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Professor John Gilmer

Professor in Pharmaceutical Chemistry (Pharmacy)

Head of School (School Office - Pharmacy & Pharmceut Sci)

  ASPIRIN   BINDING   BIOLOGICAL-MEMBRANES   BUTYRYLCHOLINESTERASE   Design, synthesis and testing of specific enzyme inhibitors   ENZYME SUBSTRATE SPECIFICITIES   HOST-GUEST CHEMISTRY   HYDROLYSIS   IMPROVED DELIVERY   Isosorbide-based therapies for Alzheimer's disease   MOLECULAR RECOGNITION   PRODRUG   Pro-drug design for tissue targeting   RECEPTORS   STEROIDS   Thyrotropin-releasing hormone-degrading ectoenzyme inhibitors in the treatment of CNS disorders
 Development of novel aspirin prodrugs
 Probing the interaction of ursodeoxycholic acid with the steroid receptor
 Investigation into highly potent inhibitors of butyrylcholinesterase

Details Date
Member, DMMC Cancer Principal Investigators, Trans-institutional grouping of Principal Investigators leading research on Cancer themes
Member, Core Technology PI's, DMMC Principal Investigators leading the development of core technology platforms.
Member, Centre for Research into Global Disease (Proposed), This consortium combines researchers with complementary interests in globally significant infectious disease. Interests include innate immunity, immune regulation, regional immunity, immune evasiob, vaccine & adjuvant development as well as drug & target development.
Invitee, Colorectal & GI Cancer Research Group (Proposed), Speculative idea to cluster PI's around collaborative study on Upper GI and Colon Cancers.Deliberately wide selection of surgeons, pathologists and academic researchers based on stated interest or publication in fields of oesophageal or colorectal cancer.To be reviewed/focused by DK/JR/PMacM.Extracted from DMMC Research Database - 8 Nov 2004.
Member, PHG Funded PI's and Researchers, All Researchers funded under Cycle 3 PRTLI - Programme for Human Genomics
Details Date From Date To
Member of European Federation of Pharmaceutical Scientists
Krzywonos-Zawadzka A, Franczak A, Olejnik A, Radomski M, Gilmer JF, Sawicki G, Woźniak M, Bil-Lula I., Cardioprotective effect of MMP-2-inhibitor-NO-donor hybrid against ischaemia/reperfusion injury., J Cell Mol Med. , 23, (4), 2019, p2836 - 2848, Journal Article, PUBLISHED  TARA - Full Text
Wang J, Radics G, Whelehan M, OÊ"Driscoll A, Healy AM, Gilmer JF, Ledwidge M, Novel Iron-Whey Protein Microspheres Protect Gut Epithelial Cells from Iron-Related Oxidative Stress and Damage and Improve Iron Absorption in Fasting Adults, Acta Haematologica, 2018, p223-232 , Journal Article, PUBLISHED  DOI
GILMER, John, Francis; IE LEDWIDGE, Mark; IE O'FLYNN, Pat; IE QUILTY, Francis; IE O'DONNELL, Kate; IE, ' COMPOUNDS AND COMPOSITIONS FOR USE IN TREATING PSORIASIS', Tomkins, WO2018172496, 2018, Trinity College Dublin and Solvotrin, Patent, SUBMITTED  URL
John Gilmer Radics Gabor Michael Whelehan Jun Wang Pat O'Flynn Mark Ledwidge, ' COMPOSITIONS AND METHODS FOR INCREASING IRON INTAKE IN A MAMMAL', na, 20190054115, 2018, Solvotrin Therapeutics LTD, Patent, SUBMITTED  URL
Sharma R, Quilty F, Gilmer JF, Long A, Byrne AM., Unconjugated secondary bile acids activate the unfolded protein response and induce golgi fragmentation via a src-kinase-dependant mechanism., Oncotarget, 8, (1), 2017, p967 - 978, Journal Article, PUBLISHED  TARA - Full Text  DOI
O'Sullivan S, Wang J, Pigott MT, Docherty N, Boyle N, Lis SK, Gilmer JF, Medina C, Inhibition of matrix metalloproteinase-9 by a barbiturate-nitrate hybrid ameliorates dextran sulphate sodium-induced colitis: effect on inflammation-related genes, British Journal of Pharmacology, 174, (7), 2017, p512 - 524, Journal Article, PUBLISHED  DOI
John Francis Gilmer Mark Ledwidge Pat O'Flynn Shona Harmon Marek Radomski Carlos Medina Martin, 'Compounds with super-aspirin effects', Foley Lardner, 09670223 (Grant), 2017, Patent, GRANTED  URL
Maria Pigott, Intestinal targeting of small molecule MMP and TGR5 ligands for inflammatory bowel disease , TCD, 2017, Notes: [PhD Thesis], Thesis, PUBLISHED
N Glezeva1, C Watson1, J Baugh1, K McDonald1, J Gilmer2, C Martin2, M Santos Martinez2, M Ledwidge1, Association between low-dose aspirin use, monocyte biomarkers, matrix metalloproteinases and outcome in HFpEF, Heart, 2016, 102, 2016, ppA5 , Conference Paper, PUBLISHED  URL
Gavin J, Quilty F, Majer F, Gilsenan G, Byrne A.M, Long A, Radics G, Gilmer J.F, A fluorescent analogue of tauroursodeoxycholic acid reduces ER stress and is cytoprotective, Bioorganic and Medicinal Chemistry Letters, 26, (21), 2016, p5369 - 5372, Notes: [Export Date: 13 January 2017], Journal Article, PUBLISHED  DOI  URL

