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Professor Matthew Campbell

Professor Of (Genetics)
Professor Of (Trinity Inst. of Neurosciences (TCIN))
      
Profile Photo

Professor Matthew Campbell

Professor Of (Genetics)

 Matthew.Campbell@tcd.ie

 3531896 2484/1482

Professor Of (Trinity Inst. of Neurosciences (TCIN))


  AGE-RELATED MACULOPATHY   Alzheimer's Disease   BLOOD-BRAIN-BARRIER   Cell signalling, proliferation & differentiation   Cellular Biology   ENDOTHELIAL CELLS   Genetics   INFLAMMATION   Molecular Biology   Molecular Genetics   Neurobiology   neurodegeneration   Neuroscience   siRNA technology   TIGHT JUNCTIONS   Transgenics   Vision
Project Title
 Eye-D: Therapeutic target identification for degenerative eye disease
From
1/11/2021
To
31/10/2025
Summary
This project is focused on identifying the molecular cause of blindness including age related macular degeneration (AMD), glaucoma and inherited retinal diseases. It is an industry academic consortium and involves collaboration with Roche, Eli Lilly and Progressive Vision as well as a collaboration with the Irish charity Fighting Blindness Ireland.
Funding Agency
SFI
Programme
SFI-SPP
Project Title
 Retina Rhythm:Investigating the role of the inner retina in age-related macular degeneration (AMD)
From
1/7/2020
To
30/6/2025
Summary
This is an ERC project focused on identifying the earliest causes of age related macular degeneration (AMD). The central hypothesis is that AMD is driven by a dysfunction of blood vessels in the inner retina and that regulating the integrity of these vessels may stabilise the condition.
Funding Agency
European Research Council
Programme
Consolidator Award
Project Type
Basic research

Details Date
Member of the scientific review committee of Moorfields Eye Charity, UK. 2020 - present
Editorial board member for Investigative Ophthalmology and Vision Science (IOVS) 2022
Language Skill Reading Skill Writing Skill Speaking
English Fluent Fluent Fluent
Details Date From Date To
Associate Editor, Fluids and Barriers of the CNS 2021 Present
Member of the Executive committee of FutureNeuro 2016 Present
Member of the SAB of the Alternating Hemiplegia of Childhood (AHCF) charity 2024 Present
Member of the SAB of the Moorfields Hospital Charity 2020 Present
Vice Chair, Sight Research UK, SAB 2024 Present
Associate Editor, IOVS 2022 2024
Member of International Society for Eye Research. 2010-present: International Brain Barriers Society (IBBS). 2014 Present
Hashimoto Y, Greene C, Hanley N, Hudson N, Henshall D, Sweeney KJ, O'Brien DF, Campbell M., Pumilio-1 mediated translational control of claudin-5 at the blood-brain barrier., Fluids and barriers of the CNS, 21, (1), 2024, p52 , Journal Article, PUBLISHED  DOI
Hashimoto Y, Campbell M., Eyes on glutamate in angiogenesis and barrier formation., Neuron, 112, (12), 2024, p1895-1897 , Journal Article, PUBLISHED  DOI
Cathomas F, Lin HY, Chan KL, Li L, Parise LF, Alvarez J, Durand-de Cuttoli R, Aubry AV, Muhareb S, Desland F, Shimo Y, Ramakrishnan A, Estill M, Ferrer-Pérez C, Parise EM, Wilk CM, Kaster MP, Wang J, Sowa A, Janssen WG, Costi S, Rahman A, Fernandez N, Campbell M, Swirski FK, Nestler EJ, Shen L, Merad M, Murrough JW, Russo SJ., Circulating myeloid-derived MMP8 in stress susceptibility and depression., Nature, 626, (8001), 2024, p1108-1115 , Journal Article, PUBLISHED  DOI
Vázquez-Liébanas E, Mocci G, Li W, Laviña B, Reddy A, O'Connor C, Hudson N, Elbeck Z, Nikoloudis I, Gaengel K, Vanlandewijck M, Campbell M, Betsholtz C, Mäe MA., Mosaic deletion of claudin-5 reveals rapid non-cell-autonomous consequences of blood-brain barrier leakage., Cell reports, 43, (3), 2024, p113911 , Journal Article, PUBLISHED  DOI
Hashimoto Y, Besmond C, Boddaert N, Munnich A, Campbell M., A loss of function mutation in CLDN25 causing Pelizaeus-Merzbacher-like leukodystrophy., Human molecular genetics, 33, (12), 2024, p1055-1063 , Journal Article, PUBLISHED  DOI
Porkoláb G, Mészáros M, Szecskó A, Vigh JP, Walter FR, Figueiredo R, Kálomista I, Hoyk Z, Vizsnyiczai G, Gróf I, Jan JS, Gosselet F, Pirity MK, Vastag M, Hudson N, Campbell M, Veszelka S, Deli MA., Synergistic induction of blood-brain barrier properties., Proceedings of the National Academy of Sciences of the United States of America, 121, (21), 2024, pe2316006121 , Journal Article, PUBLISHED  DOI
Wakonigg Alonso C, McElhatton F, O'Mahony B, Campbell M, Pollak TA, Stokes PRA., The blood-brain barrier in bipolar disorders: A systematic review., Journal of affective disorders, 361, 2024, p434-444 , Journal Article, PUBLISHED  DOI
Greene C, Connolly R, Brennan D, Laffan A, O'Keeffe E, Zaporojan L, O'Callaghan J, Thomson B, Connolly E, Argue R, Meaney JFM, Martin-Loeches I, Long A, Cheallaigh CN, Conlon N, Doherty CP, Campbell M., Author Correction: Blood-brain barrier disruption and sustained systemic inflammation in individuals with long COVID-associated cognitive impairment., Nature neuroscience, 27, (5), 2024, p1019 , Journal Article, PUBLISHED  DOI
Greene C., Connolly R., Brennan D., Laffan A., O'Keeffe E., Zaporojan L., O'Callaghan J., Thomson B., Connolly E., Argue R., Meaney J.F.M., Martin-Loeches I., Long A., Cheallaigh C.N., Conlon N., Doherty C.P., Campbell M., Correction to: Blood"brain barrier disruption and sustained systemic inflammation in individuals with long COVID-associated cognitive impairment (Nature Neuroscience, (2024), 27, 3, (421-432), 10.1038/s41593-024-01576-9), Nature Neuroscience, 27, (5), 2024, p1019-, Journal Article, PUBLISHED  DOI
Greene C, Connolly R, Brennan D, Laffan A, O'Keeffe E, Zaporojan L, O'Callaghan J, Thomson B, Connolly E, Argue R, Meaney JFM, Martin-Loeches I, Long A, Cheallaigh CN, Conlon N, Doherty CP, Campbell M., Blood-brain barrier disruption and sustained systemic inflammation in individuals with long COVID-associated cognitive impairment., Nature neuroscience, 27, (3), 2024, p421-432 , Journal Article, PUBLISHED  DOI
  

