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Dr. Andreea Phelan

Research Fellow (Biochemistry)
      
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Dr. Andreea Phelan

Research Fellow (Biochemistry)

 petrasan@tcd.ie

 


Project Title
 A pilot study to characterise resident memory T cells in the skin of hidradenitis suppurativa patients
From
1st October 2019
To
30th September 2020
Summary
The purpose of this study is to carry out a detailed phenotypical analysis of resident memory T cells in uninvolved and lesional HS skin using state of the art flow cytometry, in order to better understand HS pathogenesis. This study will serve as a pilot study to leverage further funding.
Funding Agency
British Skin Foundation
Programme
Small Grant Award
Project Type
Postdoctorate research fellow
Project Title
 
From
1st July 2019
To
30th June 2020
Summary
Composition of innate lymphoid cell subsets in skin and blood of patients with hidradenitis suppurative and correlation with disease severity and response to treatment
Funding Agency
The city of Dublin skin and cancer hospital charity
Project Title
 Targeting dysregulated bioenergetics in the inflamed rheumatoid arthritis joint
From
February 2016
To
June 2019
Summary
This project aims to: 1.Identify the bioenergetics profile of cells from the joints of RA patients and to correlate the presence of glycolytic markers with disease activity and response to treatment; 2. Determine the role of hypoxia in promoting glycolysis and inflammation in synovial T cells and fibroblasts and 3. Assess the therapeutic potential of compounds targeting glycolysis in RA.
Funding Agency
Health Research Board
Project Type
Postdoctorate Research Fellow
Person Months
41
Project Title
 Functional studies on human γδ T cells and their interactions with dendritic cells and B cells
From
September 2011
To
September 2015
Summary
To investigate the reciprocal activating interactions between human gammadelta T cells, dendritic cells and B cells in healthy individuals and explore their use as immunotherapeutic agents.
Funding Agency
Science foundation Ireland
Project Type
PhD researcher
Person Months
48
Project Title
 Characterisation of the stimulatory properties of synthetic α-galactosylceramide for human invariant natural killer T cells
From
April 2011
To
July 2011
Summary
The aim of this study was to investigate the potential of various glycolipids in stimulating iNKT cells to mediate cytotoxicity, T helper function and cytokine secretion and to identify ligands of iNKT cells with potential for immunotherapy.
Funding Agency
Trinity College Dublin
Project Type
Postgraduate researcher
Person Months
4

