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Professor Matthew Campbell

Professor (Genetics)

Professor (Trinity Inst. of Neurosciences (TCIN))

  AGE-RELATED MACULOPATHY   Alzheimer's Disease   BLOOD-BRAIN-BARRIER   Cell signalling, proliferation & differentiation   Cellular Biology   ENDOTHELIAL CELLS   Genetics   INFLAMMATION   Molecular Biology   Molecular Genetics   Neurobiology   neurodegeneration   Neuroscience   siRNA technology   TIGHT JUNCTIONS   Transgenics   Vision
 Eye-D: Therapeutic target identification for degenerative eye disease
 Retina Rhythm:Investigating the role of the inner retina in age-related macular degeneration (AMD)

Details Date
Member of the scientific review committee of Moorfields Eye Charity, UK. 2020 - present
Language Skill Reading Skill Writing Skill Speaking
English Fluent Fluent Fluent
Details Date From Date To
Associate Editor, Fluids and Barriers of the CNS 2021 Present
Member of International Society for Eye Research. 2010-present: International Brain Barriers Society (IBBS). 2014 Present
Dion-Albert, L. and Cadoret, A. and Doney, E. and Kaufmann, F.N. and Dudek, K.A. and Daigle, B. and Parise, L.F. and Cathomas, F. and Samba, N. and Hudson, N. and Lebel, M. and Aardema, F. and Ait Bentaleb, L. and Beauchamp, J. and Bendahmane, H. and Benoit, E. and Bergeron, L. and Bertone, A. and Bertrand, N. and Berube, F.-A. and Blanchet, P. and Boissonneault, J. and Bolduc, C.J. and Bonin, J.-P. and Borgeat, F. and Boyer, R. and Breault, C. and Breton, J.-J. and Briand, C. and Brodeur, J. and Brule, K. and Brunet, L. and Carriere, S. and Chartrand, C. and Chenard-Soucy, R. and Chevrette, T. and Cloutier, E. and Cloutier, R. and Cormier, H. and Cote, G. and Cyr, J. and David, P. and De Benedictis, L. and Delisle, M.-C. and Deschenes, P. and Desjardins, C.D. and Desmarais, G. and Dubreucq, J.-L. and Dumont, M. and Dumais, A. and Ethier, G. and Feltrin, C. and Felx, A. and Findlay, H. and Fortier, L. and Fortin, D. and Fortin, L. and Francois, N. and Gagne, V. and Gagnon, M.-P. and Gignac-Hens, M.-C. and Giguere, C.-E. and Godbout, R. and Grou, C. and Guay, S. and Guillem, F. and Hachimi-Idrissi, N. and Herry, C. and Hodgins, S. and Homayoun, S. and Jemel, B. and Joyal, C. and Kouassi, E. and Labelle, R. and Lafortune, D. and Lahaie, M. and Lahlafi, S. and Lalonde, P. and Landry, P. and Lapaige, V. and Larocque, G. and Larue, C. and Lavoie, M. and Leclerc, J.-J. and Lecomte, T. and Lecours, C. and Leduc, L. and Lelan, M.-F. and Lemieux, A. and Lesage, A. and Letarte, A. and Lepage, J. and Levesque, A. and Lipp, O. and Luck, D. and Lupien, S. and Lusignan, F.-A. and Lusignan, R. and Luyet, A.J. and Lynhiavu, A. and Melun, J.-P. and Morin, C. and Nicole, L. and Noel, F. and Normandeau, L. and O†Connor, K. and Ouellette, C. and Parent, V. and Parizeau, M.-H. and Pelletier, J.-F. and Pelletier, J. and Pelletier, M. and Plusquellec, P. and Poirier, D. and Potvin, S. and Prevost, G. and Prevost, M.-J. and Racicot, P. and Racine-Gagne, M.-F. and Renaud, P. and Ricard, N. and Rivet, S. and Rolland, M. and Sasseville, M. and Safadi, G. and Smith, S. and Smolla, N. and Stip, E. and Teitelbaum, J. and Thibault, A. and Thibault, L. and Thibault, S. and Thomas, F. and Todorov, C. and Tourjman, V. and Tranulis, C. and Trudeau, S. and Trudel, G. and Vacri, N. and Valiquette, L. and Vanier, C. and Villeneuve, K. and Villeneuve, M. and Vincent, P. and Wolfe, M. and Xiong, L. and Zizzi, A. and Campbell, M. and Turecki, G. and Mechawar, N. and Menard, C., Vascular and blood-brain barrier-related changes underlie stress responses and resilience in female mice and depression in human tissue, Nature Communications, 13, (1), 2022, Notes: [cited By 1], Journal Article, PUBLISHED  DOI
Greene, C. and Hanley, N. and Reschke, C.R. and Reddy, A. and MÀe, M.A. and Connolly, R. and Behan, C. and O†Keeffe, E. and Bolger, I. and Hudson, N. and Delaney, C. and Farrell, M.A. and O†Brien, D.F. and Cryan, J. and Brett, F.M. and Beausang, A. and Betsholtz, C. and Henshall, D.C. and Doherty, C.P. and Campbell, M., Microvascular stabilization via blood-brain barrier regulation prevents seizure activity, Nature Communications, 13, (1), 2022, Notes: [cited By 1], Journal Article, PUBLISHED  DOI
Gibbons, L. and Ozaki, E. and Greene, C. and Trappe, A. and Carty, M. and Coppinger, J.A. and Bowie, A.G. and Campbell, M. and Doyle, S.L., SARM1 Promotes Photoreceptor Degeneration in an Oxidative Stress Model of Retinal Degeneration, Frontiers in Neuroscience, 16, (852114), 2022, Notes: [cited By 0], Journal Article, PUBLISHED  TARA - Full Text  DOI
Ozaki, E. and Delaney, C. and Campbell, M. and Doyle, S.L., Minocycline suppresses disease-associated microglia (DAM) in a model of photoreceptor cell degeneration, Experimental Eye Research, 217, (108953), 2022, Notes: [cited By 1], Journal Article, PUBLISHED  TARA - Full Text  DOI
Chang, J.-H. and Greene, C. and Frudd, K. and Araujo dos Santos, L. and Futter, C. and Nichols, B.J. and Campbell, M. and Turowski, P., Methamphetamine enhances caveolar transport of therapeutic agents across the rodent blood-brain barrier, Cell Reports Medicine, 3, (1), 2022, Notes: [cited By 1], Journal Article, PUBLISHED  DOI
Greene, C. and Campbell, M., Immunohistochemical Analysis of Tight Junction Proteins, Methods in Molecular Biology, 2492, 2022, p307-314 , Notes: [cited By 0], Journal Article, PUBLISHED  DOI
Amoo, M. and O'Halloran, P.J. and Henry, J. and Ben Husien, M. and Brennan, P. and Campbell, M. and Caird, J. and Curley, G.F., Permeability of the Blood-Brain Barrier after Traumatic Brain Injury: Radiological Considerations, Journal of Neurotrauma, 39, (1-2), 2022, p20-34 , Notes: [cited By 3], Journal Article, PUBLISHED  DOI
Boyce, M. and Xin, Y. and Chowdhury, O. and Shang, P. and Liu, H. and Koontz, V. and Strizhakova, A. and Nemani, M. and Hose, S. and Zigler, J.S. and Campbell, M. and Sinha, D. and Handa, J.T. and Kaarniranta, K. and Qian, J. and Ghosh, S., Microgliaâ€"Neutrophil Interactions Drive Dry AMD-like Pathology in a Mouse Model, Cells, 11, (22), 2022, Notes: [cited By 0], Journal Article, PUBLISHED  DOI
Hashimoto, Y. and Poirier, K. and Boddaert, N. and Hubert, L. and Aubart, M. and Kaminska, A. and Alison, M. and Desguerre, I. and Munnich, A. and Campbell, M., Recurrent de novo mutations in CLDN5 induce an anion-selective blood-brain barrier and alternating hemiplegia, Brain : a journal of neurology, 145, (10), 2022, p3374-3382 , Notes: [cited By 2], Journal Article, PUBLISHED  DOI
Parker E, Aboghazleh R, Mumby G, Veksler R, Ofer J, Newton J, Smith R, Kamintsky L, Jones CMA, O'Keeffe E, Kelly E, Doelle K, Roach I, Yang LT, Moradi P, Lin JM, Gleason AJ, Atkinson C, Bowen C, Brewer KD, Doherty CP, Campbell M, Clarke DB, van Hameren G, Kaufer D, Friedman A., Concussion susceptibility is mediated by spreading depolarization-induced neurovascular dysfunction, Brain, 2021, Journal Article, PUBLISHED

