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Dr. Adriele Prina Mello

Ussher Assistant Professor (Clinical Medicine)
      
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Dr. Adriele Prina Mello

Ussher Assistant Professor (Clinical Medicine)

 prinamea@tcd.ie

 


Adriele Prina-Mello, PhD, is an Ussher Assistant Professor in Translational Nanomedicine, Department of Clinical Medicine at the Trinity Translational Medicine Institute, School of Medicine. AMBER centre Investigator, CRANN Principal Investigator at Trinity College, Dublin. Chair of the working group in Characterization and Toxicology at the European Technology Platform for Nanomedicine. Expert Member of Nanosafety cluster, the EC Task Force in Characterization and European Materials Characterisation Council. Founder and Director of the Laboratory for Biological Characterization of Advanced Materials, the Irish-branch of the European Nanomedicine Characterization Laboratory (EU-NCL), the flagship infrastructure project funded by the European Commission, in partnership with the US-National Cancer Institute Nano Characterization Laboratory)for enabling Translational Nanomedicine. My objective is to drive LBCAM to become a core nanomedicine enabling infrastructure for educational training (e.g., undergraduates, postgraduates) and international collaboration with academia, industry, clinicians and public bodies. Prina-Mello's research interests are focused on the translation of nanotechnology-enabled products (e.g., medical device, medicinal drugs, hybrid products such as theranostics); advanced materials and their multifunctional solutions; device and instrumentation applications into the medical research area as Nanomedicine tools with the potential to become next generation medical standards or standards of care. The key Nanomedicine areas of interest where I have developed expertise are: 1)Nanodiagnostics: advanced in vitro/ in vivo diagnostic and imaging devices and instrumentation. 2) Theranostics and Personalised Medicine: therapeutics based on nanotechnology and multilayered structures for localised and personalised medicine. 3) Regenerative Medicine: biomedical devices and nanotechnology and nanomaterials applied to tissue engineering. 4) Nanocharacterization and Safety: safe-by-design, responsible innovation development and regulatory compliance. Credited with more than 70 peer-review publications, 6 book chapters, 2 Booklets (as editor), 2 Special Issue (as topic editor), 7 invited scientific reviews, > 25 invited lectures, >50 conference proceedings, >100 posters. (all indexed in Google Scholars, Research Gate, or RSS, April 2016) Contributed to educational and learning by lecturing undergraduate students in Medicine and postgraduate Master degrees in Molecular Medicine, Translational Oncology, Pharmaceutical Science. Since 2010 provided mentoring, educational training, and transferable skills to more than 15 students who are now accomplished professionals. Prina-Mello's scientific and teaching international collaborators are the results of the extensive European Commission involvement and research projects activity. Prina-Mello is an active member at TCD of the following: Trinity Cancer committee, AMBER/CRANN Environmental, Health, and Safety (EHS) platform, the TTMI TARGET Radiobiology group, the TTMI outreach committee, the TTMI Health and Safety, the Translational Child Health and Paediatrics forum, the St. James's Intensive Care Unit research group.
  Bioelectromagnetism   Bioengineering   Biomagnetism   Biomaterials   Biomechanics   Biomechanics, Biomedical Engineering   Biomedical Engineering   Biomedical sciences   Biophysics   Bioreactors   Biosensors   Biotechnology   Cell and tissue development   Cell Communication   Cytoskelton, cell division   Intra and intercellular signalling   Mechanical Engineering   Medical Devices Engineering   Microelectronics technology   Multisensory technology, multi sensing   Nano Biotechnology   Nanochemistry   Nano-Materials   NanoMedicine   Nanotechnology   Neurobiology   Stem Cell biology and hematopoiesis   Surface and interface physics   Tissue Culture
Project Title
 SAFETY TESTING IN THE LIFE CYCLE OF NANOTECHNOLOGY-ENABLED MEDICAL TECHNOLOGIES FOR HEALTH
From
1 April 2019
To
31 Mar 2023
Summary
SAFE-N-MEDTECH will build an innovative open access platform to offer companies and reference laboratories, the capabilities, knowhow, networks and services required for the development, testing, assessment, upscaling and market exploitation of nanotechnology-based Medical and Diagnosis Devices. This across the whole Life Cycle of nano-enabled MTs.
Funding Agency
European Union
Programme
Horizon 2020
Project Type
Open Test Bed Innovation
Project Title
 EXpanding Platforms for Efficacious mRNA Therapeutics
From
1 Jun 2019
To
31 may 2023
Summary
EXPERT is to create an off-the-shelf mRNA-delivering nanomedicine platform that is manufactured via a quality-by-design approach that meet the requirements for GMP scaling up and clinical translation.
Funding Agency
European Union
Programme
Horizon 2020
Project Type
RIA
Project Title
 Regulatory Science Framework for Nano(bio)material-based Medical Products and Devices
From
2017
To
2021
Summary
REFINE proposes a Regulatory Science Framework for the risk-benefit assessment of medical products and medical devices that are based on nanomedicines and biomaterials. The heart of our framework is the development of a product-specific Decision Support System that identifies the most efficient way to deliver the data required by regulation by the best-fitting methods. The decision tree will explicate the product's specific regulatory challenges and the priorities of both missing data and missing methods to match these challenges. It will thus allow planning a cost-and time efficient strategy both for necessary measurements and for the advancement of methods. Our approach is aligned with the industrial R&D practice of stage gating.
Funding Agency
European Union
Programme
H2020
Project Type
NMBP
Project Title
 European Nanomedicine Characterisation Laboratory
From
2016
To
2019
Summary
To provide a trans-disciplinary testing infrastructure covering a comprehensive set of preclinical characterisation assays (physical, chemical, in-vitro and in-vivo biological testing) allowing researchers to fully comprehend the bio distribution, metabolism, pharmacokinetics, safety profiles and immunological effects of their Med-NPs.
Funding Agency
European Union
Programme
H2020
Project Type
INFRASTRCUTURE
Project Title
 Risk Management of Biomaterials
From
2017
To
2021
Summary
BIORIMA aims to develop an Integrated Risk Management (IRM) framework for NBM used in ATMP and MD. The BIORIMA IRM framework is a structure upon which the validated tools and methods for materials, exposure, hazard and risk identification/assessment and management are allocated plus a rationale for selecting and using them to manage and reduce the risk for specific NBM used in ATMP and MD.
Funding Agency
European Union
Programme
H2020
Project Type
NMBP

