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Professor Anne Marie Healy

Professor (Pharmacy)
25/6/7 WESTLAND ROW
      
Profile Photo

Professor Anne Marie Healy

Professor (Pharmacy)
25/6/7 WESTLAND ROW

 healyam@tcd.ie

 3531896 1444


Anne Marie Healy is Professor of Pharmaceutics and Pharmaceutical Technology at Trinity College Dublin with over 30 years of experience in pharmaceutical sciences research and education. Her research programme focuses on the physicochemical and solid-state properties of active pharmaceutical ingredients and excipients, and on how these properties are influenced by formulation and processing strategies. This work has led to the development of innovative solid dosage forms for oral and pulmonary delivery and has improved our understanding of drug solubility and bioavailability enhancement. She has published extensively, with over 70% of her publications in the last decade involving international co-authors. Her work has been supported by multiple national and international funding agencies. Prof. Healy has a longstanding record of interdisciplinary collaboration and leadership in major research consortia, including serving as Co-Principal Investigator and Theme Leader for the Research Ireland Centre for Pharmaceuticals (SSPC), and as co-lead of the Engineering and Physical Sciences Research Council (EPSRC)-Research Ireland (RI) Centre for Doctoral Training in Transformative Pharmaceutical Technologies. She is a member of the Editorial Advisory Boards of Molecular Pharmaceutics and the Journal of Aerosol Medicine and Pulmonary Drug Delivery, and is an Editor of the International Journal of Pharmaceutics. Prof. Healy has supervised 26 PhD students to completion and mentored nearly 30 postdoctoral researchers, many of whom have progressed to successful careers in academia and industry. She is committed to advancing pharmaceutical science through collaborative, translational research and to training the next generation of scientists through inclusive, multidisciplinary programmes.
  Amorphous Materials   Computer modelling of pharmaceutical systems   Materials Sciences   Mechanisms of dissolution   Mechanisms of drug release from solid dosage forms   Pharmaceutical co-crystals   Pharmaceutical dissolution testing   Pharmaceutical processing   Pharmaceutical Sciences   pulmonary drug delivery   SPRAY DRYING
Project Title
 Inhalable formulations of novel gallium compounds for the treatment of lung infections
From
May 2025
To
Summary
In this project we will develop gallium-based compounds and formulations designed for pulmonary drug delivery to treat lung infections, particularly those resistant to oral therapy.
Funding Agency
Research Ireland
Programme
ARC Hub for Therapeutics
Project Title
 Investigating spray coating in the fluidized bed to generate amorphous solid dispersions with and without mesoporous silica
From
March 2025
To
February 2029
Summary
The aim of this project is to investigate spray coating in the fluidized bed in the generation of ASDs by comparing the coating of non-pareil microcrystalline cellulose (MCC) beads with active pharmaceutical ingredient (API)-polymer combinations compared to API-polymer-mesoporous silica combinations
Funding Agency
Research Ireland/InnoGlobal Research Ltd.
Programme
SSPC, The Research Ireland Centre for Pharmaceuticals
Project Type
PhD project
Project Title
 Co-processing Active Pharmaceutical Ingredients by Co-precipitation as a Transformative Technology in Drug Substance Manufacture for Oral Solid Dosage Forms
From
2023
To
2027
Summary
In this project we will develop co-precipitation as a viable technology for the production of amorphous solid dispersions in Drug Substance facilities and with improved processability for Drug Product manufacture.
Funding Agency
Trinity College Dublin
Programme
Panoz Pharmaceutical Innovation PhD Scholarship Programme
Project Type
PhD project
Project Title
 Enhancement of Bioavailability using Engineered Active Pharmaceutical Ingredient Ionic Liquids (API-ILs)
From
2023
To
2027
Summary
The project aims to advance the state of the art in ionic liquids for enhancement of permeability of orally delivered drugs. This will build up on-going research in the development engineered Ionic Liquid Drugs where the candidate will optimize current approaches and evolve new strategies in this research field.
Funding Agency
Research Ireland and EPSRC
Programme
Centre for Doctoral Training (CDT) in Transformative Pharmaceutical Technologies
Project Title
 Biopharmaceutical Assessment of Excipients Used in Inhalation Drug Delivery
From
2023
To
2027
Summary
This project will investigate the effect that inhaled excipients have on in vitro drug dissolution and in vitro and ex vivo drug permeation and absorption kinetics and mechanisms.
Funding Agency
Research Ireland and EPSRC
Programme
Centre for Doctoral Training (CDT) in Transformative Pharmaceutical Technologies

