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Professor Maeve Caldwell

Professor in Neuroscience (Physiology)
Professor in Neuroscience (Trinity Inst. of Neurosciences (TCIN))
LLOYD INSTITUTE
      
Profile Photo

Professor Maeve Caldwell

Professor in Neuroscience (Physiology)
LLOYD INSTITUTE

 caldwelm@tcd.ie

 3531896 1019

Professor in Neuroscience (Trinity Inst. of Neurosciences (TCIN))


Project Title
 Examining the interplay of the immune system with brain cells in Parkinson's disease
From
01/04/2020
To
31/01/2024
Summary
Age is the primary risk factor for the development of a neurodegenerative disease such as Parkinson's disease with projected disease burden expected to increase 2-fold in Ireland by 2036. The overall burden is likely to keep increasing unless mechanistic based strategies for alleviating this age related neural decline are discovered and exploited for prevention or therapy. The potential role of the astrocytes as either a cellular target or as a secondary participant in the pathogenesis of neurodegenerative disease has gained attention in recent years as has the role of the immune system. However, our understanding of astrocytic mechanisms in response to stress/injury is incomplete compared to that of neurons and our understanding of the role the immune system plays is still in its infancy. The aim of this project is to determine the interplay between T cells (specifically Th17 cells) and astrocytes and how either cell type alone or following stimulation of the astrocytes with microglial secreted factors affects the survival of midbrain dopamine neurons. We will generate midbrain dopamine neurons and midbrain astrocytes from a number of induced pluripotent stem cell lines, including idiopathic Parkinson's and normal controls and we will isolate Th17 lymphocytes from whole blood of Parkinson's patients and controls. In addition, we will utilise Mass Spectroscopy to determine what factors are secreted by astrocytes. Specifically we will collect astrocyte conditioned media before and after their exposure to Th17 cells or microglial secreted factors and determine what factors are detrimental to dopamine neuronal survival. This body of work will determine how the interplay of the immune system with cells of the brain is implicated in the pathogenesis of Parkinson's disease
Funding Agency
HRB
Programme
ILP-POR-2019-058
Project Title
 Apolipoprotein-E genotype influences inflammation in Alzheimer's Disease
From
01/10/2020
To
31/09/2024
Summary
Funding Agency
SFI
Programme
Frontiers
Project Type
Project
Person Months
48
Project Title
 PARKIE: Parkinson's community Awareness of Research; emphasis on Knowledge and Information Exchange
From
01/11/2022
To
31/10/2023
Summary
Funding Agency
HRB
Programme
Knowledge Transfer Award
Project Type
KTA Award
Person Months
11

MacMahon Copas A.N., McComish S.F., Petrasca A., McCormack R., Ivers D., Stricker A., Fletcher J.M., Caldwell M.A., CD4+ T cell-associated cytokines induce a chronic pro-inflammatory phenotype in induced pluripotent stem cell-derived midbrain astrocytes, GLIA, 2024, Journal Article, PUBLISHED  DOI
Cheng L., Caldwell M.A., Cho K.-S., Mellough C.B., Editorial: Stem cell-derived retinal and brain organoid culture for disease modeling, Frontiers in Cellular Neuroscience, 18, 2024, Journal Article, PUBLISHED  DOI
Jimenez-Moreno N., Kollareddy M., Stathakos P., Moss J.J., Anton Z., Shoemark D.K., Sessions R.B., Witzgall R., Caldwell M., Lane J.D., ATG8-dependent LMX1B-autophagy crosstalk shapes human midbrain dopaminergic neuronal resilience, The Journal of cell biology, 222, (5), 2023, Journal Article, PUBLISHED  DOI
Crompton L.A., Mccomish S.F., Steward T.G.J., Whitcomb D.J., Lane J.D., Caldwell M.A., Human stem cell-derived ventral midbrain astrocytes exhibit a region-specific secretory profile, Brain Communications, 5, (2), 2023, Journal Article, PUBLISHED  DOI
Maughan, J. and Gouveia, P.J. and Gonzalez, J.G. and Leahy, L.M. and Woods, I. and O'Connor, C. and McGuire, T. and Garcia, J.R. and O†Shea, D.G. and McComish, S.F. and Kennedy, O.D. and Caldwell, M.A. and Dervan, A. and Coleman, J.N. and O'Brien, F.J., Collagen/pristine graphene as an electroconductive interface material for neuronal medical device applications, Applied Materials Today, 29, (101629), 2022, Notes: [cited By 0], Journal Article, PUBLISHED  TARA - Full Text  DOI
McComish S.F., MacMahon Copas A.N., Caldwell M.A., Human Brain-Based Models Provide a Powerful Tool for the Advancement of Parkinson"s Disease Research and Therapeutic Development, Frontiers in Neuroscience, 16, 2022, Journal Article, PUBLISHED  DOI
Caldwell MA, Sarah F. McComish, Adina N. MacMahon Copas, Maeve A. Caldwell, Human Brain-Based Models Provide a Powerful Tool for the Advancement of Parkinson"s Disease Research and Therapeutic Development, Frontiers in Neuroscience, 16, 2022, Journal Article, PUBLISHED  DOI
Stathakos P., Jimenez-Moreno N., Crompton L.A., Nistor P.A., Badger J.L., Barbuti P.A., Kerrigan T.L., Randall A.D., Caldwell M.A., Lane J.D., A monolayer hiPSC culture system for autophagy/mitophagy studies in human dopaminergic neurons, Autophagy, 17, (4), 2021, p855 - 871, p855-871 , Journal Article, PUBLISHED  DOI
Crompton L.A., McComish S.F., Stathakos P., Cordero-Llana O., Lane J.D., Caldwell M.A., Efficient and scalable generation of human ventral midbrain astrocytes from human-induced pluripotent stem cells, Journal of Visualized Experiments, (176), 2021, Journal Article, PUBLISHED  DOI
Caldwell MA, Lucy A. Crompton, Sarah F. McComish, Petros Stathakos, Oscar Cordero-Llana, Jon D. Lane, Maeve A. Caldwell, Efficient and Scalable Generation of Human Ventral Midbrain Astrocytes from Human-Induced Pluripotent Stem Cells, Journal of Visualized Experiments, (176), 2021, Journal Article, PUBLISHED  DOI
  

Page 1 of 10
Derivation of Neural Stem Cells from the Developing and Adult Human Brain in, Human Neural Stem Cells , 2018, pp3 - 20, [Maeve A. Caldwell], Book Chapter, PUBLISHED
Derivation of Neural Stem Cells from the Developing and Adult Human Brain in, Human Neural Stem Cells, 2018, pp3 - 20, [Maeve A. Caldwell], Book Chapter, PUBLISHED