Page 1 of 3
Details Date
Guest Associate Editor in Nanobiotechnology and Nanomedicine - Frontiers in Bioengineering and Biotechnology, Nanobiotechnology Sep 2019
Editorial Board Member of Precision Nanomedicine June 2018
Editorial Board Member of Nature Scientific Reports - Nature Publishers Jan 2018
Academy of NanoGagliato, organising committee Dec-2016
Erasmus Mundus Joint Master Degree "Nanomedicine for Drug Delivery" (NANOMED EMJMD) - associated lecturer Dec 2018
European Commission Expert-advisor for Joint Institute for Innovation Policy (NANODATA project) Dec-2016
NANOFAR associated member for european educational doctorate Sept-2016
Nano World Cancer day - organising committee Dec-2012
European Commission Expert Advisor Task Force Characterization Mar-2016
EuroNanoForum 2013 - International Advisory Group Area Nanomedicine, Healthcare, Nanobiotechnology and Biomaterials Jan-2012
Language Skill Reading Skill Writing Skill Speaking
English Fluent Fluent Fluent
French Basic Basic Basic
Italian Fluent Fluent Fluent
Details Date From Date To
Member of the BioNanoNet, the Austrian research network in the fields of nanotoxicology, sensor technologies and health and safety including (nano-)medicine. 2018 to date
Member of European Technology Platform (ETP) in Nanomedicine 2009 to date
Chair of the Toxicology and Characterisation working group at the European Technology Platform in Nanomedicine (ETPN) 2012 2019
Vice-chairman of Nanodiagnostic Working Group - European Technology Platform in Nanomedicine 2009 2012
Member of the European Society of Molecular Imaging 2011 2015
Member of the Institution of Engineers of Ireland 1998 2008
Member of the European Society of Biomechanics 2004 2010
Member of the European Bioelectromagnetics Association 2004 2008
Membro dell'ordine degli Ingegneri Italiani 1998 2000
Member of the Bioelectromagnetics Society 2005 2006
Zamira V. Díaz"Riascos, Monserrat Llaguno"Munive, Nuria Lafuente-Gómez, Yurena Luengo, Sarah J. Holmes, Jeanne Volatron, Oihane Ibarrola, Sandra Mancilla, Francesca Sarno, José Javier Aguirre, Sarah Razafindrakoto, Paul Southern, Francisco J. Terán, Anna Keogh, Gorka Salas, Adriele Prina"Mello, Juan Carlos Lacal, Ángel del Pozo, Quentin A. Pankhurst, Manuel Hidalgo, Florence Gazeau, Álvaro Somoza, Simó Schwartz, Ibane Abasolo, Preclinical Development of Magnetic Nanoparticles for Hyperthermia Treatment of Pancreatic Cancer, ACS Applied Materials & Interfaces, 17, (2), 2025, p2924 - 2939, p2924-2939 , Journal Article, PUBLISHED  DOI
Soliman, M.G. and Trinh, D.N. and Ravagli, C. and Meleady, P. and Henry, M. and Movia, D. and Doumett, S. and Cappiello, L. and Prina-Mello, A. and Baldi, G. and Monopoli, M.P., Development of a fast and simple method for the isolation of superparamagnetic iron oxide nanoparticles protein corona from protein-rich matrices, Journal of Colloid and Interface Science, 659, 2024, p503-519 , Notes: [cited By 0], Journal Article, PUBLISHED  DOI
Parot, J. and Mehn, D. and Jankevics, H. and Markova, N. and Carboni, M. and Olaisen, C. and Hoel, A.D. and Sigfúsdóttir, M.S. and Meier, F. and Drexel, R. and Vella, G. and McDonagh, B. and Hansen, T. and Bui, H. and Klinkenberg, G. and Visnes, T. and Gioria, S. and Urban-Lopez, P. and Prina-Mello, A. and Borgos, S.E. and Caputo, F. and Calzolai, L., Quality assessment of LNP-RNA therapeutics with orthogonal analytical techniques, Journal of Controlled Release, 367, 2024, p385-401 , Notes: [cited By 0], Journal Article, PUBLISHED  DOI
