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Dr. Friedrich Wetterling

Assistant Professor (Electronic & Elect. Engineering)
      
Profile Photo

Dr. Friedrich Wetterling

Assistant Professor (Electronic & Elect. Engineering)

 FRIEDRICH.WETTERLING@tcd.ie

 


Assistant Professor for Biomedical Circuits and Systems at Trinity College and head of The MediCAS Lab, a position anchored at the Department of Electronic and Electrical Engineering within the School of Engineering. He led the radio-frequency and system development of an innovative implantable device for congestive heart failure monitoring at FIRE1 (2016-2024). He was a Marie-Curie Research Fellow at Trinity College where he developed a novel monitoring method for cardiac function using inductively coupled resonators, i.e. radio-frequency cardiography (2013-2015). Prior to that he led the Magnetic Resonance Methods and Imaging group at the Chair for Computer Assisted Clinical Medicine, Heidelberg University (2009-2012) where his team captured the first whole body tomographic image set solely based upon the local sodium concentration in a human. In 2010, he was awarded the Siemens Prize for establishing Sodium-23 Magnetic Resonance Imaging for stroke tissue viability assessment at the annual meeting of the German Medical Physics Association (DGMP) in Freiburg, Germany. He is a member of the International Society for Magnetic Resonance in Medicine (ISMRM). He has authored and co-authored over 40 publications in peer-reviewed scientific journals and conferences papers. And he has authored more than 30 patent applications. Dr. Friedrich Wetterling is head of the Medical Circuits and Systems Lab (MediCAS) at the department of Electronics and Electrical Engineering where he and his team are researching and developing: - #accessible devices that are remotely deployable using portable, wearable, and implantable circuits - #sustainable systems that reduce the need of finite resources such as helium - #meaningful solutions offering physiologically-relevant and accurate measurements to monitor and to manage chronic health conditions
  Magnetic Resonance Imaging (MRI)   Medical Devices   Radio-frequency resonator / coil systems for MRI   Tissue viability imaging after ischaemic stroke   Tissue viability imaging after tumor-therapy   Whole-body sodium-MRI in patients   X-nuclei MRI (i.e. 13C, 19F, 23Na, 31P, 35Cl, 39K)
Project Title
 Smart and wireless optical sensors for intra-vascular monitoring of blood volume in congestive heart failure
From
October 2024
To
September 2026
Summary
Funding Agency
The Naughton Fellowship Committee
Programme
Naughton Faculty Research Accelerator Program
Project Type
Seed
Person Months
12
Project Title
 Unlocking the potential of ultrahigh field 23Na magnetic resonance to quantify tissue sodium content for probing viability of the heart: where physics, biology and medicine meet
From
1 January 2018
To
31 December 2019
Summary
Cardiovascular diseases (CVD) are the leading cause of death with 60% of CVDs associated with coronary artery diseases (CAD). CAD is the major cause of myocardial infarction (MI), commonly known as heart attack, which can be life threatening and places a huge socio-economic burden on the EU. The most widely used therapy for CAD is revascularization, and myocardial viability is a determining factor and predictor for patient outcomes. Magnetic resonance imaging (MRI) has become a mainstay of clinical diagnosis, but so far has seen limited use in the study of the heart. Here I aim to unlock the potential of myocardial viability imaging with physiometabolic MRI to provide a new instrument for the diagnosis and assessment of therapy success of CAD. Therefore I propose a quantitative approach based on MRI of sodium (23Na) that will allow me to observe new features of the working heart, at a level of resolution that will be highly valuable in understanding, finely diagnosing, and designing treatments for CVD. To meet this goal I pursue the development of cutting edge sodium MRI technology. Its capacity for quantitative assessment of sodium tissue content will be validated in model systems and in healthy subjects. The clinical applicability of 23Na MRI for viability imaging will be examined in revascularized MI patients. For this purpose I will leverage the sensitivity gain inherent to ultrahigh field MRI (B0"7.0 T), capitalize on my outstanding expertise in the field of physiometabolic MRI and build on my interdisciplinary skills formed around MRI physics. In this project, this expertise will be taken to the next level to elucidate the progression of sodium concentration in ischemic myocardial tissue. This research will eliminate the main barriers to the study of tissue viability and will open entirely new possibilities for non-invasive, in vivo phenotyping as a tool for individualised medicine tailored to offset a major socio-economic burden on the EU induced by CVD.
Funding Agency
European Commission
Programme
HORIZON-2020 FRAMEWORK PROGRAMM
Project Type
Research Fellowship
Project Title
 A non-invasive deep brain stimulation device
From
2013
To
2014
Summary
Funding Agency
Enterprise Ireland
Programme
Commercialisation Feasibility
Person Months
3
Project Title
 Development of a nuclear magnetic resonance imaging technique for the accurate detection and quantification of tissue sodium concentration in animal models of disease.
From
01/05/2006
To
27/09/2009
Summary
Funding Agency
Science Foundation Ireland
Programme
SFI Research Frontiers Programme
Person Months
40

