Skip Trinity Banner Navigation

Skip to main content »

Trinity College Dublin

Personal Information
College Photo Name Mills, Kingston
Main Department Biochemistry
College Title Professor
E-mail kingston.mills@tcd.ie
College Tel +353 1 896 3573
Web http://www.tcd.ie/Biochemistry/research/k_mills.php
Fax +353 1 677 2086
 
Representations
Details Date
Member, Irish Branch Committee of the Society for General Microbiology. 1994-1997
Member, Immunology & Pathology Committee of the Health Research Board. 1994-2000
Irish representative at the International Union of Immunological Societies and the European Federation of Immunology Societies. 1994-1998
Member, Expert Committee on Blood Products and Vaccines of Irish Medicines Board. 1996-2001
Member, WHO International Committee on DNA Vaccines. 1996-present
More Representations>>>
 
Membership of Professional Institutions, Associations, Societies
Details Date From Date To
American Society for Microbiology
International Society for Mucosal Immunology
British Society for Immunology
British and Irish Society for General Microbiology
Biochemical Society
More Memberships>>>
 
Awards and Honours
Award Date
Elected to Fellowship of Trinity College Dublin 2004
Elected to fellowship of The Royal Academy of Medicine in Ireland 1994
Royal Irish Academy Award in Biochemistry 2004
Inaugural Annual Award of Irish Society for Immunology 2002
Awarded Graves Medal and present the 39th Annual Graves Lecture 1999
More Awards and Honours>>>
 
Languages
Language Skill Reading Skill Writing Skill Speaking
English Fluent Fluent Fluent
 
Description of Research Interests
A major interest of my research is to understand the effector immune responses that protect us against infection and cancer and how, when uncontrolled this can lead to autoimmune diseases. I am particularly interested the factors that affect the induction, of the distinct subpopulations of CD4+ T cells, termed Th1, Th2 and T regulatory (Treg) and Th17 cells, and the role of innate immune system, in particular dendritic cells, in directing T cell responses. The work has direct application to the development of new or improved vaccines and includes studies on Bordetella pertussis, Fasciola hepatica, influenza virus and hepatitis C virus. In the last number of years my group has focused on immune regulation and immune modulation by pathogens. This has been made possible through PI and Strategic research cluster (SRC) awards from Science Foundation Ireland. The aims are to examine the role of pathogen-derived molecules in modulating immune responses, with particular reference to the induction, regulation and function of T cell subtypes and the induction and control of inflammatory responses. Our hypothesis is that the study of immunomodulation by microbial pathogens is an ideal approach to understand mechanisms of protective immunity and immunoregulation in vivo and will allow the identification and characterization of novel immunomodulatory molecules with potential as therapies for immune mediated diseases. We have identified molecules capable of specifically suppressing or enhancing immune response that regulate or mediate certain human diseases. The application of this research is the development of new or improved vaccines against infectious diseases, active immunotherapeutics against cancer and anti-inflammatory therapeutics against autoimmune diseases. A recent SFI PI award on ‘the role of regulatory T cell control of pathogenic and effector T cells and their manipulation as potential therapies for human disease’ is focused on the interface between innate and adaptive immunity, specifically how we can manipulate dendritic cells to selectively alter the balance of regulatory (Treg) versus effector (Th1 or Th2) or pathogenic (Th17). Our aim is to design new approaches to treat autoimmunity by enhancing induction of Treg which suppress Th17 cells and to develop new infectious diseases vaccines and cancer immunotherapeutics by enhancing induction of Th1 and Th2 cells, while inhibiting Treg cells.
 
