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Dr. Nollaig Bourke

Associate Professor (Medical Gerontology)
ST JAMESS HOSPITAL
      
Profile Photo

Dr. Nollaig Bourke

Associate Professor (Medical Gerontology)
ST JAMESS HOSPITAL

 nbourke@tcd.ie

 3531896 2682


  Age related diseases   AGEING   AGE-RELATED-CHANGES   Angiogenesis, oncology, cardiovascular biology, inflammation   Biomarkers of disease   BLOODBORNE VIRUSES   CELLULAR IMMUNE-RESPONSE   CHRONIC INFLAMMATION   CYTOKINE GENES   Cytokine modulation of immune responses   Cytokine signalling   Disease Prevention   GENE REGULATION   GENE-EXPRESSION   GENOMICS   HEPATITIS-C VIRUS   Hormones   HUMAN IMMUNODEFICIENCY VIRUS (HIV)   Immune system   Infectious Diseases   Inflammation   Molecular basis to inflammation and innate immunity   REPRODUCTIVE HORMONES   TYPE I INTERFERONS   VIRUS INFECTION   VIRUS-INFECTED PATIENTS
Details Date From Date To
Irish Society of Immunology 2008
Society for Mucosal Immunology 2016 2018
International Cytokine and Interferon Society (ICIS) 2014
Victorian Infection and Immunity Network, Australia 2012 2017
Australian Centre for HIV and Hepatitis Virology Research (ACH2) 2013 2015
Dyer AH, Dolphin H, Morrison L, Kenny T, Fallon PG, Cunningham C, O'Connor A, Lawlor B, O'Farrelly C, Bourke NM, Kennelly SP, NILVAD Study Group, Systemic inflammation, delirium and clinical progression in mild-moderate Alzheimer disease., EBioMedicine, 2026, Journal Article, PUBLISHED  DOI
Murphy DM, Batten I, O'Farrell A, Carlile SR, O'Rourke SA, Court C, Morris B, Leisching G, Jameson G, Connolly SA, Dyer AH, McGrath JP, McNally E, Basdeo SA, IFN-Y-induced trained immunity enhances killing of priority pathogens in healthy and genetically vulnerable individuals., JCI insight, 2026, Journal Article, PUBLISHED  DOI
Dyer AH, Dunne J, Dolphin H, Morrison L, O'Connor A, Fullam S, Kenny T, Fallon A, O'Dowd S, Bourke NM, Conlon NP, Kennelly SP; TIMC"BRAiN Study Group., Clinical performance of the fully automated Lumipulse plasma p-tau217 assay in mild cognitive impairment and mild dementia, Alzheimers Dement (Amst) ., 2025, Journal Article, PUBLISHED  DOI
Fung Ka Yee, de Geus Eveline D, Ying Le, Cumming Helen, Bourke Nollaig, Foster Samuel C, Hertzog Paul J, Expression of Interferon Epsilon in Mucosal Epithelium is Regulated by Elf3 , Molecular and cellular biology , 44 , (8 ), 2024, p334 - 343 , Journal Article, PUBLISHED  DOI  URL
L Morrison, AH Dyer, H Dolphin, I Batten, C Reddy, M Widdowson, CP Woods, J Gibney, NM Bourke, SP Kennelly, Circulating Interleukin-17A is associated with executive function in middle aged adults with and without type 2 diabetes, Brain, Behavior, & Immunity - Health, 41, (November), 2024, p100862-, Journal Article, PUBLISHED  DOI
Adam H Dyer, Helena Dolphin, Antoinette O'Connor, Laura Morrison, Gavin Sedgwick, Conor Young, Emily Killeen, Conal Gallagher, Aoife McFeely, Eimear Connolly, Naomi Davey, Paul Claffey, Paddy Doyle, Shane Lyons, Christine Gaffney, Ruth Ennis, Cathy McHale, Jasmine Joseph, Graham Knight, Emmet Kelly, Cliona O'Farrelly, Aoife Fallon, Sean O'Dowd, Nollaig M Bourke, Sean P Kennelly, Performance of plasma p-tau217 for the detection of amyloid-ß positivity in a memory clinic cohort using an electrochemiluminescence immunoassay, Alzheimer's Research & Therapy, 2024, Journal Article, PUBLISHED  DOI
Laura Morrison, Adam H Dyer, Helena Dolphin, Isabelle Killane, Nollaig M Bourke, Matthew Widdowson, Conor P Woods, James Gibney, Richard B Reilly, Sean P Kennelly, Discrete Relationships between Spatiotemporal Gait Characteristics and Domain-Specific Neuropsychological Performance in Midlife, Sensors, 2024, Journal Article, PUBLISHED  DOI
Bertrand A, Sugrue J, Lou T, Bourke N.M, Quintana-Murci L, Saint-André V, O'Farrelly C, Duffy D, Impact of socioeconomic status on healthy immune responses in humans, Immunology and Cell Biology, 2024, Journal Article, PUBLISHED  DOI  URL
Dyer AH, Dolphin H, McElheron M, Bourke NM, Kennelly SP, Moving from "vulnerability" to "inter-individual variability" in defining a place for the biology of ageing in geriatric medicine., European geriatric medicine, 2023, Journal Article, PUBLISHED  DOI
Adam H Dyer, Helena Dolphin, Antoinette O'Connor, Laura Morrison, Gavin Sedgwick, Aoife McFeely, Emily Killeen, Conal Gallagher, Naomi Davey, Eimear Connolly, Shane Lyons, Conor Young, Christine Gaffney, Ruth Ennis, Cathy McHale, Jasmine Joseph, Graham Knight, Emmet Kelly, Cliona O'Farrelly, Nollaig M Bourke, Aoife Fallon, Sean O'Dowd, Sean P Kennelly, Protocol for the Tallaght University Hospital Institute for Memory and Cognition-Biobank for Research in Ageing and Neurodegeneration, BMJ Open, 2023, Journal Article, PUBLISHED  DOI
  

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Ann Monaghan, Nollaig Bourke, Aisling O'Halloran, Mark Ward, Feng Xue, Glenn Jennings, Rose Anne Kenny and Roman Romero-Ortuno, New self-reported exhaustion during the COVID-19 Pandemic, TILDA Report, 2021, Report, PUBLISHED
De Looze, C., Ward, M., McDowell, C., Bourke, N., Kenny R.A., Preparing for COVID-19 vaccination: important learnings from the Irish Longitudinal Study on Ageing (TILDA), Dublin, TILDA, December, 2020, Report, PUBLISHED

  


My research focuses on understanding how the immune system changes with age and the role immune dysregulation plays in age-related disease initiation and pathology. In particular, I am interested in investigating how the initiation and regulation of innate immune responses, such as inflammation and anti-viral immunity, change with age, with a focus on how these processed are related to biological ageing and age-associated physiological decline.