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Dr. Adrian Bracken

Assoc Prof in Medical Molecular Genetics (Genetics)
29 WESTLAND ROW


In 2021, I was elected an EMBO Member for outstanding achievement in the life sciences. My lab has made several seminal discoveries in the field of cancer epigenetics. In particular, we provided key contributions to the understanding of the molecular mechanisms of how Polycomb group proteins regulate cell-fate decisions in stem cells and in cancer. For example, in 2018, my lab discovered a new family of vertebrate specific Polycomb group proteins, called PALI1 and PALI2, that link nuclear receptor signalling and chromatin biology (Conway et al., Molecular Cell) and, in 2019, we explored how different Polycomb Repressive complexes (PRC2.1 and PRC2.2) interplay to direct deposition of the H3K27me3 epigenetic modification (Healy et al., Molecular Cell). In research that forms the basis of this grant proposal, my lab recently studied an incurable childhood cancer called 'H3-K27M-mutant diffuse midline glioma' and demonstrated that EZH2 inhibitor drugs are a mechanistically anchored treatment strategy, based on modelling the consequences of the H3-K27M cancer causing gene on the underlying biology (Brien et al., Nature Genetics, 2021). My lab is also focused on genetic predisposition to cancer and we are using our expertise in chromatin biology to explore the contribution of regulatory elements in the 'non-coding genome'. Additionally, several exciting ongoing projects in the lab are studying the roles of chromatin regulators in developmental disorders and cancer.
  Cancer Genetics   Cellular identity   Chromatin biology   Epigenetics   Gene expression control   Polycomb proteins   Stem Cell Biology   The EZH2 oncogene
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Gu L, Casserly D, Brady G, Carpenter S, Bracken AP, Fitzgerald KA, Unterholzner L, Bowie AG., Myeloid cell nuclear differentiation antigen controls the pathogen-stimulated type I interferon cascade in human monocytes by transcriptional regulation of IRF7., Nature communications, 13, (1), 2022, p14 , Journal Article, PUBLISHED  TARA - Full Text  DOI
Brien GL, Bressan RB, Monger C, Gannon D, Lagan E, Doherty AM, Healy E, Neikes H, Fitzpatrick DJ, Deevy O, Grant V, Marqués-Torrejón MA, Alfazema N, Pollard SM, Bracken AP., Simultaneous disruption of PRC2 and enhancer function underlies histone H3.3-K27M oncogenic activity in human hindbrain neural stem cells., Nature Genetics, 53, (8), 2021, p1221 - 1232, Journal Article, PUBLISHED  TARA - Full Text
Lynch, S.M. and Russell, N.M. and Barron, S. and Wang, C.-J.A. and Loughman, T. and Dynoodt, P. and Fender, B. and Lopez-Ruiz, C. and O'Grady, A. and Sheehan, K.M. and Fay, J. and Amberger-Murphy, V. and Saha, A. and Klinger, R. and Gonzalez, C.A. and Al-Attar, N. and Rahman, A. and O'Leary, D. and Lanigan, F.T. and Bracken, A.P. and Crown, J. and Kelly, C.M. and O'Connor, D.P. and Gallagher, W.M., Prognostic value of the 6-gene OncoMasTR test in hormone receptorâ€"positive HER2-negative early-stage breast cancer: Comparative analysis with standard clinicopathological factors, European Journal of Cancer, 152, 2021, p78-89 , Notes: [cited By 0], Journal Article, PUBLISHED  DOI
Huang, Z. and Liang, N. and Goñi, S. and Damdimopoulos, A. and Wang, C. and Ballaire, R. and Jager, J. and Niskanen, H. and Han, H. and Jakobsson, T. and Bracken, A.P. and Aouadi, M. and Venteclef, N. and Kaikkonen, M.U. and Fan, R. and Treuter, E., The corepressors GPS2 and SMRT control enhancer and silencer remodeling via eRNA transcription during inflammatory activation of macrophages, Molecular Cell, 81, (5), 2021, p953-968.e9 , Notes: [cited By 10], Journal Article, PUBLISHED  DOI
Glancy, E. and Ciferri, C. and Bracken, A.P., Structural basis for PRC2 engagement with chromatin, Current Opinion in Structural Biology, 67, 2020, p135-144 , Journal Article, PUBLISHED  TARA - Full Text  DOI
Lanigan F, Gallagher WM and Bracken AP., 'A method of predicting risk of recurrence of cancer', TCD and UCD, US 10,557,175, 2020, Jointly owned by TCD and UCD, Notes: [The invention relates to a method of predicting the risk of tumour recurrence in a subject. Specifically, the invention relates to a method of predicting the risk of early-stage node -negative breast cancer, prostate cancer and other tumour recurrence], Patent, GRANTED  URL
Healy E, Mucha M, Glancy E, Fitzpatrick DJ, Conway E, Neikes HK, Monger C, Van Mierlo G, Baltissen MP, Koseki Y, Vermeulen M, Koseki H, and Bracken AP. , PRC2.1 and PRC2.2 synergize to co-ordinate H3K27 tri-methylation, Molecular Cell, 2019, p437-452.e6 , Journal Article, PUBLISHED  DOI
Deevy O and Bracken AP., PRC2 functions in development and congenital disorders, Development, 146, (19), 2019, pdev181354 , Journal Article, PUBLISHED  TARA - Full Text  DOI
Bracken AP, Brien GL and Verrijzer CP., Dangerous Liaisons: Interplay between SWI/SNF, NuRD and Polycomb in Chromatin Regulation and Cancer. , Genes & Development, 33, 2019, p1 - 24, Journal Article, PUBLISHED  TARA - Full Text  DOI
Lanigan F, Gallagher WM and Bracken AP., 'A method of predicting risk of recurrence of cancer,', TCD and UCD, EP3194621, 2019, Jointly owned by TCD and UCD, Notes: [The invention relates to a method of predicting the risk of tumour recurrence in a subject. Specifically, the invention relates to a method of predicting the risk of early-stage node -negative breast cancer, prostate cancer and other tumour recurrence], Patent, GRANTED  URL
  

