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Trinity College Dublin

Personal Information
College Photo Name Preston, Roger
Main Department Clinical Medicine
College Title Assistant Professor in Immunology
E-mail prestonr@tcd.ie
College Tel  
 
Biography
Roger Preston obtained his BSc. (Hons) in Molecular Biology from University of Aberdeen, and then completed a MSc. in Bioengineering at the University of Strathclyde. He was awarded his PhD by Imperial College London in 2004. Upon returning to Ireland, his research was funded by a Health Research Board Research Fellowship. He is currently funded by a prestigious Science Foundation Ireland Starting Investigator Research Grant. He is the recipient of research prizes from Haematology Association of Ireland (Scholar Award), Novo Nordisk ('Access-To-Insight' Research Award) and Bayer HealthCare (Hemophilia Program, Early Investigator Award).
 
Membership of Professional Institutions, Associations, Societies
Details Date From Date To
International Society of Thrombosis and Haemostasis 2007
Haematology Association of Ireland 2009 2010
 
Awards and Honours
Award Date
Bayer HealthCare Hemophilia Program - Early Career Investigator Award 2013
Health Research Board Research Fellowship 2006-2009
Science Foundation Ireland Starting Investigator 2009
Haematology Association of Ireland Scholar Award 2010
Novo Nordisk Access-To-Insight Award 2010
 
Languages
Language Skill Reading Skill Writing Skill Speaking
English Fluent Fluent Fluent
French Medium Medium Basic
 
Description of Research Interests
Administration of recombinant versions of endogenous plasma proteins is a common therapeutic approach to hematological and inflammatory disorders, but can be expensive, immunogenic and associated with undesirable side-effects. Dr. Preston’s research seeks to address these deficiencies by generating enhanced recombinant therapeutics through innovative bioengineering of existing plasma proteins. To date, his group has developed a number of unique recombinant mutant plasma proteins possessing enhanced properties with significant therapeutic potential. These novel drug candidates have been created via manipulation of enzymatic activity, protein interaction, substrate recognition and post-translational modification. The ultimate aim of this approach is to develop new treatment approaches for adult and paediatric inflammatory, haemostatic and malignant diseases. Dr. Preston’s research group is currently funded by a combination of charitable, governmental and industrial sources. These include the Paediatric Research in Translational Immunology Program at the National Children’s Research Centre, a Science Foundation Ireland Starting Investigator Award and a Bayer Hemophilia Program Early Career Investigator Award.
 
Research Interests
Blood Diseases Hemophilia Thrombosis
 
Publications and Other Research Outputs
Peer Reviewed
McGrath RT, McKinnon TA, Byrne B, O' Kennedy R, Terraube V, McRae E, Preston RJ, Laffan MA, and O'Donnell JS., Expression of terminal 2-6 linked sialic acid on von Willebrand factor specifically enhances proteolysis by ADAMTS13 Blood, Blood, 115, (13), 2010, p2666-2673
DOI
Bridges DJ, Bunn J, van Mourik JA, Grau G, Preston RJ, Molyneux M, Combes V, O'Donnell JS, de Laat B, Craig A., Rapid activation of endothelial cells enables P. falciparum adhesion to platelet decorated von Willebrand factor strings, Blood, 115, (7), 2010, p1472-1474
DOI
Preston, RJ, Tran, S, Johnson, JA, Ainle, FN, Harmon, S, White, B, Smith, OP, Jenkins, PV, Dahlbäck, B, O'Donnell, JS, Platelet factor 4 impairs the anticoagulant activity of activated protein C., The Journal of Biological Chemistry, 284, (9), 2009, p5869 - 5875
TARA - Full Text
Cunningham, MS, Preston, RJ, O'Donnell, JS, Does antithrombotic therapy improve survival in cancer patients?, Blood Reviews, 23, (3), 2009, p129 - 135
DOI
Preston, RJ, Morse, C, Murden, SL, Brady, SK, O'Donnell, JS, Mumford, AD, The protein C omega-loop substitution Asn2Ile is associated with reduced protein C anticoagulant activity., British Journal of Haematology, 144, (6), 2008, p946 - 953
DOI
More Publications and Other Research Outputs >>>
 

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Last Updated:25-APR-2014