Details Date From Date To
International Society for Magnetic Resonance in Medicine (ISMRM)
IEEE Engineering in Medicine and Biology Society
IEEE Sensors Council
Aristokleous N, Collopy D , Wetterling F., Sweeney F., O'Cearbhaill E., O"Rourke M., IN SILICO MODELLING OF FLOW-INDUCED COLLAPSE OF BLOOD VESSELS: A COMPARATIVE STUDY OF VOLUME STATUSES, 29th Annual Conference of the Section of Bioengineering of the Royal Academy of Medicine in Ireland (BinI 2024), Belfast, Northern Ireland, 26-27 January 2024, 2024, Conference Paper, PUBLISHED  TARA - Full Text
Wetterling Friedrich, Kittipibul Veraprapas, Fudim Marat, Measurement inaccuracy reported via the Manufacturer and User Facility Device Experience database for an implantable pulmonary artery pressure sensor: recalibration direction and magnitude results, European Heart Journal, European Society of Cardiology, London, 31 August 2024, 45, (Supplement 2), 2024, pp2 , Conference Paper, PUBLISHED  TARA - Full Text
Wetterling Friedrich,Conway Conor, Hunt Shane, Bokde Arun, and Kokarem Anil, Ultra-low field Magnetic Resonance Imaging of the human forearm in the arths Magnetic Field of Dublin, Ireland., British and Irish Chapter of the International Society for Magnetic Resonance in Medicine, Nottingham, UK, 11-13 September 2024, 2024, pp98 - 99, Conference Paper, PUBLISHED  TARA - Full Text
Málek F, Došká" P, Wetterling F, Marešová Z, Reddy V, Neužil P, MONITORING OF VOLUME STATUS USING A NOVEL SENSOR FOR THE ASSESSMENT OF INFERIOR VENA CAVA AREA AND COLLAPSIBILITY IN A PATIENT WITH HFREF RECEIVING ADVANCED HEART FAILURE THERAPIES, Czech Cardiovascular Research and Innovation Days 2023, Prague, Czech Republic, 20-21 November 2023, 2023, pp1 , Conference Paper, PUBLISHED  TARA - Full Text
Málek F, Došká" P, Wetterling F, Marešová Z, Reddy V, Neužil P, HOW INFERIOR VENA CAVA COLLAPSIBILITY INDEX FROM A NOVEL IMPLANTABLE SENSOR CORRELATES WITH ESTIMATED PLASMA VOLUME AND NT-PROBNP: A STUDY IN PATIENTS WITH CHRONIC HEART FAILURE, Czech Cardiovascular Research and Innovation Days 2023, Prague, Czech Republic, 20-21 November 2023, 2023, pp1 , Conference Paper, PUBLISHED  TARA - Full Text
Wetterling F, Sheridan WS, Testani JM, Borlaug BA, Fudim M, Damman K, Gray A, Gaines P, Poloczek M, Madden S, Tucker J, Buxo T, Gaul R, Corcoran L, Sweeney F, Burkhoff D., Safety and performance of a novel implantable sensor in the inferior vena cava under acute and chronic intravascular volume modulation., European journal of heart failure, 25, (5), 2023, p754-763 , Journal Article, PUBLISHED  DOI
Wacker M, Wetterling F, Feczko T, Arkelius K, Arnou A, Lellouche J, Ansar S, Advanced theranostic nanocarrier-mediated delivery of NGF in a combination therapy trigger enhanced recovery after stroke, Journal of Cerebral Blood Flow & Metabolism, BRAIN and BRAIN-PET 2022, Glasgow, Scotland, 28 May - 1 June 2022, 42, (1S), 2022, pp263 - 264, Conference Paper, PUBLISHED
Ivey-Miranda JB, Wetterling F, Gaul R, Sheridan S, Asher JL, Rao VS, Maulion C, Mahoney D, Mebazaa A, Gray AP, Burkhoff D, Cowie MR, Cox ZL, Butler J, Fudim M, McDonald K, Damman K, Borlaug BA, Testani JM., Changes in inferior vena cava area represent a more sensitive metric than changes in filling pressures during experimental manipulation of intravascular volume and tone., European journal of heart failure, 24, (3), 2022, p455-462 , Journal Article, PUBLISHED  DOI
Raikhelkar J, Kebed K, Narang A, Kruse E, Weatherford S, Imamura T., Wetterling F, Nguyen A, Sayer G, Lang R., Uriel N., Inferior Vena Cava Collapsibility Index Assessed by 3D Echocardiography: A Novel Tool for the Assessment of Right Atrial Pressure in Heart Failure Patients, Journal of the American Society of Echocardiography, 32, (6), 2019, pp130 - 131, Conference Paper, PUBLISHED
Mostajeran M, Wetterling F, Blixt FW, Edvinsson L, Ansar S., Acute mitogen-activated protein kinase 1/2 inhibition improves functional recovery and vascular changes after ischaemic stroke in rat-monitored by 9.4 T magnetic resonance imaging., Acta physiologica (Oxford, England), 223, (1), 2018, pe12985 , Journal Article, PUBLISHED  DOI
  

