Skip to main content

Trinity College Dublin, The University of Dublin

Menu Search


Trinity College Dublin By using this website you consent to the use of cookies in accordance with the Trinity cookie policy. For more information on cookies see our cookie policy.

      
Profile Photo

Dr. Ronan O'Toole

Visiting Research Fellow (School of Nursing & Midwifery)
      
Profile Photo

Dr. Ronan O'Toole

Visiting Research Fellow (School of Nursing & Midwifery)

 otooler3@tcd.ie

 


  ANTIMICROBIAL RESISTANCE   Infectious Diseases   MICROBIOLOGY   PHYLOGENETICS   Tuberculosis
Project Title
 Role of Mycobacterium tuberculosis phylogenetic lineage in TB disease in Ireland
From
To
Summary
The objective of this project is to relate Mycobacterium tuberculosis lineage data determined using SNP, LSP and MIRU-24 analyses to patient demographics and disease phenotypes in Ireland. The project is being conducted in collaboration with Prof. Thomas Rogers (Trinity College Dublin), Prof. Joseph Keane (St. James's Hospital, Dublin), and Dr. Margaret Fitzgibbon (Irish Mycobacteria Reference Laboratory).
Project Title
 Determination of phylogenetic lineages of Mycobacterium tuberculosis isolates in New Zealand
From
To
Summary
The objective of the project is to determine the genetic lineages of Mycobacterium tuberculosis present in New Zealand using SNP, LSP and MIRU-24 analyses and to relate the lineage data to transmission, patient demographics, and disease phenotypes. The project is being conducted in collaboration with Dr. Joshua Freeman and Dr. Indira Basu (Auckland City Hospital), and Dr. James Bower (LabPLUS, Auckland District Health Board).
Project Title
 Synthetic gene array analysis for determining the mode of action of unique tuberculosis drugs
From
To
Summary
For the determination of specific cellular pathways targeted by candidate drugs, the applicant has conducted global transposon mutagenesis in Mycobacterium smegmatis. The mutant library has been utilised for the identification of suppressor and enhancer mutations which modulate susceptibility to anti-mycobacterial inhibitors. These data provide information on the mode of action of tuberculosis lead compounds. This project is being conducted in collaboration with Prof. Greg Cook (University of Otago).
Project Title
 Development of a single-target tuberculosis/HIV drug
From
To
Summary
Antagonism and overlapping toxicities between tuberculosis and anti-retroviral drugs pose a significant challenge to control efforts. The aim of this project is to determine whether a single target, dual inhibitor would be feasible in the treatment of HIV/TB co-infections. This project is being conducted in collaboration with Mudassar Altaf (Victoria University of Wellington) and Prof. Ted Baker and Dr. Stephanie Dawes (University of Auckland).

Details Date From Date To
Working Group on New TB Drugs, Stop TB Partnership 2011 present
New Zealand Microbiological Society 2003 present
American Society for Microbiology 1999 present
Society for General Microbiology, UK 1999 present
Gautam S.S, Haug G, Cooley L.A, Mac Aogáin M, O'Toole R.F, Intercontinental translocation of latent multidrug-resistant tuberculosis to Australia demonstrated by whole genome sequencing, Medical Journal of Australia, 210, (5), 2019, p236 - 236.e1, Journal Article, PUBLISHED  DOI  URL
Roycroft E, O'Toole RF, Fitzgibbon MM, Montgomery L, O'Meara M, Downes P, Jackson S, O'Donnell J, Laurenson IF, McLaughlin AM, Keane J, Rogers TR., Molecular epidemiology of multi- and extensively-drug-resistant mycobacterium tuberculosis in ireland, 2001-2014., The Journal of infection, 76, (1), 2018, p55-67 , Journal Article, PUBLISHED  DOI
Leong, K.W.C. and Cooley, L.A. and Anderson, T.L. and Gautam, S.S. and McEwan, B. and Wells, A. and Wilson, F. and Hughson, L. and O'Toole, R.F., Emergence of Vancomycin-Resistant Enterococcus faecium at an Australian Hospital: A Whole Genome Sequencing Analysis, Scientific Reports, 8, (1), 2018, p6274-, Notes: [cited By 1], Journal Article, PUBLISHED  TARA - Full Text  DOI
Leong, K.W.C. and Cooley, L.A. and O'Toole, R.F., Draft genome sequence of new vancomycin-resistant Enterococcus faecium sequence type 1421, Genome Announcements, 6, (20), 2018, pe00438-18 , Notes: [cited By 0], Journal Article, PUBLISHED  TARA - Full Text  DOI
Gautam, S.S. and Aogáin, M.M. and Cooley, L.A. and Haug, G. and Fyfe, J.A. and Globan, M. and O†Toole, R.F., Molecular epidemiology of tuberculosis in Tasmania and genomic characterisation of its first known multi-drug resistant case, PLoS ONE, 13, (2), 2018, p1--, Notes: [cited By 0], Journal Article, PUBLISHED  TARA - Full Text  DOI
O'Toole R.F, Development of a New Genome-Wide MLST Scheme for High-Resolution Typing of Diverse Mycobacterium tuberculosis Complex Strains, EBioMedicine, 34, 2018, p6 - 7, Journal Article, PUBLISHED  TARA - Full Text  DOI  URL
Shastri M.D, Shukla S.D, Chong W.C, Dua K, Peterson G.M, Patel R.P, Hansbro P.M, Eri R, O'Toole R.F, Role of oxidative stress in the pathology and management of human tuberculosis, Oxidative Medicine and Cellular Longevity, 2018, 2018, Journal Article, PUBLISHED  DOI  URL
Hyland I.K, O'Toole R.F, Smith J.A, Bissember A.C, Progress in the Development of Platelet-Activating Factor Receptor (PAFr) Antagonists and Applications in the Treatment of Inflammatory Diseases, ChemMedChem, 13, (18), 2018, p1873 - 1884, Journal Article, PUBLISHED  DOI  URL
O'Toole R.F, Gautam S.S, The host microbiome and impact of tuberculosis chemotherapy, Tuberculosis, 113, 2018, p26 - 29, Journal Article, PUBLISHED  DOI  URL
Roycroft E, O'Toole RF, Fitzgibbon MM, Montgomery L, O'Meara M, Downes P, Jackson S, O'Donnell J, Laurenson IF, McLaughlin AM, Keane J, Rogers TR, Molecular epidemiology of multi and extensively drug-resistant Mycobacterium tuberculosis in Ireland, 2001-2004, Journal of Infection, 76, (1), 2018, p55 - 67, Notes: [ PMID: 29031637], Journal Article, PUBLISHED  DOI
  

Page 1 of 6

  


Tuberculosis, Mycobacterium Genus, Bacterial Phylogenetics, Metagenomics, Infectious Diseases, Molecular Diagnostics, Epidemiology, Healthcare Infection Control, Antibiotic Discovery, Target Validation, Drug Development, Environmental Microbiology, Bacterial Pathogenesis, Signal Transduction, Drug Resistance Mechanisms