Page 1 of 2
Details Date
Oral presentation at the New Horizons in Rheumatology international biennial meeting. Title of the talk: "Targeting cellular metabolism in CD4-stimulated synovial fibroblasts reduces inflammation and joint degradation in rheumatoid arthritis". November 2018
Oral presentation at the annual Irish Society for Immunology meeting. Title of the talk: "Targeting cellular metabolism in CD4-stimulated synovial fibroblasts reduces inflammation and joint degradation in rheumatoid arthritis". August 2018
Oral presentation at an international congress (British Society for Immunology congress). Title of the talk: "Human synovial fibroblasts and CD4 T cells cooperate to promote inflammation in the RA synovial joint". Brighton, UK, December 2017.
Oral presentation at a national meeting (Institute of Molecular Medicine Annual Meeting). Title of the talk: "Human Vγ9Vδ2 T cells induce B cell and DC maturation - applications for cancer immunotherapy". Dublin, November 2014
Oral presentation at a national meeting (Institute of Molecular Medicine Annual Meeting). Title of the talk: "Human Vγ9Vδ2 T cells can selectively promote TH1 or TH2 responses via interactions with dendritic cells or B cells in vitro". November 2013
Oral presentation at a national meeting (School of Medicine Postgraduate research day). Title of the talk: "Reciprocal activating interactions between Vγ9Vδ2 T cells, B cells and dendritic cells". September 2012
Invited talk to the "Rheumatology Seminar Series" held at St. Vincent's University Hospital. Title of the talk: "T cells and synovial fibroblasts cooperate to promote inflammation in the joint". November 2017
Invited talk to the "Immunology Seminar Series" held at St. James's Hospital. Title of the talk: "Functional studies on human γδ T cells and their interactions with dendritic cells and B cells". April 2016
Details Date From Date To
Member of the Research Ethics Committee in the School of Biochemistry and Immuonology Aug 2019 Present
President of the TBSI Postdoc Society 2021-Present. Vice-president 2019-2021. 2019 Present
Postdoctorate representative on the Executive Committee for School of Biochemistry&Immunology 2018 Present
Cluxton D, Petrasca A, Moran B, Fletcher JM, Differential regulation of human Treg and Th17 cells by fatty acid synthesis and glycolysis, Frontiers in Immunology, 10, 2019, p115-, Journal Article, PUBLISHED  TARA - Full Text  DOI
Petrasca A, Melo AM, Breen EP, Doherty DG, Human Vδ3+ γδ T cells induce maturation and IgM secretion by B cells, Immunology Letters, 196, 2018, 126-134 , Journal Article, PUBLISHED  DOI  URL
Melo AM, Zhang L, Dockry EF, Petrasca A, Ghnewa YG, Morrissey ME, O'Reilly C, Bruen R, O'Meara A, Lysaght J, Zhu X, Doherty DG, Novel thioglycoside analogs of α-galactosylceramide stimulate cytotoxicity and preferential Th1 cytokine production by human invariant natural killer T cells, Frontiers in Immunology, 2018, Journal Article, PUBLISHED  TARA - Full Text
Dunne PJ, Maher CO, Freeley M, Petrasca A, Orikiiriza J, Dunne MR, Reidy D, O'Dea S, Loy A, Woo J, Long A, Rogers TR, Mulcahy F, Doherty DG, CD3ε expression defines functionally-distinct subsets of Vδ1 T cells in patients with HIV infection, Frontiers in Immunology, 2018, Journal Article, PUBLISHED
Brennan K, McSharry BP, Keating S, Petrasca A, O'Reilly VP, Keane J, Doherty DG, Gardiner CM, Human Natural Killer cell expression of ULBP2 is associated with a mature functional phenotype., Human immunology, 77, (10), 2016, p876-885 , Journal Article, PUBLISHED  DOI
Petrasca A, Doherty DG, Human Vδ2+ γδ T cells differentially induce maturation, cytokine production, and alloreactive T cell stimulation by dendritic cells and B cells, Frontiers in Immunology, 2014, 650-, Journal Article, PUBLISHED  TARA - Full Text  DOI  URL
Kennedy A, Petrasca A, Doherty DG, Hennessy M, Spiers JP, HIV-1 Tat clade-specific cytokine induction in monocytes/macrophages is not evidenced in total or V"9V"2 T lymphocytes., AIDS (London, England), 28, (1), 2014, p131-3 , Journal Article, PUBLISHED  URL
Murphy N, Petrasca A, Murphy NM, Reilly VO, Evans P, Doherty DG, Zhu XM, Synthesis and immunostimulatory activity of two alpha-S-galactosyl phenyl-capped ceramides, ARKIVOC, 2013, p363-377 , Journal Article, PUBLISHED  URL
  

Andreea Petrasca, Derek G. Doherty, Vδ2 T cells differentially stimulate the production of proinflammatory cytokines by dendritic cells and B cells, Medimond International Proceedings, 15th International Congress of Immunology, Milan, Italy, 22-27 August 2013, edited by Medimond s.r.l. , Monduzzi editore, 2014, pp21 - 24, Conference Paper, PUBLISHED

  


Award Date
Travel Bursary for British Society of Immunology Congress December 2014
I am really passionate about scientific and biomedical research and my background includes immunology, molecular medicine and neuroscience. Specific fields of interest include cell biology,immunology, immunometabolism, translational medicine and oncology.