Page 1 of 12
1. K Mulfaul, E Ozaki, K Brennan, M Campbell, S Doyle, Investigating a role for Toll like receptor signaling in the pathogenesis of Age Related Macular Degeneration (AMD). , Investigative Ophthalmology & Visual Science, , ARVO, Seattle, 57 (12), (5010-5010), 2016, Conference Paper, PUBLISHED
10. C Doherty, E Wallace, M Campbell, P Humphries, Evaluation of an Acute RNAi-Mediated Therapeutic for Visual Dysfunction Associated with Traumatic Brain Injury., Neurology 2012, SAINT JAMES HOSPITAL DUBLIN (IRELAND), 2012, Conference Paper, PUBLISHED
12. GA Grant, C Wilson, M Campbell, S Li, P Humphries, A Johnson, Reversible Opening of the Blood-brain Barrier by Targeted Suppression of Claudin 5 To Enhance Drug Delivery into Brain Tumors. , Annals of Neurology , 2012, Conference Paper, PUBLISHED
Brankin B, Campbell M, Humphries M, Kennan A, Kenna P, Humphries P, Zonulas occluden 1 expression in retinas from Rho-/-C129 mice, INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, 45, (Suppl. 2), 2004, ppU179 - U179, Meeting Abstract, PUBLISHED


Award Date
Science Foundation Ireland, Young Researcher of the year 2020
European Research Council Consolidator Award 2020
Irish Research Council Laureate Award. 2018
Association for Ocular Pharmacology and Therapeutics, National Eye Institute (NEI) award 2015
Association for Research in Vision and Ophthalmology, NEI travel Award 2015
Genentech/ARVO fellowship in recognition of my research on AMD 2015
Science Foundation Ireland, President of Ireland Young Researcher Award (PIYRA) 2013
"Pro-Retina" travel award for XVth International Symposium on Retinal Degenerations 2012
Appointed Senior Research Fellow, TCD 2012
Roche Research Award, Smurfit Institute of Genetics 2010
Fighting Blindness Ireland Research Scholarship 2002