Ripoll-Viladomiu, I. and Prina-Mello, A. and Movia, D. and Marignol, L., Extracellular vesicles and the †six Rs†in radiotherapy, Cancer Treatment Reviews, 129, (102799), 2024, Notes: [cited By 0], Journal Article, PUBLISHED  DOI
Caputo, F. and Favre, G. and Borchard, G. and Calzolai, L. and Fisicaro, P. and Frejafon, E. and GÃŒnday-TÃŒreli, N. and Koltsov, D. and Minelli, C. and Nelson, B.C. and Parot, J. and Prina-Mello, A. and Zou, S. and Ouf, F.-X., Toward an international standardisation roadmap for nanomedicine, Drug Delivery and Translational Research, 14, (9), 2024, p2578-2588 , Notes: [cited By 1], Journal Article, PUBLISHED  DOI
Moen, A. and Johnsen, H. and Hristozov, D. and Zabeo, A. and Pizzol, L. and Ibarrola, O. and Hannon, G. and Holmes, S. and Debebe Zegeye, F. and Vogel, U. and Prina Mello, A. and Zienolddiny-Narui, S. and Wallin, H., Inflammation related to inhalation of nano and micron sized iron oxides: a systematic review, Nanotoxicology, 2024, Notes: [cited By 0], Journal Article, PUBLISHED  DOI
Simone Marcone, Jolanda Spadavecchia, Memona Khan, Gabriele Vella, Fiona O"Connell, Marzia Pendino, Meghana Menon, Claire Donohoe, Narayanasamy Ravi, John V. Reynolds, Stephen G. Maher, Niamh Lynam"Lennon, Breandán N. Kennedy, Adriele Prina"Mello, Jacintha O"Sullivan, Targeting Radiation Resistance in Oesophageal Adenocarcinoma with Pyrazinib-Functionalised Gold Nanoparticles, Cancers, 16, (23), 2024, p4007 - 4007, p4007-4007 , Journal Article, PUBLISHED  DOI
Gary Hannon, Bethany J. Heaton, Alexander J. Plant-Hately, Christopher David, Neill J. Liptrott, Ainhoa Egizabal, Ana Ayerdi-Izquierdo, Noelia Álvarez, Oihane Ibarrola, Andres Arbona Celaya, Alberto Pérez, Nerea Lazcanoiturburu, Iris Luzuriagaf, Fikirte Debebe Zegeye, Shanbeh Zienolddiny, An Jacobs, Alexandra Van Driessche, Inge Nelissen, Ibane Abasolo, Fernanda Andrade, Nora Ventosa, Elisabet González"Mira, Aida Carreño, Adriele Prina"Mello, Interlaboratory comparison of endotoxin contamination assessment of nanomaterials, Nanoscale, 2024, Journal Article, PUBLISHED  DOI
Maitiú Ó Murchú, Xuehua Lin, Melissa Anne Tutty, Christina Cahill, Ian S. Miller, Lasse Jensen, Adriele Prina"Mello, Niamh Lynam"Lennon, Stephen G. Maher, Helena Kelly, Jacintha O"Sullivan, Enhancing cancer radiotherapy efficacy using NanOx, a novel oxygenating perfluorocarbon nanoemulsion that reverses tumour hypoxia., Cancer Letters, 2024, p217406 - 217406, p217406-217406 , Journal Article, PUBLISHED  DOI
Huber, M.J. and Ivleva, N.P. and Booth, A.M. and Beer, I. and Bianchi, I. and Drexel, R. and Geiss, O. and Mehn, D. and Meier, F. and Molska, A. and Parot, J. and SÞrensen, L. and Vella, G. and Prina-Mello, A. and Vogel, R. and Caputo, F., Physicochemical characterization and quantification of nanoplastics: applicability, limitations and complementarity of batch and fractionation methods, Analytical and Bioanalytical Chemistry, 415, (15), 2023, p3007-3031 , Notes: [cited By 4], Journal Article, PUBLISHED  DOI
  

