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Dr. Michael Monaghan

Associate Professor (Mechanical, Manuf & Biomedical Eng)
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Dr. Michael Monaghan is an Associate Professor in Biomedical Engineering at Trinity College Dublin, the University of Dublin. His group's primary research areas are in biomaterials (in particular electroconductive biomaterials), advanced processing and rational design of biomaterials, cardiac tissue regeneration, and real-time imaging of extracellular matrix components and metabolism in differentiation and disease. He leads a number of interdiciplinary projects between other academic groups and industry ranging from immunometabolism, evaluation of fibrosis, biomaterial synthesis and induced pluripotent stem cell derivitisation of cardiac organoids.

Dr. Monaghan performed his Postdoctoral research in Germany as a recipient of a prestigious Marie Curie Individual Fellowship. His research was coordinated between the Department of Cell and Tissue Engineering in the Fraunhofer Institute for Interfacial Engineering and Biotechnology and the Department of Women's Health in University Clinic Tubingen. During this period he has published a number of key papers in the field of human valvulogenesis, embryonic stem cell research, cardiomyocyte differentiation, biomaterials and non-invasive optical characterisation (Raman microspectroscopy, fluorescent lifetime imaging (FLIM), multiphoton and second harmonic generation (SHG) imaging). Dr. Monaghan received both his B.Eng (Biomedical) and Ph.D. (Biomedical Engineering) from the National University of Ireland Galway (NUIG). During his Ph.D. Dr. Monaghan received a number of research awards such as travel awards from the European Molecular Biology Organisation (EMBO) and the German Academic Exchange Service (DAAD), and the 2015 Julia Polak European Doctorate Award in recognition of the achievements made during his Ph.D.

Dr. Monaghan is actively involved in the tissue engineering and regenerative medicine international society (TERMIS); previously as Chair of the EU Student and Young Investigator Section, and recently promoted full EU Council Member. He is council member of Matrix Biology Ireland and acts as treasurer of this society. More details of his groups resources and research can be found on the groups website. Lab Website: www.monaghanlab.com
  2ND HARMONIC GENERATION   3D Imaging Analysis   Bioengineering and radiologic imaging   Biomaterials   COLLAGEN   CONFOCAL IMAGING   Confocal photoluminescence imaging   DRUG TARGETING   DRUG-DELIVERY SYSTEM   EXTRACELLULAR MATRIX (ECM)   GENE SILENCING   GENE-THERAPY   Regenerative Medicine   Tissue Engineering
 Engineering animal-free accurate models of the annulus fibrosis in vitro using morphometrical data applied to the 4D deposition of melt electrowritten fibres to achieve true anisotropy and lamellar orientations
 Doctoral Network for a Shared Excellence of Fluorescent Lifetime Imaging Microscopy in Biomedical Applications
 Enabling Melt ElectroWriting of Electroconductive, Geometrically Defined 3D Biomaterials to Promote the Maturation of Cardiomyocytes for Cardiac Regeneration
 Development of minimally invasive neuromodulatory electroconductive hydrogel in combination with physical stimuli for spinal cord regeneration
 The role of macrophage polarization in the generation of functional engineered mature myocardium organoids

