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Dr. Mark Ward

Medical Scientist (Histopathology)
      
Profile Photo

Dr. Mark Ward

Medical Scientist (Histopathology)

 


Dr. Mark Ward graduated from Trinity College Dublin in 2012 with a BA (Mod.) in Biochemistry. Following this, he completed his PhD in 2016 in the Department of Pharmacology and Therapeutics in Trinity College Dublin investigating the role of Protein Phosphatase 2A (PP2A) in the regulation of matrix metalloproteinases in liver cancer. His current research focuses on the area of "Liquid Biopsy" and the isolation and molecular characterisation of rare circulating tumour cells (CTCs) and the identification of somatic tumour specific mutations in circulating tumour DNA (ctDNA). His research interests also include the role of platelets/immune cells in mediating cancer metastasis and the mechanisms of tumour associated thrombosis in gynaecological cancers. https://orcid.org/0000-0002-9356-7246
  BREAST CANCER   cancer inflammation   Circulating Tumour Cells   ctDNA   Extracellular vesicles (EVs)   Gynaecological cancer   INFLAMMATION   Inflammation and coagulation syndromes   Liquid Biopsy   METASTASIS   NEUTROPHILS   Ovarian Cancer   OVARIAN VEIN-THROMBOSIS   PLATELETS   THROMBIN
Project Title
 Using liquid biopsy to better understand immunotherapy and antibody"drug conjugates in triple-negative breast cancer
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Summary
Funding Agency
Trinity St James's Cancer Institute