Page 1 of 25
Adriele Prina-Mello, NANOWOW 6 weeks course, May to June 2018, In:NANOWOW 6 weeks course, 2018, Dublin, Notes: [6 weeks course for Stepaside educate together primary school], Meetings /Conferences Organised, PRESENTED
NANOMED 2018, NANOMED workshop, 3-4 Dec 2018, In:NANOMED workshop, 2018, Pavia, Italy, Notes: [Invited and Keynote ], Meetings /Conferences Organised, PRESENTED
Adriele Prina-Mello, Development of liver 3D model as alternative to animals, Trinity Translational Medicine Institute Seminar, TTMI, TCD Dublin, 24 Apr 2018, 2018, Notes: [Invited ], Oral Presentation, PRESENTED
Adriele Prina-Mello, Characterization in nanomedicine: Lesson learnt from the EUNCL (European Nanomedicine Characterisation Laboratory) and REFINE Project., 3rd Italian-Swedish Workshop on NanoBioMaterials - From safety assessment to biomedical uses, Turin (Italy), 22-23 Mar 2018, 2018, Notes: [Invited Speaker and Chairman], Oral Presentation, PRESENTED
Adriele Prina-Mello, Charles University delegation visit to TCD, 6-7 Nov 2017, In:Charles University, Faculty of Medicine in Hradec Kralove, 2017, Dublin, Notes: [Organiser and TCD main ], Meetings /Conferences Organised, PRESENTED
Adriele Prina-Mello, TCD joint work toward First In Man: Advanced translational work, NANOGAGLIATO 2017, Gagliato (Italy), 25 Jul 2017, 2017, Notes: [Invited talk, chairman, organisers], Oral Presentation, PRESENTED
Adriele Prina-Mello, Exosome and Extracellular Vesicle Characterisation using Nanoparticle Tracking Analysis, NUIG REMEDI seminar, Galway, 1 dec 2016, 2016, Oral Presentation, PRESENTED
Adriele Prina-Mello, MULTIFUNCTIONAL NANOMATERIALS: Regulatory aspects and safe-by-design approach, Special NANO-Course-1 Nanomaterials, Nanotoxicology and Immunomodulation by Nanoparticles, Kazan, Russia, 14-17 Nov 2016, 2016, Notes: [Invited - international], Oral Presentation, PRESENTED
Adriele Prina-Mello, NANOMATERIALS in MEDICINE: Structural And Physical-chemical aspects, Special NANO-Course-1 Nanomaterials, Nanotoxicology and Immunomodulation by Nanoparticles, Kazan, Russia, 14-17 Nov 2016, 2016, Oral Presentation, PRESENTED
Adriele Prina-Mello, Nanotechnology for cancer diagnostics , Cytometry Society of Ireland, TBSI, TCD, Dublin, 8 Nov 2016, 2016, Notes: [Invited], Oral Presentation, PRESENTED