Page 1 of 15
1. K Mulfaul, E Ozaki, K Brennan, M Campbell, S Doyle, Investigating a role for Toll like receptor signaling in the pathogenesis of Age Related Macular Degeneration (AMD). , Investigative Ophthalmology & Visual Science, , ARVO, Seattle, 57 (12), (5010-5010), 2016, Conference Paper, PUBLISHED
10. C Doherty, E Wallace, M Campbell, P Humphries, Evaluation of an Acute RNAi-Mediated Therapeutic for Visual Dysfunction Associated with Traumatic Brain Injury., Neurology 2012, SAINT JAMES HOSPITAL DUBLIN (IRELAND), 2012, Conference Paper, PUBLISHED
12. GA Grant, C Wilson, M Campbell, S Li, P Humphries, A Johnson, Reversible Opening of the Blood-brain Barrier by Targeted Suppression of Claudin 5 To Enhance Drug Delivery into Brain Tumors. , Annals of Neurology , 2012, Conference Paper, PUBLISHED
Brankin B, Campbell M, Humphries M, Kennan A, Kenna P, Humphries P, Zonulas occluden 1 expression in retinas from Rho-/-C129 mice, INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, 45, (Suppl. 2), 2004, ppU179 - U179, Meeting Abstract, PUBLISHED

  


Award Date
Science Foundation Ireland, Young Researcher of the year 2020
European Research Council Consolidator Award 2020
Irish Research Council Laureate Award. 2018
Association for Ocular Pharmacology and Therapeutics, National Eye Institute (NEI) award 2015
Association for Research in Vision and Ophthalmology, NEI travel Award 2015
Genentech/ARVO fellowship in recognition of my research on AMD 2015
Science Foundation Ireland, President of Ireland Young Researcher Award (PIYRA) 2013
"Pro-Retina" travel award for XVth International Symposium on Retinal Degenerations 2012
Appointed Senior Research Fellow, TCD 2012
Roche Research Award, Smurfit Institute of Genetics 2010
Fighting Blindness Ireland Research Scholarship 2002
Fellow of the Szeged Academy of Science, Hungary 2021
Fellow of TCD 2018