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Language Skill Reading Skill Writing Skill Speaking
English Fluent Fluent Fluent
French Medium Basic Basic
Irish Medium Basic Basic
Spanish Medium Basic Basic
Details Date From Date To
Member of Pharmacists in Industry, Education and Regulatory (PIER) 2013 date
Member of the Academy of Pharmaceutical Scientists (UK) 2005 date
Member of AAPS (American Association of Pharmaceutical Scientists) 2000 date
Member of the Pharmaceutical Society of Ireland 1990 date
O'Connell P., Yoon J.H., Geever L.M., Kumar D., Healy A.-M., Serrano D.R., Accelerated predictive stability (APS) strategies applied to screening pharmaceutical formulations: A comparison of spray dried and hot melt extruded nifedipine amorphous solid dispersions, International Journal of Pharmaceutics, 683, 2025, Journal Article, PUBLISHED  DOI
Kate Tolan, Mohammed Ali Selo, Ismael Obaidi, Peter O"Connell, Michael Carty, Shipra Nagar, Anne Marie Healy, Helen Sheridan, The effects of upstream processing on the chemical profile and immunomodulating activity of Echinacea purpurea tinctures, Phytochemistry Letters, 68, 2025, 102971, Journal Article, PUBLISHED  TARA - Full Text  DOI
O'Brien, Denis and Healy, Anne Marie and Harkin, Andrew and Cadogan, Cathal, A systematic review of manipulations to pharmaceutical dosage forms used in psychotropic tapering plans, British Journal of Clinical Pharmacology, 91, (7), 2025, p1899 â€" 1913 , Notes: [Cited by: 1], Journal Article, PUBLISHED  DOI
Tsolaki E., McCartney F., Healy A.M., Brayden D.J., Ferguson S., Solidified ionic liquid-based formulations of metformin with enhanced GI epithelial permeability, International Journal of Pharmaceutics, 678, 2025, Journal Article, PUBLISHED  DOI
Stocker M.W., Healy A.M., Ferguson S., A fluidised bed particle engineering approach for simultaneous encapsulation and granulation of an API-based ionic liquid, Powder Technology, 457, 2025, Journal Article, PUBLISHED  DOI
Fernandez-Garcia R., Walsh D., O'Connell P., Passero L.F.D., de Jesus J.A., Laurenti M.D., Dea-Ayuela M.A., Ballesteros M.P., Lalatsa A., Bolas-Fernandez F., Healy A.M., Serrano D.R., Targeted Oral Fixed-Dose Combination of Amphotericin B-Miltefosine for Visceral Leishmaniasis, Molecular Pharmaceutics, 22, (3), 2025, p1437 - 1448, p1437-1448 , Journal Article, PUBLISHED  DOI
Ram N.H., Dhondale M.R., Singh M., Mishra B., Agrawal A.K., Healy A.M., Kumar D., The impact of crystal habit on the pharmaceutical properties of active pharmaceutical ingredients, CrystEngComm, 27, (27), 2025, p4614 - 4633, p4614-4633 , Review, PUBLISHED  DOI
Autzen Virtanen, A. and Myslinska, M. and Healy, A.M. and Power, E. and Madi, A. and Siven, M., The challenge of downstream processing of spray dried amorphous solid dispersions into minitablets designed for the paediatric population - A sustainable product development approach, European Journal of Pharmaceutical Sciences, 196, (106752), 2024, Notes: [cited By 1], Journal Article, PUBLISHED  DOI
Andrews, G.P. and Healy, A.M. and Topp, E.M., Introducing the Molecular Pharmaceutics Special Issue on "Advances in Small and Large Molecule Pharmaceutics Research across Ireland", Molecular Pharmaceutics, 21, (8), 2024, p3693-3694 , Notes: [cited By 0], Journal Article, PUBLISHED  DOI
Piatek, M. and Grassiri, B. and O'Ferrall, L.M. and Piras, A.M. and Batoni, G. and Esin, S. and O'Connor, C. and Griffith, D. and Healy, A.M. and Kavanagh, K., Quantitative proteomic analysis reveals Ga(III) polypyridyl catecholate complexes disrupt Aspergillus fumigatus mitochondrial function, Journal of Biological Inorganic Chemistry, 29, 2024, p707 - 717, Notes: [cited By 0], Journal Article, PUBLISHED  DOI
  