Research Interests
ACELLULAR PERTUSSIS-VACCINE ACTIVATION PATHWAY ANTIGEN Autoimmune Diseases (Multiple Sclerosis, Rheumatoid Arthritis)
BACTERIAL BACTERIAL INFECTION BACTERIAL LIPOPOLYSACCHARIDE BACTERIAL TOXINS
BIODEGRADABLE MICROPARTICLE BLOOD MONONUCLEAR-CELLS BORDETELLA PERTUSSIS CD4+ T CELLS
CELL-MEDIATED-IMMUNITY CHOLERA-TOXIN CYCLIC-AMP CYTOKINE PRODUCTION
CYTOKINES DEMYELINATION ENDOTOXIN EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS
FILAMENTOUS HEMAGGLUTININ GROWTH-FACTOR-BETA HOST-DEFENSE HUMAN DENDRITIC CELLS
HUMAN-IMMUNODEFICIENCY-VIRUS IL-1 IL-1 RECEPTOR IL-1/MAP KINASES
IL-10 IL-12 IL-4 IMMUNE-RESPONSES
IMMUNOSUPPRESSION INFLAMMATION INTERFERON-GAMMA INTERLEUKIN-1
INTERLEUKIN-1 BETA INTERLEUKIN-1 RECEPTOR ANTAGONIST INTERLEUKIN-1 RECEPTORS INTERLEUKIN-1-BETA
INTERLEUKIN-1-BETA MESSENGER-RNA INTERLEUKIN-2 Immunotherapies for Cancer Infectious Diseases
LEUKOCYTE ADHESION MOLECULES LIPOPOLYSACCHARIDE MACROPHAGES MAP KINASE
MONOCLONAL-ANTIBODIES MONOCYTE MULTIPLE-SCLEROSIS MURINE MACROPHAGES
MYELIN BASIC-PROTEIN NF-KAPPA-B NITRIC-OXIDE NITRIC-OXIDE SYNTHASE
PHOSPHORYLATION PROTEINS SEIZURE SIGNAL-TRANSDUCTION
SIGNAL-TRANSDUCTION PATHWAYS SURFACE PROTEIN T LYMPHOCYTES T-CELL ACTIVATION
T-CELLS T-LYMPHOCYTE ACTIVATION TH1 CELL TH1 CELLS
TRANSCRIPTION FACTOR VACCINATION VIRAL-INFECTIONS Vaccines
 
Research Projects
Project title The local immune response to a respiratory pathogen
Summary €38,000
Funding Agency Health Research Board project grant
Programme
Type of Project
Date from 1993
Date to 1996
Person Months


Project title Investigations on the mechanism of immunity to B. pertussis in a murine model
Summary €283,000
Funding Agency Wellcome Trust project grant
Programme
Type of Project
Date from 1994
Date to 1997
Person Months


Project title Programme EVA "Vaccine Delivery systems for the selective induction of cellular immune responses with candidate HIV vaccines
Summary €38,000
Funding Agency EU Biomed-1
Programme
Type of Project
Date from 1994
Date to 1996
Person Months


Project title T cell responses to Bordetella pertussis in children and the development of an acellular pertussis vaccine
Summary €38,000
Funding Agency The Health Research Board project grant
Programme
Type of Project
Date from 1994
Date to 1997
Person Months


Project title Cellular immune responses to HIV
Summary Support for Postdoctoral fellow plus €13,000 for consumables costs
Funding Agency Commonwealth AIDS Research Grants
Programme
Type of Project
Date from 1994
Date to 1995
Person Months


More Research Projects>>>
 
Publications and Other Research Outputs
Peer Reviewed
Jones SA, Mills KH, Harris J., Autophagy and inflammatory diseases., Immunology and Cell Biology, 91, (3), 2013, p250-258
DOI
Galvin, K.C., Dyck, L., Marshall, N.A., Stefanska, A.M., Walsh, K.P., Moran, B., Higgins, S.C., (...), Mills, K.H.G., Blocking retinoic acid receptor-α enhances the efficacy of a dendritic cell vaccine against tumours by suppressing the induction of regulatory T cells, Cancer Immunology, Immunotherapy, 62, (7), 2013, 1273-1282
DOI
Morine, M.J., Toomey, S., McGillicuddy, F.C., Reynolds, C.M., Power, K.A., Browne, J.A., Loscher, C., (...), Roche, H.M., Network analysis of adipose tissue gene expression highlights altered metabolic and regulatory transcriptomic activity in high-fat-diet-fed IL-1RI knockout mice, Journal of Nutritional Biochemistry, 24, (5), 2013, p788-795
Notes: [ ]
DOI
Mills, K.H.G., Dungan, L.S., Jones, S.A., Harris, J., The role of inflammasome-derived IL-1 in driving IL-17 responses, Journal of Leukocyte Biology, 93, (4), 2013, p489-497
DOI
More Publications and Other Research Outputs >>>
 

Log in to the TCD Portal

Contact:helpdesk@tcd.ie
Last Updated:24-APR-2014