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Details Date
Elected Treasurer- Matrix Biology Ireland 2017 Meeting 30 Nov 2016
Elected Council Member -Tissue Engineering and Regenerative Medicine International Society (EU Chapter) 01-Jan-2018
Reviewer for leading journals in the fields of Biomaterials and Tissue Engineering (selection only): Biomaterials, RSC Biomaterials Science, Advanced Optical Materials, ACS Biomaterials Science and Engineering, Macromolecular Materials and Engineering, Small, Macromolecular Bioscience, Advanced Functional Materials, Advanced NanoBiomed Research, Advanced Materials Technologies, Journal of Controlled Release, Molecular Therapy, Advanced Healthcare Materials, Tissue Engineering Part A, Tissue Engineering Part B, Acta Biomaterialia, ACS Applied Materials and Interfaces, Advanced Drug Delivery Reviews, Lab on a Chip, Nature Scientific Reports, Journal of Tissue Engineering and Regenerative Medicine, npj 2D Materials and Applications 2015-Present
External Examiner PhD Thesis Progress- Royal College of Surgeons in Ireland 2017
Grant Reviewer for National and International Granting Bodies Including: European Research Council ADVANCED GRANTS European Research Council Starting Grants Wellcome Trust (2020-Present) MRC-AMED Regenerative Medicine and Stem Cell Research Initiative (2020- Present) Israel Science Foundation (2020-Present) Marie Sklowdowska-Curie Individual Fellowships (2019-Present) Freiburg Institute for Advanced Studies Deutsche Forschungsgemeinschaft (DFG) (2029-Present) Canada Foundation for Innovation (CFI) through the John R. Evans Leaders Fund (2021) 2018
Language Skill Reading Skill Writing Skill Speaking
English Fluent Fluent Fluent
German Medium Medium Medium
Details Date From Date To
Royal Academy of Medicine in Ireland (RAMI)- Bioengineering Section 2017 Present
MBI- Matrix Biology Ireland (elected council member and Society Treasurer) 2016 Present
ESB- European Society for Biomaterials 2010 Present
TERMIS - Tissue Engineering and Regenerative Medicine Society 2009 Present
DGMB-German Matrix Biology Society 2013 2016
Funded Investigator: SFI Funded Centre AMBER (Advanced Materials and BioEngineering Research) 2019 Present
Funded Investigator: SFI Funded Centre CÚRAM (Designing The Next Generation of 'Smart' Medical Devices) 2019 Present
Meenakshi Suku, Lesley Forrester, Manus Biggs, Michael Monaghan, Functional cardiac organoids modeling the inflammatory environment of myocardial infarction , Meeting of the European Chapter of the Tissue Engineering and Regenerative Medicine International Society, Manchester, UK, March 2023, 2023, Conference Paper, PUBLISHED
Monaghan MG, Non-invasive classification of macrophage polarisation by 2P-FLIM and machine learning, Meeting of the European Chapter of the Tissue Engineering and Regenerative Medicine International Society, Manchester, UK, March 2023, 2023, Conference Paper, PUBLISHED
Monaghan MG, Crosslinked extracellular matrix biomaterials functionalized with 2D-nanomaterial MXenes for cardiac tissue engineering drive iPSC-derived cardiomyocyte maturation, Meeting of the European Chapter of the Tissue Engineering and Regenerative Medicine International Society, Manchester. UK, March 2023, 2023, Conference Paper, PUBLISHED
Monaghan MG, Non-Invasive classification of macrophage polarisation by 2P-FLIM and machine learning, Meeting of the European Chapter of the Tissue Engineering and Regenerative Medicine International Society, Krakow, Poland, July 2022, 2022, Conference Paper, PUBLISHED
Solazzo M, Monaghan MG, ELECTROCONDUCTIVE SCAFFOLDS FOR IN VITRO CARDIAC MODELS, Meeting of the European Chapter of the Tissue Engineering and Regenerative Medicine International Society, Krakow, Poland, July 2022, 2022, Conference Paper, PUBLISHED
Michael Monaghan, Optimization, Prediction and Smart Design for Anisotropically and Mechanically Matching Biomaterial Scaffolds Using Melt-Electrowriting, Gordon Research Conference: Bioinspired Materials, Les Diablerets, Switzerland, June 2022, 2022, Conference Paper, PUBLISHED
Leahy, L.M. Woods, I., Gutierrez-Gonzalez, J, Monaghan, M. G, Dervan, A., O"Brien, F.J., DEVELOPMENT OF AN ELECTROCONDUCTIVE, 3D-PRINTED SCAFFOLD DESIGNED TO PROMOTE AXONAL REGROWTH AFTER SPINAL CORD INJURY, European Society for Biomaterials Annual Meeting 2022, Bordeaux, France, September 2022, 2022, Conference Paper, PUBLISHED
Leahy, L.M., Woods, I., Gutierrez-Gonzalez, J., Monaghan, M. G, Dervan, A. O"Brien, F.J, DEVELOPMENT OF AN ELECTROCONDUCTIVE, 3D-PRINTED SCAFFOLD DESIGNED TO PROMOTE AXONAL REGROWTH AFTER SPINAL CORD INJURY, Meeting of the European Chapter of the Tissue Engineering and Regenerative Medicine International Society, Krakow, Poland, July 2022, 2022, Conference Paper, PUBLISHED
Nuno G.B. Neto, Sinead O"Rourke, Mimi Zhang, Hannah Fitzgerald, Aisling Dunne, Michael Monaghan, Non-Invasive classification of macrophage polarisation by 2P-FLIM and machine learning, Microscopy Society of Ireland 2022 Meeting, Galway, Ireland, 2022, Conference Paper, PUBLISHED
Lianne Shanley, Olwyn Mahon, Sinead O'Rourke, Nuno Neto, Michael Monaghan, Daniel Kelly, Aisling Dunne, PARTICLE SIZE ALTERS MACROPHAGE METABOLISM: IMPLICATIONS FOR BONE TISSUE ENGINEERING, Irish Society for Immunology 2022 Annual Meeting, Maynooth, Co. Kildare, 1-2nd September 2022, 2022, Conference Paper, PUBLISHED
  