  


Page 1 of 3
Award Date
Malvern Invited Talk at European NanoMedicine 2017 April 2017
FutureFlash! Best EC Project competition - EuroNanoForum 2015 July 2015
M.Sc. in Translational Oncology - Best new postgraduate course award as lecturer April 2014
EuroNanoForum 2013, Poster prize June 2013
Best Toxicology Paper 2012 - Society of Toxicology March 2012
International Academy of Nanomedicine - Second World Congress of Nanomedicine October 2010
Bioelectromagnetics Society and European Bioelectromagnetics Association award 2005
IEI/Medtronic Bioengineering Award Medal 2003
Calgary Award at the World Congress of Biomechanics, Calgary (Canada) 2002
Student award, 5th International Conference on Cellular Engineering, Aachen (Germany) 2001
Prina-Mello's research interests are focused on: 1) Advanced Translational Research of NanoMedicine (from Pre-clinical to Clinical, Precision, Personalised, Targeted nanomedicine), 2) Therapeutics based on nanotechnology and multilayered structures, 3) Theranostics and Personalised Medicine (in vitro/ in vivo diagnostic, imaging and treatment), 4) Dynamic interaction between nano-developed-products and biologically relevant models (nanotoxicology, nanobiocompatibility, nanosafety and nanobiotechnology), 5) Microfluidic systems applied to ultra-sensitive diagnostics (lab-on-a chip) 6) Biomedical devices and Tissue engineering applications of nanotechnology and nanomaterials, 7) Nanomedicine Characterization and Safety 8) In vitro complex models and tissue mimetic 9) Compliance to 3Rs principle 10) Development of Regulatory Science and Policy for nanotechnology-enabled medicine. Additional interests are also in pre-clinical screening, interdisciplinary science and research for nanomedicine and nanotechnology-based medical technology development (e.g., biomaterials, biocompatibility, high throughput and content screening, multiparametric analysys, data mining, bioelectromagnetisms biophysics, biomechanics, single cell assay and cellular engineering).