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Healy E, Bracken AP., If You Like It Then You Shoulda Put Two "RINGs" on It: Delineating the Roles of vPRC1 and cPRC1, Molecular Cell, 77, (4), 2020, p685-687 , Journal Article, PUBLISHED
(ed.), Anticancer innovative therapy: Highlights from the ninth annual meeting, Cytokine Growth Factor Rev., Milan, Italy., 51, January, 2019, 2020, 1 - 9 p, Proceedings of a Conference, PUBLISHED
Brien GL, Bracken AP., The 3D Genome: EZH2 Comes into the Fold., Trends in Molecular Medicine, 25, (5), 2019, p362 - 365, Journal Article, PUBLISHED
Streubel G, Bracken AP., MED23: a new Mediator of H2B monoubiquitylation., The EMBO Journal, 34, (23), 2015, p2863-2864 , Journal Article, PUBLISHED
Benitah, S.A., Bracken, A., Dou, Y., Huangfu, D., Ivanova, N., Koseki, H., Laurent, L., Lim, D.A., Meshorer, E., Pombo, A., Sander, M., Xu, G.L., Stem cell epigenetics: Looking forward, Cell Stem Cell, 14, (6), 2014, p706-709 , Journal Article, PUBLISHED
Turner SA, Bracken AP., A "complex" issue: deciphering the role of variant PRC1 in ESCs., Cell Stem Cell, 12, (2), 2013, p145-146 , Journal Article, PUBLISHED

  

Award Date
Elected an EMBO Member for outstanding achievement in the life sciences (Nominated by Nobel Prize Winner Thomas Cech). June 2021
Irish Research Council Advanced Laureate Awardee 2019-2023
Elected Fellow of Trinity College Dublin (FTCD) 2018-
Science Foundation Ireland Principal Investigator (IvP) Awardee 2017-2022
EUROLIFE Distinguished Lecture Prize Awardee 2016
Science Foundation Ireland 'Principal Investigator Career Advancement' (PICA) Awardee 2010-2015