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Dr. Silvin Knight

Senior Research Fellow (Medical Gerontology)
      
Profile Photo

Dr. Silvin Knight

Senior Research Fellow (Medical Gerontology)

 SILVIN.KNIGHT@tcd.ie

 


Dr Silvin Knight is a Senior Research Fellow and Biostatistician at The Irish Longitudinal Study on Ageing (TILDA), Trinity College Dublin (TCD), where he leads innovative research at the intersection of neurovascular health, ageing, and advanced data analytics. With a multidisciplinary background spanning medical physics, biostatistics, and biomedical engineering, Dr Knight has established himself as a leading expert in quantitative modelling of hemodynamic autoregulation, and data driven applications in healthcare. Dr Knight's current research focuses on quantitative modelling of neurocardiovascular networks using advanced imaging and sensing technologies, including Near-Infrared Spectroscopy (NIRS), Finometer, and Arterial Spin Labelling (ASL) MRI. He has pioneered novel methodologies, such as blood pressure signal entropy, to predict frailty, cognitive decline, and mortality, with findings published in high-impact journals like Neuroimage, Neurobiology of Aging, and Entropy. His work has significant clinical implications, informing early risk stratification and intervention strategies for ageing-related conditions. In addition to his research, Dr Knight chairs the TILDA MRI Research Group, where he mentors early-career researchers and fosters interdisciplinary collaboration. He has co-supervised / mentored numerous MD, MSc, and PhD students, all of whom have gone on to successful careers in academia and clinical practice. His leadership in this group has driven advancements in data-driven predictive modelling of ageing and multimodal neuroimaging analysis. Prior to joining TILDA, Dr Knight's research focused on methodological development for quantitative MRI and ultrasound imaging. During his PhD at Trinity College Dublin (funded by the Irish Cancer Society), he developed innovative techniques to improve the sensitivity and specificity of Dynamic Contrast-Enhanced (DCE) MRI for prostate cancer detection. His work in this area has influenced the design of optimised imaging protocols and contributed to the development of several anthropomorphic phantoms for quality assurance in medical imaging. Dr Knight holds a BSc in Physics (with Medical Physics and Bioengineering) from Technological University Dublin, where he graduated with first-class honours. Before transitioning to physics and biomedical engineering in 2010, he spent over a decade in the design and advertising industry as a graphic designer and project manager. This unique background has equipped him with exceptional skills in communication, visualisation, and project leadership, which he applies to his research and mentorship roles. Dr Knight is also an active contributor to the scientific community, serving as an Associate Editor for the IEEE Journal of Translational Engineering in Health and Medicine since 2022 and a Review Editor for Frontiers in Physiology, Frontiers in Physics, and Frontiers in Network Physiology since 2020. His work has been featured in major media outlets, including The Irish Times, Yahoo!, and MSN, and his public engagement efforts have reached millions through video abstracts and social media campaigns.
Details Date
Associate Editor for The IEEE Journal of Translational Engineering in Health and Medicine (JTEHM) 1/1/2022
Silvin Knight, Eoin Duggan, Feng Xue, Roman Romero-Ortuno, Investigating Skeletal Muscle Pump Function Using Thigh EMG, Thigh NIRS, And Stroke Volume Data In The FRAILMatics Physiological Cohort, Age and Ageing, IGS 2024, Ireland, 53, (Issue Supplement_4), Oxford Academic, 2024, Conference Paper, PUBLISHED  DOI  URL
Toni Mockler, Silvin Knight, Peter Hartley, Emma Connolly, Feng Xue, Eoin Duggan, Roman Romero-Ortuno, Relationship Between Lifestyle Factors and Accelerometery Based Motion Capture Analysis During An Active Stand In Healthy Older Adults, Age and Ageing, IGS 2024, Ireland, 53, (Supplement_4), 2024, Conference Paper, PUBLISHED  DOI  URL
Feng Xue, Silvin Knight, Emma Connolly, Morgana Afonso Shirsath, Louise Newman, Eoin Duggan, Rose Anne Kenny and Roman Romero-Ortuno, Functional Clustering of Systolic Blood Pressure and Frontal Brain Oxygenation During an Active Stand Test in The Irish Longitudinal Study on Ageing (TILDA): A Comparison of Tissue Saturation Index Versus Absolute Oxygenated Hemoglobin Concentration Approaches, IEEE SENSORS JOURNAL, 2024, Journal Article, PUBLISHED  DOI  URL
A., Shirsath M., O'Connor J.D., Boyle R., Newman L., Knight S.P., Hernandez B., Whelan R., Meaney J.F., Kenny R.A., Slower speed of blood pressure recovery after standing is associated with accelerated brain aging: Evidence from The Irish Longitudinal Study on Ageing (TILDA), Cerebral Circulation - Cognition and Behavior, 6, 2024, Journal Article, PUBLISHED  DOI  DOI
Feng Xue, Silvin P. Knight, Emma Connolly, Aisling M. O"Halloran, Morgana Afonso Shirsath, Louise Newman, Eoin Duggan, Rose Anne Kenny, Roman Romero-Ortuno, Were Frailty Identification Criteria Created Equal? A Comparative Case Study on Continuous Non-Invasively Collected Neurocardiovascular Signals during an Active Standing Test in the Irish Longitudinal Study on Ageing (TILDA), Sensors, 24, (2), 2024, p442-, Journal Article, PUBLISHED  TARA - Full Text  DOI  URL
Simon C, Bolton DAE, Meaney JF, Kenny RA, Simon VA, De Looze C, Knight S, Ruddy KL., White matter fibre density in the brain's inhibitory control network is associated with falling in low activity older adults., The European journal of neuroscience, 2024, Journal Article, PUBLISHED  TARA - Full Text  DOI
Emma Connolly, Silvin P. Knight, Eoin Duggan, Siobhan Scarlett, Louise Newman, Mark Cahill, Rose Anne Kenny, Sarah L. Doyle, Roman Romero-Ortuno, Cardiovascular autonomic function and progression of age-related macular degeneration in The Irish Longitudinal Study of Ageing (TILDA), Investigative Ophthalmology & Visual Science, 2024, Journal Article, PUBLISHED  TARA - Full Text  DOI
Hu J, Craig MS, Knight SP, De Looze C, Meaney JF, Kenny RA, Chen X, Chappell MA, Regional changes in cerebral perfusion with age when accounting for changes in gray-matter volume., Magnetic resonance in medicine, 2024, Journal Article, PUBLISHED  DOI
Morgana A. Shirsath , John D. O"Connor , Rory Boyle , Louise Newman , Silvin P. Knight, Belinda Hernandez , Robert Whelan , James F. Meaney, Rose Anne Kenny, Slower speed of blood pressure recovery after standing is associated with accelerated brain aging: Evidence from The Irish Longitudinal Study on Ageing (TILDA), Cerebral Circulation - Cognition and Behavior, 2024, p1-7 , Notes: [doi: 10.1016/j.cccb.2024.100212], Journal Article, PUBLISHED  TARA - Full Text  DOI
Gutiérrez-Zúñiga R, Davis J.R., Boyle R, De Looze C, Meaney J, Whelan R, Kenny R.A., Knight S.P., Romero-Ortuño R, Brain connectivity in frailty: insights from The Irish Longitudinal Study on Ageing (TILDA), Neurobiology of Aging, 2023, Journal Article, PUBLISHED  TARA - Full Text  DOI  URL
  

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