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Test, Test, 2021, Report, PUBLISHED
Healy, A.M., Parojčić, J., Srcic, S., Juppo, A., Andrews, G., McSweeney, N, Glennon, B., Lu trik, M, Jones, I. Milne, J. Corrigan, B. Kinahan, M., Tully, R. , Linking industry and academia in teaching pharmaceutical development and manufacture (LIAT-Ph), European Industrial Pharmacy, 21, 2014, p9 - 10, Journal Article, PUBLISHED
Healy, A.M., Linking Industry and Academe. A case study, FORUM, Spring , 2014, p38-, Journal Article, PUBLISHED
F Tewes, L Tajber, C Ehrhardt, AM Healy, Formulation of colistin-ambroxol microparticles for passive targeting of lung infections, AAPS J, 25th Annual Meeting of the AAPS, Washington, DC, 23-27/11/2011, 13, (S2), 2011, ppM1046 , Meeting Abstract, PUBLISHED
Crean, A.M., Healy, A.M., Changing concepts for 21st Century Drug Product Manufacturing, UK and Ireland Controlled Release Society (UKICRS) Newsletter , 2011, - 4-5, Miscellaneous, PUBLISHED
Paluch, K.J., Tajber, L., Corrigan, O.I., Healy, A.M., Solid state characterisation of novel active pharmaceutical ingredients: co-crystal of (R,S) salbutamol mono-adipate and (R,S) salbutamol hemisuccinate, Solid State Pharmaceutical Cluster Meeting, Limerick, 2010, 2010, Poster, PUBLISHED
Paluch K., Tajber L., Healy A.M., Corrigan O. , Impact of solvent variable on chlorothiazide and chlorothiazide sodium physico-chemical properties, processed by spray drying, All Ireland Schools of Pharmacy 31st Research Seminar, Dublin, 2009, 2009, Meeting Abstract, PRESENTED
Paluch K, Tajber L, Corrigan OI, Healy AM, An investigation of the effect of spray drying from different solvents on the physicochemical properties of chlorothiazide and chlorothiazide sodium, IRCSET Symposium Innovation fuelling the Smart Society, Dublin, 2009, 2009, Poster, PRESENTED
Paluch, K., Tajber, L., Healy, A.M. and Corrigan, O.I., Solid-state characteristics of spray dried chlorothiazide, chlorothiazide-PVP composites, sodium chlorothiazide and sodium chlorothiazide-PVP composites, All Ireland Schools of Pharmacy 30th Research Seminar, Cork, 2008, 2008, Meeting Abstract, PRESENTED
D'Arcy, D.M., Corrigan, O.I. and Healy, A.M., Dissolution modelling of off-centre compacts in the paddle dissolution apparatus, Schools of Pharmacy Research Seminar, Trinity College Dublin, 21st to 22nd March, 2005, pp33 (abstract) , Conference Paper, PUBLISHED

  


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Award Date
Science Foundation Ireland Mentorship Award 2023
Trinity College Dublin Innovation Awards - Consultancy Award 2022
Pharma Education and Training Award - for the CDT in Transformative Pharmaceutical Technologies 2022
Trinity College Dublin Innovation Awards - Industry Engagement Award 2021
SSPC (The Science Foundation Ireland Research Centre for Pharmaceuticals) Researcher of the Year 2019
Special Visiting Researcher Fellowship - awarded by CNPq (Conselho Nacional de Desenvolvimento Científico e Tecnológico, Brazil) 2014
Fellowship of Trinity College Dublin 2010
My research programme is focused on obtaining an increased understanding of the physicochemical properties of active and excipient materials used in a variety of different dosage forms, and on using that knowledge to improve product design in terms of in vitro and subsequently in vivo performance. My current research spans two principal strands: (i) Pharmaceutical material science; (ii) Particle engineering for pulmonary drug delivery. (i) Pharmaceutical material science: My research in this area is aimed at understanding how solid state and micromeritic characteristics of drug and excipient materials are impacted by pharmaceutical processing, and how formulation and/or processing may be optimised so as to control physicochemical characteristics and drug product performance, particularly for oral solid dosage forms. Current research efforts focus on co-processed Active Pharmaceutical Ingredients, including amorphous solid dispersions, deep eutectic solvents and ionic liquids. In collaboration with Assoc. Prof. Steven Ferguson (UCD, SSPC), we have combined formulation and engineering expertise to advance co-processed APIs, resulting in multiple co-authored publications and two patent applications on spray-encapsulated ionic liquids. (ii) Particle engineering for pulmonary drug delivery: My group has internationally recognised expertise in spray-drying-based formulation and particle engineering for dry powder inhalation. This expertise led to my involvement in an NIH-funded €8 million international project (2016-2021) led by UCSF, aimed at developing a novel mucolytic therapy for lung diseases such as cystic fibrosis and asthma. The project resulted in a UCSF spinout, Aer Therapeutics, of which I am academic co-founder. Recent collaborations with experts in chemistry, microbiology, and pharmaceutics, including the SSPC community and the University of Pisa, focus on developing inhalable antifungal agents for pulmonary delivery.