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Trinity College Dublin

Personal Information
College Photo Name Mills, Kingston
Main Department Biochemistry
College Title Professor
E-mail kingston.mills@tcd.ie
College Tel +353 1 896 3573
Web http://www.tcd.ie/Biochemistry/research/k_mills.php
Fax +353 1 677 2086
 
Biography
Kingston Mills is Professor of Experimental Immunology, School of Biochemistry and Immunology, Trinity College Dublin (TCD). He is Head of The Centre for the Study of Immunology at Trinity Biomedical Sciences Institute and Theme Champion for Immunology, Inflammation and Infection at TCD. He is a graduate of TCD and trained at as a Postdoctoral Fellow at University College London and the National Institute for Medical Research, Mill Hill, London, before joining the Scientific Staff of NIBSC, Herts, UK. He returned to Ireland in 1993 to take up an academic position at National University of Ireland, Maynooth. He was appointed to a Personal Chair at Trinity College Dublin in 2001 and was Head of the School of Biochemistry and Immunology from 2008-2011. He heads an active research team focusing on T cells in infection, autoimmunity and cancer. He is co-founder of Opsona Therapeutics and TriMod Therapeutics, biotech companies focusing on the development of immunotherapeutics for inflammatory diseases and cancer.
 
Representations
Details Date
Member, Irish Branch Committee of the Society for General Microbiology. 1994-1997
Member, Immunology & Pathology Committee of the Health Research Board. 1994-2000
Irish representative at the International Union of Immunological Societies and the European Federation of Immunology Societies. 1994-1998
Member, Expert Committee on Blood Products and Vaccines of Irish Medicines Board. 1996-2001
Member, WHO International Committee on DNA Vaccines. 1996-2000
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Membership of Professional Institutions, Associations, Societies
Details Date From Date To
American Association of Immunologists 2006-
American Society for Microbiology
International Society for Mucosal Immunology
British Society for Immunology
British and Irish Society for General Microbiology
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Awards and Honours
Award Date
Royal Academy of Medicine in Ireland Doctor award in Respiratory Medicine and best overall paper 2014
Laboratory Scientist of the year and Laboratory of the year, Irish Lab awards 2013
Elected to Fellowship of Trinity College Dublin 2004
Royal Irish Academy Award in Biochemistry 2004
Inaugural Annual Award of Irish Society for Immunology 2002
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Languages
Language Skill Reading Skill Writing Skill Speaking
English Fluent Fluent Fluent
 
Description of Research Interests
A major interest of my research is to understand the effector immune responses that protect us against infection and cancer and how, when uncontrolled this can lead to autoimmune diseases. I am particularly interested the factors that affect the induction, of the distinct subpopulations of CD4+ T cells, termed Th1, Th2 and T regulatory (Treg) and Th17 cells, and the role of innate immune system, in particular dendritic cells, in directing T cell responses. The work has direct application to the development of new or improved vaccines and includes studies on Bordetella pertussis, Fasciola hepatica, influenza virus and hepatitis C virus. In the last number of years my group has focused on immune regulation and immune modulation by pathogens. This has been made possible through PI and Strategic research cluster (SRC) awards from Science Foundation Ireland. The aims are to examine the role of pathogen-derived molecules in modulating immune responses, with particular reference to the induction, regulation and function of T cell subtypes and the induction and control of inflammatory responses. Our hypothesis is that the study of immunomodulation by microbial pathogens is an ideal approach to understand mechanisms of protective immunity and immunoregulation in vivo and will allow the identification and characterization of novel immunomodulatory molecules with potential as therapies for immune mediated diseases. We have identified molecules capable of specifically suppressing or enhancing immune response that regulate or mediate certain human diseases. The application of this research is the development of new or improved vaccines against infectious diseases, active immunotherapeutics against cancer and anti-inflammatory therapeutics against autoimmune diseases. A recent SFI PI award on ‘the role of regulatory T cell control of pathogenic and effector T cells and their manipulation as potential therapies for human disease’ is focused on the interface between innate and adaptive immunity, specifically how we can manipulate dendritic cells to selectively alter the balance of regulatory (Treg) versus effector (Th1 or Th2) or pathogenic (Th17). Our aim is to design new approaches to treat autoimmunity by enhancing induction of Treg which suppress Th17 cells and to develop new infectious diseases vaccines and cancer immunotherapeutics by enhancing induction of Th1 and Th2 cells, while inhibiting Treg cells.
 
