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Dr. Hugh Kearney

Clinical Senior Lecturer ()
      
Profile Photo

Dr. Hugh Kearney

Clinical Senior Lecturer ()

 KEARNEYH@tcd.ie

 


Dr Kearney completed a PhD in University College London investigating the use of spinal cord MRI in MS and its association with disability. He completed his clinical training in neurology in Ireland, including a two-year postdoctoral fellowship in genomics with FutureNeuro. He currently works as a consultant neurologist in St James's Hospital, and is leading the newly established MS unit. He is also part of the Academic Unit of Neurology in Trinity College Dublin, and is developing a research group focused on translational research in multiple sclerosis, including the development of diagnostic biomarkers.
  Diagnostic biomarker   MRI   Multiple Sclerosis
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Details Date From Date To
Irish Institute of Clinical Neuroscience
American Academy of Neurology
European Academy of Neurology
Otalora-Alcaraz, A., Cui Sun, M., Hofma, N., Costelloe, L., Kearney, H., Prenderville, J.A., Downer, E.J., Elevated expression of the NLRP3 inflammasome in post-mortem brain white matter and immune cells in multiple sclerosis., Multiple Sclerosis and Related Disorders., 12;47(4):338, 2026, Journal Article, PUBLISHED
Oró-Nolla, M., Cui Sun, M., Reilly, T., Anandarajah, J., Otalora-Alcaraz, A., Costelloe, L., Kearney, H., Magee, R., Nolan, Y.M., Downer, E.J., Downregulation of dual-specificity phosphatase 1 (DUSP1) in post-mortem brain white matter in progressive multiple sclerosis., Neurological Sciences., 108:107040, 2026, Journal Article, PUBLISHED
Orefice NS, Meijns NRC, Di Martino E, Schepers M, Tiane A, Schenk GJ, Kearney H, Vanmierlo T, Luchicchi A., PAD2-mediated citrullination of MBP and early myelin destabilization in multiple sclerosis., Journal of autoimmunity, 161, 2026, p103577 , Journal Article, PUBLISHED  DOI
Savio M, Kearney H, Giunti G., Evaluating the evidence behind multidisciplinary roles for a multiple sclerosis unit: A systematic literature review., Multiple sclerosis and related disorders, 95, 2025, p106342 , Journal Article, PUBLISHED  DOI
Savio, M., Kearney, H., Downer, E.J., Neurologist's perspectives on cannabis-based medicines: results from a national survey., Irish Journal of Medical Science., (194(2)), 2025, p687-697 , Journal Article, PUBLISHED  DOI
Almudena Otálora-Alcaraz, Thomas Reilly, Martí Oró-Nolla, Melody Cui Sun, Lisa Costelloe, Hugh Kearney, Pabitra H. Patra, Eric J. Downer, The NLRP3 inflammasome: a central player in multiple sclerosis, Biochemical Pharmacology, (232:116667), 2024, Journal Article, PUBLISHED  DOI
Bradley M, Field RH, O'Rourke M, Stoke J, Murphy SM, Kearney H., Novel phenotype of SIN3A-related disorder diagnosed in adulthood with multi-system involvement., European journal of human genetics : EJHG, 32, (3), 2024, p257-259 , Journal Article, PUBLISHED  DOI
Eltahir M, Abkur T, Kearney H, Rice CM., Lingual epilepsy due to cortical demyelination involving the frontal operculum., Practical neurology, 24, (3), 2024, p248-249 , Journal Article, PUBLISHED  DOI
Dungan L, Dunne J, Savio M, Kalaszi M, McElheron M, Lynagh Y, O'Driscoll K, Roche C, Qureshi A, Crowley B, Conlon N, Kearney H., Disease-Modifying Treatments for Multiple Sclerosis Affect Measures of Cellular Immune Responses to EBNA-1 Peptides., Neurology(R) neuroimmunology & neuroinflammation, 11, (3), 2024, pe200217 , Journal Article, PUBLISHED  DOI
Carton RJ, Doyle MG, Kearney H, Steward CA, Lench NJ, Rogers A, Heinzen EL, McDonald S, Fay J, Lacey A, Beausang A, Cryan J, Brett F, El-Naggar H, Widdess-Walsh P, Costello D, Kilbride R, Doherty CP, Sweeney KJ, O'Brien DF, Henshall DC, Delanty N, Cavalleri GL, Benson KA., Somatic variants as a cause of drug-resistant epilepsy including mesial temporal lobe epilepsy with hippocampal sclerosis., Epilepsia, 65, (5), 2024, p1451-1461 , Journal Article, PUBLISHED  DOI
  

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Award Date
Harold Miller Prize at INA 2015
Harold Miller Prize at INA 2018
Neuropathology fellowship award 2018
I am a neurologist working in St James's Hospital and run the multiple sclerosis (MS) service. Arising from my clinical work my research interests are based in MS and link to clinical observations. There are two research priorities that my work focuses on: delay to diagnosis and misdiagnosis. To address these problems I am developing new diagnostic biomarkers through clinically based research.