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Professor Ursula Fearon

Professor of Molecular Rheumatology (Clinical Medicine)

 

Professor of Molecular Rheumatology (School Office - Medicine)

  ANGIOGENESIS   CELL SIGNALLING   CELL-MIGRATION   CELLULAR INVASION   Cytokine signalling   ENERGY-METABOLISM   HYPOXIA   Immunology, Immunotherapy   Mitochondrial function   Rheumatology and rheumatological disorders
 To identify the underlying mechanisms involved in driving the distinct pathogenesis observed in PsA and RA, and to define how these impacts on therapeutic response
 - Identification of molecular signatures of Synovial Inflammation

Igea A, Carvalheiro T, Malvar-Fernández B, Martinez-Ramos S, Rafael-Vidal C, Niemantsverdriet E, Varadé J, Fernández-Carrera A, Jimenez N, McGarry T, Rodriguez-Trillo A, Veale D, Fearon U, Conde C, Pego-Reigosa JM, González-Fernández Á, Reedquist KA, Radstake TRDJ, van der Helm-Van Mil AH, García S., Semaphorin3B plays a central role in serum-induced arthritis model and is reduced in patients with rheumatoid arthritis., Arthritis & rheumatology (Hoboken, N.J.), 2022, Journal Article, PUBLISHED  DOI
Marzaioli V, Canavan M, Floudas A, Flynn K, Mullan R, Veale DJ, Fearon U., CD209/CD14+ Dendritic Cells Characterization in Rheumatoid and Psoriatic Arthritis Patients: Activation, Synovial Infiltration, and Therapeutic Targeting., Frontiers in Immunology, 2022, Journal Article, PUBLISHED
Floudas A, Gorman A, Neto N, Monaghan MG, Elliott Z, Fearon U, Marzaioli V., Inside the Joint of Inflammatory Arthritis Patients: Handling and Processing of Synovial Tissue Biopsies for High Throughput Analysis., Frontiers in medicine, 9, 2022, p830998 , Journal Article, PUBLISHED  DOI
Fearon U, Hanlon MM, Floudas A, Veale DJ., Cellular metabolic adaptations in rheumatoid arthritis and their therapeutic implications. , Nature reviews. Rheumatology, 2022, Journal Article, PUBLISHED  DOI
Clare Cunningham1,2, Sarah Wade1,2, Carl Orr2, Achilleas Floudas1,2, Trudy McGarry1, Siobhan Wade, AChilleas Floudas, Sian Cregan, Ursula Fearon, Douglas J Veale., Serum miRNAs signature in Rheumatoid Arthritis and 'at risk individuals', Frontiers in Immunology, Mar, fimmu.2021.633, 2021, Journal Article, PUBLISHED
Murray K, Floudas A, Murray C, Fabre A, Crown J, Fearon U, Veale D, First use of tofacitinib to treat an immune checkpoint inhibitor-induced arthritis., BMJ, Feb 4;14(2):e238851., 2021, Journal Article, PUBLISHED
McGarry T, Hanlon MM, Marzaioli V, Cunningham CC, Krishna V, Murray K, Hurson C, Gallagher P, Nagpal S, Veale DJ, Fearon U, Rheumatoid arthritis CD14+ monocytes display metabolic and inflammatory dysfunction, a phenotype that precedes clinical manifestation of disease., Clin Transl Immunology, Feb 19;10(1):e1237. , 2021, Journal Article, PUBLISHED
Murray K, Turk M, Alammari Y, Young F, Gallagher P, Saber T, Fearon U, Veale DJ., Long-term remission and biologic persistence rates: 12-year real-world data., Arthritis Res Ther, Jan 13;23(1):25., 2021, Journal Article, PUBLISHED
Murray K, Quinn S, Turk M, O'Rourke A, Molloy E, O'Neill L, Mongey AB, Fearon U, Veale DJ., COVID-19 and rheumatic musculoskeletal disease patients: infection rates, attitudes and medication adherence in an Irish population., Rheumatology, Feb 1;60(2):902-906, 2021, Journal Article, PUBLISHED
Achilleas Floudas, Mary Canavan, Trudy McGarry, Ronan Mullan, Sunil Nagpal, Doug Veale, Ursula Fearon, ACPA status correlates with differential immune profile in patients with Rheumatoid Arthritis, Cells, In press, 2021, Journal Article, PUBLISHED
  

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Rheumatoid Arthritis in, editor(s)John H Stone , Current Diagnosis and Treatment, McGraw Hill, 2021, pp149 - 166, [Douglas Veale, Ursula Fearon], Book Chapter, PUBLISHED