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Personal Information
College Photo Name Senge, Mathias
Main Department Chemistry
College Title Chair of Organic Chemistry
College Tel +353 1 896 8537
Fax +353 1 896 8536
Prof. Senge was born in Silbach, Germany in 1961. After service in the Air Force he studied chemistry in Freiburg, Amherst, Marburg, and Lincoln and graduated from the Philipps Universität Marburg in 1986. After a Ph.D. thesis in plant biochemistry with Prof. Horst Senger in Marburg (1989) and a postdoctoral fellowship with Prof. Kevin M. Smith at UC Davis, he moved to the Freie Universität Berlin and received his habilitation in Organic Chemistry in 1996. From 1996 on he was a Heisenberg fellow at the Freie Universität Berlin and UC Davis and held visiting professorships at Greifswald and Potsdam. In 2002 he was appointed Professor of Organic Chemistry at the Universität Potsdam and since 2005 holds the Chair of Organic Chemistry at Trinity College Dublin. He was the recipient of fellowships from the Studienstiftung des Deutschen Volkes and the Deutsche Forschungsgemeinschaft; recently he was named a Science Foundation Ireland Research Professor. His main interests are the chemistry and biochemistry of tetrapyrroles, photobiology, crystallography, and medicinal and bioorganic chemistry.
Details Date
Over 125 invited presentations at universities, research centers and international scientific meetings.
Membership of Professional Institutions, Associations, Societies
Details Date From Date To
ACS, American Chemical Society
ASP, American Society for Photobiology
ESP, European Society for Photobiology
EPA, European Photochemical Association
EPPM, European Platform of Photomedicine and Photodiagnosis (2008-
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Awards and Honours
Award Date
Fellow, Trinity College Dublin 2006
SFI Fellows - Research Professorship Award (2004-2009) 2004
Heisenberg-Fellowship of the Deutsche Forschungsgemeinschaft (1997-2002) 1997
Habilitation fellowship of the Deutsche Forschungsgemeinschaft (1994-1996) 1994
Post doctoral research fellowship of the Deutsche Forschungsgemeinschaft (1990-1992) 1990
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Language Skill Reading Skill Writing Skill Speaking
English Fluent Fluent Fluent
German Fluent Fluent Fluent
Description of Research Interests
The main research area of my group is synthetic bioorganic chemistry and my interests focus primarily on problems of chemical biology that can be solved with a combination of modern organic synthesis and biological, and physicochemical methods. Special topics are: Bioorganic and biological chemistry; heterocyclic and natural product chemistry; development of new synthetic methods, bioinorganic chemistry; catecholase and cytochrome model reactions; regulation of enzymatic reactions on a molecular level; enantioselective catalysts; medicinal chemistry, esp. photodynamic cancer therapy, porphyrias, malaria, schizophrenia; photobiology; photosynthesis; structure and function relationship in biologically active molecules; structure determination and conformational analysis of natural products and coordination compounds. In addition we have smaller research projects in the area of novel photonics materials and enantioselective oxidation catalysts. The group has many national and international collaborations with groups from industry, medicine, physcial chemistry and structural science and is funded exclusively by external grants.
Research Interests
Biochemistry, metabolism Biomedical sciences Biomolecules, Bioplastics, Biopolymers Biopharmaceutical aspects of drug delivery systems
Bioreactors Catalysis Chemical Biology Chemistry and Health
Conformational analysis of molecules Crystal engineering Crystallography Design and synthesis of drugs
Development of drugs for malaria, Cancer and inflammatory diseases Development, prevention and treatment of mental disease or disorder Drug Development Drug development
Drug development and evaluation Drug discovery Enzymology and catalysis Fine chemicals, dyes and inks
Hetrocyclic chemistry Hydrogen bonding Malaria Medicinal Chemistry
Molecular electronics Neurochemistry and neuropharmacology New materials, supramolecular structures Oesophageal cancer
Optical materials Organic Chemistry Organic chemistry Organometallic chemistry
Orphan drugs Pharmacologically active heterocycles Photobiology Photochemistry and photophysics
Photodynamic Cancer Therapy Photodynamic Therapy Photomedicine Photonic Networks
Photosynthesis Photovoltaic systems, cells and modules manufacturing Plant Biochemistry Plant physiology
Porphyrin Chemistry Pro drug systems Protein chemistry, structure and folding Radiotherapy, Biological response modifiers and chemoprevention
Recognition and targeting Schizophrenia Solid state chemistry Synthesis and new molecules
Research Projects
Project title Tetrapyrroles in Biology, Chemistry, and Medicine
Funding Agency SFI
Programme SFI Fellows - Research Professorship
Type of Project
Date from 2005
Date to 2010
Person Months

Publications and Other Research Outputs
Peer Reviewed
Senge MO, 5,15-Bis(4-pentyl-oxyphen-yl)porphyrin., Acta crystallographica. Section E, Structure reports online, 69, (Pt 7), 2013, po1048
Ryan, A. A. and Senge, M. O. , Synthesis and Functionalization of Triply Fused Porphyrin Dimers, European Journal of Organic Chemistry, 2013, (18), 2013, p3700–3711
Rogers, L.; Majer, F.; Sergeeva, N. N.; Paszko, E.; Gilmer, J. F.; Senge, M. O., Synthesis and biological evaluation of Foscan® bile acid conjugates to target esophageal cancer cells, Bioorganic & Medicinal Chemistry Letters, 23, (9), 2013, p2495–2499.
Zawadzka, M.; Wang, J.; Blau, W. J.; Senge, M. O., Solvent effect on the nonlinear absorption of 5,10-A2B2 meso substituted porphyrins, Photochemical and Photobiological Sciences, 12, 2013, p1811–1823
TARA - Full Text  DOI
Röder, B., Büchner, M., Rückmann, I., Senge, M.O., Correlation of photophysical parameters with macrocycle distortion in porphyrins with graded degree of saddle distortion , Photochemical and Photobiological Sciences, 9, (8), 2010, p1152-1158
TARA - Full Text
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Last Updated:23-SEP-2014