| Staff Details | ||||
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| Personal Information | ||
| Name | Senge, Mathias | |
| Main Department | Chemistry | |
| College Title | Chair of Organic Chemistry | |
| sengem@tcd.ie | ||
| College Tel | +353 1 896 8537 | |
| Web | http://www.tcd.ie/Chemistry/staff/people/mos/main index.htm | |
| Fax | +353 1 896 8536 | |
| Biography | |
| Prof. Senge was born in Silbach, Germany in 1961. After service in the Air Force he studied chemistry in Freiburg, Amherst, Marburg, and Lincoln and graduated from the Philipps Universität Marburg in 1986. After a Ph.D. thesis in plant biochemistry with Prof. Horst Senger in Marburg (1989) and a postdoctoral fellowship with Prof. Kevin M. Smith at UC Davis, he moved to the Freie Universität Berlin and received his habilitation in Organic Chemistry in 1996. From 1996 on he was a Heisenberg fellow at the Freie Universität Berlin and UC Davis and held visiting professorships at Greifswald and Potsdam. In 2002 he was appointed Professor of Organic Chemistry at the Universität Potsdam and since 2005 holds the Chair of Organic Chemistry at Trinity College Dublin. He was the recipient of fellowships from the Studienstiftung des Deutschen Volkes and the Deutsche Forschungsgemeinschaft; recently he was named a Science Foundation Ireland Research Professor. His main interests are the chemistry and biochemistry of tetrapyrroles, photobiology, crystallography, and medicinal and bioorganic chemistry. | |
| Representations |
| Details | Date |
| Over 100 invited presentations at universities, research centers and international scientific meetings. |
| Membership of Professional Institutions, Associations, Societies |
| Details | Date From | Date To |
| ACS, American Chemical Society | ||
| ASP, American Society for Photobiology | ||
| ESP, European Society for Photobiology | ||
| EPA, European Photochemical Association | ||
| EPPM, European Platform of Photomedicine and Photodiagnosis (2008- | ||
| More Memberships>>> | ||
| Awards and Honours | |
| Award | Date |
| SFI Fellows - Research Professorship Award (2004-2009) | 2004 |
| Heisenberg-Fellowship of the Deutsche Forschungsgemeinschaft (1997-2002) | 1997 |
| Habilitation fellowship of the Deutsche Forschungsgemeinschaft (1994-1996) | 1994 |
| Post doctoral research fellowship of the Deutsche Forschungsgemeinschaft (1990-1992) | 1990 |
| Studienabschluss Stipendium des Vereins der chemischen Industrie | 1989 |
| More Awards and Honours>>> | |
| Languages |
| Language | Skill Reading | Skill Writing | Skill Speaking |
| English | Fluent | Fluent | Fluent |
| German | Fluent | Fluent | Fluent |
| Description of Research Interests |
| The main research area of my group is synthetic bioorganic chemistry and my interests focus primarily on problems of chemical biology that can be solved with a combination of modern organic synthesis and biological, and physicochemical methods. Special topics are: Bioorganic and biological chemistry; heterocyclic and natural product chemistry; development of new synthetic methods, bioinorganic chemistry; catecholase and cytochrome model reactions; regulation of enzymatic reactions on a molecular level; enantioselective catalysts; medicinal chemistry, esp. photodynamic cancer therapy, porphyrias, malaria, schizophrenia; photobiology; photosynthesis; structure and function relationship in biologically active molecules; structure determination and conformational analysis of natural products and coordination compounds. In addition we have smaller research projects in the area of novel photonics materials and enantioselective oxidation catalysts. The group has many national and international collaborations with groups from industry, medicine, physcial chemistry and structural science and is funded exclusively by external grants. |
| Research Interests | |||
| Biochemistry, metabolism | Biomedical sciences | Biomolecules, Bioplastics, Biopolymers | Biopharmaceutical aspects of drug delivery systems |
| Bioreactors | Catalysis | Chemical Biology | Chemistry and Health |
| Conformational analysis of molecules | Crystal engineering | Crystallography | Design and synthesis of drugs |
| Development of drugs for malaria, Cancer and inflammatory diseases | Development, prevention and treatment of mental disease or disorder | Drug Development | Drug development |
| Drug development and evaluation | Drug discovery | Enzymology and catalysis | Fine chemicals, dyes and inks |
| Hetrocyclic chemistry | Hydrogen bonding | Malaria | Medicinal Chemistry |
| Molecular electronics | Neurochemistry and neuropharmacology | New materials, supramolecular structures | Oesophageal cancer |
| Optical materials | Organic Chemistry | Organic chemistry | Organometallic chemistry |
| Orphan drugs | Pharmacologically active heterocycles | Photobiology | Photochemistry and photophysics |
| Photodynamic Cancer Therapy | Photodynamic Therapy | Photomedicine | Photonic Networks |
| Photosynthesis | Photovoltaic systems, cells and modules manufacturing | Plant Biochemistry | Plant physiology |
| Porphyrin Chemistry | Pro drug systems | Protein chemistry, structure and folding | Radiotherapy, Biological response modifiers and chemoprevention |
| Recognition and targeting | Schizophrenia | Solid state chemistry | Synthesis and new molecules |
| Research Projects | |
| Project title | Tetrapyrroles in Biology, Chemistry, and Medicine |
| Summary | |
| Funding Agency | SFI |
| Programme | SFI Fellows - Research Professorship |
| Type of Project | |
| Date from | 2005 |
| Date to | 2010 |
| Person Months | |
| Publications |
| Peer Reviewed |
| Oliver B. Locos, Claudia C. Heindl, Ariadna Corral, Mathias O. Senge, Eoin M. Scanlan, Efficient Synthesis of Glycoporphyrins by Microwave-Mediated Click Reactions, European Journal of Organic Chemistry, 2010, (6), 2010, p1026 - 1028 DOI |
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| Krasnikov, SA, Sergeeva, NN, Sergeeva, YN, Senge, MO, Cafolla, AA, Self-assembled rows of Ni porphyrin dimers on the Ag(111) surface, Physical Chemistry Chemical Physics, 12, (25), 2010, p6666-6671 Url TARA - Full Text DOI |
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| Röder, B., Büchner, M., Rückmann, I., Senge, M.O., Correlation of photophysical parameters with macrocycle distortion in porphyrins with graded degree of saddle distortion , Photochemical and Photobiological Sciences, 9, (8), 2010, p1152-1158 Url TARA - Full Text DOI |
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| Senge, M.O., Davis, M, (5,15-Dianthracen-9-yl-10,20-dihexyl-porphyrinato)nickel(II): A planar nickel(II) porphyrin, Acta Crystallographica Section E: Structure Reports Online, 66, (7), 2010, pm790 Url TARA - Full Text DOI |
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| Senge, M.O., Davis, M, Porphyrin (porphine) A neglected parent compound with potential, Journal of Porphyrins and Phthalocyanines, 14, (7), 2010, p557-567 DOI |
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| More Publications>>> | |
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