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Meenakshi Suku, Lesley Forrester, Manus Biggs, Michael Monaghan, Tuning macrophage polarization to model myocardial infarction in the generation of functional cardiac organoids, 28th Annual Conference of the section of Bioengineering of the Royal Academy of Medicine in Ireland, Enfield Ireland, January 2023, 2023, Conference Paper, PUBLISHED
Sara Corbezzolo, Meenakshi Suku, Locke Davenport Huyer, Milica Radisic Michael G. Monaghan, Melt electrowriting of synclastically curved patches compensating the mechanical anisotropy of the infarcted myocardium, 28th Annual Conference of the section of Bioengineering of the Royal Academy of Medicine in Ireland, Enfield, Ireland, January 2023, 2023, Conference Paper, PUBLISHED
Monaghan Michael, MXene and Conductive Polymers in Tissue Engineering, Joint 2D Nanomaterials meeting between RCD and Royal College of Surgeons in Ireland, RCSI, Dublin, Ireland, October 2022, 2022, Invited Talk, PUBLISHED
Michael Monaghan, MXene and Conductive Polymers for Tissue Engineering, Ghent Bioengineering Research Seminar, Ghent, Belgium , October 2022, 2022, Ruslan Dmitriev, Invited Talk, PUBLISHED
Michael Monaghan, Engineering Non-invasive Tools to Profile Cell Metabolism in Differentiation and Disease, Tissue and Cell Engineering Society (TCES) Annual Meeting (joint with the EPSRC Funded Centres for Doctoral Training, Birmingham, UK, 14th June 2022, 2022, Invited Talk, PUBLISHED
Monaghan MG, ELectroconductive Biomaterial Patches and Scaffolds to Match the Mechanical Anisotropy of Organ-specific Tissues, Beacon Mini Symposium, Ireland-Canada University Foundation, Online, 2021, 2021, Invited Talk, PUBLISHED
Fitzgerald H., Williams D. G., Campbell N. K., Barry P, O'Rourke S. A. Neto N., Monaghan M. G., Nolan D. P., Dunne A, Trypanosoma brucei secreted aromatic ketoacids activate the Nrf2/HO-1 pathway and suppress pro-inflammatory responses in primary murine and human immune cells, . 34th Conference of the European Macrophage and Dendritic Cell Society. Virtual conference , Online, 24-25th June, 2021, Meeting Abstract, PUBLISHED
O'Rourke S., Neto N., Devilly E., Shanley L., Dunne A., Monaghan M. G, ., Immunometabolism in atherosclerosis: Investigating cholesterol crystals as potent drivers of metabolic reprogramming and M1 macrophage polarisation, 34th Conference of the European Macrophage and Dendritic Cell Society, Online, 24-25th June , 2021, Meeting Abstract, PUBLISHED
Shanley L., Mahon O. R., O'Rourke S. A., Neto N., Monaghan M. G., Kelly D., Dunne A, Particle size alters macrophage metabolism: Implications for bone tissue engineering, 6th European Congress for Immunology Meeting, Online, 1-4th September , 2021, Meeting Abstract, PUBLISHED
Shanley L., Mahon O. R., O'Rourke S. A., Neto N., Monaghan M. G., Kelly D., Dunne A, Particle size alters macrophage metabolism: Implications for bone tissue engineering, 34th Conference of the European Macrophage and Dendritic Cell Society, Online, 24-25th June , 2021, Meeting Abstract, PUBLISHED

  

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Award Date
Senior author on paper awarded the 'Engineers Ireland Biomedical Research Medal' from the Society of Engineers Ireland. Awarded to Dr Matteo Solazzo 2022
European Doctoral Award, Issued by the European Society of Biomaterials 2015
Deutscher Akademischer Austausch Dienst, Short Term Travel Award to conduct research in University Hospital Tübingen 2012
EMBO Short Term Travel Award to conduct research in Fraunhofer IGB Stuttgart 2011
Roche Best Poster Award, NCBES Research day 2008
NUI Galway College of Engineering and Informatics Research Fellow 2007
University Scholar (Based on end of term results) NUI Galway 2005
The focus of the Monaghan lab (www.monaghanlab.com) is the development of novel biomaterial design-based strategies to regenerate or repair damaged tissues and restore biomechanical function using informed and optimised design approaches. Core Research Areas: . Cardiac tissue engineering and cell derivitisation from multi/pluripotent stem cell sources . Macrophage assessment and inclusion in advanced biomaterial culture platforms. . In silico predictive modelling and optimisation of biomaterial geometries . Electroconductive biomaterial synthesis, fabrication and applications . Advanced non-linear microscopy using multiphoton microscopy for non-invasive imaging of extracellular matrix . Advanced fluoresecent lifetime imaging microscopy (FLIM) in the assessment of cellular metabolism during disease, differentiation and regeneration. . Melt-electrowriting development, optimisation and application Our lab is leading new approaches for biomaterial fabrication and design using advanced biomaterials, tissue engineering, biofabrication and in silico predictive modelling. This workis creating a paradigm shift in which the scientific community, industry partners and clinical investigators approach biomaterial design. Our lab is recognised internationally as world class where we am regularly invited to deliver keynote talks at major international meetings, and our papers have received awards for being most downloaded in our field. Members of the team have also been awarded prizes at national/international level in recognition of the scientific quality of our labs work. I have coordinated and elevated the Med3DP initiative over the past five years (www.med3dp.com) which develops medical devices for healthcare using 3D printing technology, demonstrating research led teaching and student led learning. Our lab also has collaborative funding with small-medium enterprises such as Spraybase® (Bioprinting; next generation implantable devices) and I am a funded investigator in the SFI funded centres AMBER and CURAM. My work spans across and engages with several disciplines which includes Physics and Chemistry, Computer Science, Biochemistry and Immunology, Pharmacy, Surgery, Oncology and Endocrinology. This is strongly reflective in our illustrious repertoire of publications. Link to Google Scholar: https://scholar.google.com/citations?user=X1mgIbEAAAAJ&hl=en&oi=sra