Details Date From Date To
The Irish Society for Gynaecological Oncology (ISGO) 2016 Present
European Association for Cancer Research 2018 Present
Hindes MT, McElligott AM, Best OG, Ward MP, Selemidis S, Miles MA, Nturubika BD, Gregory PA, Anderson PH, Logan JM, Butler LM, Waugh DJ, O'Leary JJ, Hickey SM, Thurgood LA, Brooks DA., Metabolic reprogramming, malignant transformation and metastasis: Lessons from chronic lymphocytic leukaemia and prostate cancer., Cancer letters, 611, 2025, p217441 , Journal Article, PUBLISHED  TARA - Full Text  DOI
LEWIS, F., WARD, M. P., SAADEH, F. A., O'GORMAN, C., MAGUIRE, P. J., BEIRNE, J. P., KAMRAN, W., IBRAHIM, E., NORRIS, L., KELLY, T., HURLEY, S., HENDERSON, B., KANJUGA, M., O'DRISCOLL, L., GATELY, K., ONER, E., SAINI, V. M., CADOO, K., MARTIN, C., O'LEARY, J. J. & O'TOOLE, S. A., A pilot study evaluating the feasibility of enriching and detecting circulating tumour cells from peripheral and ovarian veins in rare epithelial ovarian carcinomas, European Journal of Surgical Oncology, 2025, Journal Article, PUBLISHED
Ward MP, Ibrahim EM, O'Toole SA, Marchocki Z, O'Leary JJ, Saadeh FA, Norris LA., Chemotherapy alters thrombomodulin and factor VIIIc expression resulting in acquired activated protein C resistance and enhanced thrombin generation in cancer associated thrombosis., Thrombosis research, 246, 2024, p109251 , Journal Article, PUBLISHED  DOI
Ward, Mark P., O'Toole, Sharon A., O'Leary, John J., Potential role of the CD39-CD73 ATP-adenosine pathway in platelet mediated dissemination of circulating tumour cells, British Journal of Cancer, 2024, Journal Article, PUBLISHED  DOI
M Saini, Volga, Oner, Ezgi, Ward, Mark P., Hurley, Sinead, Henderson, Brian David, Lewis, Faye, Finn, Stephen P., Fitzmaurice, Gerard J., O'Leary, John J., O'Toole, Sharon, O'Driscoll, Lorraine, Gately, Kathy, A comparative study of circulating tumor cell isolation and enumeration technologies in lung cancer, Molecular Oncology, 2024, Journal Article, PUBLISHED  DOI
Lewis F, Beirne J, Henderson B, Norris L, Cadoo K, Kelly T, Martin C, Hurley S, Kanjuga M, O'Driscoll L, Gately K, Oner E, Saini V, Brooks D, Selemidis S, Kamran W, Haughey N, Maguire P, O'Gorman C, Saadeh FA, Ward MP, O'Leary JJ, O'Toole SA., Unravelling the biological and clinical challenges of circulating tumour cells in epithelial ovarian carcinoma., Cancer letters, 2024, p217279 , Journal Article, PUBLISHED  DOI
Nturubika BD, Logan J, Johnson IRD, Moore C, Li KL, Tang J, Lam G, Parkinson-Lawrence E, Williams DB, Chakiris J, Hindes M, Brooks RD, Miles MA, Selemidis S, Gregory P, Weigert R, Butler L, Ward MP, Waugh DJJ, O'Leary JJ, Brooks DA., Components of the Endosome-Lysosome Vesicular Machinery as Drivers of the Metastatic Cascade in Prostate Cancer., Cancers, 17, (1), 2024, p43 , Journal Article, PUBLISHED  DOI
Bates M, Mohamed BM, Ward MP, Kelly TE, O'Connor R, Malone V, Brooks R, Brooks D, Selemidis S, Martin C, O'Toole S, O'Leary JJ., Circulating tumour cells: The Good, the Bad and the Ugly., Biochim Biophys Acta Rev Cancer, 1878, (2), 2023, p188863 , Journal Article, PUBLISHED  TARA - Full Text  DOI
Mohamed BM, Ward MP, Bates M, Spillane CD, Kelly T, Martin C, Gallagher M, Heffernan S, Norris L, Kennedy J, Saadeh FA, Gleeson N, Brooks DA, Brooks RD, Selemidis S, O'Toole S, O'Leary JJ., Ex vivo expansion of circulating tumour cells (CTCs)., Scientific reports, 13, (1), 2023, p3704 - 3704, Journal Article, PUBLISHED  DOI
Logan JM, Hopkins AM, Martini C, Sorvina A, Tewari P, Prabhakaran S, Huzzell C, Johnson IRD, Hickey SM, Ung BS, Lazniewska J, Brooks RD, Moore CR, Caruso MC, Karageorgos L, Martin CM, O'Toole S, Bogue Edgerton L, Ward MP, Bates M, Selemidis S, Esterman A, Heffernan S, Keegan H, NĂ­ Mhaolcatha S, O'Connor R, Malone V, Carter M, Ryan K, Clarke A, Brady N, Klebe S, Samaratunga H, Delahunt B, Sorich MJ, Moretti K, Butler LM, O'Leary JJ, Brooks DA., Prediction of Prostate Cancer Biochemical and Clinical Recurrence Is Improved by IHC-Assisted Grading Using Appl1, Sortilin and Syndecan-1., Cancers, 15, (12), 2023, p3215 , Journal Article, PUBLISHED  DOI
  

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Mark P. Ward, Bashir M. Mohamed, Laura Kane, Mark Bates, Janina Berghoff, Cathy L. Spillane, Tanya Kelly, John Kennedy, Feras A. Saadeh, Karsten Hokamp, Noreen Gleeson, Orla Sheils, Cara Martin, Michael Gallagher, Sean Hannify, Eric P. Dixon, Sharon A. O'Toole and John J. O'Leary, Influence of platelets and neutrophils on circulating tumour cells, AACR Annual Meeting , Philadelphia, PA, 2020; April 27-28, 80, (16), American Association for Cancer Research, 2020, Poster, PUBLISHED

  


Award Date
IACR Senior Investigator Award 2024
Liquid Biopsy (CTCs, ctDNA, EVs) in cancer, cancer associated thrombosis and platelet/immune cell mediated cancer metastasis.