cassidy L.M., The first genomic portrait of a Neanderthal family, Nature, 610, (7932), 2022, p454 - 455, p454-455 , Journal Article, PUBLISHED
Lara M. Cassidy, Sizing it up: a commentary on "An archaeology of Ireland for the Information Age."2, Emania, 25, 2020, p45 - 52, Journal Article, PUBLISHED


Award Date
Honorary Life Fellowship at the Galton Institute October 2019
Best Postdoctoral Talk, ISHG Conference Sept 2018
Gold medalist in Human Genetics (BA) May 2013
Leslie Bloomer Prize in Human Genetics (BA) May 2012
Overall winner in the Life Sciences Category at the Undergraduate Awards 2013
Our group is is working to create a dense temporal catalogue of Irish genetic variation across 10,000 years of the island's habitation. Within this there are several major streams of inquiry: 1. Natural Selection and Disease: Leveraging the unique case study that Ireland presents, as an isolated island with long-term demographic continuity, to study the genomic architecture of mutational load, disease and selective forces. 2. Demography: Characterising prehistoric and Medieval demography in Ireland, Britain and further afield using haplotype-based approaches to provide fine-scale resolution. This includes defining the geographic and cultural forces that have encouraged the build up and break down of genetic structure across Ireland and Europe through time. 3. Social Organisation: Ancient genomes also provide evidence of kinship and descent systems in the absence of written records. They can inform on social stratification, inequality and elite mobility, allowing us to reconstruct the social structure of past societies. 4. Microbiome and Pathogen Evolution: Alongside human genomes we are also carrying out a large survey ancient microbiomes, documenting shifts associated with dietary transitions and host-pathogen co-evolution.