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Toware Gaseous Mediator Hybrid Drugs in, editor(s)Michael Decker , Design of Hybrid Molecules for Drug Development, Oxford : Elsevier, 2017, pp47-81 , [John F. Gilmer], Book Chapter, PUBLISHED
N Glezeva, C Watson, J Baugh, K McDonald, J Gilmer, C Martin, M Santos Martinez, M Ledwidge, Association between low-dose aspirin use, monocyte biomarkers, matrix metalloproteinases and outcome in HFpEF, BMJ Publishing Group Ltd and British Cardiovascular Society, 102, (supplement 9), 2017, ppA5 , Conference Paper, PUBLISHED
Fran Quilty, "Mechanistic Studies into the Effect of Deoxycholic Acid on Oesophageal Cancer Initiation and Progression", 2016, Notes: [PhD Thesis], Thesis, PUBLISHED
Shivashini Kirthi Jeyarajah, Barry Hall, Mary Hussey, John Gilmer, Jun Wang, Carlos Medina, Deirdre McNamara, Low Infliximab Trough Levels Are Not Predictive of Disease Activity in Clinical Practice, Gastroenterology, 148, (4), 2015, ppS-8Am 65 , Conference Paper, PUBLISHED
S Etzbach, JJ Salomon, F Májer, MN Mohd Najib, CM Lehr, JF Gilmer, C Ehrhardt, Fluorescence-labelled bile acids as novel tools to measure organic anionic transporting polypeptide (OATP) function, AAPS Workshop on Drug Transporters in ADME: From the Bench to the Bedside, Bethesda, MD, 14-16/03/2011, 2011, ppW3020 , Meeting Abstract, PUBLISHED
JJ Salomon, S Etzbach, F Májer, JF Gilmer, CM Lehr, C Ehrhardt, Fluorescent bile acids for the assessment of organic anionic transporting polypeptide (OATP) function, AAPS J, 25th Annual Meeting of the AAPS, Washington, DC, 23-27/10/2011, 13, (S2), 2011, ppT2119 , Meeting Abstract, PUBLISHED


Award Date
Visitng Professor in Medicine Chemistry, University of Wurzburg 2014-
Winner, Big Ideas, Enterprise Ireland for Commercialization in The Life Sciences 2010
i) Enzyme inhibitors . Isosorbide-based inhibitors of butyrylcholinesterase (BuChE) and acetylcholinesterase (AChE): synthesis and biochemistry; the role of BuChE in Alzheimer's disease . Rational design of selective covalent inhibitors of COX-2 . Rational design, synthesis and testing of inhibitors for thyrotropin-releasing hormone-degrading ectoenzyme (TRH-DE) ii) Prodrugs and metabolic hydrolysis . Design and evaluation of aspirin-based antiplatelet agents with reduced gastric toxicity relative to aspirin . Intelligent prodrug carrier systems for targeting corticosteroids to the colon . Exploring metabolic vectors for site specific drug delivery