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| Dr Mike Wride obtained a BSc (Hons) in Physiology and Biochemistry with Nutrition from Southampton University, UK in 1990. He then went to the University of Alberta, Edmonton, Alberta, Canada where he obtained his PhD in 1996 in the Department of Physiology under the supervision of Prof Esmond J Sanders. Mike's PhD thesis work was on the role of tumour necrosis factor alpha in embryonic development. During his PhD and subsequent Post-Doc work in Edmonton, Mike became interested in apoptosis in development and, in particular, in the development of the ocular lens, which uses apoptosis signalling pathways in order to clear itself of organelles during development, thereby creating a transparent structure essential for correct vision. In 1998, Mike moved to Prof. Derrick Rancourt's laboratory at the University of Calgary, Alberta, Canada where he carried out work on the identification and characterisation of genes expressed during early embryonic stem (ES) cell differentiation into neurons. This initiated an interest in the use of microarrays in order to carry out global analyses of gene expression. Mike soon began to use microarray analysis to identify genes expressed during lens development, focusing on apoptosis gene expression. In 2002, Mike returned to the UK to join Cardiff University as a Senior Research Associate in the laboratory of Prof. Sir Martin Evans (Nobel Laureate, Physiology or Medicine, 2007) and carried out work identifying genes differentially expressed in the lens during the onset of cataract (opacity of the lens). In 2003, Mike joined the School of Optometry and Vision Sciences in Cardiff as a lecturer and continued his interest in eye development and disease, carrying out further analyses of apoptosis gene expression and function during lens development. Collaboration with colleagues in Cardiff also includes work on cornea differentiation in order to identify stem cell markers and more recently work investigating the role of apoptosis signalling pathways in retinal ganglion cell (RGC) differentiation and dendrite remodelling. Mike joined the Zoology Department at TCD as a lecturer in October 2007 and is the Ocular Development and Neurobiology Research Group leader. |
| Award |
Date |
| The Children's Research Centre, Our Lady's Children's Hospital Crumlin, Dublin (with Prof. Prem Puri, Crumlin Hospital). The Role of Homeobox Genes in the Development of The Zebrafish Enteric Nervous System: Implications For the Molecular Genetic Basis of Hirschsprung’s Disease. |
2009-2012 |
| The Wellcome Trust Biomedical Summer Vacation Scholarship. Gene Expression Analysis following exposure of Stem Cells to Ultrasound in a Standing Wave Trap. |
2009 |
| Ireland-Newfoundland Partnership: Academic Bursary |
2009 |
| National Eye Research Centre (NERC) PhD Studentship (Wride M.A., Morgan J.E. and Albon J; Cardiff). The role of caspases and inhibitors of cell death (IAPs) in retinal ganglion cell (RGC) death and dendritic remodelling. |
2007-2010 |
| BBSRC Research Grant (Morgan J.E., Drexler W, Votruba, M, Wride M.A.; Cardiff): In vitro detection of neuronal programmed cell death by ultrahigh resolution optic coherence tomography |
2007-2009 |
| More Awards and Honours>>> |
| Project title |
The role of inhibitors of apoptosis (IAPs) during chick retinal ganglion cell (RGC) development |
| Summary |
Characterisation of the spatio-temporal pattern of expression of inhibitors of apoptosis (IAPs) during retinal ganglion cell (RGC) development. Characterisation of the functions of selected IAPs in RGC development using in vitro models of RGC differentiation. |
| Funding Agency |
The Government of Saudi Arabia |
| Programme |
Ocular Development and Neurobiology |
| Type of Project |
|
| Date from |
2010 |
| Date to |
present |
| Person Months |
36 |
|
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| Project title |
The Role of Homeobox Genes in the Development of The Zebrafish Enteric Nervous System: Implications For the Molecular Genetic Basis of Hirschsprung’s Disease |
| Summary |
Normal intestinal motility requires coordinated interaction of the enteric nervous system (ENS), smooth muscle cells and interstitial cells of Cajal (ICCs). The ENS is a network of nerve cells and glia that lies within the walls of the gastrointestinal tract. Developmental disorders of the ENS can result in life threatening intestinal obstruction at birth. Hirschsprung’s disease (HSCR, aganglionic megacolon) is the commonest, occurring in 1 in 5000 live births. The primary pathology of HSCR is an absence of ganglion cells in the distal gut which leads to intestinal obstruction, resulting in considerable morbidity and mortality. Development of the ENS requires a number of distinct steps that include neural crest cell migration, colonization of the gut, proliferation, and differentiation into neuronal and glial phenotypes. During the past 15 years, there has been an explosion of information about the genes that control the development of the ENS. The Homeobox (Hox) genes are extremely important in development being involved in patterning the early embryo. In Drosophila, Hox genes have been shown by both molecular and genetic analyses to regulate major events in patterning and specification during development. Here we will use zebrafish as a model system to investigate the role of homeobox genes in ENS development. |
| Funding Agency |
The Children's Research Centre, Our Lady's Children's Hospital Crumlin, Dublin |
| Programme |
Neurobiology |
| Type of Project |
PhD Project: Reshma Dodnath |
| Date from |
April 1, 2009 |
| Date to |
|
| Person Months |
36 |
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Wride M.A., Wormstone I.M. (Eds) , The Ocular Lens: A Classic Model for Development, Physiology and Disease, 2011, -
Notes: [Themed Issue of Philosophical Transactions of the Royal Society B.] |
| Wride M.A., Wormstone I.M., Introduction: The Ocular Lens: A Classic Model for Development, Physiology and Disease. , Philosophical Transactions of the Royal Society B, In Press, (366), 2011, p1190 - 1192 |
| Wride MA, Lens fibre cell differentiation and organelle loss: many paths lead to clarity., Philosophical Transactions of the Royal Society B, 366, 2011, p1219 - 1233 |
Doodnath R, Dervan A, Wride MA, Puri P, Zebrafish: an exciting model for investigating the spatio-temporal pattern of enteric nervous system development, Pediatric Surgery International, 26, 2010, p1217 - 1221
DOI |
Kisiswa L., Albon J., Morgan J.E., Wride M.A., Cellular inhibitor of apoptosis (cIAP1) is down-regulated during retinal ganglion cell (RGC) maturation., Experimental Eye Research, 91, 2010, p739 - 747
Url TARA - Full Text
DOI |
| More Publications>>> |
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Last Updated:16-MAY-2012 |