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Dr. Michael Carty

Assistant Professor (Clinical Microbiology)

 Exploring native Irish plant extracts for immunomodulatory properties
 Defining the potential for pyroptosis, an immunogenic form of cell death, in cancer subtypes
 The role of inflammasomes in tumour cell death following infection with oncolytic viruses
 How the innate immune system drives T cell dysfunction in chronic infection, sepsis and cancer

Details Date
I am a member of the editorial advisory board of the scientific journal Biochemical Pharmacology.
I am a review editor of the scientific journal Frontiers in Immunology.
Details Date From Date To
International Cytokine & Interferon Society (ICIS) 2004 Present
Irish Society for Immunology (ISI) 2004 Present
Ryan, T.A.J. and Hooftman, A. and Rehill, A.M. and Johansen, M.D. and Brien, E.C.O. and Toller-Kawahisa, J.E. and Wilk, M.M. and Day, E.A. and Weiss, H.J. and Sarvari, P. and Vozza, E.G. and Schramm, F. and Peace, C.G. and Zotta, A. and Miemczyk, S. and Nalkurthi, C. and Hansbro, N.G. and McManus, G. and O†Doherty, L. and Gargan, S. and Long, A. and Dunne, J. and Cheallaigh, C.N. and Conlon, N. and Carty, M. and Fallon, P.G. and Mills, K.H.G. and Creagh, E.M. and Donnell, J.S.O. and Hertzog, P.J. and Hansbro, P.M. and McLoughlin, R.M. and Wygrecka, M. and Preston, R.J.S. and ZasÅ'ona, Z. and Neill, L.A.J.O., Dimethyl fumarate and 4-octyl itaconate are anticoagulants that suppress Tissue Factor in macrophages via inhibition of Type I Interferon, Nature Communications, 14, (1), 2023, Notes: [cited By 0], Journal Article, PUBLISHED  TARA - Full Text  DOI
Laura K Finnegan, Naomi Chadderton, Paul F Kenna, Arpad Palfi, Michael Carty, Andrew G Bowie, Sophia Millington-Ward, Gwyneth Jane Farrar, SARM1 Ablation Is Protective and Preserves Spatial Vision in an In Vivo Mouse Model of Retinal Ganglion Cell Degeneration, International Journal of Molecular Sciences, 2022, Journal Article, PUBLISHED  TARA - Full Text  URL
Claudia Feriotti, Joana Sa-Pessoa, Ricardo Calderon-Gonzalez, Lili Gu, Brenda Morris, Ryoichi Sugisawa, Jose L Insua, Michael Carty, Amy Dumigan, Rebecca J Ingram, Adrien Kissenpfening, Andrew G Bowie, Jose A Bengoechea, Klebsiella pneumoniae hijacks the Toll-IL-1R protein SARM1 in a type I IFN-dependent manner to antagonize host immunity., Cell Reports, 40, (6), 2022, p111167-, Journal Article, PUBLISHED  DOI  URL
Ciara G Doran, Ryoichi Sugisawa, Michael Carty, Fiona Roche, Claire Fergus, Karsten Hokamp, Vincent P Kelly, Andrew G Bowie, CRISPR/Cas9-mediated SARM1 knockout and epitope-tagged mice reveal that SARM1 does not regulate nuclear transcription, but is expressed in macrophages, Journal of Biological Chemistry, 297, (6), 2021, Journal Article, PUBLISHED  TARA - Full Text  DOI  URL
Feng Gu, Aileen Krüger, Hannes G Roggenkamp, Rick Alpers, Dmitri Lodygin, Vincent Jaquet, Franziska Möckl, Lola C Hernandez C, Kai Winterberg, Andreas Bauche, Anette Rosche, Helmut Grasberger, John Y Kao, Daniel Schetelig, René Werner, Katrin Schröder, Michael Carty, Andrew G Bowie, Samuel Huber, Chris Meier, Hans-Willi Mittrücker, Joerg Heeren, Karl-Heinz Krause, Alexander Flügel, Björn-Philipp Diercks, Andreas H Guse, Dual NADPH oxidases DUOX1 and DUOX2 synthesize NAADP and are necessary for Ca2+ signaling during T cell activation, Science Signaling, 14, (709), 2021, Journal Article, PUBLISHED  URL
Carty M, Guy C, Bowie AG., Detection of Viral Infections by Innate Immunity., Biochemical pharmacology, 183, 2021, p114316 , Journal Article, PUBLISHED  TARA - Full Text  DOI
Ozaki, Ema, Gibbons, Luke, Neto, Nuno GB, Kenna, Paul, Carty, Michael, Humphries, Marian, Humphries, Pete, Campbell, Matthew, Monaghan, Michael, Bowie, Andrew and Doyle, Sarah L, SARM1 deficiency promotes rod and cone photoreceptor cell survival in a model of retinal degeneration, Life Science Alliance, 3, (5), 2020, Journal Article, PUBLISHED  TARA - Full Text  DOI
Carty M, Bowie AG., SARM: from immune regulator to cell executioner., Biochemical pharmacology, 2019, p52-62 , Journal Article, PUBLISHED  DOI
Carty, M. and Kearney, J. and Shanahan, K.A. and Hams, E. and Sugisawa, R. and Connolly, D. and Doran, C.G. and Muñoz-Wolf, N. and GÃ"rtler, C. and Fitzgerald, K.A. and Lavelle, E.C. and Fallon, P.G. and Bowie, A.G., Cell Survival and Cytokine Release after Inflammasome Activation Is Regulated by the Toll-IL-1R Protein SARM, Immunity, 50, (6), 2019, p1412-1424.e6 , Notes: [cited By 0], Journal Article, PUBLISHED  DOI
Dempsey A, Keating SE, Carty M, Bowie AG., Poxviral protein E3-altered cytokine production reveals that DExD/H-box helicase 9 controls Toll-like receptor-stimulated immune responses., The Journal of biological chemistry, 293, (39), 2018, p14989-15001 , Journal Article, PUBLISHED  DOI

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Award Date
Sheldon Wolf prize for cytokine research from the International Cytokine Society 2006
Best oral presentation at Ulster Immunology Group/ British Society of Immunology /Irish society of Immunology conference 2006
I am interested in the mechanisms that drive and regulate the inflammatory response. This includes how the innate immune system functions in sensing infections and in eliciting an immune response. I am also interested in how the innate immune system impacts the adaptive immune response in health and how this is dysregulated in diseases such as sepsis, cancer and autoimmunity. My current research focuses on exploring native Irish plant extracts for bioactive compounds that block the innate immune response. To achieve this goal I am collaborating with NatPro here in TCD. I am also interested in how aspects of the innate immune system such as inflammasomes and an inflammatory form of cell death known as pyroptosis can be harnessed in the treatment of cancers. My interest in the area of cancer also extends to oncolytic viruses which may exert an anti-tumour response by activating inflammasomes and triggering pyroptotic cell death.