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Hanson S Gifford III, Conor M Hanley, Jessi Johnson, Pablo Martin, Stephen Sheridan, Douglas S Sutton, Fiachra M Sweeney, Friedrich Wetterling, 'Wireless resonant circuit and variable inductance vascular monitoring implants and anchoring structures therefore', USPTO, 2023, 26 March 2024, Foundry Innovation and Research 1 Ltd, Patent, GRANTED
Hanson S Gifford III, Conor M Hanley, Jessi Johnson, Pablo Martin, Shriram Raghunathan, Stephen Sheridan, Douglas S Sutton, Fiachra M Sweeney, Friedrich Wetterling, 'Wireless vascular monitoring implants', USPTO, 10806352, 2020, 24 March 2024, Foundry Innovation & Research1, Ltd.,Dublin(IE), Patent, GRANTED

  


Award Date
AI Ireland award for best use of robotic process automation and cognitive Artificial Intelligence (AI) 2021
Intel Prize at DCU Hackathon for presenting a low cost MRI solution to assess beef quality (as part of the Bó Selecta team) 2015
Enterprise Ireland Commercialization Feasibility Grant (15.000EUR): A non-invasive deep brain stimulation device 2014
Poster Prize (Ultra High Field Symposium, Berlin), Multi-nuclear magnetic resonance imaging at ultra-high magnetic field strength: probing sodium-23, chlorine-35, potassium-39, and phosphorus-31 signals in tissue deprived of arterial blood supply 2013
Summa Cum Laude Merit Award (International Society for Magnetic Resonance in Medicine), 'In vivo Hydrogen-1, Sodium-23, Phosphorus-31, and Potassium-39 Magnetic Resonance Imaging after Middle Cerebral Artery Occlusion' 2012
Summa Cum Laude Merit Award (International Society for Magnetic Resonance in Medicine), 'Temporally-resolved imaging of renal sodium-23 changes after furosemid injection' 2012
Siemens Young Investigator Award (German Society for Medical Physics), 'Sodium Concentration as a Marker for Tissue Viability after Ischaemic Stroke' 2010
Selected member (by research proposal) of the 4th excellence initiative for molecular and disease-related imaging; German Science Foundation (DFG), Aachen, Germany 2010
Selected member (by research proposal) of the 4th excellence initiative "molecular and disease-related imaging" 2010 German research association (DFG), Aachen, Germany 2010
AstraZeneca Award (British Chapter of the International Society for Magnetic Resonance Imaging) for 'outstanding, innovative research with potential utility in medicine or medical research' 2009
Award for the best oral presentation from a young scientist (Association of Physical Scientists in Medicine), 'A Dual RF Resonator System for Sodium MRI' 2008