Research Interests
ACELLULAR PERTUSSIS-VACCINE ACTIVATION PATHWAY ANTIGEN Autoimmune Diseases (Multiple Sclerosis, Rheumatoid Arthritis)
BACTERIAL BACTERIAL INFECTION BACTERIAL LIPOPOLYSACCHARIDE BACTERIAL TOXINS
BIODEGRADABLE MICROPARTICLE BLOOD MONONUCLEAR-CELLS BORDETELLA PERTUSSIS CD4+ T CELLS
CELL-MEDIATED-IMMUNITY CHOLERA-TOXIN CYTOKINE PRODUCTION CYTOKINES
DEMYELINATION ENDOTOXIN EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS FILAMENTOUS HEMAGGLUTININ
GROWTH-FACTOR-BETA HOST-DEFENSE HUMAN DENDRITIC CELLS HUMAN-IMMUNODEFICIENCY-VIRUS
IL-1 IL-1 RECEPTOR IL-1/MAP KINASES IL-10
IL-12 IL-4 IMMUNE-RESPONSES IMMUNOSUPPRESSION
INFLAMMATION INTERFERON-GAMMA INTERLEUKIN-1 INTERLEUKIN-1 BETA
INTERLEUKIN-1 RECEPTOR ANTAGONIST INTERLEUKIN-1 RECEPTORS INTERLEUKIN-1-BETA INTERLEUKIN-1-BETA MESSENGER-RNA
INTERLEUKIN-2 Immunotherapies for Cancer Infectious Diseases LEUKOCYTE ADHESION MOLECULES
LIPOPOLYSACCHARIDE MACROPHAGES MAP KINASE MONOCLONAL-ANTIBODIES
MONOCYTE MULTIPLE-SCLEROSIS MURINE MACROPHAGES MYELIN BASIC-PROTEIN
NF-KAPPA-B NITRIC-OXIDE PHOSPHORYLATION PROTEINS
SEIZURE SIGNAL-TRANSDUCTION SIGNAL-TRANSDUCTION PATHWAYS SURFACE PROTEIN
T LYMPHOCYTES T-CELL ACTIVATION T-CELLS T-LYMPHOCYTE ACTIVATION
TH1 CELL TH1 CELLS TRANSCRIPTION FACTOR VACCINATION
VIRAL-INFECTIONS Vaccines
 
Research Projects
Project title The local immune response to a respiratory pathogen
Summary €38,000
Funding Agency Health Research Board project grant
Programme
Type of Project
Date from 1993
Date to 1996
Person Months


Project title Investigations on the mechanism of immunity to B. pertussis in a murine model
Summary €283,000
Funding Agency Wellcome Trust project grant
Programme
Type of Project
Date from 1994
Date to 1997
Person Months


Project title Programme EVA "Vaccine Delivery systems for the selective induction of cellular immune responses with candidate HIV vaccines
Summary €38,000
Funding Agency EU Biomed-1
Programme
Type of Project
Date from 1994
Date to 1996
Person Months


Project title T cell responses to Bordetella pertussis in children and the development of an acellular pertussis vaccine
Summary €38,000
Funding Agency The Health Research Board project grant
Programme
Type of Project
Date from 1994
Date to 1997
Person Months


Project title Cellular immune responses to HIV
Summary Support for Postdoctoral fellow plus €13,000 for consumables costs
Funding Agency Commonwealth AIDS Research Grants
Programme
Type of Project
Date from 1994
Date to 1995
Person Months


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Publications and Other Research Outputs
Peer Reviewed
Jones SA, Mills KH, Harris J., Autophagy and inflammatory diseases., Immunology and Cell Biology, 91, (3), 2013, p250-258
DOI
Galvin, K.C., Dyck, L., Marshall, N.A., Stefanska, A.M., Walsh, K.P., Moran, B., Higgins, S.C., (...), Mills, K.H.G., Blocking retinoic acid receptor-α enhances the efficacy of a dendritic cell vaccine against tumours by suppressing the induction of regulatory T cells, Cancer Immunology, Immunotherapy, 62, (7), 2013, 1273-1282
DOI
Morine, M.J., Toomey, S., McGillicuddy, F.C., Reynolds, C.M., Power, K.A., Browne, J.A., Loscher, C., (...), Roche, H.M., Network analysis of adipose tissue gene expression highlights altered metabolic and regulatory transcriptomic activity in high-fat-diet-fed IL-1RI knockout mice, Journal of Nutritional Biochemistry, 24, (5), 2013, p788-795
Notes: [ ]
DOI
Mills, K.H.G., Dungan, L.S., Jones, S.A., Harris, J., The role of inflammasome-derived IL-1 in driving IL-17 responses, Journal of Leukocyte Biology, 93, (4), 2013, p489-497
DOI
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Last Updated:02-SEP-2014